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Misinterpretations of the clinical and imaging findings are common. Clinical manifestations depend on the location of the inflammatory lesion and on compression of neural structures leading to functional deficits. A dural biopsy is commonly needed for a definitive diagnosis. Immunomodulatory therapy is considered the therapy of choice.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Four patients with IgG4-related hypertrophic pachymeningitis were identified over a 5-year period. Patient-related characteristics including age, preoperative workup, signs and symptoms of patients, and diagnostic procedures were evaluated. Furthermore, the surgical treatment and 5-year follow-up outcomes were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were two adults and two adolescents (mean age 32\u00a0years; range 15 to 67\u00a0years). Two patients were male, and two were female. No history of disease was known in any of the patients. Clinical symptoms were epilepsy (<jats:italic>n<\/jats:italic>\u2009=\u20092), ataxia and nausea (<jats:italic>n<\/jats:italic>\u2009=\u20091), and facial nerve palsy (<jats:italic>n<\/jats:italic>\u2009=\u20091). MR imaging studies showed contrast enhancing lesions in the temporal region in two patients, and in the cerebellar region in the other two patients. Subtotal resection was performed in two instances and a biopsy via a suboccipital retrosigmoid approach was obtained in the other two patients. Histochemical and immunohistochemical investigations revealed an IgG 4 disease in all of these patients. Immunomodulatorry therapy led to clinical stability during follow-up of 5\u00a0years in all four cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The diagnosis of IgG4-related hypertrophic pachymeningitis is challenging, but is of great relevance as treatment differs significantly from other forms of pachymeningitis and a specific therapeutic approach may avoid long-term neurological complications. Our series contributes to a better clinical characterization of this rare disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00701-022-05340-5","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T03:38:26Z","timestamp":1660707506000},"page":"2781-2787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["IgG4-related hypertrophic pachymeningitis with tumor-like intracranial and intracerebral lesions"],"prefix":"10.1007","volume":"164","author":[{"given":"Majid","family":"Esmaeilzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mete","family":"Dadak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oday","family":"Atallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"M\u00f6hn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Skripuletz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozbeh","family":"Banan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim K.","family":"Krauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"5340_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s11940-017-0450-9","volume":"19","author":"B Baptista","year":"2017","unstructured":"Baptista B, Casian A, Gunawardena H, D\u2019Cruz D, Rice CM (2017) Neurological manifestations of IgG4-related disease. 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