{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:00:26Z","timestamp":1778698826092,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T00:00:00Z","timestamp":1220313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1007\/s00702-008-0097-5","type":"journal-article","created":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T14:53:01Z","timestamp":1220280781000},"page":"1523-1528","source":"Crossref","is-referenced-by-count":20,"title":["Association analysis of Rgs7 variants with panic disorder"],"prefix":"10.1007","volume":"116","author":[{"given":"Christa","family":"Hohoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Domschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Fritze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borwin","family":"Bandelow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Krakowitzky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Rothermundt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Arolt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Deckert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,9,2]]},"reference":[{"key":"97_CR1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J et al (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263\u2013265","journal-title":"Bioinformatics"},{"key":"97_CR2","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/bioinformatics\/bti473","volume":"21","author":"K Cartharius","year":"2005","unstructured":"Cartharius K, Frech K, Grote K et al (2005) MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21:2933\u20132942","journal-title":"Bioinformatics"},{"key":"97_CR3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/1096-8628(20010108)105:1<105::AID-AJMG1072>3.0.CO;2-P","volume":"105","author":"RR Crowe","year":"2001","unstructured":"Crowe RR, Goedken R, Samuelson S et al (2001) Genomewide survey of panic disorder. Am J Med Genet 105:105\u2013109","journal-title":"Am J Med Genet"},{"issue":"7","key":"97_CR4","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/sj.npp.1301557","volume":"33","author":"H Cui","year":"2007","unstructured":"Cui H, Nishiguchi N, Ivleva E, Yanagi M, Fukutake M, Nushida H, Ueno Y, Kitamura N, Maeda K, Shirakawa O (2007) Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims. Neuropsychopharmacology 33(7):1537\u20131544","journal-title":"Neuropsychopharmacology"},{"key":"97_CR5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/hmg\/8.4.621","volume":"8","author":"J Deckert","year":"1999","unstructured":"Deckert J, Catalano M, Syagailo YV et al (1999) Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 8:621\u2013624","journal-title":"Hum Mol Genet"},{"key":"97_CR6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S146114570400416X","volume":"7","author":"K Domschke","year":"2004","unstructured":"Domschke K, Freitag CM, Kuhlenbaumer G et al (2004) Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women. Int J Neuropsychopharmacol 7:183\u2013188","journal-title":"Int J Neuropsychopharmacol"},{"key":"97_CR7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ajmg.b.10058","volume":"118","author":"M Ebihara","year":"2003","unstructured":"Ebihara M, Ohba H, Hattori E et al (2003) Transcriptional activities of cholecystokinin promoter haplotypes and their relevance to panic disorder susceptibility. Am J Med Genet B Neuropsychiatr Genet 118:32\u201335","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"97_CR8","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.biopsych.2006.04.018","volume":"60","author":"AJ Fyer","year":"2006","unstructured":"Fyer AJ, Hamilton SP, Durner M et al (2006) A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci. Biol Psychiatry 60:388\u2013401","journal-title":"Biol Psychiatry"},{"key":"97_CR9","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ajmg.1496","volume":"105","author":"J Gelernter","year":"2001","unstructured":"Gelernter J, Bonvicini K, Page G et al (2001) Linkage genome scan for loci predisposing to panic disorder or agoraphobia. Am J Med Genet 105:548\u2013557","journal-title":"Am J Med Genet"},{"key":"97_CR10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.euroneuro.2005.04.006","volume":"15","author":"RD Goodwin","year":"2005","unstructured":"Goodwin RD, Faravelli C, Rosi S et al (2005) The epidemiology of panic disorder and agoraphobia in Europe. Eur Neuropsychopharmacol 15:435\u2013443","journal-title":"Eur Neuropsychopharmacol"},{"key":"97_CR11","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/FPC.0b013e32800ffbb4","volume":"17","author":"L