{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:25:51Z","timestamp":1790101551672,"version":"4.0.1"},"reference-count":432,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s00702-011-0698-2","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T03:57:59Z","timestamp":1314763079000},"page":"1661-1690","source":"Crossref","is-referenced-by-count":68,"title":["Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation"],"prefix":"10.1007","volume":"118","author":[{"given":"Mahmoud M.","family":"Iravani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"issue":"12","key":"698_CR1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4065\/74.12.1239","volume":"74","author":"JE Ahlskog","year":"1999","unstructured":"Ahlskog JE (1999) Medical treatment of later-stage motor problems of Parkinson disease. Mayo Clin Proc 74(12):1239\u20131254","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"698_CR2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/mds.1090","volume":"16","author":"JE Ahlskog","year":"2001","unstructured":"Ahlskog JE, Muenster MD (2001) Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord 16(3):448\u2013458","journal-title":"Mov Disord"},{"key":"698_CR3","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0006-8993(93)91069-5","volume":"625","author":"GM Alexander","year":"1993","unstructured":"Alexander GM, Schwartzman RJ, Grothusen JR, Brainard L, Gordon SW (1993) Changes in brain dopamine receptors in MPTP parkinsonian monkeys following L-dopa treatment. Brain Res 625:276\u2013282","journal-title":"Brain Res"},{"issue":"37","key":"698_CR4","doi-asserted-by":"crossref","first-page":"8432","DOI":"10.1523\/JNEUROSCI.1289-05.2005","volume":"25","author":"M Andersson","year":"2005","unstructured":"Andersson M, Usiello A, Borgkvist A, Pozzi L, Dominguez C, Fienberg AA, Svenningsson P, Fredholm BB, Borrelli E, Greengard P, Fisone G (2005) Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32\u00a0kDa at the protein kinase A site in striatal projection neurons. J Neurosci 25(37):8432\u20138438","journal-title":"J Neurosci"},{"key":"698_CR5","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1006\/nbdi.2001.0413","volume":"8","author":"OV Anichtchik","year":"2001","unstructured":"Anichtchik OV, Peitsaro N, Rinne JO, Kalimo H, Panula P (2001) Distribution and modulation of histamine H(3) receptors in basal ganglia and frontal cortex of healthy controls and patients with Parkinson\u2019s disease. Neurobiol Dis 8:707\u2013716","journal-title":"Neurobiol Dis"},{"issue":"Suppl 4","key":"698_CR6","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/S1353-8020(09)70844-2","volume":"15","author":"A Antonini","year":"2009","unstructured":"Antonini A, Odin P (2009) Pros and cons of apomorphine and l-dopa continuous infusion in advanced Parkinson\u2019s disease. Parkinsonism Relat Disord 15(Suppl 4):S97\u2013S100","journal-title":"Parkinsonism Relat Disord"},{"issue":"Suppl 2","key":"698_CR7","doi-asserted-by":"crossref","first-page":"S305","DOI":"10.1007\/s00415-010-5714-1","volume":"257","author":"A Antonini","year":"2010","unstructured":"Antonini A, Ursino G, Calandrella D, Bernardi L, Plebani M (2010) Continuous dopaminergic delivery in Parkinson\u2019s disease. J Neurol 257(Suppl 2):S305\u2013S308","journal-title":"J Neurol"},{"issue":"1","key":"698_CR8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0165-0173(98)00050-2","volume":"29","author":"R Anwyl","year":"1999","unstructured":"Anwyl R (1999) Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res Brain Res Rev 29(1):83\u2013120","journal-title":"Brain Res Brain Res Rev"},{"issue":"4","key":"698_CR9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.neuropharm.2009.01.002","volume":"56","author":"R Anwyl","year":"2009","unstructured":"Anwyl R (2009) Metabotropic glutamate receptor-dependent long-term potentiation. Neuropharmacology 56(4):735\u2013740","journal-title":"Neuropharmacology"},{"issue":"2","key":"698_CR10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0006-8993(94)91511-3","volume":"667","author":"R Arai","year":"1994","unstructured":"Arai R, Karasawa N, Geffard M, Nagatsu T, Nagatsu I (1994) Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous l-DOPA in the rat, with reference to the involvement of aromatic l-amino acid decarboxylase. Brain Res 667(2):295\u2013299","journal-title":"Brain Res"},{"issue":"3","key":"698_CR11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-3940(95)11817-G","volume":"195","author":"R Arai","year":"1995","unstructured":"Arai R, Karasawa N, Geffard M, Nagatsu I (1995) l-DOPA is converted to dopamine in serotonergic fibers of the striatum of the rat: a double-labeling immunofluorescence study. Neurosci Lett 195(3):195\u2013198","journal-title":"Neurosci Lett"},{"issue":"2","key":"698_CR12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00702-002-0777-5","volume":"110","author":"T Archer","year":"2003","unstructured":"Archer T, Fredriksson A (2003) An antihypokinesic action of alpha2-adrenoceptors upon MPTP-induced behaviour deficits in mice. J Neural Transm 110(2):183\u2013200","journal-title":"J Neural Transm"},{"issue":"3","key":"698_CR13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0306-4522(83)90212-9","volume":"10","author":"MA Ariano","year":"1983","unstructured":"Ariano MA (1983) Distribution of components of the guanosine 3\u2032,5\u2032-phosphate system in rat caudate-putamen. Neuroscience 10(3):707\u2013723","journal-title":"Neuroscience"},{"key":"698_CR14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/sj.bjp.0704053","volume":"133","author":"JA Arias-Montano","year":"2001","unstructured":"Arias-Montano JA, Floran B, Garcia M, Aceves J, Young JM (2001) Histamine H(3) receptor-mediated inhibition of depolarization-induced, dopamine D(1) receptor-dependent release of [(3)H]-gamma-aminobutyric acid from rat striatal slices. Br J Pharmacol 133:165\u2013171","journal-title":"Br J Pharmacol"},{"key":"698_CR15","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/302832a0","volume":"302","author":"JM Arrang","year":"1983","unstructured":"Arrang JM, Garbarg M, Schwartz JC (1983) Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 302:832\u2013837","journal-title":"Nature"},{"key":"698_CR16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/327117a0","volume":"327","author":"JM Arrang","year":"1987","unstructured":"Arrang JM, Garbarg M, Lancelot JC, Lecomte JM, Pollard H, Robba M, Schunack W, Schwartz JC (1987) Highly potent and selective ligands for histamine H3-receptors. Nature 327:117\u2013123","journal-title":"Nature"},{"issue":"1\u20133","key":"698_CR17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2006.03.041","volume":"537","author":"JC Ashton","year":"2006","unstructured":"Ashton JC, Darlington CL, Smith PF (2006) Co-distribution of the cannabinoid CB1 receptor and the 5-HT transporter in the rat amygdale. Eur J Pharmacol 537(1\u20133):70\u201371","journal-title":"Eur J Pharmacol"},{"issue":"Suppl 1","key":"698_CR18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuropharm.2004.06.020","volume":"47","author":"G Aston-Jones","year":"2004","unstructured":"Aston-Jones G, Harris GC (2004) Brain substrates for increased drug seeking during protracted withdrawal. Neuropharmacology 47(Suppl 1):167\u2013179","journal-title":"Neuropharmacology"},{"issue":"1","key":"698_CR19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.20296","volume":"57","author":"I Aubert","year":"2005","unstructured":"Aubert I, Guigoni C, Hakansson K, Li Q, Dovero S, Barthe N, Bioulac BH, Gross CE, Fisone G, Bloch B, Bezard E (2005) Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia. Ann Neurol 57(1):17\u201326","journal-title":"Ann Neurol"},{"issue":"7","key":"698_CR20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1212\/WNL.35.7.949","volume":"35","author":"PA Ballard","year":"1985","unstructured":"Ballard PA, Tetrud JW, Langston JW (1985) Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases. Neurology 35(7):949\u2013956","journal-title":"Neurology"},{"issue":"2","key":"698_CR21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1055\/s-2007-979482","volume":"30","author":"T Baptista","year":"1997","unstructured":"Baptista T, Lopez ME, Teneud L, Contreras Q, Alastre T, de Quijada M, Araujo de Baptista E, Alternus M, Weiss SR, Musseo E, Paez X, Hernandez L (1997) Amantadine in the treatment of neuroleptic-induced obesity in rats: behavioral, endocrine and neurochemical correlates. Pharmacopsychiatry 30(2):43\u201354","journal-title":"Pharmacopsychiatry"},{"issue":"3","key":"698_CR22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1212\/01.WNL.0000073136.00548.D4","volume":"61","author":"W Bara-Jimenez","year":"2003","unstructured":"Bara-Jimenez W, Sherzai A, Dimitrova T, Favit A, Bibbiani F, Gillespie M, Morris MJ, Mouradian MM, Chase TN (2003) Adenosine A(2A) receptor antagonist treatment of Parkinson\u2019s disease. Neurology 61(3):293\u2013296","journal-title":"Neurology"},{"issue":"8","key":"698_CR23","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","volume":"38","author":"NM Barnes","year":"1999","unstructured":"Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38(8):1083\u20131152","journal-title":"Neuropharmacology"},{"issue":"33","key":"698_CR24","doi-asserted-by":"crossref","first-page":"14845","DOI":"10.1073\/pnas.1009874107","volume":"107","author":"HS Bateup","year":"2010","unstructured":"Bateup HS, Santini E, Shen W, Birnbaum S, Valjent E, Surmeier DJ, Fisone G, Nestler EJ, Greengard P (2010) Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proc Natl Acad Sci USA 107(33):14845\u201314850","journal-title":"Proc Natl Acad Sci USA"},{"key":"698_CR25","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/sleep\/16.8.713","volume":"16","author":"PM Becker","year":"1993","unstructured":"Becker PM, Jamieson AO, Brown WD (1993) Dopaminergic agents in restless legs syndrome and periodic limb movements of sleep: response and complications of extended treatment in 49 cases. Sleep 16:713\u2013716","journal-title":"Sleep"},{"issue":"18","key":"698_CR26","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1007\/s00018-008-8263-3","volume":"65","author":"C Bellone","year":"2008","unstructured":"Bellone C, Luscher C, Mameli M (2008) Mechanisms of synaptic depression triggered by metabotropic glutamate receptors. Cell Mol Life Sci 65(18):2913\u20132923","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"698_CR27","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/mds.23245","volume":"25","author":"P Belujon","year":"2010","unstructured":"Belujon P, Lodge DJ, Grace AA (2010) Aberrant striatal plasticity is specifically associated with dyskinesia following levodopa treatment. Mov Disord 25(11):1568\u20131576","journal-title":"Mov Disord"},{"issue":"4","key":"698_CR28","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/(SICI)1096-9861(19960513)368:4<553::AID-CNE7>3.0.CO;2-3","volume":"368","author":"V Bernard","year":"1996","unstructured":"Bernard V, Gardiol A, Faucheux B, Bloch B, Agid Y, Hirsch EC (1996) Expression of glutamate receptors in the human and rat basal ganglia: effect of the dopaminergic denervation on AMPA receptor gene expression in the striatopallidal complex in Parkinson\u2019s disease and rat with 6-OHDA lesion. J Comp Neurol 368(4):553\u2013568","journal-title":"J Comp Neurol"},{"issue":"1","key":"698_CR29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0306-4522(88)90130-3","volume":"26","author":"MJ Besson","year":"1988","unstructured":"Besson MJ, Graybiel AM, Nastuk MA (1988) [3H]SCH 23390 binding to D1 dopamine receptors in the basal ganglia of the cat and primate: delineation of striosomal compartments and pallidal and nigral subdivisions. Neuroscience 26(1):101\u2013119","journal-title":"Neuroscience"},{"issue":"3","key":"698_CR30","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1046\/j.1471-4159.2000.741166.x","volume":"74","author":"R Betarbet","year":"2000","unstructured":"Betarbet R, Porter RH, Greenamyre JT (2000) GluR1 glutamate receptor subunit is regulated differentially in the primate basal ganglia following nigrostriatal dopamine denervation. J Neurochem 74(3):1166\u20131174","journal-title":"J Neurochem"},{"issue":"8","key":"698_CR31","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/35086062","volume":"2","author":"E Bezard","year":"2001","unstructured":"Bezard E, Brotchie JM, Gross CE (2001) Pathophysiology of levodopa-induced dyskinesia: potential for new therapies. Nat Rev Neurosci 2(8):577\u2013588","journal-title":"Nat Rev Neurosci"},{"key":"698_CR32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejphar.2003.11.065","volume":"485","author":"E Bezard","year":"2004","unstructured":"Bezard E, Hill MP, Crossman AR, Brotchie JM, Michel A, Grimee R, Klitgaard H (2004) Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque. Eur J Pharmacol 485:159\u2013164","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"698_CR33","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1212\/WNL.57.10.1829","volume":"57","author":"F Bibbiani","year":"2001","unstructured":"Bibbiani F, Oh JD, Chase TN (2001) Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models. Neurology 57(10):1829\u20131834","journal-title":"Neurology"},{"issue":"1","key":"698_CR34","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-4886(03)00250-4","volume":"184","author":"F Bibbiani","year":"2003","unstructured":"Bibbiani F, Oh JD, Petzer JP, Castagnoli N Jr, Chen JF, Schwarzschild MA, Chase TN (2003) A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson\u2019s disease. Exp Neurol 184(1):285\u2013294","journal-title":"Exp Neurol"},{"issue":"2","key":"698_CR35","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.expneurol.2005.08.017","volume":"196","author":"F Bibbiani","year":"2005","unstructured":"Bibbiani F, Oh JD, Kielaite A, Collins MA, Smith C, Chase TN (2005) Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp Neurol 196(2):422\u2013429","journal-title":"Exp Neurol"},{"issue":"10","key":"698_CR36","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1111\/j.1460-9568.2006.04790.x","volume":"23","author":"C Bishop","year":"2006","unstructured":"Bishop C, Taylor JL, Kuhn DM, Eskow KL, Park JY, Walker PD (2006) MDMA and fenfluramine reduce l-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation. Eur J Neurosci 23(10):2669\u20132676","journal-title":"Eur J Neurosci"},{"issue":"Pt 2","key":"698_CR37","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/brain\/awp314","volume":"133","author":"T Bjorklund","year":"2010","unstructured":"Bjorklund T, Carlsson T, Cederfjall EA, Carta M, Kirik D (2010) Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson\u2019s disease. Brain 133(Pt 2):496\u2013511","journal-title":"Brain"},{"key":"698_CR38","first-page":"103","volume":"45","author":"PJ Blanchet","year":"1995","unstructured":"Blanchet PJ, Gomez-Mancilla B, Bedard PJ (1995) DOPA-induced \u201cpeak dose\u201d dyskinesia: clues implicating D2 receptor-mediated mechanisms using dopaminergic agonists in MPTP monkeys. J Neural Transm Suppl 45:103\u2013112","journal-title":"J Neural Transm Suppl"},{"issue":"1","key":"698_CR39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0014-2999(96)00309-3","volume":"309","author":"PJ Blanchet","year":"1996","unstructured":"Blanchet PJ, Grondin R, Bedard PJ, Shiosaki K, Britton DR (1996) Dopamine D1 receptor desensitization profile in MPTP-lesioned primates. Eur J Pharmacol 309(1):13\u201320","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"698_CR40","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/mds.870130507","volume":"13","author":"PJ Blanchet","year":"1998","unstructured":"Blanchet PJ, Konitsiotis S, Chase TN (1998) Amantadine reduces levodopa-induced dyskinesias in parkinsonian monkeys. Mov Disord 13(5):798\u2013802","journal-title":"Mov Disord"},{"issue":"3","key":"698_CR41","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0022-3565(24)35003-7","volume":"290","author":"PJ Blanchet","year":"1999","unstructured":"Blanchet PJ, Konitsiotis S, Whittemore ER, Zhou ZL, Woodward RM, Chase TN (1999) Differing effects of N-methyl-d-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys. J Pharmacol Exp Ther 290(3):1034\u20131040","journal-title":"J Pharmacol Exp Ther"},{"key":"698_CR42","first-page":"251","volume":"91","author":"PJ Blanchet","year":"2003","unstructured":"Blanchet PJ, Metman LV, Chase TN (2003) Renaissance of amantadine in the treatment of Parkinson\u2019s disease. Adv Neurol 91:251\u2013257","journal-title":"Adv Neurol"},{"issue":"2","key":"698_CR43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF02260966","volume":"7","author":"R Bockelmann","year":"1994","unstructured":"Bockelmann R, Wolf G, Ransmayr G, Riederer P (1994) NADPH-diaphorase\/nitric oxide synthase containing neurons in normal and Parkinson\u2019s disease putamen. J Neural Transm Park Dis Dement Sect 7(2):115\u2013121","journal-title":"J Neural Transm Park Dis Dement Sect"},{"key":"698_CR44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902370102","volume":"237","author":"JP Bolam","year":"1985","unstructured":"Bolam JP, Powell JF, Wu JY, Smith AD (1985) Glutamate decarboxylase-immunoreactive structures in the rat neostriatum: a correlated light and electron microscopic study including a combination of Golgi impregnation with immunocytochemistry. J Comp Neurol 237:1\u201320","journal-title":"J Comp Neurol"},{"issue":"1","key":"698_CR45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00002826-199402000-00008","volume":"17","author":"V Bonifati","year":"1994","unstructured":"Bonifati V, Fabrizio E, Cipriani R, Vanacore N, Meco G (1994) Buspirone in levodopa-induced dyskinesias. Clin Neuropharmacol 17(1):73\u201382","journal-title":"Clin Neuropharmacol"},{"issue":"Pt 3","key":"698_CR46","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/brain\/124.3.546","volume":"124","author":"T Boraud","year":"2001","unstructured":"Boraud T, Bezard E, Bioulac B, Gross CE (2001) Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey. Brain 124(Pt 3):546\u2013557","journal-title":"Brain"},{"issue":"1","key":"698_CR47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mds.870050103","volume":"5","author":"S Boyce","year":"1990","unstructured":"Boyce S, Clarke CE, Luquin R, Peggs D, Robertson RG, Mitchell IJ, Sambrook MA, Crossman AR (1990a) Induction of chorea and dystonia in parkinsonian primates. Mov Disord 5(1):3\u20137","journal-title":"Mov Disord"},{"issue":"5","key":"698_CR48","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/00002826-199010000-00006","volume":"13","author":"S Boyce","year":"1990","unstructured":"Boyce S, Rupniak NM, Steventon MJ, Iversen SD (1990b) Nigrostriatal damage is required for induction of dyskinesias by l-DOPA in squirrel monkeys. Clin Neuropharmacol 13(5):448\u2013458","journal-title":"Clin Neuropharmacol"},{"issue":"13","key":"698_CR49","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1523\/JNEUROSCI.22-13-05669.2002","volume":"22","author":"N Breysse","year":"2002","unstructured":"Breysse N, Baunez C, Spooren W, Gasparini F, Amalric M (2002) Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism. J Neurosci 22(13):5669\u20135678","journal-title":"J Neurosci"},{"issue":"1","key":"698_CR50","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1001\/archneurol.2009.287","volume":"67","author":"MA Brodsky","year":"2010","unstructured":"Brodsky MA, Park BS, Nutt JG (2010) Effects of a dopamine agonist on the pharmacodynamics of levodopa in Parkinson disease. Arch Neurol 67(1):27\u201332","journal-title":"Arch Neurol"},{"key":"698_CR51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/archneurol.2010.260","volume":"68","author":"JM Bronstein","year":"2011","unstructured":"Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ Jr, Moro E, Vitek JL, Weaver FM, Gross RE, DeLong MR (2011) Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol 68:165","journal-title":"Arch Neurol"},{"issue":"2","key":"698_CR52","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ana.410310209","volume":"31","author":"DJ Brooks","year":"1992","unstructured":"Brooks DJ, Ibanez V, Sawle GV, Playford ED, Quinn N, Mathias CJ, Lees AJ, Marsden CD, Bannister R, Frackowiak RS (1992) Striatal D2 receptor status in patients with Parkinson\u2019s disease, striatonigral degeneration, and progressive supranuclear palsy, measured with 11C-raclopride and positron emission tomography. Ann Neurol 31(2):184\u2013192","journal-title":"Ann Neurol"},{"issue":"2","key":"698_CR53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/WNF.0b013e3181d137d2","volume":"33","author":"DJ Brooks","year":"2010","unstructured":"Brooks DJ, Papapetropoulos S, Vandenhende F, Tomic D, He P, Coppell A, O\u2019Neill G (2010) An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers. Clin Neuropharmacol 33(2):55\u201360","journal-title":"Clin Neuropharmacol"},{"issue":"6","key":"698_CR54","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/mds.870130603","volume":"13","author":"JM Brotchie","year":"1998","unstructured":"Brotchie JM (1998) Adjuncts to dopamine replacement: a pragmatic approach to reducing the problem of dyskinesia in Parkinson\u2019s disease. Mov Disord 13(6):871\u2013876","journal-title":"Mov Disord"},{"issue":"35","key":"698_CR55","doi-asserted-by":"crossref","first-page":"11073","DOI":"10.1523\/JNEUROSCI.23-35-11073.2003","volume":"23","author":"TM Brown","year":"2003","unstructured":"Brown TM, Brotchie JM, Fitzjohn SM (2003) Cannabinoids decrease corticostriatal synaptic transmission via an effect on glutamate uptake. J Neurosci 23(35):11073\u201311077","journal-title":"J Neurosci"},{"issue":"12","key":"698_CR56","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/syn.20569","volume":"62","author":"A Brusco","year":"2008","unstructured":"Brusco A, Tagliaferro P, Saez T, Onaivi ES (2008) Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse 62(12):944\u2013949","journal-title":"Synapse"},{"issue":"4","key":"698_CR57","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0306-4522(01)00531-0","volume":"109","author":"MM Bucheler","year":"2002","unstructured":"Bucheler MM, Hadamek K, Hein L (2002) Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice. Neuroscience 109(4):819\u2013826","journal-title":"Neuroscience"},{"issue":"2","key":"698_CR58","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/syn.20709","volume":"64","author":"K Buck","year":"2010","unstructured":"Buck K, Ferger B (2010) The selective alpha1 adrenoceptor antagonist HEAT reduces l-DOPA-induced dyskinesia in a rat model of Parkinson\u2019s disease. Synapse 64(2):117\u2013126","journal-title":"Synapse"},{"issue":"2","key":"698_CR59","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neuroscience.2009.12.032","volume":"166","author":"K Buck","year":"2010","unstructured":"Buck K, Voehringer P, Ferger B (2010a) Site-specific action of l-3,4-dihydroxyphenylalanine in the striatum but not globus pallidus and substantia nigra pars reticulata evokes dyskinetic movements in chronic l-3,4-dihydroxyphenylalanine-treated 6-hydroxydopamine-lesioned rats. Neuroscience 166(2):355\u2013358","journal-title":"Neuroscience"},{"issue":"2","key":"698_CR60","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1471-4159.2009.06482.x","volume":"112","author":"K Buck","year":"2010","unstructured":"Buck K, Voehringer P, Ferger B (2010b) The alpha(2) adrenoceptor antagonist idazoxan alleviates l-DOPA-induced dyskinesia by reduction of striatal dopamine levels: an in vivo microdialysis study in 6-hydroxydopamine-lesioned rats. J Neurochem 112(2):444\u2013452","journal-title":"J Neurochem"},{"issue":"1","key":"698_CR61","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0304-3940(92)90628-K","volume":"142","author":"P Calabresi","year":"1992","unstructured":"Calabresi P, Maj R, Mercuri NB, Bernardi G (1992a) Coactivation of D1 and D2 dopamine receptors is required for long-term synaptic depression in the striatum. Neurosci Lett 142(1):95\u201399","journal-title":"Neurosci Lett"},{"issue":"11","key":"698_CR62","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1523\/JNEUROSCI.12-11-04224.1992","volume":"12","author":"P Calabresi","year":"1992","unstructured":"Calabresi P, Maj R, Pisani A, Mercuri NB, Bernardi G (1992b) Long-term synaptic depression in the striatum: physiological and pharmacological characterization. J Neurosci 12(11):4224\u20134233","journal-title":"J Neurosci"},{"issue":"4 Suppl 1","key":"698_CR63","first-page":"S60","volume":"47","author":"P Calabresi","year":"2000","unstructured":"Calabresi P, Giacomini P, Centonze D, Bernardi G (2000a) Levodopa-induced dyskinesia: a pathological form of striatal synaptic plasticity? Ann Neurol 47(4 Suppl 1):S60\u2013S68 discussion S68\u201369","journal-title":"Ann Neurol"},{"issue":"22","key":"698_CR64","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.1523\/JNEUROSCI.20-22-08443.2000","volume":"20","author":"P Calabresi","year":"2000","unstructured":"Calabresi P, Gubellini P, Centonze D, Picconi B, Bernardi G, Chergui K, Svenningsson P, Fienberg AA, Greengard P (2000b) Dopamine and cAMP-regulated phosphoprotein 32\u00a0kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. J Neurosci 20(22):8443\u20138451","journal-title":"J Neurosci"},{"issue":"Suppl 3","key":"698_CR65","doi-asserted-by":"crossref","first-page":"S570","DOI":"10.1002\/mds.22019","volume":"23","author":"P Calabresi","year":"2008","unstructured":"Calabresi P, Di Filippo M, Ghiglieri V, Picconi B (2008) Molecular mechanisms underlying levodopa-induced dyskinesia. Mov Disord 23(Suppl 3):S570\u2013S579","journal-title":"Mov Disord"},{"issue":"1","key":"698_CR66","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00001756-200001170-00034","volume":"11","author":"LF Callado","year":"2000","unstructured":"Callado LF, Hopwood SE, Hancock PJ, Stamford JA (2000) Effects of dizocilpine (MK 801) on noradrenaline, serotonin and dopamine release and uptake. Neuroreport 11(1):173\u2013176","journal-title":"Neuroreport"},{"issue":"47","key":"698_CR67","doi-asserted-by":"crossref","first-page":"46741","DOI":"10.1074\/jbc.M306451200","volume":"278","author":"M Canals","year":"2003","unstructured":"Canals M, Marcellino D, Fanelli F, Ciruela F, de Benedetti P, Goldberg SR, Neve K, Fuxe K, Agnati LF, Woods AS, Ferre S, Lluis C, Bouvier M, Franco R (2003) Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Biol Chem 278(47):46741\u201346749","journal-title":"J Biol Chem"},{"issue":"1","key":"698_CR68","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1124\/jpet.107.125666","volume":"323","author":"X Cao","year":"2007","unstructured":"Cao X, Liang L, Hadcock JR, Iredale PA, Griffith DA, Menniti FS, Factor S, Greenamyre JT, Papa SM (2007) Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys. J Pharmacol Exp Ther 323(1):318\u2013326","journal-title":"J Pharmacol Exp Ther"},{"issue":"Pt 7","key":"698_CR69","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/brain\/awm082","volume":"130","author":"M Carta","year":"2007","unstructured":"Carta M, Carlsson T, Kirik D, Bjorklund A (2007) Dopamine released from 5-HT terminals is the cause of l-DOPA-induced dyskinesia in parkinsonian rats. Brain 130(Pt 7):1819\u20131833","journal-title":"Brain"},{"issue":"4","key":"698_CR70","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0306-4522(02)00542-0","volume":"115","author":"L Cathala","year":"2002","unstructured":"Cathala L, Guyon A, Eugene D, Paupardin-Tritsch D (2002) Alpha2-adrenoceptor activation increases a cationic conductance and spontaneous GABAergic synaptic activity in dopaminergic neurones of the rat substantia nigra. Neuroscience 115(4):1059\u20131065","journal-title":"Neuroscience"},{"issue":"2","key":"698_CR71","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1471-4159.2006.04124.x","volume":"99","author":"MA Cenci","year":"2006","unstructured":"Cenci MA, Lundblad M (2006) Post- versus presynaptic plasticity in l-DOPA-induced dyskinesia. J Neurochem 99(2):381\u2013392","journal-title":"J Neurochem"},{"issue":"Suppl 4","key":"698_CR72","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S1353-8020(09)70828-4","volume":"15","author":"MA Cenci","year":"2009","unstructured":"Cenci MA, Ohlin KE (2009) Rodent models of treatment-induced motor complications in Parkinson\u2019s disease. Parkinsonism Relat Disord 15(Suppl 4):S13\u2013S17","journal-title":"Parkinsonism Relat Disord"},{"issue":"8","key":"698_CR73","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1046\/j.1460-9568.1998.00285.x","volume":"10","author":"MA Cenci","year":"1998","unstructured":"Cenci MA, Lee CS, Bjorklund A (1998) l-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA. Eur J Neurosci 10(8):2694\u20132706","journal-title":"Eur J Neurosci"},{"issue":"15","key":"698_CR74","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1523\/JNEUROSCI.23-15-06245.2003","volume":"23","author":"D Centonze","year":"2003","unstructured":"Centonze D, Grande C, Usiello A, Gubellini P, Erbs E, Martin AB, Pisani A, Tognazzi N, Bernardi G, Moratalla R, Borrelli E, Calabresi P (2003) Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons. J Neurosci 23(15):6245\u20136254","journal-title":"J Neurosci"},{"issue":"6","key":"698_CR75","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuint.2007.02.002","volume":"50","author":"M Chalimoniuk","year":"2007","unstructured":"Chalimoniuk M, Langfort J (2007) The effect of subchronic, intermittent l-DOPA treatment on neuronal nitric oxide synthase and soluble guanylyl cyclase expression and activity in the striatum and midbrain of normal and MPTP-treated mice. Neurochem Int 50(6):821\u2013833","journal-title":"Neurochem Int"},{"issue":"3","key":"698_CR76","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1615\/CritRevNeurobiol.v13.i3.20","volume":"13","author":"F Chaperon","year":"1999","unstructured":"Chaperon F, Thiebot MH (1999) Behavioral effects of cannabinoid agents in animals. Crit Rev Neurobiol 13(3):243\u2013281","journal-title":"Crit Rev Neurobiol"},{"issue":"Suppl 2","key":"698_CR77","doi-asserted-by":"crossref","first-page":"II36","DOI":"10.1007\/PL00007759","volume":"247","author":"TN Chase","year":"2000","unstructured":"Chase TN, Oh JD, Konitsiotis S (2000) Antiparkinsonian and antidyskinetic activity of drugs targeting central glutamatergic mechanisms. J Neurol 247(Suppl 2):II36\u2013II42","journal-title":"J Neurol"},{"issue":"11 Suppl 6","key":"698_CR78","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1212\/01.WNL.0000095223.08711.48","volume":"61","author":"TN Chase","year":"2003","unstructured":"Chase TN, Bibbiani F, Bara-Jimenez W, Dimitrova T, Oh-Lee JD (2003) Translating A2A antagonist KW6002 from animal models to parkinsonian patients. Neurology 61(11 Suppl 6):S107\u2013S111","journal-title":"Neurology"},{"issue":"1\u20132","key":"698_CR79","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0006-8993(96)01098-0","volume":"743","author":"Q Chen","year":"1996","unstructured":"Chen Q, Reiner A (1996) Cellular distribution of the NMDA receptor NR2A\/2B subunits in the rat striatum. Brain Res 743(1\u20132):346\u2013352","journal-title":"Brain Res"},{"key":"698_CR80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-2999(94)90498-7","volume":"259","author":"J Clapham","year":"1994","unstructured":"Clapham J, Kilpatrick GJ (1994) Thioperamide, the selective histamine H3 receptor antagonist, attenuates stimulant-induced locomotor activity in the mouse. Eur J Pharmacol 259:107\u2013114","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"698_CR81","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0165-6147(90)90011-V","volume":"11","author":"GL Collingridge","year":"1990","unstructured":"Collingridge GL, Singer W (1990) Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol Sci 11(7):290\u2013296","journal-title":"Trends Pharmacol Sci"},{"key":"698_CR1009","doi-asserted-by":"crossref","unstructured":"Conn PJ, Battaglia G, Marino MJ, Nicoletti F (2005) Metabotropic glutamate receptors in the basal ganglia motor circuit. Nat Rev Neurosci 6:787\u2013798","DOI":"10.1038\/nrn1763"},{"key":"698_CR82","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.1007\/s00415-010-5728-8","volume":"257","author":"M Contin","year":"2010","unstructured":"Contin M, Martinelli P (2010) Pharmacokinetics of levodopa. J Neurol 257:S253\u2013S261","journal-title":"J Neurol"},{"issue":"5","key":"698_CR83","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1046\/j.1471-4159.2001.00201.x","volume":"76","author":"JC Corvol","year":"2001","unstructured":"Corvol JC, Studler JM, Schonn JS, Girault JA, Herve D (2001) Galpha(olf) is necessary for coupling D1 and A2a receptors to adenylyl cyclase in the striatum. J Neurochem 76(5):1585\u20131588","journal-title":"J Neurochem"},{"issue":"11","key":"698_CR84","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJM197603112941101","volume":"294","author":"GC Cotzias","year":"1976","unstructured":"Cotzias GC, Papavasiliou PS, Tolosa ES, Mendez JS, Bell-Midura M (1976) Treatment of Parkinson\u2019s disease with aporphines. Possible role of growth hormone. N Engl J Med 294(11):567\u2013572","journal-title":"N Engl J Med"},{"issue":"1","key":"698_CR85","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.expneurol.2007.01.024","volume":"205","author":"H Cox","year":"2007","unstructured":"Cox H, Togasaki DM, Chen L, Langston JW, Di Monte DA, Quik M (2007) The selective kappa-opioid receptor agonist U50, 488 reduces l-dopa-induced dyskinesias but worsens parkinsonism