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We assessed the role of hypnosis during the SF fixation in PD patients undergoing awake bilateral subthalamic nucleus (STN) DBS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>\n              <jats:italic>N<\/jats:italic>\u2009=\u200919 patients were included (<jats:italic>N<\/jats:italic>\u2009=\u200913 males, mean age 63\u00a0years; <jats:italic>N<\/jats:italic>\u2009=\u200910 allocated to the hypnosis and <jats:italic>N<\/jats:italic>\u2009=\u20099 allocated to the control groups). Patients were randomly assigned to the interventional (hypnosis and local anesthesia) or non-interventional (local anesthesia only) groups. The primary outcome was the pain perceived (the visual analogue scale (VAS)). Secondary outcomes were stress, anxiety, and depression, as measured by the perceived stress scale (PSS) and hospital anxiety and depression scale (HADS). Procedural distress was measured using the peritraumatic distress inventory (PDI-13).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the hypnosis group, VAS<jats:sub>mean<\/jats:sub> was 5.6\u2009\u00b1\u20092.1, versus 6.4\u2009\u00b1\u20091.2 in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.31). Intervention and control groups reported similar VAS<jats:sub>max<\/jats:sub> scores (7.6\u2009\u00b1\u20092.1 versus 8.6\u2009\u00b1\u20091.6 (<jats:italic>p<\/jats:italic>\u2009=\u20090.28), respectively). Both groups had similar HADS scores (6.2\u2009\u00b1\u20094.3 versus 6.7\u2009\u00b1\u20091.92, <jats:italic>p<\/jats:italic>\u2009=\u20090.72 (HADSa) and 6.7\u2009\u00b1\u20094.2 versus 7.7\u2009\u00b1\u20093, <jats:italic>p<\/jats:italic>\u2009=\u20090.58 (HADSd)), so were the PSS scores (26.1\u2009\u00b1\u20096.3 versus 25.1\u2009\u00b1\u20097, <jats:italic>p<\/jats:italic>\u2009=\u20090.75). Evolutions of VAS<jats:sub>mean<\/jats:sub> (<jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\u2009=\u20090.93, 95% CI [0.2245, 1.825], <jats:italic>p<\/jats:italic>\u2009=\u20090.03) and PDI-13 scores (<jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\u2009=\u20090.94, 95% CI [1.006, 6.279], <jats:italic>p<\/jats:italic>\u2009=\u20090.02) significantly differ over follow-up with patients in the hypnosis groups showing lower scores.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In this unblinded, randomized study, hypnosis does not influence pain, anxiety, and distress during awake SF fixation but modulates pain memory over time and may prevent the integration of awake painful procedures as a bad experience into the autobiographical memory of patients suffering from PD. A randomized controlled study with more data is necessary to confirm our findings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00701-024-05943-0","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T09:09:44Z","timestamp":1709024984000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and reliability of hypnosis in stereotaxy: a randomized study"],"prefix":"10.1007","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-5827","authenticated-orcid":false,"given":"Sabina","family":"Catalano Chiuv\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3886-0159","authenticated-orcid":false,"given":"Shahan","family":"Momjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4447-4585","authenticated-orcid":false,"given":"Marco Vincenzo","family":"Corniola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"5943_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00207144.2013.841471","volume":"62","author":"T Adachi","year":"2014","unstructured":"Adachi T, Fujino H, Nakae A, Mashimo T, Sasaki J (2014) A meta-analysis of hypnosis for chronic pain problems: a comparison between hypnosis, standard care, and other psychological interventions. 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