{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:44:09Z","timestamp":1768283049116,"version":"3.49.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100011852","name":"Paracelsus Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011852","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Brain abscesses can lead to severe clinical outcomes, including death. Most studies on brain abscesses focus either on patient cohorts including postsurgical\/posttraumatic abscesses. This study aimed to assess the clinical presentation and postoperative outcomes in a homogeneous group of patients with primary, pyogenic brain abscesses who underwent surgical treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We retrospectively analyzed consecutive patients with pyogenic brain abscesses treated surgically at our center from 2008 to 2023. The primary endpoint was a modified Rankin Scale (mRS) score of\u2009\u2265\u20093 at discharge. Secondary endpoint was preoperative clinical status (mRS\u2009\u2265\u20093). We statistically correlated clinical, radiographic, and microbiological parameters with these endpoints.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 60 patients (36.7% female) with a mean age of 48.5\u2009\u00b1\u200920.8\u00a0years were included in this study. Six patients (10.0%) had an unfavorable postoperative outcome, including two deaths (3.3%). Significant risk factors for poor outcomes included preoperative disturbance of consciousness (DOC) (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) and elevated preoperative C-reactive protein (CRP) levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Larger abscess volume (37.4\u00a0mL vs. 16.1\u00a0mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.065) and shorter mean distance to the ventricles (3\u00a0mm vs. 11.42\u00a0mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.086) trended toward significance. The length of intensive care unit (ICU) stay was significantly longer for patients with unfavorable outcomes (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Upon admission, eighteen patients (30.0%) had an mRS score of\u2009\u2265\u20093. Elevated leukocyte count was identified as a significant risk factor for poor preoperative status (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). Median clinical performance, measured by mRS, improved throughout the treatment course and during follow-up from 2 to 0.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Preoperative DOC and elevated CRP levels were identified as predictors of unfavorable outcomes. Elevated leukocyte count was a predictor for poor preoperative status.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00701-025-06559-8","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:35:47Z","timestamp":1747269347000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of laboratory and radiographic parameters on the clinical presentation and outcome of surgically treated patients with primary brain abscesses"],"prefix":"10.1007","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-3369","authenticated-orcid":false,"given":"Adrian","family":"Liebert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eibl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri","family":"Lukin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-6381","authenticated-orcid":false,"given":"Ralph","family":"Bertram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3181-3667","authenticated-orcid":false,"given":"Joerg","family":"Steinmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Michael","family":"Schebesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2673-1979","authenticated-orcid":false,"given":"Leonard","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"6559_CR1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2175-3018","author":"MF Ahmed","year":"2023","unstructured":"Ahmed MF, Rana S, Zahan KFI, Munira S, Islam MS, Haque M, Pahwa B, Aydin L, Umana GEE, Chaurasia B (2023) Brain abscess: a comparison of surgical outcomes between conventional burr hole aspiration and endoscope-assisted evacuation. 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Informed consent was waived due to the retrospective study design. The study and that informed consent was waived were approved by the Institutional Review Board, Paracelsus Medical University, Nuremberg, IRB 2024.05.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and informed consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"140"}}