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This study aimed to analyze the efficacy of CVC in patients with glioma and BM as well as procedure-associated morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center retrospective study included all patients treated with CVC placement for acquired space-occupying cysts deriving from previously treated glioma or BMs between 1\/2010 and 12\/2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 57 patients with a median age of 47\u00a0years (IQR 38\u201363) were identified. Focal neurological deficits were the predominant symptoms in 60% of patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934), followed by cephalgia in 14% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), and epileptic seizures in 21.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912). Accurate CVC placement was achieved in all but one case requiring revision surgery due to malposition. Three months after CVC implantation, 70% of patients showed symptomatic improvement. Multivariate logistic regression analysis identified the development of space-occupying cysts later in the course of the disease (OR 1.014;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and a higher reduction of cyst-volume postoperatively (OR 1.055;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) were significant predictors of postoperative symptomatic improvement following CVC placement. Local cyst recurrence was observed in three cases during follow-up MRI after an average time of 5\u00a0months (range 3\u20139\u00a0months). Further complications included secondary malresorptive hydrocephalus in three cases and meningeosis neoplastica in one patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stereotactic implantation of CVC is an efficient treatment option for patients suffering from symptomatic space-occupying cysts from BMs or glioma, independently from their CNS WHO grade. However, a vigilant approach is crucial regarding potential complications and treatment failures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00701-024-05931-4","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:02:01Z","timestamp":1706227321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of cysto-ventricular catheter implantation for space-occupying cysts arising from glioma and brain metastasis: a retrospective study"],"prefix":"10.1007","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2647-7256","authenticated-orcid":false,"given":"Sebastian","family":"Niedermeyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole A.","family":"Terpolilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Nerlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schmutzer-Sondergeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Quach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Thon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"5931_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s11060-021-03864-x","volume":"155","author":"S Akmal","year":"2021","unstructured":"Akmal S, Ginalis EE, Patel NV, Aiken R, Dicpinigaitis AJ, Hanft SJ (2021) Leptomeningeal disease in glioblastoma: endgame or opportunity? 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