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An evaluation of the anatomical validity of the display of the DRT with respect to modern stereotactic planning systems and across different tracking environments has not been performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Distinct dMRI and anatomical magnetic resonance imaging (MRI) data of high and low quality from 9 subjects were used. Six subjects had repeated MRI scans and therefore entered the analysis twice. Standardized DICOM structure templates for volume of interest definition were applied in native space for all investigations. For tracking BrainLab Elements (BrainLab, Munich, Germany), two tensor deterministic tracking (FT2), MRtrix IFOD2 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.mrtrix.org\">https:\/\/www.mrtrix.org<\/jats:ext-link>), and a global tracking (GT) approach were used to compare the display of the uncrossed (DRTu) and crossed (DRTx) fiber structure after transformation into MNI space. The resulting streamlines were investigated for congruence, reproducibility, anatomical validity, and penetration of anatomical way point structures.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In general, the DRTu can be depicted with good quality (as judged by waypoints). FT2 (surgical) and GT (neuroscientific) show high congruence. While GT shows partly reproducible results for DRTx, the crossed pathway cannot be reliably reconstructed with the other (iFOD2 and FT2) algorithms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Since a direct anatomical comparison is difficult in the individual subjects, we chose a comparison with two research tracking environments as the best possible \u201cground truth.\u201d FT2 is useful especially because of its manual editing possibilities of cutting erroneous fibers on the single subject level. An uncertainty of 2\u00a0mm as mean displacement of DRTu is expectable and should be respected when using this approach for surgical planning. Tractographic renditions of the DRTx on the single subject level seem to be still illusive.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00701-021-04890-4","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T05:02:36Z","timestamp":1624856556000},"page":"2809-2824","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A detailed analysis of anatomical plausibility of crossed and uncrossed streamline rendition of the dentato-rubro-thalamic tract (DRT(T)) in a commercial stereotactic planning system"],"prefix":"10.1007","volume":"163","author":[{"given":"Volker A.","family":"Coenen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian E.","family":"Sajonz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Reinacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph P.","family":"Kaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Urbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Reisert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"4890_CR1","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.nicl.2018.01.008","volume":"18","author":"H Akram","year":"2018","unstructured":"Akram H, Dayal V, Mahlknecht P et al (2018) Connectivity derived thalamic segmentation in deep brain stimulation for tremor. 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Ethics approval was obtained under no. 528\/15 (Institutional Review board\/Ethics committee of Freiburg University). All subjects volunteered for the scanning procedure and gave informed consent prior to inclusion in the study. Research was performed according to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"VAC receives an ongoing collaborative grant from BrainLab (Munich, Germany). This work was not specifically funded and is based on institutional funds only.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"VAC receives an ongoing collaborative grant from BrainLab (Munich, Germany); he has received travel support and honoraria from Boston Scientific, USA; VAC serves as medical advisor for CorTec, Freiburg, Germany, and CereGate, Munich. BES receives a research grant from CereGate, Hamburg, Germany. PCR receives research support from Else Kr\u00f6ner-Fresenius Foundation (Germany) and Fraunhofer Foundation (Germany). He has received personal honoraria for lectures or advice from Boston Scientific (USA) and Brainlab (Germany) and is consultant for Boston Scientific (USA) and Inomed (Germany). HU has nothing to disclose. MR has nothing to disclose. CPK has nothing to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}