{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:48:42Z","timestamp":1791910122263,"version":"4.3.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurochir"],"DOI":"10.1007\/s00701-026-06974-5","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:34:01Z","timestamp":1784352841000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical outcomes and predictors of recurrence following endoscopic endonasal marsupialization of Rathke\u2019s cleft cysts"],"prefix":"10.1007","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3866-4569","authenticated-orcid":false,"given":"Raywat","family":"Noiphithak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supapitch","family":"Subenja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bheem","family":"Pongsukvechkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pree","family":"Nimmannitya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"issue":"5","key":"6974_CR1","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.3171\/2024.3.JNS232740","volume":"141","author":"HN Algattas","year":"2024","unstructured":"Algattas HN, Gersey ZC, Fernandes Cabral D et al (2024) Endoscopic endonasal resection of Rathke cleft cysts: a single-institution analysis of 148 consecutive patients. J Neurosurg 141(5):1352\u20131362","journal-title":"J Neurosurg"},{"key":"6974_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-023-01347-y","author":"MB Alsavaf","year":"2023","unstructured":"Alsavaf MB, Wu K, Gosal J, Finger G, Koch B, Abouammo M, Prevedello L, Carrau R, Prevedello D (2023) Endoscopic endonasal marsupialization of Rathke cleft cysts: clinical outcomes and risk factors analysis of visual impairment, pituitary dysfunction, and CSF leak. Pituitary. https:\/\/doi.org\/10.1007\/s11102-023-01347-y","journal-title":"Pituitary"},{"key":"6974_CR3","doi-asserted-by":"publisher","unstructured":"Amano K, Masui K, Oda Y, Komori T, Seki Y, Ichihara A, Kawamata T (2025) Histopathological inflammation in Rathke\u2019s cleft cysts: correlation with clinical and radiological features. https:\/\/doi.org\/10.21203\/rs.3.rs-7361846\/v1","DOI":"10.21203\/rs.3.rs-7361846\/v1"},{"issue":"Suppl 3","key":"6974_CR4","first-page":"e101","volume":"82","author":"L Arko","year":"2021","unstructured":"Arko L, Lee JCM, Godil S, Hanz SZ, Anand VK, Schwartz TH (2021) Endonasal endoscopic fenestration of Rathke\u2019s cleft cysts: whether to leave the fenestration open or closed? J Neurol Surg B Skull Base 82(Suppl 3):e101\u2013e104","journal-title":"J Neurol Surg B Skull Base"},{"issue":"4","key":"6974_CR5","doi-asserted-by":"publisher","first-page":"577","DOI":"10.3171\/jns.2004.101.4.0577","volume":"101","author":"RJ Benveniste","year":"2004","unstructured":"Benveniste RJ, King WA, Walsh J, Lee JS, Naidich TP, Post KD (2004) Surgery for Rathke cleft cysts: technical considerations and outcomes. J Neurosurg 101(4):577\u2013584","journal-title":"J Neurosurg"},{"issue":"3","key":"6974_CR6","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11102-005-1755-3","volume":"7","author":"D Billeci","year":"2004","unstructured":"Billeci D, Marton E, Tripodi M, Orvieto E, Longatti P (2004) Symptomatic Rathke\u2019s cleft cysts: a radiological, surgical and pathological review. Pituitary 7(3):131\u2013137","journal-title":"Pituitary"},{"issue":"3","key":"6974_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11102-025-01521-4","volume":"28","author":"RB Dolovac","year":"2025","unstructured":"Dolovac RB, King J, Ovenden C, Kam J, Wang YY, Goldschlager T, Castle-Kirszbaum M (2025) Impact of sella floor reconstruction on Rathke cleft cyst recurrence: a systematic review and meta-analysis. Pituitary 28(3):49","journal-title":"Pituitary"},{"key":"6974_CR8","doi-asserted-by":"publisher","first-page":"e664","DOI":"10.1016\/j.wneu.2022.08.064","volume":"167","author":"JG Eide","year":"2022","unstructured":"Eide JG, Salmon MK, Kshirsagar RS et al (2022) Reconstruction with mucosal graft reduces recurrence after endoscopic surgery of Rathke cleft cyst. World Neurosurg 167:e664\u2013e669","journal-title":"World Neurosurg"},{"issue":"6","key":"6974_CR9","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.3171\/2013.8.JNS13777","volume":"119","author":"J Fan","year":"2013","unstructured":"Fan J, Peng Y, Qi S, Zhang X, Qiu B, Pan J (2013) Individualized surgical strategies for Rathke cleft cyst based on cyst location. J Neurosurg 119(6):1437\u20131446","journal-title":"J Neurosurg"},{"issue":"2","key":"6974_CR10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3171\/jns.2002.96.2.0209","volume":"96","author":"S Hama","year":"2002","unstructured":"Hama S, Arita K, Nishisaka T et al (2002) Changes in the epithelium of Rathke cleft cyst associated with inflammation. J Neurosurg 96(2):209\u2013216","journal-title":"J Neurosurg"},{"issue":"2","key":"6974_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s11060-013-1272-6","volume":"117","author":"SJ Han","year":"2014","unstructured":"Han SJ, Rolston JD, Jahangiri A, Aghi MK (2014) Rathke\u2019s cleft cysts: review of natural history and surgical outcomes. J Neurooncol 117(2):197\u2013203","journal-title":"J Neurooncol"},{"issue":"2","key":"6974_CR12","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0303-8467(01)00121-4","volume":"103","author":"M Isono","year":"2001","unstructured":"Isono M, Kamida T, Kobayashi H, Shimomura T, Matsuyama J (2001) Clinical features of symptomatic Rathke\u2019s cleft cyst. Clin Neurol Neurosurg 103(2):96\u2013100","journal-title":"Clin Neurol Neurosurg"},{"issue":"2","key":"6974_CR13","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11102-025-01511-6","volume":"28","author":"A Jian","year":"2025","unstructured":"Jian A, Wang YY, Goldschlager T, Castle-Kirszbaum M, Kam J, Zhao YC, King J (2025) Headache relief following endoscopic drainage of Rathke\u2019s cleft cyst. Pituitary 28(2):40","journal-title":"Pituitary"},{"issue":"6","key":"6974_CR14","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.3171\/2019.8.JNS191103","volume":"133","author":"H Kino","year":"2020","unstructured":"Kino H, Akutsu H, Tanaka S et al (2020) Endoscopic endonasal cyst fenestration into the sphenoid sinus using the mucosa coupling method for symptomatic Rathke\u2019s cleft cyst: a novel method for maintaining cyst drainage to prevent recurrence. J Neurosurg 133(6):1710\u20131720","journal-title":"J Neurosurg"},{"issue":"10","key":"6974_CR15","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1002\/lary.28053","volume":"129","author":"EC Kuan","year":"2019","unstructured":"Kuan EC, Trent MS, Luu NN, Kohanski MA, Tong CC, O\u2019Malley BW, Adappa ND, Palmer JN (2019) Preventing restenosis of marsupialized Rathke cleft cysts using a nasoseptal flap lining. Laryngoscope 129(10):2258\u20132261","journal-title":"Laryngoscope"},{"key":"6974_CR16","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/B978-0-444-59602-4.00017-4","volume":"124","author":"S Larkin","year":"2014","unstructured":"Larkin S, Karavitaki N, Ansorge O (2014) Rathke\u2019s cleft cyst. Handb Clin Neurol 124:255\u2013269","journal-title":"Handb Clin Neurol"},{"issue":"4","key":"6974_CR17","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1055\/s-0042-1755572","volume":"84","author":"A Lazutkin","year":"2023","unstructured":"Lazutkin A, Hachem RA, Codd PJ, Zomorodi AR, Jang DW (2023) Use of tympanostomy T-tube for endoscopic endonasal marsupialization of small Rathke\u2019s cleft cysts: a case series. J Neurol Surg B Skull Base 84(4):401\u2013404","journal-title":"J Neurol Surg B Skull Base"},{"issue":"4","key":"6974_CR18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.14791\/btrt.2023.0025","volume":"11","author":"D Lee","year":"2023","unstructured":"Lee D, Kim JH, Park D-H, Kang S-H, Park K-J (2023) Recurrence of Rathke\u2019s cleft cyst following surgery and histopathological considerations for recurrence: a case presentation. Brain Tumor Res Treat 11(4):266\u2013270","journal-title":"Brain Tumor Res Treat"},{"issue":"7","key":"6974_CR19","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3345\/kjp.2010.53.7.759","volume":"53","author":"HH Lim","year":"2010","unstructured":"Lim HH, Yang SW (2010) Risk factor for pituitary dysfunction in children and adolescents with Rathke\u2019s cleft cysts. Korean J Pediatr 53(7):759\u2013765","journal-title":"Korean J Pediatr"},{"issue":"Suppl 3","key":"6974_CR20","first-page":"e105","volume":"82","author":"R Limb","year":"2021","unstructured":"Limb R, King J (2021) Relationship between recurrence rates of Rathke\u2019s cleft cysts and surgical approaches to sellar reconstruction. J Neurol Surg B Skull Base 82(Suppl 3):e105\u2013e111","journal-title":"J Neurol Surg B Skull Base"},{"issue":"5","key":"6974_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103519","volume":"43","author":"A Madapoosi","year":"2022","unstructured":"Madapoosi A, Uram Z, Tsiang J, Pecoraro N, Patel C, Germanwala AV (2022) Rathke\u2019s cleft cyst marsupialization and repair with a free mucosal graft - video case report and literature review. Am J Otolaryngol 43(5):103519","journal-title":"Am J Otolaryngol"},{"key":"6974_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1413810","volume":"15","author":"EL Men\u00e9ndez-Torre","year":"2024","unstructured":"Men\u00e9ndez-Torre EL, Guti\u00e9rrez-Hurtado A, Ollero MD et al (2024) Natural history and surgical outcomes of Rathke\u2019s cleft cysts: a Spanish multicenter study. Front Endocrinol (Lausanne) 15:1413810","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"11","key":"6974_CR23","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.3390\/brainsci12111482","volume":"12","author":"M Millesi","year":"2022","unstructured":"Millesi M, Lai C, Lau R et al (2022) Endoscopic treatment of