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Sensitivity and specificity values were pooled and Bayesian meta-analysis was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The Resistance to outflow (Rout) sensitivity was 76.9%; 81.6% and 36.6% for a Rout cut off of respectively 12, 14 and 18\u00a0mmHg\/ml\/min. Specificity rose with higher Rout cut off and was 34.0%; 37.2% and 78.0% for a cut off of respectively 12, 14 and 18\u00a0mmHg\/ml\/min. The negative predictive value was low for each cut off and was at most 33.3%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The LIT proves poor negative predictive value and appears an ineffective tool in the prediction of non-response to a shunting procedure. Therefore, in its present form and based on its current parameters, it cannot be used as a test to exclude patients from shunt implantation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00701-025-06591-8","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T05:30:21Z","timestamp":1751261421000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The diagnostic value of the lumbar infusion test to predict symptomatic improvement after shunting for normal pressure hydrocephalus. A meta-analysis"],"prefix":"10.1007","volume":"167","author":[{"given":"M. W. 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