{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:32:50Z","timestamp":1762090370013,"version":"build-2065373602"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinik M\u00fcnchen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Although Rathke cleft cysts (RCC) are benign lesions of the sellar region, recurrence is frequent after surgical treatment. Nuclear translocation of \u00df-catenin (NT\u00dfC), a key effector of the wnt-signaling pathway that is responsible for cell renewal, has been shown to act as a proto-oncogene and is considered to be a potential risk factor for increased recurrence in RCC. In this study, we analyzed a surgically treated cohort into patients with and without NT\u00dfC expression in order to identify clinical and imaging differences and further evaluate the risk of recurrence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with resection of RCC between 04\/2001 and 11\/2020 were included. Histological specimens were immunohistochemically stained for \u00df-catenin. Study endpoints were time to cyst recurrence (TTR) and functional outcome. Functional outcome included ophthalmological and endocrinological data. Furthermore, MRI data were assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Seventy-three patients (median age 42.3 years) with RCC underwent mainly transsphenoidal cyst resection (95.9%), 4.1% via transcranial approach. Immunohistochemical staining for \u00df-catenin was feasible in 61\/73 (83.6%) patients, with nuclear translocation detected in 13\/61 cases (21.3%). Patients with and without NT\u00dfC were equally likely to present with endocrine dysfunction before surgery (<jats:italic>p<\/jats:italic> = 0.49). Postoperative new hypopituitarism occurred in 14\/73 (19.2%) patients. Preoperative visual impairment was equal in both groups (<jats:italic>p<\/jats:italic> = 0.52). Vision improved in 8\/21 (33.3%) patients and visual field deficits in 22\/34 (64.7%) after surgery. There was no difference in visual and perimetric outcome between patients with and without NT\u00dfC (<jats:italic>p<\/jats:italic> = 0.45 and <jats:italic>p<\/jats:italic> = 0.23, respectively). On preoperative MRI, cyst volume (9.9 vs. 8.2 cm<jats:sup>3<\/jats:sup>; <jats:italic>p<\/jats:italic> = 0.4) and evidence of hemorrhage (30.8% vs. 35.4%; <jats:italic>p<\/jats:italic> = 0.99) were equal and postoperative cyst volume decreased significantly in both groups (0.7 vs. 0.5 cm<jats:sup>3<\/jats:sup>; <jats:italic>p<\/jats:italic> &lt; 0.0001 each). Cyst progression occurred in 13\/73 (17.8%) patients after 39.3 \u00b1 60.3 months. Cyst drainage with partial removal of the cyst wall resulted in improved recurrence-free survival without increasing the risk of complications compared with cyst fenestration alone. Patients with postoperative diabetes insipidus had an increased risk for recurrence according to multivariate analysis (<jats:italic>p<\/jats:italic> = 0.005). NT\u00dfC was evident in 4\/15 patients (26.7%) and was not associated with a higher risk for recurrence (<jats:italic>p<\/jats:italic> = 0.67).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Transnasal transsphenoidal cyst drainage with partial removal of the cyst wall reduces the risk of recurrence without increasing the risk of complications compared with fenestration of the cyst alone. Patients with postoperative diabetes insipidus seem to have an increased risk for recurrence. In contrast, NT\u00dfC was not associated with a higher risk of recurrence and did not provide stratification for clinically distinct patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00701-023-05733-0","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T07:01:59Z","timestamp":1690959719000},"page":"2435-2444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nuclear translocation of beta catenin in patients with Rathke cleft cysts\u2014clinical and imaging characteristics and risk of recurrence"],"prefix":"10.1007","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-0630","authenticated-orcid":false,"given":"Michael","family":"Schmutzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Thorsteinsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Weller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Rachinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schichor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Thon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Ueberschaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"5733_CR1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3171\/jns.2005.102.2.0189","volume":"102","author":"CJ Aho","year":"2005","unstructured":"Aho CJ, Liu C, Zelman V, Couldwell WT, Weiss MH (2005) Surgical outcomes in 118 patients with Rathke cleft cysts. 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