in MPTP-treated primates. Exp Neurol 205(1):101\u2013107","journal-title":"Exp Neurol"},{"issue":"Pt 4","key":"698_CR86","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1046\/j.1469-7580.2000.19640519.x","volume":"196","author":"AR Crossman","year":"2000","unstructured":"Crossman AR (2000) Functional anatomy of movement disorders. J Anat 196(Pt 4):519\u2013525","journal-title":"J Anat"},{"issue":"17","key":"698_CR87","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1073\/pnas.88.17.7797","volume":"88","author":"TM Dawson","year":"1991","unstructured":"Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Snyder SH (1991) Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci USA 88(17):7797\u20137801","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 12","key":"698_CR88","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1093\/brain\/awh290","volume":"127","author":"R Fuente-Fernandez de la","year":"2004","unstructured":"de la Fuente-Fernandez R, Sossi V, Huang Z, Furtado S, Lu JQ, Calne DB, Ruth TJ, Stoessl AJ (2004) Levodopa-induced changes in synaptic dopamine levels increase with progression of Parkinson\u2019s disease: implications for dyskinesias. Brain 127(Pt 12):2747\u20132754","journal-title":"Brain"},{"key":"698_CR89","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.brainresbull.2005.12.009","volume":"69","author":"A Dekundy","year":"2006","unstructured":"Dekundy A, Pietraszek M, Schaefer D, Cenci MA, Danysz W (2006) Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson\u2019s disease. Brain Res Bull 69:318\u2013326","journal-title":"Brain Res Bull"},{"issue":"1","key":"698_CR90","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbr.2007.01.013","volume":"179","author":"A Dekundy","year":"2007","unstructured":"Dekundy A, Lundblad M, Danysz W, Cenci MA (2007) Modulation of l-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model. Behav Brain Res 179(1):76\u201389","journal-title":"Behav Brain Res"},{"key":"698_CR410","doi-asserted-by":"crossref","unstructured":"DeLong MR, Wichmann T (2007) Circuits and circuit disorders of the basal ganglia. Arch Neurol 64:20\u201324","DOI":"10.1001\/archneur.64.1.20"},{"issue":"6","key":"698_CR91","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1046\/j.1471-4159.2000.0752434.x","volume":"75","author":"V Di Marzo","year":"2000","unstructured":"Di Marzo V, Breivogel CS, Tao Q, Bridgen DT, Razdan RK, Zimmer AM, Zimmer A, Martin BR (2000) Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain. J Neurochem 75(6):2434\u20132444","journal-title":"J Neurochem"},{"issue":"3","key":"698_CR92","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/1531-8257(200005)15:3<459::AID-MDS1006>3.0.CO;2-3","volume":"15","author":"DA Di Monte","year":"2000","unstructured":"Di Monte DA, McCormack A, Petzinger G, Janson AM, Quik M, Langston WJ (2000) Relationship among nigrostriatal denervation, parkinsonism, and dyskinesias in the MPTP primate model. Mov Disord 15(3):459\u2013466","journal-title":"Mov Disord"},{"key":"698_CR93","doi-asserted-by":"crossref","first-page":"14273","DOI":"10.1523\/JNEUROSCI.1894-10.2010","volume":"30","author":"JK Dreyer","year":"2010","unstructured":"Dreyer JK, Herrik KF, Berg RW, Hounsgaard JD (2010) Influence of phasic and tonic dopamine release on receptor activation. J Neurosci 30:14273\u201314283","journal-title":"J Neurosci"},{"issue":"2\u20133","key":"698_CR94","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0014-2999(98)00254-4","volume":"350","author":"C Dugast","year":"1998","unstructured":"Dugast C, Souliere F, Schmitt P, Casanovas JM, Fattaccini CM, Mocaer E, Lesourd M, Renaud B, Artigas F, Hamon M, Chouvet G (1998) Is the potent 5-HT1A receptor agonist, alnespirone (S-20499), affecting dopaminergic systems in the rat brain? Eur J Pharmacol 350(2\u20133):171\u2013180","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"698_CR95","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0022-3565(24)39197-9","volume":"293","author":"GE Duncan","year":"2000","unstructured":"Duncan GE, Miyamoto S, Leipzig JN, Lieberman JA (2000) Comparison of the effects of clozapine, risperidone, and olanzapine on ketamine-induced alterations in regional brain metabolism. J Pharmacol Exp Ther 293(1):8\u201314","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"698_CR96","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2165\/00002512-199914050-00002","volume":"14","author":"F Durif","year":"1999","unstructured":"Durif F (1999) Treating and preventing levodopa-induced dyskinesias: current and future strategies. Drugs Aging 14(5):337\u2013345","journal-title":"Drugs Aging"},{"issue":"3","key":"698_CR97","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1212\/WNL.48.3.658","volume":"48","author":"F Durif","year":"1997","unstructured":"Durif F, Vidailhet M, Assal F, Roche C, Bonnet AM, Agid Y (1997) Low-dose clozapine improves dyskinesias in Parkinson\u2019s disease. Neurology 48(3):658\u2013662","journal-title":"Neurology"},{"issue":"1","key":"698_CR98","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0169-328X(98)00259-9","volume":"63","author":"DJ Eve","year":"1998","unstructured":"Eve DJ, Nisbet AP, Kingsbury AE, Hewson EL, Daniel SE, Lees AJ, Marsden CD, Foster OJ (1998) Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson\u2019s disease. Brain Res Mol Brain Res 63(1):62\u201371","journal-title":"Brain Res Mol Brain Res"},{"key":"698_CR99","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/ana.410240303","volume":"24","author":"G Fabbrini","year":"1988","unstructured":"Fabbrini G, Mouradian MM, Juncos JL, Schlegel J, Mohr E, Chase TN (1988) Motor fluctuations in Parkinson\u2019s disease: central pathophysiological mechanisms, Part I. Ann Neurol 24:366\u2013371","journal-title":"Ann Neurol"},{"issue":"10","key":"698_CR100","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/mds.21475","volume":"22","author":"G Fabbrini","year":"2007","unstructured":"Fabbrini G, Brotchie JM, Grandas F, Nomoto M, Goetz CG (2007) Levodopa-induced dyskinesias. Mov Disord 22(10):1379\u20131389","journal-title":"Mov Disord"},{"issue":"Suppl 2","key":"698_CR101","first-page":"S56","volume":"64","author":"S Fahn","year":"2008","unstructured":"Fahn S (2008) How do you treat motor complications in Parkinson\u2019s disease: medicine, surgery, or both? Ann Neurol 64(Suppl 2):S56\u2013S64","journal-title":"Ann Neurol"},{"issue":"6","key":"698_CR103","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/sj.npp.1300407","volume":"29","author":"E Fernandez-Espejo","year":"2004","unstructured":"Fernandez-Espejo E, Caraballo I, Rodriguez de Fonseca F, Ferrer B, El Banoua F, Flores JA, Galan-Rodriguez B (2004) Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid function. Neuropsychopharmacology 29(6):1134\u20131142","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"698_CR104","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00441-006-0266-5","volume":"326","author":"F Ferraguti","year":"2006","unstructured":"Ferraguti F, Shigemoto R (2006) Metabotropic glutamate receptors. Cell Tissue Res 326(2):483\u2013504","journal-title":"Cell Tissue Res"},{"issue":"10","key":"698_CR105","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0166-2236(97)01096-5","volume":"20","author":"S Ferre","year":"1997","unstructured":"Ferre S, Fredholm BB, Morelli M, Popoli P, Fuxe K (1997) Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci 20(10):482\u2013487","journal-title":"Trends Neurosci"},{"issue":"18","key":"698_CR106","doi-asserted-by":"crossref","first-page":"11940","DOI":"10.1073\/pnas.172393799","volume":"99","author":"S Ferre","year":"2002","unstructured":"Ferre S, Karcz-Kubicha M, Hope BT, Popoli P, Burgueno J, Gutierrez MA, Casado V, Fuxe K, Goldberg SR, Lluis C, Franco R, Ciruela F (2002) Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Proc Natl Acad Sci USA 99(18):11940\u201311945","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"698_CR107","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1476-5381.2010.00723.x","volume":"160","author":"S Ferre","year":"2010","unstructured":"Ferre S, Lluis C, Justinova Z, Quiroz C, Orru M, Navarro G, Canela EI, Franco R, Goldberg SR (2010) Adenosine-cannabinoid receptor interactions. Implications for striatal function. Br J Pharmacol 160(3):443\u2013453","journal-title":"Br J Pharmacol"},{"issue":"6","key":"698_CR108","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1046\/j.1460-9568.2003.02896.x","volume":"18","author":"B Ferrer","year":"2003","unstructured":"Ferrer B, Asbrock N, Kathuria S, Piomelli D, Giuffrida A (2003) Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias. Eur J Neurosci 18(6):1607\u20131614","journal-title":"Eur J Neurosci"},{"issue":"3","key":"698_CR109","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0169-328X(92)90173-9","volume":"14","author":"JS Fink","year":"1992","unstructured":"Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM (1992) Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res Mol Brain Res 14(3):186\u2013195","journal-title":"Brain Res Mol Brain Res"},{"issue":"22","key":"698_CR110","doi-asserted-by":"crossref","first-page":"20196","DOI":"10.1074\/jbc.M213140200","volume":"278","author":"C Fiorentini","year":"2003","unstructured":"Fiorentini C, Gardoni F, Spano P, Di Luca M, Missale C (2003) Regulation of dopamine D1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl-d-aspartate receptors. J Biol Chem 278(22):20196\u201320202","journal-title":"J Biol Chem"},{"issue":"3","key":"698_CR111","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1124\/mol.105.016667","volume":"69","author":"C Fiorentini","year":"2006","unstructured":"Fiorentini C, Rizzetti MC, Busi C, Bontempi S, Collo G, Spano P, Missale C (2006) Loss of synaptic D1 dopamine\/N-methyl-d-aspartate glutamate receptor complexes in l-DOPA-induced dyskinesia in the rat. Mol Pharmacol 69(3):805\u2013812","journal-title":"Mol Pharmacol"},{"issue":"1","key":"698_CR112","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1124\/mol.107.043885","volume":"74","author":"C Fiorentini","year":"2008","unstructured":"Fiorentini C, Busi C, Gorruso E, Gotti C, Spano P, Missale C (2008) Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Mol Pharmacol 74(1):59\u201369","journal-title":"Mol Pharmacol"},{"key":"698_CR113","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF00168771","volume":"347","author":"AE Fleckenstein","year":"1993","unstructured":"Fleckenstein AE, Lookingland KJ, Moore KE (1993) Activation of mesolimbic dopaminergic neurons following central administration of histamine is mediated by H1 receptors. Naunyn Schmiedebergs Arch Pharmacol 347:50\u201354","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"Suppl 1","key":"698_CR114","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuropharm.2008.07.002","volume":"56","author":"AE Fleckenstein","year":"2009","unstructured":"Fleckenstein AE, Volz TJ, Hanson GR (2009) Psychostimulant-induced alterations in vesicular monoamine transporter-2 function: neurotoxic and therapeutic implications. Neuropharmacology 56(Suppl 1):133\u2013138","journal-title":"Neuropharmacology"},{"issue":"6","key":"698_CR115","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/mds.10289","volume":"17","author":"SH Fox","year":"2002","unstructured":"Fox SH, Henry B, Hill M, Crossman A, Brotchie J (2002) Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson\u2019s disease. Mov Disord 17(6):1180\u20131187","journal-title":"Mov Disord"},{"issue":"9","key":"698_CR116","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/mds.22473","volume":"24","author":"SH Fox","year":"2009","unstructured":"Fox SH, Chuang R, Brotchie JM (2009) Serotonin and Parkinson\u2019s disease: on movement, mood, and madness. Mov Disord 24(9):1255\u20131266","journal-title":"Mov Disord"},{"issue":"4","key":"698_CR117","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/1098-2396(20010315)39:4<288::AID-SYN1011>3.0.CO;2-V","volume":"39","author":"D Frechilla","year":"2001","unstructured":"Frechilla D, Cobreros A, Saldise L, Moratalla R, Insausti R, Luquin M, Del Rio J (2001) Serotonin 5-HT(1A) receptor expression is selectively enhanced in the striosomal compartment of chronic parkinsonian monkeys. Synapse 39(4):288\u2013296","journal-title":"Synapse"},{"issue":"3","key":"698_CR118","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1523\/JNEUROSCI.22-03-01054.2002","volume":"22","author":"S Fredduzzi","year":"2002","unstructured":"Fredduzzi S, Moratalla R, Monopoli A, Cuellar B, Xu K, Ongini E, Impagnatiello F, Schwarzschild MA, Chen JF (2002) Persistent behavioral sensitization to chronic l-DOPA requires A2A adenosine receptors. J Neurosci 22(3):1054\u20131062","journal-title":"J Neurosci"},{"issue":"10","key":"698_CR119","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1056\/NEJM200103083441002","volume":"344","author":"CR Freed","year":"2001","unstructured":"Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski JQ, Eidelberg D, Fahn S (2001) Transplantation of embryonic dopamine neurons for severe Parkinson\u2019s disease. N Engl J Med 344(10):710\u2013719","journal-title":"N Engl J Med"},{"key":"698_CR120","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ana.1119","volume":"50","author":"A Freeman","year":"2001","unstructured":"Freeman A, Ciliax B, Bakay R, Daley J, Miller RD, Keating G, Levey A, Rye D (2001) Nigrostriatal collaterals to thalamus degenerate in parkinsonian animal models. Ann Neurol 50:321\u2013329","journal-title":"Ann Neurol"},{"issue":"3","key":"698_CR121","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/syn.20047","volume":"53","author":"FR Fusco","year":"2004","unstructured":"Fusco FR, Martorana A, Giampa C, De March Z, Farini D, D\u2019Angelo V, Sancesario G, Bernardi G (2004) Immunolocalization of CB1 receptor in rat striatal neurons: a confocal microscopy study. Synapse 53(3):159\u2013167","journal-title":"Synapse"},{"issue":"1\u20132","key":"698_CR122","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.physbeh.2007.05.034","volume":"92","author":"K Fuxe","year":"2007","unstructured":"Fuxe K, Ferre S, Genedani S, Franco R, Agnati LF (2007) Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function. Physiol Behav 92(1\u20132):210\u2013217","journal-title":"Physiol Behav"},{"issue":"7","key":"698_CR123","first-page":"620","volume":"43","author":"RV Gaikwad","year":"2005","unstructured":"Gaikwad RV, Gaonkar RK, Jadhav SA, Thorat VM, Jadhav JH, Balsara JJ (2005) Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats. Indian J Exp Biol 43(7):620\u2013625","journal-title":"Indian J Exp Biol"},{"issue":"11","key":"698_CR124","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1523\/JNEUROSCI.5326-05.2006","volume":"26","author":"F Gardoni","year":"2006","unstructured":"Gardoni F, Picconi B, Ghiglieri V, Polli F, Bagetta V, Bernardi G, Cattabeni F, Di Luca M, Calabresi P (2006) A critical interaction between NR2B and MAGUK in l-DOPA induced dyskinesia. J Neurosci 26(11):2914\u20132922","journal-title":"J Neurosci"},{"issue":"6197","key":"698_CR125","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/336385a0","volume":"336","author":"J Garthwaite","year":"1988","unstructured":"Garthwaite J, Charles SL, Chess-Williams R (1988) Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336(6197):385\u2013388","journal-title":"Nature"},{"issue":"1","key":"698_CR126","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF00230443","volume":"96","author":"P Gaspar","year":"1993","unstructured":"Gaspar P, Febvret A, Colombo J (1993) Serotonergic sprouting in primate MTP-induced hemiparkinsonism. Exp Brain Res 96(1):100\u2013106","journal-title":"Exp Brain Res"},{"issue":"1","key":"698_CR127","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1152\/jn.2001.85.1.468","volume":"85","author":"G Gerdeman","year":"2001","unstructured":"Gerdeman G, Lovinger DM (2001) CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum. J Neurophysiol 85(1):468\u2013471","journal-title":"J Neurophysiol"},{"key":"698_CR128","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev.ne.15.030192.001441","volume":"15","author":"CR Gerfen","year":"1992","unstructured":"Gerfen CR (1992) The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu Rev Neurosci 15:285\u2013320","journal-title":"Annu Rev Neurosci"},{"issue":"6","key":"698_CR129","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/1073858403255839","volume":"9","author":"CR Gerfen","year":"2003","unstructured":"Gerfen CR (2003) D1 dopamine receptor supersensitivity in the dopamine-depleted striatum animal model of Parkinson\u2019s disease. Neuroscientist 9(6):455\u2013462","journal-title":"Neuroscientist"},{"issue":"2","key":"698_CR130","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0733-8619(18)30220-2","volume":"10","author":"CR