{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:52Z","timestamp":1790856652693,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The definition of chronic adult hydrocephalus encompasses different pathological entities with overlapping characteristics, including long-standing overt ventriculomegaly in adults (LOVA), late-onset idiopathic aqueductal stenosis (LIAS) and idiopathic normal pressure hydrocephalus (iNPH). The aim of our study was to identify preoperative clinical and radiological features peculiar of these diseases providing some pathophysiology inferences on these forms of hydrocephalus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Clinical and radiological preoperative records, type of surgical treatment and clinical outcome of patients with chronic adult hydrocephalus who were surgically treated between 2013 and 2019 were retrospectively reviewed. Univariate and multivariate analyses were performed to evaluate the contribution of each variable to the differential diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 105 patients were included: 18 with LOVA, 23 with LIAS and 64 with iNPH. On multivariate analysis, an enlarged cisterna magna and a more severe ventriculomegaly were associated with the diagnosis of LOVA, while an older age and DESH with iNPH. LIAS patients tend to have an higher prevalence of raised ICP symptoms. Based on that, a clinical and radiological scoring system was developed to distinguish between iNPH and no iNPH cases. A precise cut-off value with a sensitivity of 95.1% and a specificity of 90.6% was identified.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>LOVA, LIAS and iNPH are different forms of chronic adulthood hydrocephalus and present different and peculiar clinical and radiological features, with an impact on the treatment and outcome prediction. The implementation of a clinical-radiological score for differential diagnosis may help the differentiation. Further studies are warranted.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00701-022-05215-9","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T21:03:29Z","timestamp":1651093409000},"page":"1777-1788","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Open-aqueduct LOVA, LIAS, iNPH: a comparative clinical-radiological study exploring the \u201cgrey zone\u201d between different forms of chronic adulthood hydrocephalus"],"prefix":"10.1007","volume":"164","author":[{"given":"Giorgio","family":"Palandri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3286-448X","authenticated-orcid":false,"given":"Alessandro","family":"Carretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"La Corte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Martinoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Albini-Riccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Tonon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Mazzatenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Elder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"issue":"12","key":"5215_CR1","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1007\/s00381-019-04383-x","volume":"35","author":"S Al-Hakim","year":"2019","unstructured":"Al-Hakim S, Schaumann A, Tietze A, Schulz M, Thomale U-W (2019) Endoscopic third ventriculostomy in children with third ventricular pressure gradient and open ventricular outlets on MRI. Childs Nerv Syst 35(12):2319\u20132326","journal-title":"Childs Nerv Syst"},{"key":"5215_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.wneu.2021.02.016","volume":"149","author":"F Bianchi","year":"2021","unstructured":"Bianchi F, Ducoli G, Moriconi F, Chieffo DPR, Anile C, Tamburrini G (2021) Long-standing overt ventriculomegaly in adults and endoscopic third ventriculostomy, the perfect treatment for the proper diagnosis. World Neurosurg 149:104\u2013110","journal-title":"World Neurosurg"},{"issue":"5","key":"5215_CR3","doi-asserted-by":"publisher","first-page":"687","DOI":"10.3171\/jns.1997.87.5.0687","volume":"87","author":"AJ Boon","year":"1997","unstructured":"Boon AJ, Tans JT, Delwel EJ, Egeler-Peerdeman SM, Hanlo PW, Wurzer HA, Avezaat CJ, de Jong DA, Gooskens RH, Hermans J (1997) Dutch normal-pressure hydrocephalus study: prediction of outcome after shunting by resistance to outflow of cerebrospinal fluid. J Neurosurg 87(5):687\u2013693","journal-title":"J Neurosurg"},{"issue":"1","key":"5215_CR4","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1148\/rg.351140038","volume":"35","author":"T