{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:14:35Z","timestamp":1780107275450,"version":"3.54.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005423","name":"Akademiska Sjukhuset","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Sweden covers a large land area, but is sparsely populated. The country is divided into six heterogenous healthcare regions, each with different geographic conditions and referral patterns when it comes to traumatic brain injury (TBI). This study aimed to explore the variation in demography, injury patterns, care pathways, management, and mortality (30 d) for TBI patients within the country.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A nationwide, observational study, using data from the Swedish Trauma Registry (SweTrau) between 2018\u20132022, was performed. A total of 5036 TBI patients were included. Data on demography, admission status (through Glasgow Coma Scale [GCS] value at arrival at first managing hospital), injury-related variables, and mortality (30 d) were evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The median age was 65\u00a0years (interquartile range 46\u201378), and the majority of patients were male, had sustained fall-related injuries, and were conscious upon admission. Slight, but significant differences (p\u2009&lt;\u20090.05) existed among the regions in these variables. In multivariate logistic regression models, the healthcare region (p\u2009&lt;\u20090.05) was independently associated with patient referral to a university hospital (as compared to care at a local hospital alone), craniotomy rate, and receiving an intracranial pressure-monitoring device, after adjustment for demographic and injury variables. In similar regressions regarding mortality, specific healthcare regions (p\u2009&lt;\u20090.05) were independently associated with said outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The study highlights, from a systems-level perspective, that there was a significant variation in care pathways and management among the six healthcare regions in Sweden, which might have impacted on clinical outcome. These findings call for more granular studies to understand which aspects of patient management that were particularly beneficial or detrimental for patient survival and recovery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00701-025-06557-w","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T05:44:34Z","timestamp":1746683074000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Regional variation in traumatic brain injury patterns, management and mortality: a nationwide Swedish cohort study"],"prefix":"10.1007","volume":"167","author":[{"given":"Francisco","family":"Leal-M\u00e9ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Lew\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"H\u00e5nell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Holmberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Enblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Linder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodor Svedung","family":"Wettervik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"6557_CR1","doi-asserted-by":"publisher","unstructured":"Andersson E, \u00d6st M, Dalla K, Zetterberg H, Blennow K, Nellg\u00e5rd B (2024) Acute-phase neurofilament light and glial fibrillary acidic proteins in cerebrospinal fluid predict long-term outcome after severe traumatic brain injury. Neurocrit Care.\u00a0https:\/\/doi.org\/10.1007\/s12028-024-01998-0","DOI":"10.1007\/s12028-024-01998-0"},{"issue":"3","key":"6557_CR2","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1093\/neurosurgery\/58.3.vi","volume":"58","author":"MR Bullock","year":"2006","unstructured":"Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R, Newell DW, Servadei F, Walters BC, Wilberger JE (2006) Guidelines for the surgical management of traumatic brain injury author group: Acknowledgments. Neurosurgery 58(3):S2","journal-title":"Neurosurgery"},{"issue":"1","key":"6557_CR3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1227\/NEU.0000000000001432","volume":"80","author":"N Carney","year":"2017","unstructured":"Carney N, Totten AM, O\u2019Reilly C et al (2017) Guidelines for the management of severe traumatic brain injury fourth edition. 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