Gerfen","year":"1992","unstructured":"Gerfen CR, Engber TM (1992) Molecular neuroanatomic mechanisms of Parkinson\u2019s disease: a proposed therapeutic approach. Neurol Clin 10(2):435\u2013449","journal-title":"Neurol Clin"},{"key":"698_CR1005","doi-asserted-by":"crossref","unstructured":"Gerfen CR, Surmeier DJ (2011) Modulation of striatal projection systems by dopamine. Annu Rev Neurosci 34:441\u201366","DOI":"10.1146\/annurev-neuro-061010-113641"},{"issue":"8","key":"698_CR131","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1097\/00001756-199505300-00017","volume":"6","author":"M Gerlach","year":"1995","unstructured":"Gerlach M, Oehler D, Blum-Degen D, Lange KW, Mayer B, Reichmann H, Riederer P (1995) Regional distribution and characterization of nitric oxide synthase activity in the brain of the common marmoset. Neuroreport 6(8):1141\u20131145","journal-title":"Neuroreport"},{"issue":"2","key":"698_CR132","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1034\/j.1600-0773.2003.930202.x","volume":"93","author":"Y Gilgun-Sherki","year":"2003","unstructured":"Gilgun-Sherki Y, Melamed E, Mechoulam R, Offen D (2003) The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats. Pharmacol Toxicol 93(2):66\u201370","journal-title":"Pharmacol Toxicol"},{"issue":"4","key":"698_CR133","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/7268","volume":"2","author":"A Giuffrida","year":"1999","unstructured":"Giuffrida A, Parsons LH, Kerr TM, Rodriguez de Fonseca F, Navarro M, Piomelli D (1999) Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. Nat Neurosci 2(4):358\u2013363","journal-title":"Nat Neurosci"},{"issue":"3","key":"698_CR134","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0022-3565(25)09547-3","volume":"273","author":"A Gobert","year":"1995","unstructured":"Gobert A, Lejeune F, Rivet JM, Audinot V, Newman-Tancredi A, Millan MJ (1995) Modulation of the activity of central serotoninergic neurons by novel serotonin1A receptor agonists and antagonists: a comparison to adrenergic and dopaminergic neurons in rats. J Pharmacol Exp Ther 273(3):1032\u20131046","journal-title":"J Pharmacol Exp Ther"},{"key":"698_CR135","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/mds.21226","volume":"22","author":"CG Goetz","year":"2007","unstructured":"Goetz CG, Damier P, Hicking C, Laska E, Muller T, Olanow CW, Rascol O, Russ H (2007) Sarizotan as a treatment for dyskinesias in Parkinson\u2019s disease: a double-blind placebo-controlled trial. Mov Disord 22:179\u2013186","journal-title":"Mov Disord"},{"issue":"2","key":"698_CR136","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.brainresbull.2003.08.010","volume":"62","author":"MZ Gomes","year":"2003","unstructured":"Gomes MZ, Del Bel EA (2003) Effects of electrolytic and 6-hydroxydopamine lesions of rat nigrostriatal pathway on nitric oxide synthase and nicotinamide adenine dinucleotide phosphate diaphorase. Brain Res Bull 62(2):107\u2013115","journal-title":"Brain Res Bull"},{"issue":"5","key":"698_CR137","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/00002826-199310000-00004","volume":"16","author":"B Gomez-Mancilla","year":"1993","unstructured":"Gomez-Mancilla B, Bedard PJ (1993) Effect of nondopaminergic drugs on l-dopa-induced dyskinesias in MPTP-treated monkeys. Clin Neuropharmacol 16(5):418\u2013427","journal-title":"Clin Neuropharmacol"},{"key":"698_CR138","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/mds.20828","volume":"21","author":"J Gomez-Ramirez","year":"2006","unstructured":"Gomez-Ramirez J, Johnston TH, Visanji NP, Fox SH, Brotchie JM (2006) Histamine H3 receptor agonists reduce l-dopa-induced chorea, but not dystonia, in the MPTP-lesioned nonhuman primate model of Parkinson\u2019s disease. Mov Disord 21:839\u2013846","journal-title":"Mov Disord"},{"issue":"1","key":"698_CR139","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2005.11.035","volume":"1071","author":"JP Gong","year":"2006","unstructured":"Gong JP, Onaivi ES, Ishiguro H, Liu QR, Tagliaferro PA, Brusco A, Uhl GR (2006) Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res 1071(1):10\u201323","journal-title":"Brain Res"},{"key":"698_CR140","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1460-9568.1999.00453.x","volume":"11","author":"RE Goodchild","year":"1999","unstructured":"Goodchild RE, Court JA, Hobson I, Piggott MA, Perry RH, Ince P, Jaros E, Perry EK (1999) Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington\u2019s and Parkinson\u2019s disease cases. Eur J Neurosci 11:449\u2013456","journal-title":"Eur J Neurosci"},{"issue":"1\u20132","key":"698_CR141","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0006-8993(96)00157-6","volume":"719","author":"M Goulet","year":"1996","unstructured":"Goulet M, Grondin R, Blanchet PJ, Bedard PJ, Di Paolo T (1996) Dyskinesias and tolerance induced by chronic treatment with a D1 agonist administered in pulsatile or continuous mode do not correlate with changes of putaminal D1 receptors in drug-naive MPTP monkeys. Brain Res 719(1\u20132):129\u2013137","journal-title":"Brain Res"},{"issue":"4","key":"698_CR142","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0278-5846(00)00096-8","volume":"24","author":"M Goulet","year":"2000","unstructured":"Goulet M, Grondin R, Morissette M, Maltais S, Falardeau P, Bedard PJ, Di Paolo T (2000) Regulation by chronic treatment with cabergoline of dopamine D1 and D2 receptor levels and their expression in the striatum of Parkinsonian-monkeys. Prog Neuropsychopharmacol Biol Psychiatry 24(4):607\u2013617","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"698_CR143","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0006-8993(93)90694-I","volume":"602","author":"WC Graham","year":"1993","unstructured":"Graham WC, Sambrook MA, Crossman AR (1993) Differential effect of chronic dopaminergic treatment on dopamine D1 and D2 receptors in the monkey brain in MPTP-induced parkinsonism. Brain Res 602:290\u2013303","journal-title":"Brain Res"},{"issue":"3","key":"698_CR144","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0896-6273(00)80798-9","volume":"23","author":"P Greengard","year":"1999","unstructured":"Greengard P, Allen PB, Nairn AC (1999) Beyond the dopamine receptor: the DARPP-32\/protein phosphatase-1 cascade. Neuron 23(3):435\u2013447","journal-title":"Neuron"},{"issue":"1","key":"698_CR145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF01244934","volume":"93","author":"J Grenhoff","year":"1993","unstructured":"Grenhoff J, Nisell M, Ferre S, Aston-Jones G, Svensson TH (1993) Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat. J Neural Transm Gen Sect 93(1):11\u201325","journal-title":"J Neural Transm Gen Sect"},{"issue":"8","key":"698_CR146","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1111\/j.1460-9568.1995.tb00692.x","volume":"7","author":"J Grenhoff","year":"1995","unstructured":"Grenhoff J, North RA, Johnson SW (1995) Alpha 1-adrenergic effects on dopamine neurons recorded intracellularly in the rat midbrain slice. Eur J Neurosci 7(8):1707\u20131713","journal-title":"Eur J Neurosci"},{"issue":"8","key":"698_CR147","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1212\/WNL.52.8.1673","volume":"52","author":"R Grondin","year":"1999","unstructured":"Grondin R, Bedard PJ, Hadj Tahar A, Gregoire L, Mori A, Kase H (1999) Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys. Neurology 52(8):1673\u20131677","journal-title":"Neurology"},{"issue":"2","key":"698_CR148","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s002109900167","volume":"361","author":"R Grondin","year":"2000","unstructured":"Grondin R, Hadj Tahar A, Doan VD, Ladure P, Bedard PJ (2000) Noradrenoceptor antagonism with idazoxan improves l-dopa-induced dyskinesias in MPTP monkeys. Naunyn Schmiedebergs Arch Pharmacol 361(2):181\u2013186","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"6","key":"698_CR149","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0361-9230(89)90198-6","volume":"23","author":"XM Guan","year":"1989","unstructured":"Guan XM, McBride WJ (1989) Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release. Brain Res Bull 23(6):541\u2013547","journal-title":"Brain Res Bull"},{"issue":"2","key":"698_CR150","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1046\/j.1471-4159.1994.62020807.x","volume":"62","author":"R Guevara-Guzman","year":"1994","unstructured":"Guevara-Guzman R, Emson PC, Kendrick KM (1994) Modulation of in vivo striatal transmitter release by nitric oxide and cyclic GMP. J Neurochem 62(2):807\u2013810","journal-title":"J Neurochem"},{"issue":"1","key":"698_CR151","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1460-9568.2005.04196.x","volume":"22","author":"C Guigoni","year":"2005","unstructured":"Guigoni C, Dovero S, Aubert I, Li Q, Bioulac BH, Bloch B, Gurevich EV, Gross CE, Bezard E (2005) Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning. Eur J Neurosci 22(1):283\u2013287","journal-title":"Eur J Neurosci"},{"issue":"5","key":"698_CR152","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0197-0186(97)00022-3","volume":"31","author":"JW Gurd","year":"1997","unstructured":"Gurd JW (1997) Protein tyrosine phosphorylation: implications for synaptic function. Neurochem Int 31(5):635\u2013649","journal-title":"Neurochem Int"},{"issue":"13","key":"698_CR153","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1097\/00001756-199609020-00011","volume":"7","author":"ND Guttenberg","year":"1996","unstructured":"Guttenberg ND, Klop H, Minami M, Satoh M, Voorn P (1996) Co-localization of mu opioid receptor is greater with dynorphin than enkephalin in rat striatum. Neuroreport 7(13):2119\u20132124","journal-title":"Neuroreport"},{"key":"698_CR154","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF01245971","volume":"64","author":"M Guttman","year":"1985","unstructured":"Guttman M, Seeman P (1985) l-dopa reverses the elevated density of D2 dopamine receptors in Parkinson\u2019s diseased striatum. J Neural Transm 64:93\u2013103","journal-title":"J Neural Transm"},{"issue":"2\u20133","key":"698_CR155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0014-2999(00)00310-1","volume":"399","author":"A Hadj Tahar","year":"2000","unstructured":"Hadj Tahar A, Belanger N, Bangassoro E, Gregoire L, Bedard PJ (2000) Antidyskinetic effect of JL-18, a clozapine analog, in parkinsonian monkeys. Eur J Pharmacol 399(2\u20133):183\u2013186","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"698_CR156","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.nbd.2003.10.007","volume":"15","author":"A Hadj Tahar","year":"2004","unstructured":"Hadj Tahar A, Gregoire L, Darre A, Belanger N, Meltzer L, Bedard PJ (2004) Effect of a selective glutamate antagonist on l-dopa-induced dyskinesias in drug-naive parkinsonian monkeys. Neurobiol Dis 15(2):171\u2013176","journal-title":"Neurobiol Dis"},{"issue":"7","key":"698_CR157","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nn863","volume":"5","author":"P Hagell","year":"2002","unstructured":"Hagell P, Piccini P, Bjorklund A, Brundin P, Rehncrona S, Widner H, Crabb L, Pavese N, Oertel WH, Quinn N, Brooks DJ, Lindvall O (2002) Dyskinesias following neural transplantation in Parkinson\u2019s disease. Nat Neurosci 5(7):627\u2013628","journal-title":"Nat Neurosci"},{"key":"698_CR158","doi-asserted-by":"crossref","first-page":"S268","DOI":"10.1007\/s00415-010-5719-9","volume":"257","author":"E Hametner","year":"2010","unstructured":"Hametner E, Seppi K, Poewe W (2010) The clinical spectrum of levodopa-induced motor complications. J Neurol 257:S268\u2013S275","journal-title":"J Neurol"},{"issue":"15","key":"698_CR160","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1002\/mds.22095","volume":"23","author":"RA Hauser","year":"2008","unstructured":"Hauser RA, Shulman LM, Trugman JM, Roberts JW, Mori A, Ballerini R, Sussman NM (2008) Study of istradefylline in patients with Parkinson\u2019s disease on levodopa with motor fluctuations. Mov Disord 23(15):2177\u20132185","journal-title":"Mov Disord"},{"issue":"2","key":"698_CR161","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/exnr.1998.6819","volume":"151","author":"B Henry","year":"1998","unstructured":"Henry B, Crossman AR, Brotchie JM (1998) Characterization of enhanced behavioral responses to l-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson\u2019s disease. Exp Neurol 151(2):334\u2013342","journal-title":"Exp Neurol"},{"issue":"1","key":"698_CR162","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/exnr.2001.7727","volume":"171","author":"B Henry","year":"2001","unstructured":"Henry B, Fox SH, Crossman AR, Brotchie JM (2001) Mu- and delta-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson\u2019s disease. Exp Neurol 171(1):139\u2013146","journal-title":"Exp Neurol"},{"issue":"5","key":"698_CR163","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1073\/pnas.87.5.1932","volume":"87","author":"M Herkenham","year":"1990","unstructured":"Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, de Costa BR, Rice KC (1990) Cannabinoid receptor localization in brain. Proc Natl Acad Sci USA 87(5):1932\u20131936","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"698_CR164","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0006-8993(91)90970-7","volume":"547","author":"M Herkenham","year":"1991","unstructured":"Herkenham M, Lynn AB, de Costa BR, Richfield EK (1991a) Neuronal localization of cannabinoid receptors in the basal ganglia of the rat. Brain Res 547(2):267\u2013274","journal-title":"Brain Res"},{"issue":"2","key":"698_CR165","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1523\/JNEUROSCI.11-02-00563.1991","volume":"11","author":"M Herkenham","year":"1991","unstructured":"Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC (1991b) Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci 11(2):563\u2013583","journal-title":"J Neurosci"},{"issue":"2","key":"698_CR166","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/1096-9861(20010305)431:2<139::AID-CNE1061>3.0.CO;2-0","volume":"431","author":"S Hidaka","year":"2001","unstructured":"Hidaka S, Totterdell S (2001) Ultrastructural features of the nitric oxide synthase-containing interneurons in the nucleus accumbens and their relationship with tyrosine hydroxylase-containing terminals. J Comp Neurol 431(2):139\u2013154","journal-title":"J Comp Neurol"},{"issue":"Suppl 1","key":"698_CR167","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1038\/sj.bjp.0706455","volume":"147","author":"SJ Hill","year":"2006","unstructured":"Hill SJ (2006) G-protein-coupled receptors: past, present and future. Br J Pharmacol 147(Suppl 1):S27\u2013S37","journal-title":"Br J Pharmacol"},{"key":"698_CR168","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/mds.10542","volume":"18","author":"MP Hill","year":"2003","unstructured":"Hill MP, Bezard E, McGuire SG, Crossman AR, Brotchie JM, Michel A, Grimee R, Klitgaard H (2003) Novel antiepileptic drug levetiracetam decreases dyskinesia elicited by l-dopa and ropinirole in the MPTP-lesioned marmoset. Mov Disord 18:1301\u20131305","journal-title":"Mov Disord"},{"issue":"1","key":"698_CR169","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1124\/jpet.104.066191","volume":"310","author":"MP Hill","year":"2004","unstructured":"Hill MP, Ravenscroft P, Bezard E, Crossman AR, Brotchie JM, Michel A, Grimee R, Klitgaard H (2004) Levetiracetam potentiates the antidyskinetic action of amantadine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson\u2019s disease. J Pharmacol Exp Ther 310(1):386\u2013394","journal-title":"J Pharmacol Exp Ther"},{"issue":"20","key":"698_CR170","doi-asserted-by":"crossref","first-page":"18091","DOI":"10.1074\/jbc.M107731200","volume":"277","author":"J Hillion","year":"2002","unstructured":"Hillion J, Canals M, Torvinen M, Casado V, Scott R, Terasmaa A, Hansson A, Watson S, Olah ME, Mallol J, Canela EI, Zoli M, Agnati LF, Ibanez CF, Lluis C, Franco R, Ferre S, Fuxe K (2002) Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. J Biol Chem 277(20):18091\u201318097","journal-title":"J Biol Chem"},{"issue":"33","key":"698_CR171","doi-asserted-by":"crossref","first-page":"20805","DOI":"10.1074\/jbc.272.33.20805","volume":"272","author":"C Hisatsune","year":"1997","unstructured":"Hisatsune C, Umemori H, Inoue T, Michikawa T, Kohda K, Mikoshiba K, Yamamoto T (1997) Phosphorylation-dependent regulation of N-methyl-d-aspartate receptors by calmodulin. J Biol Chem 272(33):20805\u201320810","journal-title":"J Biol Chem"},{"issue":"5","key":"698_CR172","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/BF00179315","volume":"338","author":"S Hjorth","year":"1988","unstructured":"Hjorth S, Magnusson T (1988) The 5-HT 