{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:54:58Z","timestamp":1787946898560,"version":"build-2784847793"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Helsinki including Helsinki University Central Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>It is estimated that significant (3.2%) of population carries intracranial aneurysm (IA). An increasing number of imaging studies have caused that the chance of finding an incidental aneurysm is becoming more common. Since IA rupture causes subarachnoidal hemorrhage (SAH) and have significant mortality and morbidity prophylactic treatment should be considered when IA is detected. The benefit and risk of treatment of IA is based on epidemiological estimate which takes account patient and aneurysm characteristics. However we know that aneurysm rupture is biological process where inflammation of aneurysm wall is actively leading to degeneration of aneurysm wall and finally weakens it until it bursts. Until now, there have not been imaging method to detect inflammatory process of aneurysm wall<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We created targeting immunoliposome for use in the imaging of aneurysm. Immunoliposome comprises antibodies against at least one vascular inflammatory marker associated with aneurysm inflammation and a label and\/or a contrast agent.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Histological analysis of IAs where immunoliposome comprises antibodies against vascular inflammation with a label shows promising results for selectively detecting aneurysms inflammation. In magnetic resonance imaging (MRI) we were able to detect immunoliposomes carrying gadolinium.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our work opens a new avenue for using contrast labeled immunoliposomes for detecting rupture-prone aneurysms. Immunoliposomes can cary gadolinium and selectively bind to inflammatory section of aneurysm that can be detected with MRI. Further research is needed to develop immunoliposomes to be used with MRI in humans to target treatment to those patients who benefit from it the most.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00701-023-05770-9","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:29:08Z","timestamp":1695698948000},"page":"3353-3360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immunoliposomes for detection of rupture-prone intracranial aneurysms"],"prefix":"10.1007","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-2816","authenticated-orcid":false,"given":"Behnam Rezai","family":"Jahromi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Zamotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Code","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliisa","family":"Netti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina B.","family":"Lorey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Alitalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katariina","family":"\u00d6\u00f6rni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Laakso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"Tulamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Niemel\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"5770_CR1","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1161\/CIRCIMAGING.109.896654","volume":"3","author":"D Li","year":"2010","unstructured":"Li D, Patel AR, Klibanov AL, Kramer CM, Ruiz M, Kang BY, Mehta JL, Beller GA, Glover DK, Meyer CH (2010) Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1 by SPECT\/CT and magnetic resonance. Circ Cardiovasc Imaging 3:464\u2013472. https:\/\/doi.org\/10.1161\/CIRCIMAGING.109.896654","journal-title":"Circ Cardiovasc Imaging"},{"key":"5770_CR2","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0140-6736(16)30668-7","volume":"389","author":"RL Macdonald","year":"2017","unstructured":"Macdonald RL, Schweizer TA (2017) Spontaneous subarachnoid haemorrhage. Lancet. 389:655\u2013666. https:\/\/doi.org\/10.1016\/S0140-6736(16)30668-7","journal-title":"Lancet."},{"key":"5770_CR3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/s0005-2736(99)00074-7","volume":"1419","author":"E Mastrobattista","year":"1999","unstructured":"Mastrobattista E, Storm G, van Bloois L, Reszka R, Bloemen PG, Crommelin DJ, Henricks PA (1999) Cellular uptake of liposomes targeted to intercellular adhesion molecule-1 (ICAM-1) on bronchial epithelial cells. Biochim Biophys Acta 1419:353\u2013363. https:\/\/doi.org\/10.1016\/s0005-2736(99)00074-7","journal-title":"Biochim Biophys Acta"},{"key":"5770_CR4","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1111\/ene.15046","volume":"28","author":"R Molenberg","year":"2021","unstructured":"Molenberg R, Aalbers MW, Appelman APA, Uyttenboogaart M, van Dijk JMC (2021) Intracranial aneurysm wall enhancement as an indicator of instability: a systematic review and meta-analysis. Eur J Neurol 28:3837\u20133848. https:\/\/doi.org\/10.1111\/ene.15046","journal-title":"Eur J Neurol"},{"key":"5770_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1477-3155-10-25","volume":"10","author":"LE Paulis","year":"2012","unstructured":"Paulis LE, Jacobs I, van den Akker NM, Geelen T, Molin DG, Starmans LW, Nicolay K, Strijkers GJ (2012) Targeting of ICAM-1 on vascular endothelium under static and shear stress conditions using a liposomal Gd-based MRI contrast agent. J Nanobiotechnology 10:25. https:\/\/doi.org\/10.1186\/1477-3155-10-25","journal-title":"J Nanobiotechnology"},{"issue":"24","key":"5770_CR6","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1016\/0024-3205(82)90455-6","volume":"30","author":"J Senior","year":"1982","unstructured":"Senior J, Gregoriadis G (1982) Stability of small unilamellar liposomes in serum and clearance from the circulation: the effect of the phospholipid and cholesterol components. Life Sci 30(24):2123\u20132136","journal-title":"Life Sci"},{"issue":"2","key":"5770_CR7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1517\/17425247.5.2.189","volume":"5","author":"S Sofou","year":"2008","unstructured":"Sofou S, Sgouros G (2008) Antibody-targeted liposomes in cancer therapy and imaging. Expert Opin Drug Deliv 5(2):189\u2013204","journal-title":"Expert Opin Drug Deliv"},{"issue":"3","key":"5770_CR8","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1006\/immu.1994.1027","volume":"4","author":"VP Torchilin","year":"1994","unstructured":"Torchilin VP (1994) Immunoliposomes and PEGylated immunoliposomes: possible use for targeted delivery of imaging agents. Immunomethods 4(3):244\u2013258","journal-title":"Immunomethods"},{"issue":"Suppl 1","key":"5770_CR9","doi-asserted-by":"publisher","first-page":"i58","DOI":"10.1136\/jnis.2009.002055.rep","volume":"10","author":"R Tulamo","year":"2018","unstructured":"Tulamo R, Fr\u00f6sen J, Hernesniemi J, Niemel\u00e4 M (2018) Inflammatory changes in the aneurysm wall: a review. J Neurointerv Surg 10(Suppl 1):i58\u2013i67. https:\/\/doi.org\/10.1136\/jnis.2009.002055.rep","journal-title":"J Neurointerv Surg"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-023-05770-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00701-023-05770-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-023-05770-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T08:08:50Z","timestamp":1698998930000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00701-023-05770-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,26]]},"references-count":9,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["5770"],"URL":"https:\/\/doi.org\/10.1007\/s00701-023-05770-9","relation":{},"ISSN":["0942-0940"],"issn-type":[{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,26]]},"assertion":[{"value":"4 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No need-basic science work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors Behnam Rezai Jahromi, Vladimir Zamotin, Christian Code, Eliisa Netti, Aki Laakso, Riikka Tulamo, and Mika Niemel\u00e4 have patents pending on concept presented in this manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}