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Recent research with the use of the ultrasonic method suggests specific changes in the shape of cardiac-related cerebral arterial blood volume (C<jats:sub>a<\/jats:sub>BV) pulses in NPH patients. Our study aims to provide a quantitative analysis of the shape of C<jats:sub>a<\/jats:sub>BV pulses, estimated based on transcranial Doppler ultrasonography (TCD) in NPH patients and healthy individuals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The C<jats:sub>a<\/jats:sub>BV pulses were estimated using TCD cerebral blood flow velocity signals recorded from probable NPH adults and age-matched healthy individuals at rest. The shape of the C<jats:sub>a<\/jats:sub>BV pulses was compared to a triangular shape with 27 similarity parameters calculated for every reliable C<jats:sub>a<\/jats:sub>BV pulse and compared between patients and volunteers. The diagnostic accuracy of the most prominent parameter for NPH classification was evaluated using the area under the receiver operating characteristic curve (AUC).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The similarity parameters were calculated for 31 probable NPH patients (age: 59\u00a0years (IQR: 47, 67\u00a0years), 14 females) and 23 healthy volunteers (age: 54\u00a0years (IQR: 43, 61\u00a0years), 18 females). Eighteen of 27 parameters were different between healthy individuals and NPH patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The most prominent differences were found for the ascending slope of the C<jats:sub>a<\/jats:sub>BV pulse with the AUC equal to 0.87 (95% confidence interval: 0.77, 0.97, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The findings suggest that in NPH, the ascending slope of the C<jats:sub>a<\/jats:sub>BV pulse had a slower rise, was more like a straight line, and generally was less convex than in volunteers. Prospective research is required to verify the clinical utility of these findings.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00701-023-05839-5","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T06:02:21Z","timestamp":1698386541000},"page":"4045-4054","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Brain blood flow pulse analysis may help to recognize individuals who suffer from hydrocephalus"],"prefix":"10.1007","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-514X","authenticated-orcid":false,"given":"Arkadiusz","family":"Zi\u00f3\u0142kowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2271-7737","authenticated-orcid":false,"given":"Magdalena","family":"Kasprowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-8006","authenticated-orcid":false,"given":"Marek","family":"Czosnyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Czosnyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"issue":"1\u20132","key":"5839_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF01743061","volume":"9","author":"CJJ Avezaat","year":"1986","unstructured":"Avezaat CJJ, van Eijndhoven JHM (1986) The role of the pulsatile pressure variations in intracranial pressure monitoring. 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