Greenbaum","year":"2007","unstructured":"Greenbaum L, Strous RD, Kanyas K, Merbl Y, Horowitz A, Karni O, Katz E, Kotler M, Olender T, Deshpande SN, Lancet D, Ben-Asher E, Lerer B (2007) Association of the RGS2 gene with extrapyramidal symptoms induced by treatment with antipsychotic medication. Pharmacogenet Genomics 17:519\u2013528","journal-title":"Pharmacogenet Genomics"},{"issue":"1","key":"97_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/mol.107.036285","volume":"73","author":"S Gu","year":"2007","unstructured":"Gu S, Anton A, Salim S, Blumer KJ, Dessauer CW, Heximer SP (2007) Alternative translation initiation of human RGS2 yields a set of functionally distinct proteins. Mol Pharmacol 73(1):1\u201311","journal-title":"Mol Pharmacol"},{"key":"97_CR13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0006-3223(01)01322-1","volume":"51","author":"SP Hamilton","year":"2002","unstructured":"Hamilton SP, Slager SL, Heiman GA et al (2002) Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22. Biol Psychiatry 51:591\u2013601","journal-title":"Biol Psychiatry"},{"key":"97_CR14","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/sj.npp.1300311","volume":"29","author":"SP Hamilton","year":"2004","unstructured":"Hamilton SP, Slager SL, De Leon AB et al (2004) Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder. Neuropsychopharmacology 29:558\u2013565","journal-title":"Neuropsychopharmacology"},{"key":"97_CR15","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","volume":"158","author":"JM Hettema","year":"2001","unstructured":"Hettema JM, Neale MC, Kendler KS (2001) A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158:1568\u20131578","journal-title":"Am J Psychiatry"},{"key":"97_CR16","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/sj.npp.1300703","volume":"30","author":"X Jiang","year":"2005","unstructured":"Jiang X, Xu K, Hoberman J et al (2005) BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology 30:1353\u20131361","journal-title":"Neuropsychopharmacology"},{"key":"97_CR17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1086\/501072","volume":"78","author":"B Kaabi","year":"2006","unstructured":"Kaabi B, Gelernter J, Woods SW et al (2006) Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus. Am J Hum Genet 78:543\u2013553","journal-title":"Am J Hum Genet"},{"key":"97_CR18","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S1357-2725(01)00141-8","volume":"34","author":"JH Kehrl","year":"2002","unstructured":"Kehrl JH, Sinnarajah S (2002) RGS2: a multifunctional regulator of G-protein signaling. Int J Biochem Cell Biol 34:432\u2013438","journal-title":"Int J Biochem Cell Biol"},{"key":"97_CR19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1017\/S0033291799008429","volume":"29","author":"KS Kendler","year":"1999","unstructured":"Kendler KS, Karkowski LM, Prescott CA (1999) Fears and phobias: reliability and heritability. Psychol Med 29:539\u2013553","journal-title":"Psychol Med"},{"key":"97_CR20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1096-8628(19980328)81:2<139::AID-AJMG4>3.0.CO;2-R","volume":"81","author":"JA Knowles","year":"1998","unstructured":"Knowles JA, Fyer AJ, Vieland VJ et al (1998) Results of a genome-wide genetic screen for panic disorder. Am J Med Genet 81:139\u2013147","journal-title":"Am J Med Genet"},{"key":"97_CR21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molbrainres.2003.11.014","volume":"122","author":"C Larminie","year":"2004","unstructured":"Larminie C, Murdock P, Walhin JP et al (2004) Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. Brain Res Mol Brain Res 122:24\u201334","journal-title":"Brain Res Mol Brain Res"},{"key":"97_CR22","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1007\/s00702-006-0484-8","volume":"113","author":"A Leygraf","year":"2006","unstructured":"Leygraf A, Hohoff C, Freitag C et al (2006) RGS 2 gene polymorphisms as modulators of anxiety in humans? J Neural Transm 113:1921\u20131925","journal-title":"J Neural Transm"},{"key":"97_CR23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0022-3956(86)90034-8","volume":"20","author":"S Mannuzza","year":"1986","unstructured":"Mannuzza S, Fyer AJ, Klein DF et al (1986) Schedule for affective disorders and schizophrenia\u2014lifetime version modified for the study of anxiety disorders (SADS-LA): Rationale and conceptual development. J Psychiatr Res 20:317\u2013325","journal-title":"J Psychiatr Res"},{"key":"97_CR24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2105-6-79","volume":"6","author":"VD