{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:08:45Z","timestamp":1788419325632,"version":"build-2803163510"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006390","name":"University of Lausanne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006390","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Stereotactic radiosurgery (SRS) represents a minimally invasive and valuable alternative for jugular foramen schwannomas (JFS), both as upfront and\/or adjuvant treatment (in hybrid approaches).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We conducted a retrospective review of our cases treated at the Lausanne University Hospital (CHUV) from June 2010 to October 2023. Eleven patients underwent SRS, among whom three had prior surgery, two in our center in the frame of a planned combined approach and one in another center. Two patients received \"volume-staged\" SRS. The mean age at SRS was 60\u00a0years (median 68; range 29\u201383). Cranial nerve (CN) symptoms were present in six patients, while five were asymptomatic. The mean tumor volume at SRS was 2.1\u00a0cc (median 1.2; range 0.068\u20137.3\u00a0cc), with a 12\u00a0Gy marginal dose prescribed in all cases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The mean follow-up period was 3.9\u00a0years (median 2, range 1\u20137). Cranial nerve function improved after SRS in six patients, while five remained stable. At the last follow-up, all tumors showed a decrease in volume, except for one patient, who underwent surgery at 18\u00a0months after SRS, for volumetric increase at 6 and 12\u00a0months, with further XII<jats:sup>\u2212th<\/jats:sup> CN palsy and medulla oblongata compression. Although tumor decreased at 18\u00a0months, such patient needed microsurgical resection for symptom persistence and was further controlled. The mean tumor volume at 1\u00a0year post-SRS was 1.6\u00a0cc (median 0.55; range 0.028\u20137.77\u00a0cc), at 2\u00a0years was 1.31\u00a0cc (median 0.76; range 0.19\u20135), and at 3\u00a0years was 1.32\u00a0cc (median 0.59; range 0.23\u20134.8). No adverse radiation events were observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Stereotactic radiosurgery is considered a safe and effective treatment for jugular foramen schwannomas, ensuring high rates of tumor control in all patients over the long term. The cranial nerve function improved after SRS in the 6 patients who had deficits and the other 5 patients who had no deficits remained asymptomatic. For larger tumors, combined\/hybrid approaches can be a valuable alternative, to obtain tumor control and to preserve neurological function.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00701-024-06211-x","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T20:45:37Z","timestamp":1724445937000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stereotactic radio-neurosurgery for jugular foramen schwannomas"],"prefix":"10.1007","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7793-9883","authenticated-orcid":false,"given":"Camil","family":"Bourhila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Cotrutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy Thomas","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercy","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Schiappacasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Patin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Levivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Tuleasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"6211_CR1","doi-asserted-by":"publisher","unstructured":"Aftahy AK, Groll M, Barz M, Bernhardt D, Combs SE, Meyer B, Negwer C, Gempt J (2021) Surgical Management of Jugular Foramen Schwannomas. Cancers (Basel) 13 https:\/\/doi.org\/10.3390\/cancers13164218","DOI":"10.3390\/cancers13164218"},{"key":"6211_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3340\/jkns.2008.44.5.285","volume":"44","author":"B Bakar","year":"2008","unstructured":"Bakar B (2008) The jugular foramen schwannomas: review of the large surgical series. J Korean Neurosurg Soc 44:285\u2013294. https:\/\/doi.org\/10.3340\/jkns.2008.44.5.285","journal-title":"J Korean Neurosurg Soc"},{"key":"6211_CR3","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002735","author":"LP Carlstrom","year":"2023","unstructured":"Carlstrom LP, Bauman MMJ, Oushy S, Perry A, Brown PD, Peris-Celda M, Van Gompel JJ, Graffeo CS, Link MJ (2023) Lower Cranial Nerve Schwannomas: Cohort Study and Systematic Review. Neurosurgery. https:\/\/doi.org\/10.1227\/neu.0000000000002735","journal-title":"Neurosurgery"},{"key":"6211_CR4","doi-asserted-by":"publisher","first-page":"928","DOI":"10.3171\/2017.5.JNS162894","volume":"129","author":"H Kano","year":"2018","unstructured":"Kano H, Meola A, Yang HC, Guo WY, Martinez-Alvarez R, Martinez-Moreno N, Urgosik D, Liscak R, Cohen-Inbar O, Sheehan J, Lee JYK, Abbassy M, Barnett GH, Mathieu D, Kondziolka D, Lunsford LD (2018) Stereotactic radiosurgery for jugular foramen schwannomas: an international multicenter study. J Neurosurg 129:928\u2013936. https:\/\/doi.org\/10.3171\/2017.5.JNS162894","journal-title":"J Neurosurg"},{"key":"6211_CR5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13014-022-02057-8","volume":"17","author":"YG Kim","year":"2022","unstructured":"Kim YG, Park CK, Jung NY, Jung HH, Chang JH, Chang JW, Chang WS (2022) Early-onset adverse events after stereotactic radiosurgery for jugular foramen schwannoma: a mid-term follow-up single-center review of 46 cases. Radiat Oncol 17:89. https:\/\/doi.org\/10.1186\/s13014-022-02057-8","journal-title":"Radiat Oncol"},{"key":"6211_CR6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1227\/01.neu.0000279726.90650.6d","volume":"61","author":"JJ Martin","year":"2007","unstructured":"Martin JJ, Kondziolka D, Flickinger JC, Mathieu D, Niranjan A, Lunsford LD (2007) Cranial nerve preservation and outcomes after stereotactic radiosurgery for jugular foramen schwannomas. 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