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo. Naunyn Schmiedebergs Arch Pharmacol 338(5):463\u2013471","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"698_CR173","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0022-3565(25)31520-X","volume":"208","author":"AS Hollister","year":"1979","unstructured":"Hollister AS, Breese GR, Mueller RA (1979) Role of monoamine neural systems in l-dihydroxyphenylalanine-stimulated activity. J Pharmacol Exp Ther 208(1):37\u201343","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"698_CR174","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0306-4522(99)00260-2","volume":"93","author":"M Holmberg","year":"1999","unstructured":"Holmberg M, Scheinin M, Kurose H, Miettinen R (1999) Adrenergic alpha2C-receptors reside in rat striatal GABAergic projection neurons: comparison of radioligand binding and immunohistochemistry. Neuroscience 93(4):1323\u20131333","journal-title":"Neuroscience"},{"key":"698_CR175","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/1098-2396(20001201)38:3<343::AID-SYN14>3.0.CO;2-M","volume":"38","author":"MA Honrubia","year":"2000","unstructured":"Honrubia MA, Vilaro MT, Palacios JM, Mengod G (2000) Distribution of the histamine H(2) receptor in monkey brain and its mRNA localization in monkey and human brain. Synapse 38:343\u2013354","journal-title":"Synapse"},{"key":"698_CR176","doi-asserted-by":"crossref","unstructured":"Huot P, Johnston TH, Koprich JB, Winkelmolen L, Fox SH, Brotchie JM (2011) Regulation of cortical and striatal 5-HT(1A) receptors in the MPTP-lesioned macaque. Neurobiol Aging (Epub ahead of print)","DOI":"10.1016\/j.neurobiolaging.2010.09.011"},{"issue":"3","key":"698_CR177","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.pharmthera.2005.12.001","volume":"111","author":"MJ Hurley","year":"2006","unstructured":"Hurley MJ, Jenner P (2006) What has been learnt from study of dopamine receptors in Parkinson\u2019s disease? Pharmacol Ther 111(3):715\u2013728","journal-title":"Pharmacol Ther"},{"issue":"11","key":"698_CR178","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00702-003-0033-7","volume":"110","author":"MJ Hurley","year":"2003","unstructured":"Hurley MJ, Mash DC, Jenner P (2003) Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain. J Neural Transm 110(11):1279\u20131288","journal-title":"J Neural Transm"},{"issue":"12","key":"698_CR179","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1111\/j.1460-9568.2005.04169.x","volume":"21","author":"MJ Hurley","year":"2005","unstructured":"Hurley MJ, Jackson MJ, Smith LA, Rose S, Jenner P (2005) Immunoautoradiographic analysis of NMDA receptor subunits and associated postsynaptic density proteins in the brain of dyskinetic MPTP-treated common marmosets. Eur J Neurosci 21(12):3240\u20133250","journal-title":"Eur J Neurosci"},{"issue":"5","key":"698_CR180","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1046\/j.1471-4159.1998.71051969.x","volume":"71","author":"MM Iravani","year":"1998","unstructured":"Iravani MM, Millar J, Kruk ZL (1998) Differential release of dopamine by nitric oxide in subregions of rat caudate putamen slices. J Neurochem 71(5):1969\u20131977","journal-title":"J Neurochem"},{"issue":"3","key":"698_CR181","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/(SICI)1098-2396(19990601)32:3<212::AID-SYN7>3.0.CO;2-M","volume":"32","author":"MM Iravani","year":"1999","unstructured":"Iravani MM, Muscat R, Kruk ZL (1999) MK-801 interaction with the 5-HT transporter: a real-time study in brain slices using fast cyclic voltammetry. Synapse 32(3):212\u2013224","journal-title":"Synapse"},{"issue":"3","key":"698_CR182","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1046\/j.1460-9568.2001.01408.x","volume":"13","author":"MM Iravani","year":"2001","unstructured":"Iravani MM, Costa S, Jackson MJ, Tel BC, Cannizzaro C, Pearce RK, Jenner P (2001) GDNF reverses priming for dyskinesia in MPTP-treated, l-DOPA-primed common marmosets. Eur J Neurosci 13(3):597\u2013608","journal-title":"Eur J Neurosci"},{"issue":"27","key":"698_CR183","doi-asserted-by":"crossref","first-page":"9107","DOI":"10.1523\/JNEUROSCI.23-27-09107.2003","volume":"23","author":"MM Iravani","year":"2003","unstructured":"Iravani MM, Jackson MJ, Kuoppamaki M, Smith LA, Jenner P (2003) 3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. J Neurosci 23(27):9107\u20139115","journal-title":"J Neurosci"},{"issue":"6","key":"698_CR184","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/j.1460-9568.2005.04308.x","volume":"22","author":"MM Iravani","year":"2005","unstructured":"Iravani MM, Costa S, Al-Bargouthy G, Jackson MJ, Zeng BY, Kuoppamaki M, Obeso JA, Jenner P (2005) Unilateral pallidotomy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets exhibiting levodopa-induced dyskinesia. Eur J Neurosci 22(6):1305\u20131318","journal-title":"Eur J Neurosci"},{"issue":"3","key":"698_CR185","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1124\/jpet.106.110429","volume":"319","author":"MM Iravani","year":"2006","unstructured":"Iravani MM, Tayarani-Binazir K, Chu WB, Jackson MJ, Jenner P (2006) In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with increased motor disability. J Pharmacol Exp Ther 319(3):1225\u20131234","journal-title":"J Pharmacol Exp Ther"},{"key":"698_CR186","unstructured":"Iravani MM, Stockwell KA, Tayarani-Binazir K, Jackson MJ, Rose S, Jenner P (2008) Inhibition of neuronal nitric oxide synthase as a novel target for dyskinesia suppression in primates. Soc Neurosci Abstr 139.15\/M6"},{"issue":"1\u20132","key":"698_CR187","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neulet.2006.03.064","volume":"402","author":"K Itokawa","year":"2006","unstructured":"Itokawa K, Ohkuma A, Araki N, Tamura N, Shimazu K (2006) Effect of l-DOPA on nitric oxide production in striatum of freely mobile mice. Neurosci Lett 402(1\u20132):142\u2013144","journal-title":"Neurosci Lett"},{"issue":"3","key":"698_CR188","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.pbb.2004.07.015","volume":"79","author":"MJ Jackson","year":"2004","unstructured":"Jackson MJ, Al-Barghouthy G, Pearce RK, Smith L, Hagan JJ, Jenner P (2004) Effect of 5-HT1B\/D receptor agonist and antagonist administration on motor function in haloperidol and MPTP-treated common marmosets. Pharmacol Biochem Behav 79(3):391\u2013400","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"698_CR189","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.expneurol.2006.10.005","volume":"204","author":"MJ Jackson","year":"2007","unstructured":"Jackson MJ, Smith LA, Al-Barghouthy G, Rose S, Jenner P (2007) Decreased expression of l-dopa-induced dyskinesia by switching to ropinirole in MPTP-treated common marmosets. Exp Neurol 204(1):162\u2013170","journal-title":"Exp Neurol"},{"issue":"Suppl 11","key":"698_CR190","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1002\/mds.20458","volume":"20","author":"J Jankovic","year":"2005","unstructured":"Jankovic J (2005) Motor fluctuations and dyskinesias in Parkinson\u2019s disease: clinical manifestations. Mov Disord 20(Suppl 11):S11\u2013S16","journal-title":"Mov Disord"},{"key":"698_CR191","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archneur.57.3.369","volume":"57","author":"J Jankovic","year":"2000","unstructured":"Jankovic J, Rajput AH, McDermott MP, Perl DP (2000) The evolution of diagnosis in early Parkinson disease. Parkinson Study Group. Arch Neurol 57:369\u2013372","journal-title":"Arch Neurol"},{"issue":"11 Suppl 6","key":"698_CR193","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1212\/01.WNL.0000095209.59347.79","volume":"61","author":"P Jenner","year":"2003","unstructured":"Jenner P (2003a) A2A antagonists as novel non-dopaminergic therapy for motor dysfunction in PD. Neurology 61(11 Suppl 6):S32\u2013S38","journal-title":"Neurology"},{"issue":"Suppl 1","key":"698_CR194","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00019052-200312001-00002","volume":"16","author":"P Jenner","year":"2003","unstructured":"Jenner P (2003b) Dopamine agonists, receptor selectivity and dyskinesia induction in Parkinson\u2019s disease. Curr Opin Neurol 16(Suppl 1):S3\u2013S7","journal-title":"Curr Opin Neurol"},{"issue":"9","key":"698_CR195","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrn2471","volume":"9","author":"P Jenner","year":"2008","unstructured":"Jenner P (2008) Molecular mechanisms of l-DOPA-induced dyskinesia. Nat Rev Neurosci 9(9):665\u2013677","journal-title":"Nat Rev Neurosci"},{"issue":"Suppl 4","key":"698_CR196","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/S1353-8020(09)70829-6","volume":"15","author":"P Jenner","year":"2009","unstructured":"Jenner P (2009) From the MPTP-treated primate to the treatment of motor complications in Parkinson\u2019s disease. Parkinsonism Relat Disord 15(Suppl 4):S18\u2013S23","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"698_CR197","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-3565(25)38294-7","volume":"266","author":"EA Johnson","year":"1993","unstructured":"Johnson EA, Tsai CE, Shahan YH, Azzaro AJ (1993) Serotonin 5-HT1A receptors mediate inhibition of tyrosine hydroxylation in rat striatum. J Pharmacol Exp Ther 266(1):133\u2013141","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"698_CR198","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1124\/jpet.110.166629","volume":"333","author":"TH Johnston","year":"2010","unstructured":"Johnston TH, Fox SH, McIldowie MJ, Piggott MJ, Brotchie JM (2010a) Reduction of l-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson\u2019s disease. J Pharmacol Exp Ther 333(3):865\u2013873","journal-title":"J Pharmacol Exp Ther"},{"key":"698_CR199","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/mds.23069","volume":"25","author":"TH Johnston","year":"2010","unstructured":"Johnston TH, van der Meij A, Brotchie JM, Fox SH (2010b) Effect of histamine H2 receptor antagonism on levodopa-induced dyskinesia in the MPTP-macaque model of Parkinson\u2019s disease. Mov Disord 25:1379\u20131390","journal-title":"Mov Disord"},{"issue":"45","key":"698_CR200","doi-asserted-by":"crossref","first-page":"10414","DOI":"10.1523\/JNEUROSCI.3660-05.2005","volume":"25","author":"A Kachroo","year":"2005","unstructured":"Kachroo A, Orlando LR, Grandy DK, Chen JF, Young AB, Schwarzschild MA (2005) Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. J Neurosci 25(45):10414\u201310419","journal-title":"J Neurosci"},{"issue":"4","key":"698_CR201","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/ana.410430415","volume":"43","author":"T Kanda","year":"1998","unstructured":"Kanda T, Jackson MJ, Smith LA, Pearce RK, Nakamura J, Kase H, Kuwana Y, Jenner P (1998) Adenosine A2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys. Ann Neurol 43(4):507\u2013513","journal-title":"Ann Neurol"},{"issue":"5","key":"698_CR202","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1046\/j.1471-4159.2001.00184.x","volume":"76","author":"K Kannari","year":"2001","unstructured":"Kannari K, Yamato H, Shen H, Tomiyama M, Suda T, Matsunaga M (2001) Activation of 5-HT(1A) but not 5-HT(1B) receptors attenuates an increase in extracellular dopamine derived from exogenously administered l-DOPA in the striatum with nigrostriatal denervation. J Neurochem 76(5):1346\u20131353","journal-title":"J Neurochem"},{"issue":"2","key":"698_CR203","first-page":"133","volume":"54","author":"K Kannari","year":"2002","unstructured":"Kannari K, Kurahashi K, Tomiyama M, Maeda T, Arai A, Baba M, Suda T, Matsunaga M (2002) Tandospirone citrate, a selective 5-HT1A agonist, alleviates l-DOPA-induced dyskinesia in patients with Parkinson\u2019s disease. No To Shinkei 54(2):133\u2013137","journal-title":"No To Shinkei"},{"key":"698_CR1001","unstructured":"Karlsborg M, Korbo L, Regeur L, Glad A (2010) Duodopa pump treatment in patients with advanced Parkinson\u2019s disease. Dan Med Bull 57:A4155"},{"issue":"2","key":"698_CR204","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bbr.2009.04.035","volume":"203","author":"JE Kelsey","year":"2009","unstructured":"Kelsey JE, Harris O, Cassin J (2009) The CB(1) antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson\u2019s disease. Behav Brain Res 203(2):304\u2013307","journal-title":"Behav Brain Res"},{"issue":"12","key":"698_CR205","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1111\/j.1460-9568.1996.tb01557.x","volume":"8","author":"KM Kendrick","year":"1996","unstructured":"Kendrick KM, Guevara-Guzman R, de la Riva C, Christensen J, Ostergaard K, Emson PC (1996) NMDA and kainate-evoked release of nitric oxide and classical transmitters in the rat striatum: in vivo evidence that nitric oxide may play a neuroprotective role. Eur J Neurosci 8(12):2619\u20132634","journal-title":"Eur J Neurosci"},{"key":"698_CR206","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJM198804073181402","volume":"318","author":"SJ Kish","year":"1988","unstructured":"Kish SJ, Shannak K, Hornykiewicz O (1988) Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson\u2019s disease. Pathophysiologic and clinical implications. N Engl J Med 318:876\u2013880","journal-title":"N Engl J Med"},{"key":"698_CR207","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1471-4159.1992.tb09766.x","volume":"58","author":"SJ Kish","year":"1992","unstructured":"Kish SJ, Shannak K, Rajput A, Deck JH, Hornykiewicz O (1992) Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of idiopathic Parkinson\u2019s disease. J Neurochem 58:642\u2013648","journal-title":"J Neurochem"},{"issue":"8","key":"698_CR209","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1212\/WNL.54.8.1589","volume":"54","author":"S Konitsiotis","year":"2000","unstructured":"Konitsiotis S, Blanchet PJ, Verhagen L, Lamers E, Chase TN (2000) AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys. Neurology 54(8):1589\u20131595","journal-title":"Neurology"},{"issue":"2","key":"698_CR210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2004.07.005","volume":"17","author":"C Konradi","year":"2004","unstructured":"Konradi C, Westin JE, Carta M, Eaton ME, Kuter K, Dekundy A, Lundblad M, Cenci MA (2004) Transcriptome analysis in a rat model of l-DOPA-induced dyskinesia. Neurobiol Dis 17(2):219\u2013236","journal-title":"Neurobiol Dis"},{"key":"698_CR211","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00726-005-0162-4","volume":"28","author":"RM Kostrzewa","year":"2005","unstructured":"Kostrzewa RM, Nowak P, Kostrzewa JP, Kostrzewa RA, Brus R (2005) Peculiarities of l-DOPA treatment of Parkinson\u2019s disease. Amino Acids 28:157\u2013164","journal-title":"Amino Acids"},{"issue":"1","key":"698_CR212","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0166-2236(97)01150-8","volume":"21","author":"DM Kullmann","year":"1998","unstructured":"Kullmann DM, Asztely F (1998) Extrasynaptic glutamate spillover in the hippocampus: evidence and implications. Trends Neurosci 21(1):8\u201314","journal-title":"Trends Neurosci"},{"issue":"6","key":"698_CR213","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1113\/jphysiol.2007.148064","volume":"586","author":"DM Kullmann","year":"2008","unstructured":"Kullmann DM, Lamsa K (2008) Roles of distinct glutamate receptors in induction of anti-Hebbian long-term potentiation. J Physiol 586(6):1481\u20131486","journal-title":"J Physiol"},{"issue":"Pt 12","key":"698_CR214","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1093\/brain\/awg270","volume":"126","author":"A Kumar","year":"2003","unstructured":"Kumar A, Mann S, Sossi V, Ruth TJ, Stoessl AJ, Schulzer M, Lee CS (2003) [11C]DTBZ-PET correlates of levodopa responses in asymmetric Parkinson\u2019s disease. Brain 126(Pt 12):2648\u20132655","journal-title":"Brain"},{"issue":"7","key":"698_CR215","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0197-0186(03)00080-9","volume":"43","author":"SK Lai","year":"2003","unstructured":"Lai SK, Tse YC, Yang MS, Wong CK, Chan YS, Yung KK (2003) Gene expression of glutamate receptors GluR1 and NR1 is differentially modulated in striatal neurons in rats after 6-hydroxydopamine lesion. Neurochem Int 43(7):639\u2013653","journal-title":"Neurochem Int"},{"key":"698_CR216","first-page":"575","volume":"80","author":"AE Lang","year":"1999","unstructured":"Lang AE, Lozano A, Montgomery EB, Tasker RR, Hutchison WD (1999) Posteroventral medial pallidotomy in advanced Parkinson\u2019s disease. Adv Neurol 80:575\u2013583","journal-title":"Adv Neurol"},{"issue":"1 Suppl","key":"698_CR217","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1017\/S0317167100046333","volume":"11","author":"JW Langston","year":"1984","unstructured":"Langston JW, Ballard P (1984) Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson\u2019s disease. Can J Neurol Sci 11(1 Suppl):160\u2013165","journal-title":"Can