Marinescu","year":"2005","unstructured":"Marinescu VD, Kohane IS, Riva A (2005) MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes. BMC Bioinformatics 6:79","journal-title":"BMC Bioinformatics"},{"key":"97_CR26","doi-asserted-by":"crossref","first-page":"12272","DOI":"10.1073\/pnas.220414397","volume":"97","author":"AJ Oliveira-dos-Santos","year":"2000","unstructured":"Oliveira-dos-Santos AJ, Matsumoto G, Snow BE et al (2000) Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci USA 97:12272\u201312277","journal-title":"Proc Natl Acad Sci USA"},{"key":"97_CR27","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/archpsyc.1988.01800360017003","volume":"45","author":"LN Robins","year":"1988","unstructured":"Robins LN, Wing J, Wittchen HU et al (1988) The Composite International Diagnostic Interview. An epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch Gen Psychiatry 45:1069\u20131077","journal-title":"Arch Gen Psychiatry"},{"key":"97_CR28","volume-title":"Fundamentals of biostatistics","author":"B Rosner","year":"2006","unstructured":"Rosner B (2006) Fundamentals of biostatistics, 6th edn. Duxbury Press, Pacific Grove (CA)","edition":"6"},{"key":"97_CR29","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1146\/annurev.biochem.69.1.795","volume":"69","author":"EM Ross","year":"2000","unstructured":"Ross EM, Wilkie TM (2000) GTPase-activating proteins for heterotrimeric G Proteins: regulators of G protein signalling (RGS) and RGS-like proteins. Annu Rev Biochem 69:795\u2013827","journal-title":"Annu Rev Biochem"},{"key":"97_CR30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1001\/archgenpsychiatry.2007.48","volume":"65","author":"JW Smoller","year":"2008","unstructured":"Smoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB (2008) Influence of RGS2 on anxiety-related temperament, personality, and brain function. Arch Gen Psychiatry 65:298\u2013308","journal-title":"Arch Gen Psychiatry"},{"key":"97_CR31","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1086\/375141","volume":"72","author":"TE Thorgeirsson","year":"2003","unstructured":"Thorgeirsson TE, Oskarsson H, Desnica N et al (2003) Anxiety with panic disorder linked to chromosome 9q in Iceland. Am J Hum Genet 72:1221\u20131230","journal-title":"Am J Hum Genet"},{"key":"97_CR32","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1086\/303000","volume":"67","author":"SA Tishkoff","year":"2000","unstructured":"Tishkoff SA, Pakstis AJ, Ruano G, Kidd KK (2000) The accuracy of statistical methods for estimation of haplotype frequencies: an example from the CD4 locus. Am J Hum Genet 67:518\u2013522","journal-title":"Am J Hum Genet"},{"key":"97_CR33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/383172a0","volume":"383","author":"N Watson","year":"1996","unstructured":"Watson N, Linder ME, Druey KM et al (1996) RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits. Nature 383:172\u2013175","journal-title":"Nature"},{"key":"97_CR34","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/archpsyc.1997.01830160021003","volume":"54","author":"MM Weissman","year":"1997","unstructured":"Weissman MM, Bland RC, Canino GJ et al (1997) The cross-national epidemiology of panic disorder. Arch Gen Psychiatry 54:305\u2013309","journal-title":"Arch Gen Psychiatry"},{"key":"97_CR35","volume-title":"SKID-I: strukturiertes klinisches Interview f\u00fcr DSM-IV, Achse I: Psychische St\u00f6rungen","author":"HU Wittchen","year":"1997","unstructured":"Wittchen HU (1997) SKID-I: strukturiertes klinisches Interview f\u00fcr DSM-IV, Achse I: Psychische St\u00f6rungen. Hogrefe, Goettingen"},{"key":"97_CR36","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ng1450","volume":"36","author":"B Yalcin","year":"2004","unstructured":"Yalcin B, Willis-Owen SAG, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet 36:1197\u20131202","journal-title":"Nat Genet"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-008-0097-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00702-008-0097-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-008-0097-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T04:25:10Z","timestamp":1559103910000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00702-008-0097-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,2]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["97"],"URL":"https:\/\/doi.org\/10.1007\/s00702-008-0097-5","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,2]]}}}