{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:11:24Z","timestamp":1790082684345,"version":"4.0.1"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Cancer Institute","award":["F30 CA250122"],"award-info":[{"award-number":["F30 CA250122"]}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM65841"],"award-info":[{"award-number":["T32 GM65841"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mayo Clinic Medical Scientist Training Program"},{"name":"Mayo Clinic Center for Regenerative Medicine"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"DOI":"10.1007\/s00701-022-05413-5","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T04:36:01Z","timestamp":1668746161000},"page":"935-945","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hybrid tumors with perineurioma components: a systematic review of the literature and illustrative case"],"prefix":"10.1007","volume":"165","author":[{"given":"Karina A.","family":"Lenartowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dileep D.","family":"Monie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly K.","family":"Amrami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0443-7763","authenticated-orcid":false,"given":"Robert J.","family":"Spinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"5413_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.anndiagpath.2013.12.005","volume":"18","author":"A Agaimy","year":"2014","unstructured":"Agaimy A (2014) Microscopic intraneural perineurial cell proliferations in patients with neurofibromatosis type 1. Ann Diagn Pathol 18:95\u201398. https:\/\/doi.org\/10.1016\/j.anndiagpath.2013.12.005","journal-title":"Ann Diagn Pathol"},{"key":"5413_CR2","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1097\/PAI.0b013e31820b9c5d","volume":"19","author":"A Agaimy","year":"2011","unstructured":"Agaimy A, Michal M (2011) Hybrid schwannoma-perineurioma of the gastrointestinal tract: a clinicopathologic study of 2 cases and reappraisal of perineurial cells in gastrointestinal schwannomas. Appl Immunohistochem Mol Morphol 19:454\u2013459. https:\/\/doi.org\/10.1097\/PAI.0b013e31820b9c5d","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"5413_CR3","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1038\/ng.3688","volume":"48","author":"S Agnihotri","year":"2016","unstructured":"Agnihotri S, Jalali S, Wilson MR, Danesh A, Li M, Klironomos G, Krieger JR, Mansouri A, Khan O, Mamatjan Y (2016) The genomic landscape of schwannoma. Nat Genet 48:1339\u20131348","journal-title":"Nat Genet"},{"key":"5413_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/DAD.0b013e3181639288","volume":"30","author":"WI Al-Daraji","year":"2008","unstructured":"Al-Daraji WI (2008) Granular perineurioma: the first report of a rare distinctive subtype of perineurioma. Am J Dermatopathol 30:163\u2013168","journal-title":"Am J Dermatopathol"},{"key":"5413_CR5","doi-asserted-by":"publisher","first-page":"804","DOI":"10.17826\/cumj.491823","volume":"44","author":"EK Bagir","year":"2019","unstructured":"Bagir EK, Acikalin A, Gonlusen G, Zorludemir S, Deveci MA (2019) Hybrid peripheral nerve sheath tumors. Cukurova Med J 44:804\u2013810. https:\/\/doi.org\/10.17826\/cumj.491823","journal-title":"Cukurova Med J"},{"key":"5413_CR6","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/nature08733","volume":"463","author":"R Bajpai","year":"2010","unstructured":"Bajpai R, Chen DA, Rada-Iglesias A, Zhang J, Xiong Y, Helms J, Chang C-P, Zhao Y, Swigut T, Wysocka J (2010) CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature 463:958\u2013962","journal-title":"Nature"},{"key":"5413_CR7","doi-asserted-by":"publisher","first-page":"e888","DOI":"10.4317\/jced.57035","volume":"12","author":"ML Bergamini","year":"2020","unstructured":"Bergamini ML, Noberto LP, Torres GA, Soares HA, Martins F, Costa AL, de Souza SO, Braz-Silva PH (2020) Primary intra-osseous hybrid Schwannoma-Perineurioma in the mandible. J Clin Exp Dent 12:e888\u2013e891. https:\/\/doi.org\/10.4317\/jced.57035","journal-title":"J Clin Exp Dent"},{"key":"5413_CR8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00256-019-03264-3","volume":"49","author":"SM Broski","year":"2020","unstructured":"Broski SM, Littrell LA, Howe BM, Folpe AL, Wenger DE (2020) Extraneural perineurioma: CT and MRI imaging characteristics. Skeletal Radiol 