Bosemani","year":"2015","unstructured":"Bosemani T, Orman G, Boltshauser E, Tekes A, Huisman TAGM, Poretti A (2015) Congenital abnormalities of the posterior fossa. Radiographics 35(1):200\u2013220","journal-title":"Radiographics"},{"issue":"2","key":"5215_CR5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1053\/j.sult.2016.01.005","volume":"37","author":"WG Bradley","year":"2016","unstructured":"Bradley WG (2016) Magnetic resonance imaging of normal pressure hydrocephalus. Semin Ultrasound CT MR 37(2):120\u2013128","journal-title":"Semin Ultrasound CT MR"},{"key":"5215_CR6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jocn.2018.10.147","volume":"61","author":"K Br\u00e4utigam","year":"2019","unstructured":"Br\u00e4utigam K, Vakis A, Tsitsipanis C (2019) Pathogenesis of idiopathic normal pressure hydrocephalus: a review of knowledge. J Clin Neurosci 61:10\u201313","journal-title":"J Clin Neurosci"},{"issue":"2","key":"5215_CR7","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1136\/jnnp.74.2.222","volume":"74","author":"J Burtscher","year":"2003","unstructured":"Burtscher J, Bartha L, Twerdy K, Eisner W, Benke T (2003) Effect of endoscopic third ventriculostomy on neuropsychological outcome in late onset idiopathic aqueduct stenosis: a prospective study. J Neurol Neurosurg Psychiatry 74(2):222\u2013225","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"5215_CR8","doi-asserted-by":"publisher","first-page":"741","DOI":"10.3171\/2018.8.JNS18119","volume":"132","author":"CL Craven","year":"2019","unstructured":"Craven CL, Ramkumar R, D\u2019Antona L, Thompson SD, Thorne L, Watkins LD, Toma AK (2019) Natural history of ventriculomegaly in adults: a cluster analysis. J Neurosurg 132(3):741\u2013748","journal-title":"J Neurosurg"},{"issue":"1","key":"5215_CR9","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3171\/2017.1.JNS162813","volume":"129","author":"PK Eide","year":"2018","unstructured":"Eide PK (2018) The pathophysiology of chronic noncommunicating hydrocephalus: lessons from continuous intracranial pressure monitoring and ventricular infusion testing. J Neurosurg 129(1):220\u2013233","journal-title":"J Neurosurg"},{"key":"5215_CR10","doi-asserted-by":"crossref","unstructured":"Fukuhara T, Luciano MG (2001) Clinical features of late-onset idiopathic aqueductal stenosis. Surg Neurol 55(3):132\u2013136; discussion 136\u2013137","DOI":"10.1016\/S0090-3019(01)00359-7"},{"key":"5215_CR11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.parkreldis.2019.07.021","volume":"66","author":"G Giannini","year":"2019","unstructured":"Giannini G, Palandri G, Ferrari A et al (2019) A prospective evaluation of clinical and instrumental features before and after ventriculo-peritoneal shunt in patients with idiopathic normal pressure hydrocephalus: the Bologna PRO-Hydro study. Parkinsonism Relat Disord 66:117\u2013124","journal-title":"Parkinsonism Relat Disord"},{"key":"5215_CR12","unstructured":"Giordan E, Palandri G, Lanzino G, Murad MH, Elder BD (2018) Outcomes and complications of different surgical treatments for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis. J Neurosurg Nov 1:1\u201313"},{"issue":"1","key":"5215_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12987-021-00259-y","volume":"18","author":"LM Green","year":"2021","unstructured":"Green LM, Wallis T, Schuhmann MU, Jaeger M (2021) Intracranial pressure waveform characteristics in idiopathic normal pressure hydrocephalus and late-onset idiopathic aqueductal stenosis. Fluids Barriers CNS 18(1):25","journal-title":"Fluids Barriers CNS"},{"key":"5215_CR14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1743-8454-7-18","volume":"7","author":"M Hashimoto","year":"2010","unstructured":"Hashimoto M, Ishikawa M, Mori E, Kuwana N (2010) Study of INPH on neurological improvement (SINPHONI) Diagnosis of idiopathic normal pressure hydrocephalus is supported by MRI-based scheme: a prospective cohort study. Cerebrospinal Fluid Res 7:18","journal-title":"Cerebrospinal Fluid Res"},{"issue":"4","key":"5215_CR15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1600-0404.2012.01677.x","volume":"126","author":"P Hellstr\u00f6m","year":"2012","unstructured":"Hellstr\u00f6m P, Klinge P, Tans J, Wikkels\u00f8 C (2012) A new scale for assessment of severity and outcome in iNPH. Acta Neurol Scand 126(4):229\u2013237","journal-title":"Acta Neurol Scand"},{"key":"5215_CR16","unstructured":"Hellwig