J Neurol Sci"},{"issue":"3","key":"698_CR218","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/cne.903550308","volume":"355","author":"C Le Moine","year":"1995","unstructured":"Le Moine C, Bloch B (1995) D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum. J Comp Neurol 355(3):418\u2013426","journal-title":"J Comp Neurol"},{"issue":"3","key":"698_CR219","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0306-4522(94)90464-2","volume":"62","author":"C Le Moine","year":"1994","unstructured":"Le Moine C, Kieffer B, Gaveriaux-Ruff C, Befort K, Bloch B (1994) Delta-opioid receptor gene expression in the mouse forebrain: localization in cholinergic neurons of the striatum. Neuroscience 62(3):635\u2013640","journal-title":"Neuroscience"},{"key":"698_CR220","unstructured":"Lebois EP, Jones CK, Lindsley CW (2011) The evolution of histamine H(3) antagonists\/inverse agonists. Curr Top Med Chem"},{"issue":"5400","key":"698_CR221","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1126\/science.283.5400.401","volume":"283","author":"C Ledent","year":"1999","unstructured":"Ledent C, Valverde O, Cossu G, Petitet F, Aubert JF, Beslot F, Bohme GA, Imperato A, Pedrazzini T, Roques BP, Vassart G, Fratta W, Parmentier M (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283(5400):401\u2013404","journal-title":"Science"},{"issue":"1","key":"698_CR222","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.nbd.2007.08.011","volume":"29","author":"G Levandis","year":"2008","unstructured":"Levandis G, Bazzini E, Armentero MT, Nappi G, Blandini F (2008) Systemic administration of an mGluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesias in a rodent model of Parkinson\u2019s disease. Neurobiol Dis 29(1):161\u2013168","journal-title":"Neurobiol Dis"},{"issue":"3","key":"698_CR223","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ana.21315","volume":"63","author":"PA LeWitt","year":"2008","unstructured":"LeWitt PA, Guttman M, Tetrud JW, Tuite PJ, Mori A, Chaikin P, Sussman NM (2008) Adenosine A2A receptor antagonist istradefylline (KW-6002) reduces \u201coff\u201d time in Parkinson\u2019s disease: a double-blind, randomized, multicenter clinical trial (6002-US-005). Ann Neurol 63(3):295\u2013302","journal-title":"Ann Neurol"},{"issue":"3","key":"698_CR224","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/syn.20722","volume":"64","author":"Y Li","year":"2010","unstructured":"Li Y, Huang XF, Deng C, Meyer B, Wu A, Yu Y, Ying W, Yang GY, Yenari MA, Wang Q (2010) Alterations in 5-HT2A receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats. Synapse 64(3):224\u2013230","journal-title":"Synapse"},{"key":"698_CR1002","doi-asserted-by":"crossref","unstructured":"Lin CW, Bianchi BR, Miller TR, Stashko MA, Wang SS, Curzon P, Bednarz L, Asin KE, Britton DR (1996) Persistent activation of the dopamine D1 receptor contributes to prolonged receptor desensitization: studies with A-77636. J Pharmacol Exp Ther 276:1022\u20131029","DOI":"10.1016\/S0022-3565(25)12376-8"},{"key":"698_CR225","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.tips.2005.06.007","volume":"26","author":"G Linazasoro","year":"2005","unstructured":"Linazasoro G (2005) New ideas on the origin of l-dopa-induced dyskinesias: age, genes and neural plasticity. Trends Pharmacol Sci 26:391\u2013397","journal-title":"Trends Pharmacol Sci"},{"key":"698_CR226","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/WNF.0b013e3181b52792","volume":"32","author":"G Linazasoro","year":"2009","unstructured":"Linazasoro G, Van Blercom N, Bergaretxe A, Inaki FM, Laborda E, Ruiz Ortega JA (2009) Levodopa-induced dyskinesias in Parkinson disease are independent of the extent of striatal dopaminergic denervation: a pharmacological and SPECT study. Clin Neuropharmacol 32:326\u2013329","journal-title":"Clin Neuropharmacol"},{"issue":"6","key":"698_CR227","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/j.1471-4159.2009.06556.x","volume":"112","author":"HS Lindgren","year":"2010","unstructured":"Lindgren HS, Andersson DR, Lagerkvist S, Nissbrandt H, Cenci MA (2010) l-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson\u2019s disease: temporal and quantitative relationship to the expression of dyskinesia. J Neurochem 112(6):1465\u20131476","journal-title":"J Neurochem"},{"issue":"6","key":"698_CR228","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1046\/j.1460-9568.1999.00597.x","volume":"11","author":"M Lindskog","year":"1999","unstructured":"Lindskog M, Svenningsson P, Fredholm B, Greengard P, Fisone G (1999) Mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons. Eur J Neurosci 11(6):2182\u20132186","journal-title":"Eur J Neurosci"},{"issue":"4","key":"698_CR229","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/syn.20023","volume":"52","author":"LA Liprando","year":"2004","unstructured":"Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR (2004) Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area. Synapse 52(4):233\u2013244","journal-title":"Synapse"},{"issue":"3","key":"698_CR230","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1124\/jpet.108.136580","volume":"327","author":"F Liu","year":"2008","unstructured":"Liu F, Grauer S, Kelley C, Navarra R, Graf R, Zhang G, Atkinson PJ, Popiolek M, Wantuch C, Khawaja X, Smith D, Olsen M, Kouranova E, Lai M, Pruthi F, Pulicicchio C, Day M, Gilbert A, Pausch MH, Brandon NJ, Beyer CE, Comery TA, Logue S, Rosenzweig-Lipson S, Marquis KL (2008) ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piper idin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther 327(3):827\u2013839","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"698_CR231","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-2999(99)00704-9","volume":"385","author":"E Lorenc-Koci","year":"1999","unstructured":"Lorenc-Koci E, Wolfarth S (1999) Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats. Eur J Pharmacol 385(1):39\u201346","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"698_CR232","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.0953-816x.2001.01843.x","volume":"15","author":"M Lundblad","year":"2002","unstructured":"Lundblad M, Andersson M, Winkler C, Kirik D, Wierup N, Cenci MA (2002) Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson\u2019s disease. Eur J Neurosci 15(1):120\u2013132","journal-title":"Eur J Neurosci"},{"issue":"6","key":"698_CR233","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1046\/j.1471-4159.2003.01632.x","volume":"84","author":"M Lundblad","year":"2003","unstructured":"Lundblad M, Vaudano E, Cenci MA (2003) Cellular and behavioural effects of the adenosine A2a receptor antagonist KW-6002 in a rat model of l-DOPA-induced dyskinesia. J Neurochem 84(6):1398\u20131410","journal-title":"J Neurochem"},{"issue":"1","key":"698_CR234","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.nbd.2004.01.007","volume":"16","author":"M Lundblad","year":"2004","unstructured":"Lundblad M, Picconi B, Lindgren H, Cenci MA (2004) A model of l-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function. Neurobiol Dis 16(1):110\u2013123","journal-title":"Neurobiol Dis"},{"issue":"1","key":"698_CR235","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.expneurol.2005.02.002","volume":"194","author":"M Lundblad","year":"2005","unstructured":"Lundblad M, Usiello A, Carta M, Hakansson K, Fisone G, Cenci MA (2005) Pharmacological validation of a mouse model of l-dopa-induced dyskinesia. Exp Neurol 194(1):66\u201375","journal-title":"Exp Neurol"},{"key":"698_CR236","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/01.WNF.0000220814.48360.F4","volume":"29","author":"KE Lyons","year":"2006","unstructured":"Lyons KE, Pahwa R (2006) Efficacy and tolerability of levetiracetam in Parkinson disease patients with levodopa-induced dyskinesia. Clin Neuropharmacol 29:148\u2013153","journal-title":"Clin Neuropharmacol"},{"key":"698_CR1008","doi-asserted-by":"crossref","unstructured":"MacDonald E, Kobilka BK, Scheinin M (1997) Gene targeting\u2014homing in on alpha 2-adrenoceptor-subtype function. Trends Pharmacol Sci 18:211\u2013219","DOI":"10.1016\/S0165-6147(97)01063-8"},{"key":"698_CR237","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0028-3908(03)00248-X","volume":"45","author":"M Madeja","year":"2003","unstructured":"Madeja M, Margineanu DG, Gorji A, Siep E, Boerrigter P, Klitgaard H, Speckmann EJ (2003) Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action? Neuropharmacology 45:661\u2013671","journal-title":"Neuropharmacology"},{"issue":"1","key":"698_CR238","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(03)00295-7","volume":"343","author":"T Maeda","year":"2003","unstructured":"Maeda T, Kannari K, Shen H, Arai A, Tomiyama M, Matsunaga M, Suda T (2003) Rapid induction of serotonergic hyperinnervation in the adult rat striatum with extensive dopaminergic denervation. Neurosci Lett 343(1):17\u201320","journal-title":"Neurosci Lett"},{"issue":"1\u20132","key":"698_CR239","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.brainres.2005.04.019","volume":"1046","author":"T Maeda","year":"2005","unstructured":"Maeda T, Nagata K, Yoshida Y, Kannari K (2005) Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA. Brain Res 1046(1\u20132):230\u2013233","journal-title":"Brain Res"},{"issue":"16","key":"698_CR240","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1523\/JNEUROSCI.21-16-05925.2001","volume":"21","author":"G Mannaioni","year":"2001","unstructured":"Mannaioni G, Marino MJ, Valenti O, Traynelis SF, Conn PJ (2001) Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. J Neurosci 21(16):5925\u20135934","journal-title":"J Neurosci"},{"issue":"4","key":"698_CR241","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/jnnp.70.4.554","volume":"70","author":"AJ Manson","year":"2001","unstructured":"Manson AJ, Katzenschlager R, Hobart J, Lees AJ (2001) High dose naltrexone for dyskinesias induced by levodopa. J Neurol Neurosurg Psychiatry 70(4):554\u2013556","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"698_CR242","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/cne.903500307","volume":"350","author":"A Mansour","year":"1994","unstructured":"Mansour A, Fox CA, Burke S, Meng F, Thompson RC, Akil H, Watson SJ (1994) Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. J Comp Neurol 350(3):412\u2013438","journal-title":"J Comp Neurol"},{"key":"698_CR243","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1474-4422(10)70059-4","volume":"9","author":"M Mantegazza","year":"2010","unstructured":"Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M (2010) Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol 9:413\u2013424","journal-title":"Lancet Neurol"},{"key":"698_CR244","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/mds.1149","volume":"16","author":"EC Maratos","year":"2001","unstructured":"Maratos EC, Jackson MJ, Pearce RK, Jenner P (2001) Antiparkinsonian activity and dyskinesia risk of ropinirole and l-DOPA combination therapy in drug naive MPTP-lesioned common marmosets (Callithrix jacchus). Mov Disord 16:631\u2013641","journal-title":"Mov Disord"},{"issue":"1","key":"698_CR245","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1006\/exnr.2002.8055","volume":"179","author":"EC Maratos","year":"2003","unstructured":"Maratos EC, Jackson MJ, Pearce RK, Cannizzaro C, Jenner P (2003) Both short- and long-acting D-1\/D-2 dopamine agonists induce less dyskinesia than l-DOPA in the MPTP-lesioned common marmoset (Callithrix jacchus). Exp Neurol 179(1):90\u2013102","journal-title":"Exp Neurol"},{"issue":"3","key":"698_CR246","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/1568007023339319","volume":"1","author":"MJ Marino","year":"2002","unstructured":"Marino MJ, Conn JP (2002) Modulation of the basal ganglia by metabotropic glutamate receptors: potential for novel therapeutics. Curr Drug Targets CNS Neurol Disord 1(3):239\u2013250","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"issue":"1\u20133","key":"698_CR247","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00726-001-0127-1","volume":"23","author":"MJ Marino","year":"2002","unstructured":"Marino MJ, Awad H, Poisik O, Wittmann M, Conn PJ (2002) Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia. Amino Acids 23(1\u20133):185\u2013191","journal-title":"Amino Acids"},{"issue":"7","key":"698_CR249","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/sj.npp.1301558","volume":"33","author":"AB Martin","year":"2008","unstructured":"Martin AB, Fernandez-Espejo E, Ferrer B, Gorriti MA, Bilbao A, Navarro M, Rodriguez de Fonseca F, Moratalla R (2008) Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors. Neuropsychopharmacology 33(7):1667\u20131679","journal-title":"Neuropsychopharmacology"},{"key":"698_CR250","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF02245515","volume":"111","author":"Y Masukawa","year":"1993","unstructured":"Masukawa Y, Suzuki T, Misawa M (1993) Differential modification of the rewarding effects of methamphetamine and cocaine by opioids and antihistamines. Psychopharmacology (Berl) 111:139\u2013143","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"698_CR251","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0896-6273(02)00716-X","volume":"34","author":"C Mazzucchelli","year":"2002","unstructured":"Mazzucchelli C, Vantaggiato C, Ciamei A, Fasano S, Pakhotin P, Krezel W, Welzl H, Wolfer DP, Pages G, Valverde O, Marowsky A, Porrazzo A, Orban PC, Maldonado R, Ehrengruber MU, Cestari V, Lipp HP, Chapman PF, Pouyssegur J, Brambilla R (2002) Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron 34(5):807\u2013820","journal-title":"Neuron"},{"issue":"4","key":"698_CR252","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00002826-200307000-00005","volume":"26","author":"G Meco","year":"2003","unstructured":"Meco G, Fabrizio E, Di Rezze S, Alessandri A, Pratesi L (2003) Mirtazapine in l-dopa-induced dyskinesias. Clin Neuropharmacol 26(4):179\u2013181","journal-title":"Clin Neuropharmacol"},{"key":"698_CR1006","doi-asserted-by":"crossref","unstructured":"Meco G, Stirpe P, Edito F, Purcaro C, Valente M, Bernardi S, Vanacore N (2009) Aripiprazole in l-dopa-induced dyskinesias: a one-year open-label pilot study. J Neural Transm 116:881\u2013884","DOI":"10.1007\/s00702-009-0231-z"},{"key":"698_CR253","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/ana.410080603","volume":"8","author":"E Melamed","year":"1980","unstructured":"Melamed E, Hefti F, Wurtman RJ (1980a) Nonaminergic striatal neurons convert exogenous l-dopa to dopamine in parkinsonism. Ann Neurol 8:558\u2013563","journal-title":"Ann Neurol"},{"key":"698_CR254","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0028-3908(80)90194-X","volume":"19","author":"E Melamed","year":"1980","unstructured":"Melamed E, Hefti F, Wurtman RJ (1980b) Diminished decarboxylation of l-DOPA in rat striatum after intrastriatal injections of kainic acid. Neuropharmacology 19:409\u2013411","journal-title":"Neuropharmacology"},{"issue":"21","key":"698_CR255","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.1523\/JNEUROSCI.5310-08.2009","volume":"29","author":"BH Meurers","year":"2009","unstructured":"Meurers BH, Dziewczapolski G, Shi T, Bittner A, Kamme F, Shults CW (2009) Dopamine depletion induces distinct compensatory gene expression changes in DARPP-32 signal transduction cascades of striatonigral and striatopallidal neurons. J Neurosci 29(21):6828\u20136839","journal-title":"J Neurosci"},{"key":"698_CR256","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1124\/jpet.103.062414","volume":"309","author":"MJ Millan","year":"2004","unstructured":"Millan MJ, Di Cara B, Hill M, Jackson M, Joyce JN, Brotchie J, McGuire S, Crossman A, Smith L, Jenner P, Gobert A, Peglion JL, Brocco M (2004) S32504, a novel naphtoxazine agonist at dopamine D3\/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole. J Pharmacol Exp Ther 309:921\u2013935","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"698_CR257","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0168-0102(95)00933-K","volume":"23","author":"M Minami","year":"1995","unstructured":"Minami M, Satoh M (1995) Molecular biology of the opioid receptors: structures, functions and distributions. Neurosci Res 23(2):121\u2013145","journal-title":"Neurosci Res"},{"issue":"1","key":"698_CR258","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","volume":"78","author":"C Missale","year":"1998","unstructured":"Missale C, Nash SR, Robinson SW, Jaber M, Caron MG (1998) Dopamine receptors: from structure to function. Physiol Rev 78(1):189\u2013225","journal-title":"Physiol Rev"},{"key":"698_CR259","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00001756-200001170-00032","volume":"11","author":"A