49:109\u2013114. https:\/\/doi.org\/10.1007\/s00256-019-03264-3","journal-title":"Skeletal Radiol"},{"key":"5413_CR9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1034\/j.1600-0560.2003.00108.x","volume":"30","author":"C Canales-Ibarra","year":"2003","unstructured":"Canales-Ibarra C, Magarinos G, Olsoff-Pagovich P, Ortiz-Hidalgo C (2003) Cutaneous sclerosing perineurioma of the digits: an uncommon soft-tissue neoplasm. Report of two cases with immunohistochemical analysis. J Cutan Pathol 30:577\u2013581","journal-title":"J Cutan Pathol"},{"key":"5413_CR10","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.ciresp.2018.06.022","volume":"97","author":"F Carboni","year":"2019","unstructured":"Carboni F, Valle M, Covello R (2019) Gastric hybrid schwannoma\/perineurioma. Cir Esp (Engl Ed) 97:292\u2013294. https:\/\/doi.org\/10.1016\/j.ciresp.2018.06.022","journal-title":"Cir Esp (Engl Ed)"},{"key":"5413_CR11","first-page":"163","volume":"147","author":"MA C\u00e1rdenas-Escudero","year":"2011","unstructured":"C\u00e1rdenas-Escudero MA, Shuchleib-Chaba S, Muruchi-Garr\u00f3n GW, de Le\u00f3n-Bojorge B, Ortiz-Hidalgo C (2011) A 33 year old woman with a six-year history of slight thoracic-abdominal pain. Gac Med Mex 147:163\u2013168","journal-title":"Gac Med Mex"},{"key":"5413_CR12","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1097\/PAS.0000000000001169","volume":"42","author":"JM Carter","year":"2018","unstructured":"Carter JM, Wu Y, Blessing MM, Folpe AL, Thorland EC, Spinner RJ, Jentoft ME, Wang C, Baheti S, Niu Z (2018) Recurrent genomic alterations in soft tissue perineuriomas. Am J Surg Pathol 42:1708\u20131714","journal-title":"Am J Surg Pathol"},{"key":"5413_CR13","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.prp.2014.10.014","volume":"211","author":"LT Chow","year":"2015","unstructured":"Chow LT (2015) Primary intraosseous hybrid nerve sheath tumor of femur: a hitherto undescribed occurrence in bone with secondary aneurysmal bone cyst formation resulting in pathological fracture. Pathol Res Pract 211:409\u2013414. https:\/\/doi.org\/10.1016\/j.prp.2014.10.014","journal-title":"Pathol Res Pract"},{"key":"5413_CR14","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/s41379-021-00783-0","volume":"34","author":"BC Dickson","year":"2021","unstructured":"Dickson BC, Antonescu CR, Demicco EG, Leong DI, Anderson ND, Swanson D, Zhang L, Fletcher CDM, Hornick JL (2021) Hybrid schwannoma-perineurioma frequently harbors VGLL3 rearrangement. Mod Pathol 34:1116\u20131124. https:\/\/doi.org\/10.1038\/s41379-021-00783-0","journal-title":"Mod Pathol"},{"key":"5413_CR15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12885-017-3350-1","volume":"17","author":"NU Din","year":"2017","unstructured":"Din NU, Ahmad Z, Abdul-Ghafar J, Ahmed R (2017) Hybrid peripheral nerve sheath tumors: report of five cases and detailed review of literature. BMC Cancer 17:8. https:\/\/doi.org\/10.1186\/s12885-017-3350-1","journal-title":"BMC Cancer"},{"key":"5413_CR16","doi-asserted-by":"publisher","unstructured":"Emanuel P, Pertsemlidis DS, Gordon R, Xu R (2006) Benign hybrid perineurioma-schwannoma in the colon. A case report. Ann Diagn Pathol 10:367\u2013370. https:\/\/doi.org\/10.1016\/j.anndiagpath.2005.11.004","DOI":"10.1016\/j.anndiagpath.2005.11.004"},{"key":"5413_CR17","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1093\/ajcp\/103.6.696","volume":"103","author":"TS Emory","year":"1995","unstructured":"Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins R (1995) Intraneural perineurioma: a clonal neoplasm associated with abnormalities of chromosome 22. Am J Clin Pathol 103:696\u2013704","journal-title":"Am J Clin Pathol"},{"key":"5413_CR18","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1016\/j.wneu.2021.02.099","volume":"149","author":"MC Everson","year":"2021","unstructured":"Everson MC, Pendleton C, Jack MM, Smith BW, Carter JM, Spinner RJ (2021) Sporadic malignant perineurioma: a rare diagnosis among malignant peripheral nerve sheath tumors. World Neurosurg 149:e36\u2013e41","journal-title":"World Neurosurg"},{"key":"5413_CR19","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1046\/j.1365-2559.1998.00419.x","volume":"32","author":"M Feany","year":"1998","unstructured":"Feany M, Anthony D, Fletcher C (1998) Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge. Histopathology 32:405\u2013410","journal-title":"Histopathology"},{"key":"5413_CR20","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1097\/00000478-199712000-00005","volume":"21","author":"JF Fetsch","year":"1997","unstructured":"Fetsch JF, Miettinen M (1997) Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults. Am J Surg Pathol 21:1433\u20131442","journal-title":"Am J Surg Pathol"},{"key":"5413_CR21","unstructured":"Fletcher C, Bridge J, Hogendoorn P, Mertens F (2013) WHO classification of tumors of soft tissue and bone. vol Volume 5, 4th Edition edn."