{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:08:11Z","timestamp":1792789691320,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100012910","name":"National Defense Medical College","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012910","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"DOI":"10.1007\/s00701-026-06953-w","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:14:29Z","timestamp":1781936069000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intracranial pressure changes and outcomes in the early phase of experimental subarachnoid hemorrhage: severity of subarachnoid hemorrhage and maximum intracranial pressure"],"prefix":"10.1007","volume":"168","author":[{"given":"Kazuya","family":"Fujii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1317-2966","authenticated-orcid":false,"given":"Terushige","family":"Toyooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arata","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"6953_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00701-003-0052-z","volume":"145","author":"MA Aladag","year":"2003","unstructured":"Aladag MA, Turkoz Y, Sahna E, Parlakpinar H, Gul M (2003) The attenuation of vasospasm by using a SOD mimetic after experimental subarachnoidal haemorrhage in rats. Acta Neurochir (Wien) 145:673\u2013677","journal-title":"Acta Neurochir (Wien)"},{"key":"6953_CR2","first-page":"159","volume":"20","author":"R Ayer","year":"2010","unstructured":"Ayer R, Zhang J (2010) Connecting the early brain injury of aneurysmal subarachnoid hemorrhage to clinical practice. Turk Neurosurg 20:159\u2013166","journal-title":"Turk Neurosurg"},{"key":"6953_CR3","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1161\/01.STR.26.6.1086","volume":"26","author":"JB Bederson","year":"1995","unstructured":"Bederson JB, Germano IM, Guarino L (1995) Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat. Stroke 26:1086\u20131092","journal-title":"Stroke"},{"key":"6953_CR4","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/sj.jcbfm.9600283","volume":"26","author":"J Cahill","year":"2006","unstructured":"Cahill J, Calvert JW, Zhang JH (2006) Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 26:1341\u20131353","journal-title":"J Cereb Blood Flow Metab"},{"key":"6953_CR5","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/978-1-60327-185-1_21","volume-title":"Animal models of acute neurological injuries","author":"J Cahill","year":"2009","unstructured":"Cahill J, Zhang JH (2009) Monofilament perforation subarachnoid hemorrhage rat model. In: Chen J, Xu XM, Xu ZC, Zhang JH (eds) Animal models of acute neurological injuries. Humana Press, Totowa, NJ, pp 261\u2013270"},{"key":"6953_CR6","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/jcbfm.1986.106","volume":"6","author":"TJ Delgado","year":"1986","unstructured":"Delgado TJ, Arbab MA, Diemer NH, Svendgaard NA (1986) Subarachnoid hemorrhage in the rat: cerebral blood flow and glucose metabolism during the late phase of cerebral vasospasm. J Cereb Blood Flow Metab 6:590\u2013599","journal-title":"J Cereb Blood Flow Metab"},{"key":"6953_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1161\/01.STR.12.3.273","volume":"12","author":"CG Drake","year":"1981","unstructured":"Drake CG (1981) Progress in cerebrovascular disease. Management of cerebral aneurysm. Stroke 12:273\u2013283","journal-title":"Stroke"},{"issue":"2","key":"6953_CR8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jneumeth.2010.05.005","volume":"190","author":"S Feiler","year":"2010","unstructured":"Feiler S, Friedrich B, Sch\u00f6ller K, Thal SC, Plesnila N (2010) Standardized induction of subarachnoid hemorrhage in mice by intracranial pressure monitoring. J Neurosci Methods 190(2):164\u2013170","journal-title":"J Neurosci Methods"},{"key":"6953_CR9","doi-asserted-by":"publisher","first-page":"e80101","DOI":"10.1371\/journal.pone.0080101","volume":"8","author":"V Friedrich","year":"2013","unstructured":"Friedrich V, Bederson JB, Sehba FA (2013) Gender influences the initial impact of subarachnoid hemorrhage: an experimental investigation. PLoS ONE 8:e80101","journal-title":"PLoS ONE"},{"key":"6953_CR10","first-page":"1935","volume":"122","author":"Y Gao","year":"2009","unstructured":"Gao Y, Ding XS, Xu S, Wang W, Zuo QL, Kuai F (2009) Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage. Chin Med J (Engl) 122:1935\u20131940","journal-title":"Chin Med J (Engl)"},{"key":"6953_CR11","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","volume":"26","author":"JH Garcia","year":"1995","unstructured":"Garcia JH, Wagner S, Liu KF, Hu XJ (1995) Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats Statistical validation. Stroke 26:627\u2013635","journal-title":"Stroke"},{"key":"6953_CR12","unstructured":"Gotoh O, Tamura A, Nihei H, Manaka S, Tsujita Y, Oka H, Sano K (1993) [Vasospasm and its outcome after early surgery for ruptured cerebral aneurysms: changing pattern of its incidence and outcome during this 9-year period]. No Shinkei