D, Grotenhuis JA, Tirakotai W, Riegel T, Schulte DM, Bauer BL, Bertalanffy H (2005) Endoscopic third ventriculostomy for obstructive hydrocephalus. Neurosurg Rev 28(1):1\u201334; discussion 35\u201338"},{"key":"5215_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.clineuro.2016.10.017","volume":"151","author":"J Hong","year":"2016","unstructured":"Hong J, Barrena BG, Lollis SS, Bauer DF (2016) Surgical management of arrested hydrocephalus: case report, literature review, and 18-month follow-up. Clin Neurol Neurosurg 151:79\u201385","journal-title":"Clin Neurol Neurosurg"},{"issue":"4","key":"5215_CR18","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s10143-017-0813-4","volume":"40","author":"G Ib\u00e1\u00f1ez-Botella","year":"2017","unstructured":"Ib\u00e1\u00f1ez-Botella G, Gonz\u00e1lez-Garc\u00eda L, Carrasco-Brenes A, Ros-L\u00f3pez B, Arr\u00e1ez-S\u00e1nchez M\u00c1 (2017) LOVA: the role of endoscopic third ventriculostomy and a new proposal for diagnostic criteria. Neurosurg Rev 40(4):605\u2013611","journal-title":"Neurosurg Rev"},{"issue":"3","key":"5215_CR19","doi-asserted-by":"publisher","first-page":"E3","DOI":"10.3171\/2016.6.FOCUS16193","volume":"41","author":"AM Isaacs","year":"2016","unstructured":"Isaacs AM, Bezchlibnyk YB, Yong H, Koshy D, Urbaneja G, Hader WJ, Hamilton MG (2016) Endoscopic third ventriculostomy for treatment of adult hydrocephalus: long-term follow-up of 163 patients. Neurosurg Focus 41(3):E3","journal-title":"Neurosurg Focus"},{"issue":"11","key":"5215_CR20","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1007\/s00330-008-1044-4","volume":"18","author":"K Ishii","year":"2008","unstructured":"Ishii K, Kanda T, Harada A, Miyamoto N, Kawaguchi T, Shimada K, Ohkawa S, Uemura T, Yoshikawa T, Mori E (2008) Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus. Eur Radiol 18(11):2678\u20132683","journal-title":"Eur Radiol"},{"issue":"5","key":"5215_CR21","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3171\/2008.10.JNS17667","volume":"110","author":"MD Jenkinson","year":"2009","unstructured":"Jenkinson MD, Hayhurst C, Al-Jumaily M, Kandasamy J, Clark S, Mallucci CL (2009) The role of endoscopic third ventriculostomy in adult patients with hydrocephalus. J Neurosurg 110(5):861\u2013866","journal-title":"J Neurosurg"},{"issue":"6","key":"5215_CR22","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.3171\/2015.6.JNS15162","volume":"124","author":"H Kageyama","year":"2016","unstructured":"Kageyama H, Miyajima M, Ogino I, Nakajima M, Shimoji K, Fukai R, Miyake N, Nishiyama K, Matsumoto N, Arai H (2016) Panventriculomegaly with a wide foramen of Magendie and large cisterna magna. J Neurosurg 124(6):1858\u20131866","journal-title":"J Neurosurg"},{"issue":"2","key":"5215_CR23","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000068053","volume":"38","author":"U Kehler","year":"2003","unstructured":"Kehler U, Gliemroth J (2003) Extraventricular intracisternal obstructive hydrocephalus\u2013a hypothesis to explain successful 3rd ventriculostomy in communicating hydrocephalus. Pediatr Neurosurg 38(2):98\u2013101","journal-title":"Pediatr Neurosurg"},{"issue":"3","key":"5215_CR24","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/ene.13555","volume":"25","author":"K Kockum","year":"2018","unstructured":"Kockum K, Lilja-Lund O, Larsson E-M, Rosell M, S\u00f6derstr\u00f6m L, Virhammar J, Laurell K (2018) The idiopathic normal-pressure hydrocephalus Radscale: a radiological scale for structured evaluation. Eur J Neurol 25(3):569\u2013576","journal-title":"Eur J Neurol"},{"issue":"4","key":"5215_CR25","doi-asserted-by":"publisher","first-page":"e0232275","DOI":"10.1371\/journal.pone.0232275","volume":"15","author":"K Kockum","year":"2020","unstructured":"Kockum K, Virhammar J, Riklund K, S\u00f6derstr\u00f6m L, Larsson E-M, Laurell K (2020) Diagnostic accuracy of the iNPH Radscale in idiopathic normal pressure hydrocephalus. PLoS One 15(4):e0232275","journal-title":"PLoS One"},{"key":"5215_CR26","doi-asserted-by":"crossref","unstructured":"Krauss JK, Droste DW, Vach W, Regel JP, Orszagh M, Borremans JJ, Tietz A, Seeger W (1996) Cerebrospinal fluid shunting in idiopathic normal-pressure hydrocephalus of the elderly: effect of periventricular and deep white matter lesions. Neurosurgery 39(2):292\u2013299; discussion 299\u2013300","DOI":"10.1097\/00006123-199608000-00011"},{"issue":"1","key":"5215_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000111149","volume":"25","author":"Y