},{"key":"5413_CR22","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/00000478-199702000-00005","volume":"21","author":"C Giannini","year":"1997","unstructured":"Giannini C, Scheithauer BW, Jenkins RB, Erlandson RA, Perry A, Borell TJ, Hoda RS, Woodruff JM (1997) Soft-tissue perineurioma: evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol 21:164\u2013173","journal-title":"Am J Surg Pathol"},{"key":"5413_CR23","doi-asserted-by":"publisher","unstructured":"Goyal-Honavar A, Gupta A, Chacko G, Chacko AG (2021) Trigeminal hybrid nerve sheath tumor - a case report and literature review. Br J Neurosurg 1\u20134. https:\/\/doi.org\/10.1080\/02688697.2020.1867061","DOI":"10.1080\/02688697.2020.1867061"},{"key":"5413_CR24","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1002\/path.2513","volume":"217","author":"KH Hallor","year":"2009","unstructured":"Hallor KH, Sciot R, Staaf J, Heidenblad M, Rydholm A, Bauer HC, \u00c5str\u00f6m K, Domanski HA, Meis JM, Kindblom LG (2009) Two genetic pathways, t (1; 10) and amplification of 3p11\u201312, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions. J Pathol: J Pathological Soc Great Britain Ireland 217:716\u2013727","journal-title":"J Pathol: J Pathological Soc Great Britain Ireland"},{"key":"5413_CR25","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1097\/PAS.0b013e31824d3155","volume":"36","author":"A Harder","year":"2012","unstructured":"Harder A, Wesemann M, Hagel C, Schittenhelm J, Fischer S, Tatagiba M, Nagel C, Jeibmann A, Bohring A, Mautner V-F (2012) Hybrid neurofibroma\/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients. Am J Surg Pathol 36:702\u2013709","journal-title":"Am J Surg Pathol"},{"key":"5413_CR26","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/pin.12073","volume":"63","author":"T Hayashi","year":"2013","unstructured":"Hayashi T, Hirose T, Nishimura Y, Fukuoka J, Kishikawa M (2013) Hybrid schwannoma\/perineurioma of the spinal nerve: multifocal occurrence, and recurrence as an intraneural perineurioma. Pathol Int 63:368\u2013373. https:\/\/doi.org\/10.1111\/pin.12073","journal-title":"Pathol Int"},{"key":"5413_CR27","doi-asserted-by":"publisher","first-page":"313","DOI":"10.2350\/10-06-0843-cr.1","volume":"14","author":"BD Hayes","year":"2011","unstructured":"Hayes BD, O\u2019Sullivan MJ (2011) Intranodal hybrid benign nerve sheath tumor. Pediatr Dev Pathol 14:313\u2013317. https:\/\/doi.org\/10.2350\/10-06-0843-cr.1","journal-title":"Pediatr Dev Pathol"},{"key":"5413_CR28","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/bpa.12055","volume":"23","author":"FL Heras","year":"2013","unstructured":"Heras FL, Martuza R, Caruso P, Rincon S, Stemmer-Rachamimov A (2013) 24-Year-old woman with an internal auditory canal mass hybrid peripheral nerve sheath tumor with schwannoma\/perineurioma components. Brain Pathol 23:361\u2013362. https:\/\/doi.org\/10.1111\/bpa.12055","journal-title":"Brain Pathol"},{"issue":"Supplement 1","key":"5413_CR29","doi-asserted-by":"publisher","first-page":"s156","DOI":"10.1007\/s00428-018-2422-1","volume":"473","author":"T Hirose","year":"2018","unstructured":"Hirose T, Kobayashi A, Nobusawa S, Jimbo N (2018) Hybrid schwannoma\/perineurioma is subclassified into mixed cellu-lar and combined tumour types. Virchows Arch 473(Supplement 1):s156. https:\/\/doi.org\/10.1007\/s00428-018-2422-1","journal-title":"Virchows Arch"},{"key":"5413_CR30","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1097\/pai.0000000000000896","volume":"29","author":"T Hirose","year":"2021","unstructured":"Hirose T, Kobayashi A, Nobusawa S, Jimbo N (2021) Hybrid schwannoma\/perineurioma: morphologic variations and genetic profiles. Appl Immunohistochem Mol Morphol 29:433\u2013439. https:\/\/doi.org\/10.1097\/pai.0000000000000896","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"5413_CR31","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1097\/00000478-199811000-00007","volume":"22","author":"T