Geka 21:299\u2013304. Japanese"},{"key":"6953_CR13","first-page":"43","volume":"110","author":"Y Hasegawa","year":"2011","unstructured":"Hasegawa Y, Suzuki H, Sozen T, Altay O, Zhang JH (2011) Apoptotic mechanisms for neuronal cells in early brain injury after subarachnoid hemorrhage. Acta Neurochir Suppl 110:43\u201348","journal-title":"Acta Neurochir Suppl"},{"key":"6953_CR14","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1161\/01.STR.28.3.660","volume":"28","author":"JW Hop","year":"1997","unstructured":"Hop JW, Rinkel GJ, Algra A, van Gijn J (1997) Case-fatality rates and functional outcome after subarachnoid hemorrhage: a systematic review. Stroke 28:660\u2013664","journal-title":"Stroke"},{"key":"6953_CR15","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/jcbfm.1990.140","volume":"10","author":"A Jackowski","year":"1990","unstructured":"Jackowski A, Crockard A, Burnstock G, Russell RR, Kristek F (1990) The time course of intracranial pathophysiological changes following experimental subarachnoid haemorrhage in the rat. J Cereb Blood Flow Metab 10:835\u2013849","journal-title":"J Cereb Blood Flow Metab"},{"key":"6953_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/1471-2202-10-103","volume":"10","author":"H Jeon","year":"2009","unstructured":"Jeon H, Ai J, Sabri M, Tariq A, Shang X, Chen G, Macdonald RL (2009) Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage. BMC Neurosci 10:103","journal-title":"BMC Neurosci"},{"key":"6953_CR17","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1097\/01.WCB.0000125886.48838.7E","volume":"24","author":"G Kusaka","year":"2004","unstructured":"Kusaka G, Ishikawa M, Nanda A, Granger DN, Zhang JH (2004) Signaling pathways for early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 24:916\u2013925","journal-title":"J Cereb Blood Flow Metab"},{"key":"6953_CR18","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1227\/01.NEU.0000345649.78556.26","volume":"65","author":"JY Lee","year":"2009","unstructured":"Lee JY, Sagher O, Keep R, Hua Y, Xi G (2009) Comparison of experimental rat models of early brain injury after subarachnoid hemorrhage. Neurosurgery 65:331\u2013343","journal-title":"Neurosurgery"},{"key":"6953_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40635-014-0030-1","volume":"2","author":"S Marbacher","year":"2014","unstructured":"Marbacher S, Neuschmelting V, Andereggen L, Widmer HR, von Gunten M, Takala J, Jakob SM, Fandino J (2014) Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage. Intensive Care Med Exp 2:30","journal-title":"Intensive Care Med Exp"},{"key":"6953_CR20","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1227\/01.NEU.0000338067.83059.EB","volume":"64","author":"A Munakata","year":"2009","unstructured":"Munakata A, Ohkuma H, Nakano T, Shimamura N, Asano K, Naraoka M (2009) Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage. Neurosurgery 64:423\u2013429","journal-title":"Neurosurgery"},{"key":"6953_CR21","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1097\/SHK.0b013e31824ed57c","volume":"37","author":"K Nagatani","year":"2012","unstructured":"Nagatani K, Wada K, Takeuchi S, Kobayashi H, Uozumi Y, Otani N, Fujita M, Tachibana S, Nawashiro H (2012) Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia. Shock 37:645\u2013652","journal-title":"Shock"},{"key":"6953_CR22","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1179\/016164106X115008","volume":"28","author":"RP Ostrowski","year":"2006","unstructured":"Ostrowski RP, Colohan AR, Zhang JH (2006) Molecular mechanisms of early brain injury after subarachnoid hemorrhage. Neurol Res 28:399\u2013414","journal-title":"Neurol Res"},{"key":"6953_CR23","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jneumeth.2008.04.027","volume":"172","author":"IS Park","year":"2008","unstructured":"Park IS, Meno JR, Witt CE, Suttle TK, Chowdhary A, Nguyen TS, Ngai AC, Britz GW (2008) Subarachnoid hemorrhage model in the rat: modification of the endovascular filament model. J Neurosci Methods 172:195\u2013200","journal-title":"J Neurosci Methods"},{"key":"6953_CR24","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1212\/WNL.30.10.1034","volume":"30","author":"LH Phillips 2nd","year":"1980","unstructured":"Phillips LH 2nd, Whisnant JP, O\u2019Fallon WM, Sundt TM Jr (1980) The unchanging pattern of subarachnoid hemorrhage in a community. Neurology 30:1034\u20131040","journal-title":"Neurology"},{"key":"6953_CR25","first-page":"165","volume":"52","author":"GF Prunell","year":"2003","unstructured":"Prunell GF, Mathiesen T, Diemer NH, Svendgaard NA (2003) Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat models. Neurosurgery 52:165\u2013176","journal-title":"Neurosurgery"},{"key":"6953_CR26","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1227\/01.NEU.0000103670.09687.7A","volume":"54","author":"GF Prunell","year":"2004","unstructured":"Prunell GF, Mathiesen T, Svendgaard NA (2004) Experimental subarachnoid hemorrhage: cerebral blood flow and brain metabolism during the acute