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Comorbidities and presenting factors have been suggested as risks, but only in cross-sectional studies. The objective of this study was to characterize risk factors associated with vasospasm and mortality in ruptured AVM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients from the TriNetX Research Network were included, based on the ICD-10 codes, over a period of 20\u00a0years. Cox proportional hazard models assessed the hazards of vasospasm (I67.84) and mortality separately, adjusting for age, sex, comorbidities, substance use history, presenting factors (e.g., hypernatremia, hypokalemia), criteria of the National Inpatient Sample-Subarachnoid Hemorrhage Severity Score, and location of hemorrhage. Outcomes were assessed in the first 30\u00a0days following rupture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 10,375 patients with ruptured AVMs, 523 (5.3%) died and 297 (3.0%) experienced vasospasm in the first 30\u00a0days. After matching for age and sex, vasospasm was associated with increased mortality at three months (11.1% vs. 4.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), six months (12.6% vs. 5.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and one year (13.5% vs. 6.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). Female sex was protective against vasospasm within 30\u00a0days (HR\u2009=\u20090.714,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) while the greatest risk factors present on admission included subarachnoid hemorrhage (6.086,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hydrocephalus (3.783,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and leukocytosis (2.0677,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The greatest risk factors for 30-day mortality were coma (HR\u2009=\u20093.700,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hydrocephalus (2.698,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and chronic kidney disease (1.596,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective cohort study of 10,375 adult patients with ruptured AVMs, vasospasm occurred in approximately 3%. Risk factors for vasospasm included subarachnoid hemorrhage, male sex, hydrocephalus, and leukocytosis. The presence of vasospasm was associated with a more than twofold increase in mortality at both 30\u00a0days and one year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00701-026-06816-4","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:39:32Z","timestamp":1773797972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral vasospasm following arteriovenous malformation rupture: a population-based longitudinal study"],"prefix":"10.1007","volume":"168","author":[{"given":"Isaac B.","family":"Thorman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eris","family":"Spirollari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Mubarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Elbayoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryan","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Sacknovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchenna","family":"Okafo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurmeen","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bauerschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag D.","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawaz","family":"Al-Mufti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"6816_CR1","doi-asserted-by":"publisher","first-page":"e68","DOI":"10.1016\/j.wneu.2018.07.143","volume":"120","author":"F Al-Mufti","year":"2018","unstructured":"Al-Mufti F, Amuluru K, Lander M, Mathew M, El-Ghanem M, Nuoman R, Park S, Patel V, Singh IP, Gupta G, Gandhi CD (2018) Low Glasgow Coma Score in traumatic intracranial hemorrhage predicts development of cerebral vasospasm. 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