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The risk of neurological symptoms and emotional burden may restrict participation in everyday life.The glioma diagnosis is considered chronic with a limited overall survival rate, which is particularly concerning for adolescent and young adults (AYA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a longitudinal and prospective study with consecutive inclusion, we followed the QoL in glioma patients aged 18\u201335 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946). Assessment was conducted online with the self-report measures Functional Assessment of Cancer Treatment-Brain (FACT-Br) and Major Depression Inventory (MDI). The assessment was performed consecutively pre- and postoperatively four times per year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On group level we found that the higher burden of pain, lack of energy and greater burden of seizures and decreased subjective cognitive functioning, significantly predicted the total level of QoL. Tumor grade, time since surgery, sex or number of neurosurgical interventions were not found to significant predict the overall QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results underline the importance of optimizing the seizure control and treating pain sufficiently as well as assessing fatigue and cognitive functions. By routinely screening the patients with a standardized QoL-questionnaire, unmet needs can be clarified, and rehabilitation be optimized to prevent deterioration in QoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00701-026-07028-6","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:23:23Z","timestamp":1788747803000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Copenhagen longitudinal study on quality of life in a young adult population with gliomas"],"prefix":"10.1007","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4725-5410","authenticated-orcid":false,"given":"Katrine","family":"Arnkj\u00e6r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Bruun-Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2252-8426","authenticated-orcid":false,"given":"Esben Meulengracht","family":"Flachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5598-6116","authenticated-orcid":false,"given":"Anne","family":"Norup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-9704","authenticated-orcid":false,"given":"Jane","family":"Skj\u00f8th-Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"7028_CR1","doi-asserted-by":"crossref","unstructured":"Aaronson NK, Taphoorn MJB, Heimans JJ, Postma TJ, Gundy CM, Beute GN, Slotman BJ, Klein M (2011) Compromised health-related quality of life in patients with low-grade glioma. 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The sponsors had no role in the design or the conduct of this research.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Funding was received by Life Science Innovation North Denmark, L\u00e6ge Sofus Carl Emil Friis og Hustru Olga Doris Friis Legat, Danish Comprehensive Cancer Center, Innovation Foundation Denmark in collaboration with Department of Molecular Cluster and Imaging, Copenhagen University and Novo Nordisk Foundation.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all individual participants included in this study.All procedures performed in studies involving human participants were in accordance with the ethical standards of the Research Legal in The Capital Region of Denmark (P-2020\u2013106) and with the Helsinki Declaration and its later amendments or comparable ethical standards [\n                      \n                      ].","order":5,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"242"}}