phase in three different models in the rat. Neurosurgery 54:426\u2013437","journal-title":"Neurosurgery"},{"key":"6953_CR27","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12028-007-0003-2","volume":"7","author":"JM Schmidt","year":"2007","unstructured":"Schmidt JM, Rincon F, Fernandez A, Resor C, Kowalski RG, Claassen J, Connolly ES, Fitzsimmons BF, Mayer SA (2007) Cerebral infarction associated with acute subarachnoid hemorrhage. Neurocrit Care 7:10\u201317","journal-title":"Neurocrit Care"},{"key":"6953_CR28","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0165-0270(00)00156-4","volume":"96","author":"AY Schwartz","year":"2000","unstructured":"Schwartz AY, Masago A, Sehba FA, Bederson JB (2000) Experimental models of subarachnoid hemorrhage in the rat: a refinement of the endovascular filament model. J Neurosci Methods 96:161\u2013167","journal-title":"J Neurosci Methods"},{"key":"6953_CR29","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1007\/s12975-014-0368-4","volume":"5","author":"FA Sehba","year":"2014","unstructured":"Sehba FA (2014) Rat endovascular perforation model. Transl Stroke Res 5:660\u2013668","journal-title":"Transl Stroke Res"},{"key":"6953_CR30","first-page":"615154","volume":"2013","author":"FA Sehba","year":"2013","unstructured":"Sehba FA, Pluta RM (2013) Aneurysmal subarachnoid hemorrhage models: do they need a fix? Stroke Res Treat 2013:615154","journal-title":"Stroke Res Treat"},{"key":"6953_CR31","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1161\/01.STR.16.1.58","volume":"16","author":"RA Solomon","year":"1985","unstructured":"Solomon RA, Antunes JL, Chen RY, Bland L, Chien S (1985) Decrease in cerebral blood flow in rats after experimental subarachnoid hemorrhage: a new animal model. Stroke 16:58\u201364","journal-title":"Stroke"},{"key":"6953_CR32","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","volume":"167","author":"T Sugawara","year":"2008","unstructured":"Sugawara T, Ayer R, Jadhav V, Zhang JH (2008) A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods 167:327\u2013334","journal-title":"J Neurosci Methods"},{"key":"6953_CR33","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1089\/neu.2010.1443","volume":"28","author":"S Tomura","year":"2011","unstructured":"Tomura S, Nawashiro H, Otani N, Uozumi Y, Toyooka T, Ohsumi A, Shima K (2011) Effect of decompressive craniectomy on aquaporin-4 expression after lateral fluid percussion injury in rats. J Neurotrauma 28:237\u2013243","journal-title":"J Neurotrauma"},{"key":"6953_CR34","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1227\/01.NEU.0000199346.74649.66","volume":"58","author":"H Vatter","year":"2006","unstructured":"Vatter H, Weidauer S, Konczalla J, Dettmann E, Zimmermann M, Raabe A, Preibisch C, Zanella FE, Seifert V (2006) Time course in the development of cerebral vasospasm after experimental subarachnoid hemorrhage: clinical and neuroradiological assessment of the rat double hemorrhage model. Neurosurgery 58:1190\u20131197","journal-title":"Neurosurgery"},{"key":"6953_CR35","first-page":"529","volume":"22","author":"S Yuksel","year":"2012","unstructured":"Yuksel S, Tosun YB, Cahill J, Solaroglu I (2012) Early brain injury following aneurysmal subarachnoid hemorrhage: emphasis on cellular apoptosis. Turk Neurosurg 22:529\u2013533","journal-title":"Turk Neurosurg"},{"key":"6953_CR36","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1161\/01.STR.0000182241.07096.06","volume":"36","author":"N Zhang","year":"2005","unstructured":"Zhang N, Komine-Kobayashi M, Tanaka R, Liu M, Mizuno Y, Urabe T (2005) Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke 36:2220\u20132225","journal-title":"Stroke"},{"key":"6953_CR37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10571-014-0106-1","volume":"35","author":"ZY Zhang","year":"2015","unstructured":"Zhang ZY, Sun BL, Yang MF, Li DW, Fang J, Zhang S (2015) Carnosine attenuates early brain injury through its antioxidative and anti-apoptotic effects in a rat experimental subarachnoid hemorrhage model. Cell Mol Neurobiol 35:147\u2013157","journal-title":"Cell Mol Neurobiol"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00701-026-06953-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-026-06953-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-026-06953-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:23:01Z","timestamp":1785478981000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00701-026-06953-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6953"],"URL":"https:\/\/doi.org\/10.1007\/s00701-026-06953-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9175606\/v1","asserted-by":"object"}]},"ISSN":["0942-0940"],"issn-type":[{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,20]]},"assertion":[{"value":"20 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the approval of the Institutional Animal Ethics Committee, National Defense Medical College (approval no-14006).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"195"}}