Molina-Hernandez","year":"2000","unstructured":"Molina-Hernandez A, Nunez A, Arias-Montano JA (2000) Histamine H3-receptor activation inhibits dopamine synthesis in rat striatum. Neuroreport 11:163\u2013166","journal-title":"Neuroreport"},{"key":"698_CR260","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S0028-3908(01)00144-7","volume":"41","author":"A Molina-Hernandez","year":"2001","unstructured":"Molina-Hernandez A, Nunez A, Sierra JJ, Arias-Montano JA (2001) Histamine H3 receptor activation inhibits glutamate release from rat striatal synaptosomes. Neuropharmacology 41:928\u2013934","journal-title":"Neuropharmacology"},{"issue":"10","key":"698_CR261","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1371\/journal.pbio.0050269","volume":"5","author":"K Monory","year":"2007","unstructured":"Monory K, Blaudzun H, Massa F, Kaiser N, Lemberger T, Schutz G, Wotjak CT, Lutz B, Marsicano G (2007) Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. PLoS Biol 5(10):e269","journal-title":"PLoS Biol"},{"issue":"1","key":"698_CR262","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-2999(87)90415-8","volume":"141","author":"M Morelli","year":"1987","unstructured":"Morelli M, Di Chiara G (1987) Agonist-induced homologous and heterologous sensitization to D-1- and D-2-dependent contraversive turning. Eur J Pharmacol 141(1):101\u2013107","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"698_CR263","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.pneurobio.2007.07.001","volume":"83","author":"M Morelli","year":"2007","unstructured":"Morelli M, Di Paolo T, Wardas J, Calon F, Xiao D, Schwarzschild MA (2007) Role of adenosine A2A receptors in parkinsonian motor impairment and l-DOPA-induced motor complications. Prog Neurobiol 83(5):293\u2013309","journal-title":"Prog Neurobiol"},{"issue":"1","key":"698_CR264","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/syn.20701","volume":"64","author":"T Morera-Herreras","year":"2010","unstructured":"Morera-Herreras T, Ruiz-Ortega JA, Ugedo L (2010) Two opposite effects of Delta(9)-tetrahydrocannabinol on subthalamic nucleus neuron activity: involvement of GABAergic and glutamatergic neurotransmission. Synapse 64(1):20\u201329","journal-title":"Synapse"},{"issue":"1","key":"698_CR265","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.expneurol.2007.07.021","volume":"208","author":"MG Morgese","year":"2007","unstructured":"Morgese MG, Cassano T, Cuomo V, Giuffrida A (2007) Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson\u2019s disease: role of CB(1) and TRPV1 receptors. Exp Neurol 208(1):110\u2013119","journal-title":"Exp Neurol"},{"issue":"1","key":"698_CR266","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuint.2008.10.007","volume":"54","author":"MG Morgese","year":"2009","unstructured":"Morgese MG, Cassano T, Gaetani S, Macheda T, Laconca L, Dipasquale P, Ferraro L, Antonelli T, Cuomo V, Giuffrida A (2009) Neurochemical changes in the striatum of dyskinetic rats after administration of the cannabinoid agonist WIN55, 212\u20132. Neurochem Int 54(1):56\u201364","journal-title":"Neurochem Int"},{"issue":"7","key":"698_CR267","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.neuropharm.2009.12.024","volume":"58","author":"N Morin","year":"2010","unstructured":"Morin N, Gregoire L, Gomez-Mancilla B, Gasparini F, Di Paolo T (2010) Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys. Neuropharmacology 58(7):981\u2013986","journal-title":"Neuropharmacology"},{"issue":"5","key":"698_CR268","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0026-895X(25)09534-3","volume":"50","author":"M Morissette","year":"1996","unstructured":"Morissette M, Goulet M, Calon F, Falardeau P, Blanchet PJ, Bedard PJ, Di Paolo T (1996) Changes of D1 and D2 dopamine receptor mRNA in the brains of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: correction with chronic administration of l-3,4-dihydroxyphenylalanine. Mol Pharmacol 50(5):1073\u20131079","journal-title":"Mol Pharmacol"},{"issue":"3","key":"698_CR269","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/syn.20295","volume":"60","author":"M Morissette","year":"2006","unstructured":"Morissette M, Dridi M, Calon F, Hadj Tahar A, Meltzer LT, Bedard PJ, Di Paolo T (2006) Prevention of dyskinesia by an NMDA receptor antagonist in MPTP monkeys: effect on adenosine A2A receptors. Synapse 60(3):239\u2013250","journal-title":"Synapse"},{"issue":"4","key":"698_CR270","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/ana.410220406","volume":"22","author":"MM Mouradian","year":"1987","unstructured":"Mouradian MM, Juncos JL, Fabbrini G, Chase TN (1987) Motor fluctuations in Parkinson\u2019s disease: pathogenetic and therapeutic studies. Ann Neurol 22(4):475\u2013479","journal-title":"Ann Neurol"},{"issue":"2","key":"698_CR271","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1124\/jpet.104.066548","volume":"310","author":"DL Muller","year":"2004","unstructured":"Muller DL, Unterwald EM (2004) In vivo regulation of extracellular signal-regulated protein kinase (ERK) and protein kinase B (Akt) phosphorylation by acute and chronic morphine. J Pharmacol Exp Ther 310(2):774\u2013782","journal-title":"J Pharmacol Exp Ther"},{"issue":"Pt 12","key":"698_CR272","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1093\/brain\/awn235","volume":"131","author":"A Munoz","year":"2008","unstructured":"Munoz A, Li Q, Gardoni F, Marcello E, Qin C, Carlsson T, Kirik D, Di Luca M, Bjorklund A, Bezard E, Carta M (2008) Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of l-DOPA-induced dyskinesia. Brain 131(Pt 12):3380\u20133394","journal-title":"Brain"},{"key":"698_CR273","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1358\/dot.2010.46.4.1490077","volume":"46","author":"M Murata","year":"2010","unstructured":"Murata M (2010) Zonisamide: a new drug for Parkinson\u2019s disease. Drugs Today (Barc) 46:251\u2013258","journal-title":"Drugs Today (Barc)"},{"key":"698_CR274","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ana.410430504","volume":"43","author":"MG Murer","year":"1998","unstructured":"Murer MG, Dziewczapolski G, Menalled LB, Garcia MC, Agid Y, Gershanik O, Raisman-Vozari R (1998) Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Ann Neurol 43:561\u2013575","journal-title":"Ann Neurol"},{"issue":"8","key":"698_CR275","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/ncb822","volume":"4","author":"LO Murphy","year":"2002","unstructured":"Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J (2002) Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol 4(8):556\u2013564","journal-title":"Nat Cell Biol"},{"issue":"1","key":"698_CR276","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.nbd.2010.01.012","volume":"38","author":"S Navailles","year":"2010","unstructured":"Navailles S, Bioulac B, Gross C, De Deurwaerdere P (2010) Serotonergic neurons mediate ectopic release of dopamine induced by l-DOPA in a rat model of Parkinson\u2019s disease. Neurobiol Dis 38(1):136\u2013143","journal-title":"Neurobiol Dis"},{"issue":"2","key":"698_CR277","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/35053570","volume":"2","author":"EJ Nestler","year":"2001","unstructured":"Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2(2):119\u2013128","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"698_CR278","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.bmcl.2006.11.083","volume":"17","author":"BR Neustadt","year":"2007","unstructured":"Neustadt BR, Hao J, Lindo N, Greenlee WJ, Stamford AW, Tulshian D, Ongini E, Hunter J, Monopoli A, Bertorelli R, Foster C, Arik L, Lachowicz J, Ng K, Feng KI (2007) Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines. Bioorg Med Chem Lett 17(5):1376\u20131380","journal-title":"Bioorg Med Chem Lett"},{"issue":"953","key":"698_CR279","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.170.3953.76","volume":"170","author":"KY Ng","year":"1970","unstructured":"Ng KY, Chase TN, Colburn RW, Kopin IJ (1970) l-Dopa-induced release of cerebral monoamines. Science 170(953):76\u201377","journal-title":"Science"},{"issue":"5292","key":"698_CR280","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/230331a0","volume":"230","author":"KY Ng","year":"1971","unstructured":"Ng KY, Colburn RW, Kopin IJ (1971) Effects of l-dopa on efflux of cerebral monoamines from synaptosomes. Nature 230(5292):331\u2013332","journal-title":"Nature"},{"issue":"5","key":"698_CR281","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/(SICI)1097-4547(19990301)55:5<600::AID-JNR7>3.0.CO;2-#","volume":"55","author":"NK Ng","year":"1999","unstructured":"Ng NK, Lee HS, Wong PT (1999) Regulation of striatal dopamine release through 5-HT1 and 5-HT2 receptors. J Neurosci Res 55(5):600\u2013607","journal-title":"J Neurosci Res"},{"issue":"7","key":"698_CR282","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0165-6147(96)10022-5","volume":"17","author":"AP Nicholas","year":"1996","unstructured":"Nicholas AP, Hokfelt T, Pieribone VA (1996) The distribution and significance of CNS adrenoceptors examined with in situ hybridization. Trends Pharmacol Sci 17(7):245\u2013255","journal-title":"Trends Pharmacol Sci"},{"issue":"21","key":"698_CR283","doi-asserted-by":"crossref","first-page":"8147","DOI":"10.1523\/JNEUROSCI.17-21-08147.1997","volume":"17","author":"A Nishi","year":"1997","unstructured":"Nishi A, Snyder GL, Greengard P (1997) Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J Neurosci 17(21):8147\u20138155","journal-title":"J Neurosci"},{"issue":"4","key":"698_CR284","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1073\/pnas.0409138102","volume":"102","author":"A Nishi","year":"2005","unstructured":"Nishi A, Watanabe Y, Higashi H, Tanaka M, Nairn AC, Greengard P (2005) Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Proc Natl Acad Sci USA 102(4):1199\u20131204","journal-title":"Proc Natl Acad Sci USA"},{"key":"698_CR285","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","volume":"50","author":"CM Niswender","year":"2010","unstructured":"Niswender CM, Conn PJ (2010) Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol 50:295\u2013322","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"698_CR286","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF03033506","volume":"13","author":"P Nowak","year":"2008","unstructured":"Nowak P, Bortel A, Dabrowska J, Biedka I, Slomian G, Roczniak W, Kostrzewa RM, Brus R (2008) Histamine H(3) receptor ligands modulate L-dopa-evoked behavioral responses and l-dopa derived extracellular dopamine in dopamine-denervated rat striatum. Neurotox Res 13:231\u2013240","journal-title":"Neurotox Res"},{"issue":"2","key":"698_CR287","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1212\/WNL.40.2.340","volume":"40","author":"JG Nutt","year":"1990","unstructured":"Nutt JG (1990) Levodopa-induced dyskinesia: review, observations, and speculations. Neurology 40(2):340\u2013345","journal-title":"Neurology"},{"issue":"Suppl 3","key":"698_CR288","doi-asserted-by":"crossref","first-page":"S580","DOI":"10.1002\/mds.22037","volume":"23","author":"JG Nutt","year":"2008","unstructured":"Nutt JG (2008) Pharmacokinetics and pharmacodynamics of levodopa. Mov Disord 23(Suppl 3):S580\u2013S584","journal-title":"Mov Disord"},{"issue":"13","key":"698_CR289","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/mds.22169","volume":"23","author":"JG Nutt","year":"2008","unstructured":"Nutt JG, Gunzler SA, Kirchhoff T, Hogarth P, Weaver JL, Krams M, Jamerson B, Menniti FS, Landen JW (2008) Effects of a NR2B selective NMDA glutamate antagonist, CP-101, 606, on dyskinesia and Parkinsonism. Mov Disord 23(13):1860\u20131866","journal-title":"Mov Disord"},{"issue":"10 Suppl","key":"698_CR290","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S1471-1931(00)00031-8","volume":"23","author":"JA Obeso","year":"2000","unstructured":"Obeso JA, Olanow CW, Nutt JG (2000a) Levodopa motor complications in Parkinson\u2019s disease. Trends Neurosci 23(10 Suppl):S2\u2013S7","journal-title":"Trends Neurosci"},{"issue":"4 Suppl 1","key":"698_CR291","first-page":"S22","volume":"47","author":"JA Obeso","year":"2000","unstructured":"Obeso JA, Rodriguez-Oroz MC, Rodriguez M, DeLong, Olanow CW (2000b) Pathophysiology of levodopa-induced dyskinesias in Parkinson\u2019s disease: problems with the current model. Ann Neurol 47(4 Suppl 1):S22\u2013S32 discussion S32\u201324","journal-title":"Ann Neurol"},{"issue":"Suppl 2","key":"698_CR292","first-page":"S30","volume":"64","author":"JA Obeso","year":"2008","unstructured":"Obeso JA, Marin C, Rodriguez-Oroz C, Blesa J, Benitez-Temino B, Mena-Segovia J, Rodriguez M, Olanow CW (2008) The basal ganglia in Parkinson\u2019s disease: current concepts and unexplained observations. Ann Neurol 64(Suppl 2):S30\u2013S46","journal-title":"Ann Neurol"},{"issue":"1","key":"698_CR293","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0006-8993(98)01049-X","volume":"813","author":"JD Oh","year":"1998","unstructured":"Oh JD, Russell DS, Vaughan CL, Chase TN (1998) Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: effect of dopaminergic denervation and l-DOPA administration. Brain Res 813(1):150\u2013159","journal-title":"Brain Res"},{"issue":"2","key":"698_CR294","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0006-8993(99)01121-X","volume":"821","author":"JD Oh","year":"1999","unstructured":"Oh JD, Vaughan CL, Chase TN (1999) Effect of dopamine denervation and dopamine agonist administration on serine phosphorylation of striatal NMDA receptor subunits. Brain Res 821(2):433\u2013442","journal-title":"Brain Res"},{"issue":"2","key":"698_CR295","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1006\/exnr.2002.8009","volume":"177","author":"JD Oh","year":"2002","unstructured":"Oh JD, Bibbiani F, Chase TN (2002) Quetiapine attenuates levodopa-induced motor complications in rodent and primate parkinsonian models. Exp Neurol 177(2):557\u2013564","journal-title":"Exp Neurol"},{"issue":"3","key":"698_CR296","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.10720","volume":"54","author":"CW Olanow","year":"2003","unstructured":"Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin MF, Shannon KM, Nauert GM, Perl DP, Godbold J, Freeman TB (2003) A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson\u2019s disease. Ann Neurol 54(3):403\u2013414","journal-title":"Ann Neurol"},{"issue":"2","key":"698_CR297","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/00002826-200403000-00003","volume":"27","author":"CW Olanow","year":"2004","unstructured":"Olanow CW, Damier P, Goetz CG, Mueller T, Nutt J, Rascol O, Serbanescu A, Deckers F, Russ H (2004) Multicenter, open-label, trial of sarizotan in Parkinson disease patients with levodopa-induced dyskinesias (the SPLENDID Study). Clin Neuropharmacol 27(2):58\u201362","journal-title":"Clin Neuropharmacol"},{"issue":"10 Suppl","key":"698_CR298","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/S1471-1931(00)00020-3","volume":"23","author":"SP Onn","year":"2000","unstructured":"Onn SP, West AR, Grace AA (2000) Dopamine-mediated regulation of striatal neuronal and network interactions. Trends Neurosci 23(10 Suppl):S48\u2013S56","journal-title":"Trends Neurosci"},{"key":"698_CR1000","doi-asserted-by":"crossref","unstructured":"Onofrj M, Bonanni L, Thomas A (2008) An expert opinion on safinamide in Parkinson\u2019s disease. Expert Opin Investig Drugs 17:1115\u20131125","DOI":"10.1517\/13543784.17.7.1115"},{"issue":"4","key":"698_CR299","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0028-3908(01)00083-1","volume":"41","author":"K Ossowska","year":"2001","unstructured":"Ossowska K, Konieczny J, Wolfarth S, Wieronska J, Pilc A (2001) Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats. Neuropharmacology 41(4):413\u2013420","journal-title":"Neuropharmacology"},{"issue":"4","key":"698_CR300","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuropharm.2005.04.002","volume":"49","author":"K Ossowska","year":"2005","unstructured":"Ossowska K, Konieczny J, Wolfarth S, Pilc A (2005) MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Neuropharmacology 49(4):447\u2013455","journal-title":"Neuropharmacology"},{"issue":"2","key":"698_CR301","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s12031-008-9137-8","volume":"38","author":"B Ouattara","year":"2009","unstructured":"Ouattara B, Belkhir S, Morissette M, Dridi M, Samadi P, Gregoire L, Meltzer LT, Di Paolo T (2009a) Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61\u20138048 in MPTP monkeys with levodopa-induced dyskinesias. J Mol Neurosci 38(2):128\u2013142","journal-title":"J Mol Neurosci"},{"key":"698_CR302","unstructured":"Ouattara B, Gregoire L, Morissette M, Gasparini F, Vranesic I, Bilbe G, Johns DR, Rajput A, Hornykiewicz O, Rajput AH, Gomez-Mancilla