Rathke\u2019s cleft cysts: the case for simple fenestration. Brain Sci 12(11):1482","journal-title":"Brain Sci"},{"issue":"2","key":"6974_CR24","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1365-2265.2006.02446.x","volume":"64","author":"H Nishioka","year":"2006","unstructured":"Nishioka H, Haraoka J, Izawa H, Ikeda Y (2006) Magnetic resonance imaging, clinical manifestations, and management of Rathke\u2019s cleft cyst. Clin Endocrinol (Oxf) 64(2):184\u2013188","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"6974_CR25","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/cen.14622","volume":"96","author":"M Petersson","year":"2022","unstructured":"Petersson M, Berinder K, Eden Engstr\u00f6m B et al (2022) Natural history and surgical outcome of Rathke\u2019s cleft cysts-A study from the Swedish Pituitary Registry. Clin Endocrinol (Oxf) 96(1):54\u201361","journal-title":"Clin Endocrinol (Oxf)"},{"key":"6974_CR26","doi-asserted-by":"crossref","unstructured":"Potts MB, Jahangiri A, Lamborn KR, Blevins LS, Kunwar S, Aghi MK (2011) Suprasellar Rathke cleft cysts: clinical presentation and treatment outcomes. Neurosurgery 69(5):1058\u20131068; discussion 1068\u20131067","DOI":"10.1227\/NEU.0b013e318228bcea"},{"key":"6974_CR27","doi-asserted-by":"publisher","first-page":"1065316","DOI":"10.3389\/fsurg.2022.1065316","volume":"9","author":"A Qian","year":"2022","unstructured":"Qian A, Zhou J, Zhang X, Yu J, Wang X (2022) Incidence and factors associated with the recurrence of Rathke\u2019s cleft cyst after surgery: A systematic review and meta-analysis. Front Surg 9:1065316","journal-title":"Front Surg"},{"issue":"10","key":"6974_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139609","volume":"10","author":"D Solari","year":"2015","unstructured":"Solari D, Cavallo LM, Somma T, Chiaramonte C, Esposito F, Caro MDBD, Cappabianca P (2015) Endoscopic endonasal approach in the management of Rathke\u2019s cleft cysts. PLoS One 10(10):e0139609","journal-title":"PLoS One"},{"issue":"6","key":"6974_CR29","doi-asserted-by":"publisher","first-page":"713","DOI":"10.3892\/etm.2022.11649","volume":"24","author":"C Tang","year":"2022","unstructured":"Tang C, Wang P, Liu J, Jiang H, Zhang G, Wu N (2022) Endoscopic endonasal transsphenoidal approach for symptomatic Rathke cleft cyst: a case series. Exp Ther Med 24(6):713","journal-title":"Exp Ther Med"},{"issue":"2","key":"6974_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1365-2265.2011.04235.x","volume":"76","author":"R Trifanescu","year":"2012","unstructured":"Trifanescu R, Ansorge O, Wass JAH, Grossman AB, Karavitaki N (2012) Rathke\u2019s cleft cysts. Clin Endocrinol (Oxf) 76(2):151\u2013160","journal-title":"Clin Endocrinol (Oxf)"},{"key":"6974_CR31","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.wneu.2019.08.035","volume":"131","author":"AK Wong","year":"2019","unstructured":"Wong AK, Raviv J, Ciric I, Wong RH (2019) Novel use of biodissolvable stent in treatment of recurrent Rathke cleft cyst. World Neurosurg 131:186\u2013190","journal-title":"World Neurosurg"},{"issue":"8","key":"6974_CR32","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvaf093","volume":"9","author":"H Yoshimoto","year":"2025","unstructured":"Yoshimoto H, Kato M, Ishida A et al (2025) Recovery of pituitary and visual function after Rathke\u2019s cleft cyst decompression: an 80-case institutional experience. J Endocr Soc 9(8):bvaf093","journal-title":"J Endocr Soc"},{"key":"6974_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.701177","author":"X Zhang","year":"2021","unstructured":"Zhang X, Yang J, Huang Y, Liu Y, Chen L, Chen F, Huang G (2021) Endoscopic endonasal resection of symptomatic Rathke cleft cysts: total resection or partial resection. Front Neurol. https:\/\/doi.org\/10.3389\/fneur.2021.701177","journal-title":"Front Neurol"}],"container-title":["Acta Neurochirurgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00701-026-06974-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-026-06974-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00701-026-06974-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:03:59Z","timestamp":1791907439000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00701-026-06974-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6974"],"URL":"https:\/\/doi.org\/10.1007\/s00701-026-06974-5","relation":{},"ISSN":["0942-0940"],"issn-type":[{"value":"0942-0940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"26 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was reviewed and approved by The Human Research Ethics Committee of\u00a0Thammasat University (Medicine) (IRB number: 171\/2024). Due to retrospective nature of the study utilizing de-identified data from medical records, the requirement for informed consent was waived by the ethics committee.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"239"}}