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The severity of the NVC seems associated with the outcome following microvascular decompression (MVD) surgery. This study aimed to investigate the outcome after MVD and whether it is affected by NVC severity and sex.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Methods<\/jats:title>\n              <jats:p>TN patients (<jats:italic>n<\/jats:italic>\u2009=\u2009109) were followed for 5 to 10\u00a0years after MVD. Barrow Neurology Index (BNI), Patients Global Impression of Change (PGIC), complications, and time to relapse were evaluated. The NVC severity was retrospectively reviewed from presurgical MRI. Demographic and clinical factors and NVC severity were analyzed for potential association with outcome after MVD.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Results<\/jats:title>\n              <jats:p>The success rate (BNI\u2009\u2264\u20092) was 80% after 5 to 10\u00a0years follow-up for TN patients with severe NVC (grade 2\u20133) and 56% for TN patients with mild NVC (grade 0\u20131, <jats:italic>P<\/jats:italic>\u2009=\u20090.003). No sex difference was observed in outcome for patients with both mild (<jats:italic>P<\/jats:italic>\u2009=\u20090.924) and severe NVC (<jats:italic>P<\/jats:italic>\u2009=\u20090.883) respectively. Three patients (2.8%) during the hospital stay, and two patients (1.8%) at 6\u00a0weeks, experienced a complication requiring invasive treatment. At long-term 52\/109 patients (47.7%) reported some type of persistent adverse event, of which the majority were mild and required no treatment.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Conclusions<\/jats:title>\n              <jats:p>MVD offers an 80% probability of long-term pain relief in TN patients with severe NVC, with low frequency of serious complications. NVC severity significantly affects outcome after MVD, while no sex differences in outcome were found. In consistency with previous work, the results stress the importance of adequate neuroradiological assessment of the NVC for preoperative patient selection.<\/jats:p>\n            <\/jats:sec>","DOI":"10.1007\/s00701-023-05642-2","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T07:02:08Z","timestamp":1686121328000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcome after microvascular decompression for trigeminal neuralgia in a single center\u2014relation to sex and severity of neurovascular conflict"],"prefix":"10.1007","author":[{"given":"Richard","family":"Loayza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Grabowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Semnic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Ericson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-8357","authenticated-orcid":false,"given":"Sami","family":"Abu Hamdeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"issue":"17","key":"5642_CR1","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1056\/NEJM199604253341701","volume":"334","author":"FG Barker","year":"1996","unstructured":"Barker FG, Jannetta PJ, Bissonette DJ, Larkins MV, Jho HD (1996) The long-term outcome of microvascular decompression for trigeminal neuralgia. 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