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However, the effect of nimodipine on oxygen exchange in the lungs is insufficiently explored.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study explored nimodipine medication in artificially ventilated patients with aSAH. The data collection period was divided into nimodipine-dependent (ND) and nimodipine-independent (NID) periods. Values for arterial partial pressure of oxygen (PaO<jats:sub>2<\/jats:sub>) and fraction of inspired oxygen (FiO<jats:sub>2<\/jats:sub>) were collected and compared between the periods. Patients were divided in those with lung injury (LI), defined as median Horowitz index (PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>) \u226440 kPa (\u2264300 mmHg), and without and in those with lower respiratory tract infection (LRTI) and without.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 53 out of 150 patients were artificially ventilated, and in 29 patients, the Horowitz index could be compared between ND and NID periods. A linear mixed model showed that during ND period the Horowitz index was 2.3 kPa (95% CI, 1.0\u20133.5 kPa, <jats:italic>P<\/jats:italic>&lt;0.001) lower when compared to NID period. The model suggested that in the presence of LI, ND period is associated with a decrease of the index by 2.8 kPa (95% CI, 1.2\u20134.3 kPa, <jats:italic>P<\/jats:italic>&lt;0.001). The decrease was more pronounced with LRTI than without: 3.4 kPa (95% CI, 0.8\u20136.1 kPa) vs. 2.1 kPa (95% CI, 0.7\u20133.4 kPa), <jats:italic>P<\/jats:italic>=0.011 and <jats:italic>P<\/jats:italic>=0.002, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In patients with LI or LRTI in the context of aSAH, pulmonary function may worsen with nimodipine treatment. The drop of 2 to 3 kPa of the Horowitz index in patients with no lung pathology may not outweigh the benefits of nimodipine. However, in individuals with concomitant lung injury, the effect may be clinically relevant.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00701-021-04837-9","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T23:03:47Z","timestamp":1617750227000},"page":"2715-2721","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of nimodipine on pulmonary function in artificially ventilated patients with aneurysmal subarachnoid hemorrhage"],"prefix":"10.1007","volume":"163","author":[{"given":"Justyna","family":"Lunkiewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Willms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Str\u00e4ssle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagan","family":"Narula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-2022","authenticated-orcid":false,"given":"Carl","family":"Muroi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"4837_CR1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1056\/NEJM198303173081103","volume":"308","author":"G Allen","year":"1983","unstructured":"Allen G, Ahn H, Preziosi T, Battye R, Boone S, Boone S, Chou S, Kelly D, Weir B, Crabbe R, Lavik P, Rosenbloom S, Dorsey F, Ingram C, Mellits D, Bertsch L, Boisvert D, Hundley M, Johnson R, Strom J, Transou C (1983) Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage. 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The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study or from legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}