Kubo","year":"2008","unstructured":"Kubo Y, Kazui H, Yoshida T, Kito Y, Kimura N, Tokunaga H, Ogino A, Miyake H, Ishikawa M, Takeda M (2008) Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus. Dement Geriatr Cogn Disord 25(1):37\u201345","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"2","key":"5215_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1600-0404.1999.tb00662.x","volume":"99","author":"A Larsson","year":"1999","unstructured":"Larsson A, Stephensen H, Wikkels\u00f8 C (1999) Adult patients with \u201casymptomatic\u201d and \u201ccompensated\u201d hydrocephalus benefit from surgery. Acta Neurol Scand 99(2):81\u201390","journal-title":"Acta Neurol Scand"},{"issue":"12","key":"5215_CR29","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.2176\/nmc.oa.2013-0367","volume":"54","author":"M Locatelli","year":"2014","unstructured":"Locatelli M, Draghi R, DI Cristofori A, Carrabba G, Zavanone M, Pluderi M, Spagnoli D, Rampini P (2014) Third ventriculostomy in late-onset idiopathic aqueductal stenosis treatment: a focus on clinical presentation and radiological diagnosis. Neurol Med Chir (Tokyo) 54(12):1014\u20131021","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"3","key":"5215_CR30","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s00701-020-04699-7","volume":"163","author":"P Mantovani","year":"2021","unstructured":"Mantovani P, Giannini G, Milletti D et al (2021) Anterior callosal angle correlates with gait impairment and fall risk in iNPH patients. Acta Neurochir (Wien) 163(3):759\u2013766","journal-title":"Acta Neurochir (Wien)"},{"issue":"3","key":"5215_CR31","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1515\/bmte.2002.47.3.54","volume":"47","author":"U Meier","year":"2002","unstructured":"Meier U (2002) The grading of normal pressure hydrocephalus. Biomed Tech (Berl) 47(3):54\u201358","journal-title":"Biomed Tech (Berl)"},{"issue":"11","key":"5215_CR32","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2176\/nmc.52.775","volume":"52","author":"E Mori","year":"2012","unstructured":"Mori E, Ishikawa M, Kato T et al (2012) Guidelines for management of idiopathic normal pressure hydrocephalus: second edition. Neurol Med Chir (Tokyo) 52(11):775\u2013809","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"4","key":"5215_CR33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1136\/jnnp.69.4.531","volume":"69","author":"N Morota","year":"2000","unstructured":"Morota N, Watabe T, Inukai T, Hongo K, Nakagawa H (2000) Anatomical variants in the floor of the third ventricle; implications for endoscopic third ventriculostomy. J Neurol Neurosurg Psychiatry 69(4):531\u2013534","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"5215_CR34","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/BF00301248","volume":"12","author":"S Oi","year":"1996","unstructured":"Oi S, Sato O, Matsumoto S (1996) Neurological and medico-social problems of spina bifida patients in adolescence and adulthood. Child\u2019s Nervous System 12(4):181\u2013187","journal-title":"Child\u2019s Nervous System"},{"issue":"6","key":"5215_CR35","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3171\/jns.2000.92.6.0933","volume":"92","author":"S Oi","year":"2000","unstructured":"Oi S, Shimoda M, Shibata M, Honda Y, Togo K, Shinoda M, Tsugane R, Sato O (2000) Pathophysiology of long-standing overt ventriculomegaly in adults. J Neurosurg 92(6):933\u2013940","journal-title":"J Neurosurg"},{"issue":"12","key":"5215_CR36","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.1007\/s00701-021-04983-0","volume":"163","author":"G Palandri","year":"2021","unstructured":"Palandri G, Carretta A, La Corte E, Mazzatenta D, Conti A (2021) Longstanding overt ventriculomegaly in adults (LOVA) with patent aqueduct: surgical outcome and etiopathogenesis of a possibly distinct form of chronic hydrocephalus. Acta Neurochir (Wien) 163(12):3343\u20133352","journal-title":"Acta Neurochir (Wien)"},{"issue":"4","key":"5215_CR37","first-page":"E6","volume":"22","author":"HL Rekate","year":"2007","unstructured":"Rekate HL (2007) Longstanding overt ventriculomegaly in adults: pitfalls in treatment with endoscopic third ventriculostomy. Neurosurg Focus 22(4):E6","journal-title":"Neurosurg Focus"},{"key":"5215_CR38","doi-asserted-by":"crossref","unstructured":"Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM (2005) Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery 57(3 Suppl):S4\u201316; discussion ii-v","DOI":"10.1227\/01.NEU.0000168185.29659.C5"},{"key":"5215_CR39","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0022-3476(61)80133-9","volume":"58","author":"RW Schick","year":"1961","unstructured":"Schick RW, Matson DD (1961) What is arrested hydrocephalus? J Pediatr 58:791\u2013799","journal-title":"J Pediatr"},{"issue":"8","key":"5215_CR40","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1136\/jnnp.48.8.799","volume":"48","author":"RD Torkelson","year":"1985","unstructured":"Torkelson RD, Leibrock LG, Gustavson JL, Sundell RR (1985) Neurological and neuropsychological effects of cerebral spinal fluid shunting in children with assumed arrested (\u201cnormal pressure\u201d) hydrocephalus. J Neurol Neurosurg Psychiatry 48(8):799\u2013806","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5215_CR41","doi-asserted-by":"publisher","first-page":"e30","DOI":"10.1016\/j.wneu.2021.08.068","volume":"156","author":"F Tuniz","year":"2021","unstructured":"Tuniz F, Fabbro S, Piccolo D, Vescovi MC, Bagatto D, Cramaro A, Skrap M (2021) Long-standing overt ventriculomegaly in adults (LOVA): diagnostic aspects, CSF dynamics with lumbar infusion test and treatment options in a consecutive series with long-term follow-up. World Neurosurg 156:e30\u2013e40","journal-title":"World Neurosurg"},{"issue":"1","key":"5215_CR42","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00701-016-2998-7","volume":"159","author":"R Ved","year":"2017","unstructured":"Ved R, Leach P, Patel C (2017) Surgical treatment of long-standing overt ventriculomegaly in adults (LOVA). Acta Neurochir (Wien) 159(1):71\u201379","journal-title":"Acta Neurochir (Wien)"},{"issue":"1","key":"5215_CR43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3171\/2013.8.JNS13575","volume":"120","author":"J Virhammar","year":"2014","unstructured":"Virhammar J, Laurell K, Cesarini KG, Larsson E-M (2014) The callosal angle measured on MRI as a predictor of outcome in idiopathic normal-pressure hydrocephalus. J Neurosurg 120(1):178\u2013184","journal-title":"J Neurosurg"},{"issue":"6","key":"5215_CR44","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1001\/archneur.1966.00470180083009","volume":"15","author":"HA Wilkinson","year":"1966","unstructured":"Wilkinson HA, LeMay M, Drew JH (1966) Adult aqueductal stenosis. Arch Neurol 15(6):643\u2013648","journal-title":"Arch Neurol"},{"key":"5215_CR45","doi-asserted-by":"publisher","first-page":"105366","DOI":"10.1016\/j.clineuro.2019.05.014","volume":"183","author":"L Xiao","year":"2019","unstructured":"Xiao L, Xu C, Liu Y, Dong L, Wei F, Wang L, Li D (2019) The surgical results of endoscopic third ventriculostomy in long-standing overt ventriculomegaly in adults with papilledema. Clin Neurol Neurosurg 183:105366","journal-title":"Clin Neurol Neurosurg"},{"issue":"6","key":"5215_CR46","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1002\/1522-2586(200012)12:6<808::AID-JMRI3>3.0.CO;2-N","volume":"12","author":"WT Yuh","year":"2000","unstructured":"Yuh WT, Zhu M, Taoka T, Quets JP, Maley JE, Muhonen MG, Schuster ME, Kardon RH (2000) MR imaging of pituitary morphology in idiopathic intracranial hypertension. J Magn Reson Imaging 12(6):808\u2013813","journal-title":"J Magn Reson Imaging"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-022-05215-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00701-022-05215-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-022-05215-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T06:07:19Z","timestamp":1658470039000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00701-022-05215-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["5215"],"URL":"https:\/\/doi.org\/10.1007\/s00701-022-05215-9","relation":{},"ISSN":["0942-0940"],"issn-type":[{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]},"assertion":[{"value":"6 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The prospective PRO-HYDRO study was approved by the Ethics Review Board of our Institute (Cod. CE: 14131, 23\/02\/2015.). Ethics committee approval was waived for the retrospective observational part of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients enrolled in the prospective PRO-HYDRO study gave informed consent to the use of their clinical records for research. Informed consent was waived for the retrospective observational part of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}