Hirose","year":"1998","unstructured":"Hirose T, Scheithauer BW, Sano T (1998) Perineurial malignant peripheral nerve sheath tumor (MPNST): a clinicopathologic, immunohistochemical, and ultrastructural study of seven cases. Am J Surg Pathol 22:1368\u20131378","journal-title":"Am J Surg Pathol"},{"key":"5413_CR32","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1097\/PAS.0b013e3181accc6c","volume":"33","author":"JL Hornick","year":"2009","unstructured":"Hornick JL, Bundock EA, Fletcher CD (2009) Hybrid schwannoma\/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol 33:1554\u20131561. https:\/\/doi.org\/10.1097\/PAS.0b013e3181accc6c","journal-title":"Am J Surg Pathol"},{"key":"5413_CR33","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1097\/01.pas.0000154130.87219.2c","volume":"29","author":"JL Hornick","year":"2005","unstructured":"Hornick JL, Fletcher CD (2005) Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol 29:859\u2013865","journal-title":"Am J Surg Pathol"},{"key":"5413_CR34","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1097\/01.pas.0000155166.86409.d2","volume":"29","author":"JL Hornick","year":"2005","unstructured":"Hornick JL, Fletcher CD (2005) Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol 29:845\u2013858","journal-title":"Am J Surg Pathol"},{"key":"5413_CR35","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1046\/j.0007-0963.2001.04612.x","volume":"146","author":"HY Huang","year":"2002","unstructured":"Huang HY, Sung MT (2002) Sclerosing perineuriomas affecting bilateral hands. Br J Dermatol 146:129\u2013133","journal-title":"Br J Dermatol"},{"key":"5413_CR36","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/0022-510X(64)90011-5","volume":"1","author":"JDG Imagin\u00e1rio","year":"1964","unstructured":"Imagin\u00e1rio JDG, Coelho B, Tome F, Luis MS (1964) N\u00e9vrite interstitielle hypertrophique monosymptomatique. J Neurol Sci 1:340\u2013347","journal-title":"J Neurol Sci"},{"key":"5413_CR37","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1684\/ejd.2014.2353","volume":"24","author":"Y Inatomi","year":"2014","unstructured":"Inatomi Y, Ito T, Nagae K, Yamada Y, Kiyomatsu M, Nakano-Nakamura M, Uchi H, Oda Y, Furue M (2014) Hybrid perineurioma-neurofibroma in a patient with neurofibromatosis type 1, clinically mimicking malignant peripheral nerve sheath tumor. Eur J Dermatol 24:412\u2013413. https:\/\/doi.org\/10.1684\/ejd.2014.2353","journal-title":"Eur J Dermatol"},{"key":"5413_CR38","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/pin.13034","volume":"71","author":"CS Jang","year":"2021","unstructured":"Jang CS, Chuang IC (2021) Orbital hybrid schwannoma\/perineurioma: a case presentation. Pathol Int 71:109\u2013111. https:\/\/doi.org\/10.1111\/pin.13034","journal-title":"Pathol Int"},{"key":"5413_CR39","doi-asserted-by":"publisher","first-page":"e90","DOI":"10.1097\/dad.0000000000000532","volume":"38","author":"D Kacerovska","year":"2016","unstructured":"Kacerovska D, Michal M, Kazakov DV (2016) Hybrid epithelioid schwannoma\/perineurioma. Am J Dermatopathol 38:e90-92. https:\/\/doi.org\/10.1097\/dad.0000000000000532","journal-title":"Am J Dermatopathol"},{"key":"5413_CR40","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1097\/DAD.0b013e31827e2917","volume":"35","author":"D Kacerovska","year":"2013","unstructured":"Kacerovska D, Michal M, Kuroda N, Tanaka A, Sima R, Denisjuk N, Kreuzberg B, Ricarova R, Kazakov DV (2013) Hybrid peripheral nerve sheath tumors, including a malignant variant in type 1 neurofibromatosis. Am J Dermatopathol 35:641\u2013649. https:\/\/doi.org\/10.1097\/DAD.0b013e31827e2917","journal-title":"Am J Dermatopathol"},{"key":"5413_CR41","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1097\/PAS.0000000000000899","volume":"41","author":"Y-C Kao","year":"2017","unstructured":"Kao Y-C, Ranucci V, Zhang L, Sung Y-S, Athanasian EA, Swanson D, Dickson BC, Antonescu CR (2017) Recurrent BRAF gene rearrangements in myxoinflammatory fibroblastic sarcomas, but not hemosiderotic fibrolipomatous tumors. Am J Surg Pathol 41:1456","journal-title":"Am J Surg Pathol"},{"key":"5413_CR42","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1046\/j.1440-1827.1999.00948.x","volume":"49","author":"S Karaki","year":"1999","unstructured":"Karaki S, Mochida J, Lee YH, Nishimura K, Tsutsumi Y (1999) Low-grade malignant perineurioma of the paravertebral column, transforming into a high-grade malignancy. Pathol Int 49:820\u2013825","journal-title":"Pathol Int"},{"key":"5413_CR43","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1111\/j.1440-1827.2012.02857.x","volume":"62","author":"F Kawakami","year":"2012","unstructured":"Kawakami F, Hirose T, Kimoto A, Komori T, Itoh T (2012) Plexiform perineurioma of the lip: a case report and review of literature. Pathol Int 62:704\u2013708","journal-title":"Pathol Int"},{"issue":"4","key":"5413_CR44","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1177\/1066896906293417","volume":"14","author":"DV Kazakov","year":"2006","unstructured":"Kazakov DV, Magro G, Orlov AY, Shelekhova KV, Matsko DE, Spagnolo DV, Michal M (2006) Benign Schwannoma with perineurioma-like areas: a clinicopathologic study of 11 cases. Int J Surg Pathol 14(4):320\u2013325. https:\/\/doi.org\/10.1177\/1066896906293417","journal-title":"Int J Surg Pathol"},{"key":"5413_CR45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.anndiagpath.2004.12.001","volume":"9","author":"DV Kazakov","year":"2005","unstructured":"Kazakov DV, Pitha J, Sima R, Vanecek T, Shelekhova K, Mukensnabl P, Michal M (2005) Hybrid peripheral nerve sheath tumors: schwannoma-perineurioma and neurofibroma-perineurioma. A report of three cases in extradigital locations. Ann Diagn Pathol 9:16\u201323. https:\/\/doi.org\/10.1016\/j.anndiagpath.2004.12.001","journal-title":"Ann Diagn Pathol"},{"key":"5413_CR46","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/ana.24854","volume":"81","author":"CJ Klein","year":"2017","unstructured":"Klein CJ, Wu Y, Jentoft ME, Mer G, Spinner RJ, Dyck PJB, Dyck PJ, Mauermann ML (2017) Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas. Ann Neurol 81:316\u2013321","journal-title":"Ann Neurol"},{"key":"5413_CR47","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/hed.20965","volume":"31","author":"YS Kum","year":"2009","unstructured":"Kum YS, Kim JK, Cho CH, Kim HK (2009) Intraneural reticular perineurioma of the hypoglossal nerve. Head Neck: J Sci Spec Head Neck 31:833\u2013837","journal-title":"Head Neck: J Sci Spec Head Neck"},{"key":"5413_CR48","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s00795-008-0418-7","volume":"43","author":"N Kuroda","year":"2010","unstructured":"Kuroda N, Kazakov DV, Hes O, Michal M, Goda M, Miyazaki K, Hayashi Y, Okamoto S, Lee GH (2010) Hybrid peripheral nerve sheath tumor of the nasal cavity showing schwannomatous, neurofibromatous, and perineuriomatous areas. Med Mol Morphol 43:82\u201385. https:\/\/doi.org\/10.1007\/s00795-008-0418-7","journal-title":"Med Mol Morphol"},{"key":"5413_CR49","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3171\/2012.8.Jns111841","volume":"117","author":"SS Lang","year":"2012","unstructured":"Lang SS, Zager EL, Coyne TM, Nangunoori R, Kneeland JB, Nathanson KL (2012) Hybrid peripheral nerve sheath tumor. J Neurosurg 117:897\u2013901. https:\/\/doi.org\/10.3171\/2012.8.Jns111841","journal-title":"J Neurosurg"},{"key":"5413_CR50","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13000-019-0829-x","volume":"14","author":"Y Lang","year":"2019","unstructured":"Lang Y, Liu D, Xiang P, Wang J, Li Y (2019) Primary intraosseous hybrid epithelioid schwannoma\/perineurioma in the proximal tibia: a case report of benign hybrid neoplasm with local hypercellularity. Diagn Pathol 14:51. https:\/\/doi.org\/10.1186\/s13000-019-0829-x","journal-title":"Diagn Pathol"},{"key":"5413_CR51","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1002\/1097-0142(197805)41:5<1823::AID-CNCR2820410525>3.0.CO;2-J","volume":"41","author":"SS Lazarus","year":"1978","unstructured":"Lazarus SS, Trombetta LD (1978) Ultrastructural identification of a benign perineurial cell tumor. Cancer 41:1823\u20131829","journal-title":"Cancer"},{"issue":"120\u2013131","key":"5413_CR52","first-page":"e128","volume":"154","author":"KA Lenartowicz","year":"2021","unstructured":"Lenartowicz KA, Goyal A, Mauermann ML, Wilson TJ, Spinner RJ (2021) Clinical features, natural history, and outcomes of intraneural perineuriomas: a systematic review of the literature. World Neurosurg 154(120\u2013131):e128","journal-title":"World Neurosurg"},{"key":"5413_CR53","doi-asserted-by":"publisher","first-page":"e283","DOI":"10.1016\/j.jcjo.2019.03.014","volume":"54","author":"KCP Leung","year":"2019","unstructured":"Leung KCP, Chan E, Ng HYJ, Ko TCS (2019) Novel case of hybrid perineurioma-neurofibroma of the orbit. Can J Ophthalmol 54:e283\u2013e285. https:\/\/doi.org\/10.1016\/j.jcjo.2019.03.014","journal-title":"Can J Ophthalmol"},{"key":"5413_CR54","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G, Von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803\u2013820","journal-title":"Acta Neuropathol"},{"key":"5413_CR55","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/DAD.0b013e3181c55f0e","volume":"32","author":"AC Macarenco","year":"2010","unstructured":"Macarenco AC, Macarenco RS (2010) Intradermal monophasic hybrid schwannoma-perineurioma: a diagnostic challenge. Am J Dermatopathol 32:526\u2013528. https:\/\/doi.org\/10.1097\/DAD.0b013e3181c55f0e","journal-title":"Am J Dermatopathol"},{"key":"5413_CR56","doi-asserted-by":"publisher","unstructured":"Macari-Jorge A, Ortiz-Hidalgo C (2021) Hybrid peripheral nerve sheath tumor, with myxoid schwannoma, neuroblastoma-like schwannoma, and perineurioma components. [Spanish] (Tumor hibrido de la vaina del nervio periferico, con componentes de schwannoma mixoide, schwannoma tipo neuroblastoma y perineuroma.). Gaceta Mexicana de Oncologia 20:S158\u2013S162. https:\/\/doi.org\/10.24875\/j.gamo.20000112","DOI":"10.24875\/j.gamo.20000112"},{"key":"5413_CR57","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1111\/cup.12544","volume":"42","author":"CT McLaughlin","year":"2015","unstructured":"McLaughlin CT, Kaffenberger BH, Gru AA (2015) A hybrid tumor with schwannoma-perineurioma-neurofibroma morphology. J Cutan Pathol 42:911\u2013913. https:\/\/doi.org\/10.1111\/cup.12544","journal-title":"J Cutan Pathol"},{"key":"5413_CR58","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00428-005-0057-5","volume":"447","author":"T Mentzel","year":"2005","unstructured":"Mentzel T, Kutzner H (2005) Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of skin and soft tissues. Virchows Arch 447:677\u2013682","journal-title":"Virchows Arch"},{"key":"5413_CR59","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00428-004-1102-5","volume":"445","author":"M Michal","year":"2004","unstructured":"Michal M, Kazakov DV, Belousova I, Bisceglia M, Zamecnik M, Mukensnabl P (2004) A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. Virchows Arch 445:347\u2013353. https:\/\/doi.org\/10.1007\/s00428-004-1102-5","journal-title":"Virchows Arch"},{"key":"5413_CR60","first-page":"81","volume":"53","author":"M Michal","year":"2017","unstructured":"Michal M, Kazakov DV, Michal M (2017) Hybrid peripheral nerve sheath tumors: a review. Cesk Patol 53:81\u201388","journal-title":"Cesk Patol"},{"key":"5413_CR61","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1600-0560.2011.01805.x","volume":"39","author":"C Ohata","year":"2012","unstructured":"Ohata C, Imai N, Hinogami H, Akamatsu K, Sumimura Y (2012) Hybrid schwannoma\/perineurioma: a report of two cases including a possible radiation-induced case. J Cutan Pathol 39:56\u201362. https:\/\/doi.org\/10.1111\/j.1600-0560.2011.01805.x","journal-title":"J Cutan Pathol"},{"key":"5413_CR62","doi-asserted-by":"publisher","first-page":"105906","DOI":"10.1016\/j.ijsu.2021.105906","volume":"88","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg 88:105906","journal-title":"Int J Surg"},{"key":"5413_CR63","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4132\/KoreanJPathol.2012.46.1.75","volume":"46","author":"JY Park","year":"2012","unstructured":"Park JY, Park NJ, Kim SP, Kwon KY, Lee SS (2012) A soft tissue perineurioma and a hybrid tumor of perineurioma and schwannoma. Korean J Pathol 46:75\u201378. https:\/\/doi.org\/10.4132\/KoreanJPathol.2012.46.1.75","journal-title":"Korean J Pathol"},{"key":"5413_CR64","doi-asserted-by":"publisher","first-page":"825","DOI":"10.4103\/0377-4929.91542","volume":"54","author":"B Rekhi","year":"2011","unstructured":"Rekhi B, Jambhekar NA (2011) Malignant transformation in a hybrid schwannoma\/perineurioma: addition to the spectrum of a malignant peripheral nerve sheath tumor. Indian J Pathol Microbiol 54:825\u2013828. https:\/\/doi.org\/10.4103\/0377-4929.91542","journal-title":"Indian J Pathol Microbiol"},{"key":"5413_CR65","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1034\/j.1600-0560.2001.290607.x","volume":"29","author":"AS Rosenberg","year":"2002","unstructured":"Rosenberg AS, Langee CL, Stevens GL, Morgan MB (2002) Malignant peripheral nerve sheath tumor with perineurial differentiation:\u2018malignant perineurioma.\u2019 J Cutan Pathol 29:362\u2013367","journal-title":"J Cutan Pathol"},{"key":"5413_CR66","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/ced.12370","volume":"39","author":"H Saeki","year":"2014","unstructured":"Saeki H, Ito K, Nobeyama Y, Ishiji T, Fukunaga M, Nakagawa H (2014) Hybrid peripheral nerve sheath tumour with intermingled perineuriomatous and schwannomatous areas reflected in skin ultrasonography image. Clin Exp Dermatol 39:747\u2013749. https:\/\/doi.org\/10.1111\/ced.12370","journal-title":"Clin Exp Dermatol"},{"key":"5413_CR67","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1111\/j.1440-1827.2008.02299.x","volume":"58","author":"K Sato","year":"2008","unstructured":"Sato K, Ueda Y, Miwa S, Yokogawa A, Ozaki M, Katsuda S (2008) Low-grade malignant soft-tissue perineurioma: interphase fluorescence in situ hybridization. Pathol Int 58:718\u2013722","journal-title":"Pathol Int"},{"key":"5413_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000478854","volume":"4","author":"S Shanouda","year":"2017","unstructured":"Shanouda S, Kaya G (2017) Benign cutaneous peripheral nerve sheath tumor with hybrid features: report of two cases with schwannoma\/perineurioma and schwannoma\/neurofibroma components. Dermatopathology (Basel) 4:1\u20136. https:\/\/doi.org\/10.1159\/000478854","journal-title":"Dermatopathology (Basel)"},{"key":"5413_CR69","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.anndiagpath.2008.02.012","volume":"12","author":"KV Shelekhova","year":"2008","unstructured":"Shelekhova KV, Danilova AB, Michal M, Kazakov DV (2008) Hybrid neurofibroma-perineurioma: an additional example of an extradigital tumor. Ann Diagn Pathol 12:233\u2013234. https:\/\/doi.org\/10.1016\/j.anndiagpath.2008.02.012","journal-title":"Ann Diagn Pathol"},{"key":"5413_CR70","first-page":"1528","volume":"6","author":"E Simon","year":"2017","unstructured":"Simon E, Th\u00e9z\u00e9 N, F\u00e9dou S, Thi\u00e9baud P, Faucheux C (2017) Vestigial-like 3 is a novel Ets1 interacting partner and regulates trigeminal nerve formation and cranial neural crest migration. Biology open 6:1528\u20131540","journal-title":"Biology open"},{"key":"5413_CR71","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.resinv.2014.03.001","volume":"52","author":"D Soria-C\u00e9spedes","year":"2014","unstructured":"Soria-C\u00e9spedes D, Robles-Vidal C, G\u00f3mez-Gonz\u00e1lez A, Pe\u00f1aloza-Ram\u00edrez R, Ortiz-Hidalgo C (2014) Primary pleural hybrid cellular schwannoma\/perineurioma: a case report. Respir Investig 52:269\u2013273. https:\/\/doi.org\/10.1016\/j.resinv.2014.03.001","journal-title":"Respir Investig"},{"key":"5413_CR72","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1038\/s41379-020-0580-6","volume":"33","author":"D Suster","year":"2020","unstructured":"Suster D, Michal M, Huang H, Ronen S, Springborn S, Debiec-Rychter M, Billings SD, Goldblum JR, Rubin BP, Michal M (2020) Myxoinflammatory fibroblastic sarcoma: an immunohistochemical and molecular genetic study of 73 cases. Mod Pathol 33:2520\u20132533","journal-title":"Mod Pathol"},{"key":"5413_CR73","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.anndiagpath.2005.04.016","volume":"9","author":"D Suster","year":"2005","unstructured":"Suster D, Plaza JA, Shen R (2005) Low-grade malignant perineurioma (perineurial sarcoma) of soft tissue: a potential diagnostic pitfall on fine needle aspiration. Ann Diagn Pathol 9:197\u2013201","journal-title":"Ann Diagn Pathol"},{"key":"5413_CR74","doi-asserted-by":"publisher","unstructured":"Tanner R, Falvo A, Parker D, Kennedy A (2020) Laparoscopic resection of pediatric gastric schwannoma\/perineurioma. J Pediatr Surg Case Rep 59:101496. https:\/\/doi.org\/10.1016\/j.epsc.2020.101496","DOI":"10.1016\/j.epsc.2020.101496"},{"key":"5413_CR75","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/humu.10305","volume":"23","author":"M Upadhyaya","year":"2004","unstructured":"Upadhyaya M, Han S, Consoli C, Majounie E, Horan M, Thomas NS, Potts C, Griffiths S, Ruggieri M, Von Deimling A (2004) Characterization of the somatic mutational spectrum of the neurofibromatosis type 1 (NF1) gene in neurofibromatosis patients with benign and malignant tumors. Hum Mutat 23:134\u2013146","journal-title":"Hum Mutat"},{"key":"5413_CR76","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/00000478-200104000-00008","volume":"25","author":"JFG Van Roggen","year":"2001","unstructured":"Van Roggen JFG, McMenamin ME, Belchis DA, Nielsen GP, Rosenberg AE, Fletcher CD (2001) Reticular perineurioma: a distinctive variant of soft tissue perineurioma. Am J Surg Pathol 25:485\u2013493","journal-title":"Am J Surg Pathol"},{"key":"5413_CR77","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/cup.12076","volume":"40","author":"L Wang","year":"2013","unstructured":"Wang L, Wang G, Gao T (2013) Congenital melanocytic nevus with features of hybrid schwannoma\/perineurioma. J Cutan Pathol 40:497\u2013502. https:\/\/doi.org\/10.1111\/cup.12076","journal-title":"J Cutan Pathol"},{"key":"5413_CR78","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.3171\/2017.5.JNS17905","volume":"129","author":"TJ Wilson","year":"2017","unstructured":"Wilson TJ, Howe BM, Stewart SA, Spinner RJ, Amrami KK (2017) Clinicoradiological features of intraneural perineuriomas obviate the need for tissue diagnosis. J Neurosurg 129:1034\u20131040","journal-title":"J Neurosurg"},{"key":"5413_CR79","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00428-003-0849-4","volume":"443","author":"U Yamaguchi","year":"2003","unstructured":"Yamaguchi U, Hasegawa T, Hirose T, Fugo K, Mitsuhashi T, Shimizu M, Kawai A, Ito Y, Chuman H, Beppu Y (2003) Sclerosing perineurioma: a clinicopathological study of five cases and diagnostic utility of immunohistochemical staining for GLUT1. Virchows Arch 443:159\u2013163","journal-title":"Virchows Arch"},{"key":"5413_CR80","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/1066896912454566","volume":"21","author":"X Yang","year":"2013","unstructured":"Yang X, Zeng Y, Wang J (2013) Hybrid schwannoma\/perineurioma: report of 10 Chinese cases supporting a distinctive entity. Int J Surg Pathol 21:22\u201328. https:\/\/doi.org\/10.1177\/1066896912454566","journal-title":"Int J Surg Pathol"},{"key":"5413_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-74537-4","volume":"10","author":"H Yao","year":"2020","unstructured":"Yao H, Hannum DF, Zhai Y, Hill SF, Albanus RDO, Lou W, Skidmore JM, Sanchez G, Saiakhova A, Bielas SL (2020) CHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expression. Sci Rep 10:1\u201315","journal-title":"Sci Rep"},{"key":"5413_CR82","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1046\/j.1365-2559.2002.1363c.x","volume":"40","author":"M Zamecnik","year":"2002","unstructured":"Zamecnik M, Koys F, Gomolcak P (2002) Atypical cellular perineurioma. Histopathology 40:296\u2013299","journal-title":"Histopathology"},{"key":"5413_CR83","first-page":"537","volume":"197","author":"M Zamecnik","year":"2001","unstructured":"Zamecnik M, Michal M (2001) Perineurial cell differentiation in neurofibromas: report of eight cases including a case with composite perineurioma-neurofibroma features. Pathol-Res Pract 197:537\u2013544","journal-title":"Pathol-Res Pract"},{"key":"5413_CR84","first-page":"25","volume":"4","author":"B Zelger","year":"2000","unstructured":"Zelger B, Weinlich G (2000) Perineuroma. A frequently unrecognized entity with emphasis on a plexiform variant. Adv Clin Pathol: Off J Adriatic Soc Pathol 4:25\u201333","journal-title":"Adv Clin Pathol: Off J Adriatic Soc Pathol"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-022-05413-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00701-022-05413-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-022-05413-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T10:10:10Z","timestamp":1680516610000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00701-022-05413-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":84,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["5413"],"URL":"https:\/\/doi.org\/10.1007\/s00701-022-05413-5","relation":{},"ISSN":["0942-0940"],"issn-type":[{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,18]]},"assertion":[{"value":"21 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The cases described herein were included with the informed consent of the patients prior to inclusion in this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board (IRB), Mayo IRB # 21\u2013006622.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}