B, Di Paolo T (2009b) Metabotropic glutamate receptor type 5 in levodopa-induced motor complications. Neurobiol Aging"},{"issue":"3","key":"698_CR303","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.neuroscience.2009.01.034","volume":"159","author":"FE Padovan-Neto","year":"2009","unstructured":"Padovan-Neto FE, Echeverry MB, Tumas V, Del-Bel EA (2009) Nitric oxide synthase inhibition attenuates l-DOPA-induced dyskinesias in a rodent model of Parkinson\u2019s disease. Neuroscience 159(3):927\u2013935","journal-title":"Neuroscience"},{"issue":"19","key":"698_CR304","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1523\/JNEUROSCI.5735-03.2004","volume":"24","author":"CA Paladini","year":"2004","unstructured":"Paladini CA, Williams JT (2004) Noradrenergic inhibition of midbrain dopamine neurons. J Neurosci 24(19):4568\u20134575","journal-title":"J Neurosci"},{"issue":"3","key":"698_CR305","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/85124","volume":"4","author":"CA Paladini","year":"2001","unstructured":"Paladini CA, Fiorillo CD, Morikawa H, Williams JT (2001) Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons. Nat Neurosci 4(3):275\u2013281","journal-title":"Nat Neurosci"},{"issue":"6","key":"698_CR306","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1471-4159.2009.06416.x","volume":"111","author":"DJ Park","year":"2009","unstructured":"Park DJ, West AR (2009) Regulation of striatal nitric oxide synthesis by local dopamine and glutamate interactions. J Neurochem 111(6):1457\u20131465","journal-title":"J Neurochem"},{"issue":"4","key":"698_CR307","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/mds.10186","volume":"17","author":"SG Parkin","year":"2002","unstructured":"Parkin SG, Gregory RP, Scott R, Bain P, Silburn P, Hall B, Boyle R, Joint C, Aziz TZ (2002) Unilateral and bilateral pallidotomy for idiopathic Parkinson\u2019s disease: a case series of 115 patients. Mov Disord 17(4):682\u2013692","journal-title":"Mov Disord"},{"issue":"1","key":"698_CR308","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biopsych.2005.05.044","volume":"59","author":"N Pavon","year":"2006","unstructured":"Pavon N, Martin AB, Mendialdua A, Moratalla R (2006) ERK phosphorylation and FosB expression are associated with l-DOPA-induced dyskinesia in hemiparkinsonian mice. Biol Psychiatry 59(1):64\u201374","journal-title":"Biol Psychiatry"},{"key":"698_CR309","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/mds.870100606","volume":"10","author":"RK Pearce","year":"1995","unstructured":"Pearce RK, Jackson M, Smith L, Jenner P, Marsden CD (1995) Chronic l-DOPA administration induces dyskinesias in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmoset (Callithrix Jacchus). Mov Disord 10:731\u2013740","journal-title":"Mov Disord"},{"issue":"1","key":"698_CR310","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s002130050861","volume":"142","author":"RK Pearce","year":"1999","unstructured":"Pearce RK, Jackson M, Britton DR, Shiosaki K, Jenner P, Marsden CD (1999) Actions of the D1 agonists A-77636 and A-86929 on locomotion and dyskinesia in MPTP-treated l-dopa-primed common marmosets. Psychopharmacology (Berl) 142(1):51\u201360","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"698_CR311","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s002130100733","volume":"156","author":"RK Pearce","year":"2001","unstructured":"Pearce RK, Heikkila M, Linden IB, Jenner P (2001) l-dopa induces dyskinesia in normal monkeys: behavioural and pharmacokinetic observations. Psychopharmacology (Berl) 156(4):402\u2013409","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"698_CR312","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0306-4522(98)00251-6","volume":"88","author":"D Peckys","year":"1999","unstructured":"Peckys D, Landwehrmeyer GB (1999) Expression of mu, kappa, and delta opioid receptor messenger RNA in the human CNS: a 33P in situ hybridization study. Neuroscience 88(4):1093\u20131135","journal-title":"Neuroscience"},{"issue":"Suppl 1","key":"698_CR313","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1038\/sj.bjp.0706406","volume":"147","author":"RG Pertwee","year":"2006","unstructured":"Pertwee RG (2006) Cannabinoid pharmacology: the first 66\u00a0years. Br J Pharmacol 147(Suppl 1):S163\u2013S171","journal-title":"Br J Pharmacol"},{"issue":"5","key":"698_CR314","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nn1040","volume":"6","author":"B Picconi","year":"2003","unstructured":"Picconi B, Centonze D, Hakansson K, Bernardi G, Greengard P, Fisone G, Cenci MA, Calabresi P (2003) Loss of bidirectional striatal synaptic plasticity in l-DOPA-induced dyskinesia. Nat Neurosci 6(5):501\u2013506","journal-title":"Nat Neurosci"},{"issue":"2","key":"698_CR315","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0306-4522(98)00465-5","volume":"90","author":"MA Piggott","year":"1999","unstructured":"Piggott MA, Marshall EF, Thomas N, Lloyd S, Court JA, Jaros E, Costa D, Perry RH, Perry EK (1999) Dopaminergic activities in the human striatum: rostrocaudal gradients of uptake sites and of D1 and D2 but not of D3 receptor binding or dopamine. Neuroscience 90(2):433\u2013445","journal-title":"Neuroscience"},{"issue":"11","key":"698_CR316","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1517\/13543780903241615","volume":"18","author":"A Pinna","year":"2009","unstructured":"Pinna A (2009) Novel investigational adenosine A2A receptor antagonists for Parkinson\u2019s disease. Expert Opin Investig Drugs 18(11):1619\u20131631","journal-title":"Expert Opin Investig Drugs"},{"issue":"3","key":"698_CR317","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/1098-2396(20010301)39:3<233::AID-SYN1004>3.0.CO;2-K","volume":"39","author":"A Pinna","year":"2001","unstructured":"Pinna A, Fenu S, Morelli M (2001) Motor stimulant effects of the adenosine A2A receptor antagonist SCH 58261 do not develop tolerance after repeated treatments in 6-hydroxydopamine-lesioned rats. Synapse 39(3):233\u2013238","journal-title":"Synapse"},{"issue":"11","key":"698_CR318","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","volume":"4","author":"D Piomelli","year":"2003","unstructured":"Piomelli D (2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4(11):873\u2013884","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"698_CR319","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/ana.20462","volume":"57","author":"A Pisani","year":"2005","unstructured":"Pisani A, Fezza F, Galati S, Battista N, Napolitano S, Finazzi-Agro A, Bernardi G, Brusa L, Pierantozzi M, Stanzione P, Maccarrone M (2005) High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson\u2019s disease patients. Ann Neurol 57(5):777\u2013779","journal-title":"Ann Neurol"},{"issue":"38","key":"698_CR321","doi-asserted-by":"crossref","first-page":"38ra46","DOI":"10.1126\/scitranslmed.3000976","volume":"2","author":"M Politis","year":"2010","unstructured":"Politis M, Wu K, Loane C, Quinn NP, Brooks DJ, Rehncrona S, Bjorklund A, Lindvall O, Piccini P (2010) Serotonergic neurons mediate dyskinesia side effects in Parkinson\u2019s patients with neural transplants. Sci Transl Med 2(38):38ra46","journal-title":"Sci Transl Med"},{"key":"698_CR322","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0079-6123(10)84016-6","volume":"184","author":"FA Ponce","year":"2010","unstructured":"Ponce FA, Lozano AM (2010) Deep brain stimulation state of the art and novel stimulation targets. Prog Brain Res 184:311\u2013324","journal-title":"Prog Brain Res"},{"issue":"11 Pt 2","key":"698_CR323","doi-asserted-by":"crossref","first-page":"7192","DOI":"10.1523\/JNEUROSCI.14-11-07192.1994","volume":"14","author":"RH Porter","year":"1994","unstructured":"Porter RH, Greene JG, Higgins DS Jr, Greenamyre JT (1994) Polysynaptic regulation of glutamate receptors and mitochondrial enzyme activities in the basal ganglia of rats with unilateral dopamine depletion. J Neurosci 14(11 Pt 2):7192\u20137199","journal-title":"J Neurosci"},{"key":"698_CR324","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s002109900097","volume":"360","author":"H Prast","year":"1999","unstructured":"Prast H, Tran MH, Fischer H, Kraus M, Lamberti C, Grass K, Philippu A (1999a) Histaminergic neurons modulate acetylcholine release in the ventral striatum: role of H3 histamine receptors. Naunyn Schmiedebergs Arch Pharmacol 360:558\u2013564","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"698_CR325","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s002109900098","volume":"360","author":"H Prast","year":"1999","unstructured":"Prast H, Tran MH, Lamberti C, Fischer H, Kraus M, Grass K, Philippu A (1999b) Histaminergic neurons modulate acetylcholine release in the ventral striatum: role of H1 and H2 histamine receptors. Naunyn Schmiedebergs Arch Pharmacol 360:552\u2013557","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"4 Suppl 1","key":"698_CR326","first-page":"S179","volume":"47","author":"O Rascol","year":"2000","unstructured":"Rascol O (2000) Medical treatment of levodopa-induced dyskinesias. Ann Neurol 47(4 Suppl 1):S179\u2013S188","journal-title":"Ann Neurol"},{"issue":"Suppl 1","key":"698_CR327","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1468-1331.2010.03326.x","volume":"18","author":"O Rascol","year":"2011","unstructured":"Rascol O (2011) Drugs and drug delivery in PD: optimizing control of symptoms with pramipexole prolonged-release. Eur J Neurol 18(Suppl 1):3\u201310","journal-title":"Eur J Neurol"},{"issue":"4","key":"698_CR328","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/mds.870090410","volume":"9","author":"O Rascol","year":"1994","unstructured":"Rascol O, Fabre N, Blin O, Poulik J, Sabatini U, Senard JM, Ane M, Montastruc JL, Rascol A (1994) Naltrexone, an opiate antagonist, fails to modify motor symptoms in patients with Parkinson\u2019s disease. Mov Disord 9(4):437\u2013440","journal-title":"Mov Disord"},{"key":"698_CR329","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/1531-8249(199906)45:6<736::AID-ANA7>3.0.CO;2-F","volume":"45","author":"O Rascol","year":"1999","unstructured":"Rascol O, Blin O, Thalamas C, Descombes S, Soubrouillard C, Azulay P, Fabre N, Viallet F, Lafnitzegger K, Wright S, Carter JH, Nutt JG (1999) ABT-431, a D1 receptor agonist prodrug, has efficacy in Parkinson\u2019s disease. Ann Neurol 45:736\u2013741","journal-title":"Ann Neurol"},{"issue":"4","key":"698_CR330","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/mds.1143","volume":"16","author":"O Rascol","year":"2001","unstructured":"Rascol O, Arnulf I, Peyro-Saint Paul H, Brefel-Courbon C, Vidailhet M, Thalamas C, Bonnet AM, Descombes S, Bejjani B, Fabre N, Montastruc JL, Agid Y (2001a) Idazoxan, an alpha-2 antagonist, and l-DOPA-induced dyskinesias in patients with Parkinson\u2019s disease. Mov Disord 16(4):708\u2013713","journal-title":"Mov Disord"},{"issue":"2","key":"698_CR331","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1001\/archneur.58.2.249","volume":"58","author":"O Rascol","year":"2001","unstructured":"Rascol O, Nutt JG, Blin O, Goetz CG, Trugman JM, Soubrouillard C, Carter JH, Currie LJ, Fabre N, Thalamas C, Giardina WW, Wright S (2001b) Induction by dopamine D1 receptor agonist ABT-431 of dyskinesia similar to levodopa in patients with Parkinson disease. Arch Neurol 58(2):249\u2013254","journal-title":"Arch Neurol"},{"issue":"9","key":"698_CR332","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0165-6147(97)01096-1","volume":"18","author":"PJ Richardson","year":"1997","unstructured":"Richardson PJ, Kase H, Jenner PG (1997) Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson\u2019s disease. Trends Pharmacol Sci 18(9):338\u2013344","journal-title":"Trends Pharmacol Sci"},{"key":"698_CR333","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1046\/j.1471-4159.2002.00871.x","volume":"81","author":"JO Rinne","year":"2002","unstructured":"Rinne JO, Anichtchik OV, Eriksson KS, Kaslin J, Tuomisto L, Kalimo H, Roytta M, Panula P (2002) Increased brain histamine levels in Parkinson\u2019s disease but not in multiple system atrophy. J Neurochem 81:954\u2013960","journal-title":"J Neurochem"},{"issue":"3","key":"698_CR334","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1471-4159.2004.02887.x","volume":"92","author":"RJ Rodrigues","year":"2005","unstructured":"Rodrigues RJ, Alfaro TM, Rebola N, Oliveira CR, Cunha RA (2005) Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. J Neurochem 92(3):433\u2013441","journal-title":"J Neurochem"},{"issue":"11","key":"698_CR335","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1523\/JNEUROSCI.19-11-04682.1999","volume":"19","author":"M Rodriguez","year":"1999","unstructured":"Rodriguez M, Gonzalez-Hernandez T (1999) Electrophysiological and morphological evidence for a GABAergic nigrostriatal pathway. J Neurosci 19(11):4682\u20134694","journal-title":"J Neurosci"},{"issue":"2","key":"698_CR336","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bcp.2007.01.036","volume":"74","author":"KS Rommelfanger","year":"2007","unstructured":"Rommelfanger KS, Weinshenker D (2007) Norepinephrine: the redheaded stepchild of Parkinson\u2019s disease. Biochem Pharmacol 74(2):177\u2013190","journal-title":"Biochem Pharmacol"},{"issue":"11 Suppl 6","key":"698_CR337","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1212\/01.WNL.0000095205.33940.99","volume":"61","author":"DL Rosin","year":"2003","unstructured":"Rosin DL, Hettinger BD, Lee A, Linden J (2003) Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function. Neurology 61(11 Suppl 6):S12\u2013S18","journal-title":"Neurology"},{"issue":"3","key":"698_CR338","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0163-7258(00)00098-X","volume":"88","author":"ST Rouse","year":"2000","unstructured":"Rouse ST, Marino MJ, Bradley SR, Awad H, Wittmann M, Conn PJ (2000) Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson\u2019s disease and related disorders. Pharmacol Ther 88(3):427\u2013435","journal-title":"Pharmacol Ther"},{"issue":"3","key":"698_CR339","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3940(98)00198-0","volume":"245","author":"G Rozas","year":"1998","unstructured":"Rozas G, Liste I, Guerra MJ, Labandeira-Garcia JL (1998) Sprouting of the serotonergic afferents into striatum after selective lesion of the dopaminergic system by MPTP in adult mice. Neurosci Lett 245(3):151\u2013154","journal-title":"Neurosci Lett"},{"issue":"1","key":"698_CR340","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1124\/jpet.108.150425","volume":"330","author":"D Rylander","year":"2009","unstructured":"Rylander D, Recchia A, Mela F, Dekundy A, Danysz W, Cenci MA (2009) Pharmacological modulation of glutamate transmission in a rat model of l-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling. J Pharmacol Exp Ther 330(1):227\u2013235","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"698_CR341","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.nbd.2010.05.001","volume":"39","author":"D Rylander","year":"2010","unstructured":"Rylander D, Iderberg H, Li Q, Dekundy A, Zhang J, Li H, Baishen R, Danysz W, Bezard E, Cenci MA (2010a) A mGluR5 antagonist under clinical development improves l-DOPA-induced dyskinesia in parkinsonian rats and monkeys. Neurobiol Dis 39(3):352\u2013361","journal-title":"Neurobiol Dis"},{"issue":"5","key":"698_CR342","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/ana.22097","volume":"68","author":"D Rylander","year":"2010","unstructured":"Rylander D, Parent M, O\u2019Sullivan SS, Dovero S, Lees AJ, Bezard E, Descarries L, Cenci MA (2010b) Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia. Ann Neurol 68(5):619\u2013628","journal-title":"Ann Neurol"},{"key":"698_CR343","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0304-3940(94)90279-8","volume":"178","author":"JH Ryu","year":"1994","unstructured":"Ryu JH, Yanai K, Watanabe T (1994) Marked increase in histamine H3 receptors in the striatum and substantia nigra after 6-hydroxydopamine-induced denervation of dopaminergic neurons: an autoradiographic study. Neurosci Lett 178:19\u201322","journal-title":"Neurosci Lett"},{"key":"698_CR344","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-3806(95)00055-I","volume":"87","author":"JH Ryu","year":"1995","unstructured":"Ryu JH, Yanai K, Sakurai E, Kim CY, Watanabe T (1995) Ontogenetic development of histamine receptor subtypes in rat brain demonstrated by quantitative autoradiography. Brain Res Dev Brain Res 87:101\u2013110","journal-title":"Brain Res Dev Brain Res"},{"issue":"3","key":"698_CR345","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0306-4522(98)00100-6","volume":"86","author":"J Sallinen","year":"1998","unstructured":"Sallinen J, Haapalinna A, Viitamaa T, Kobilka BK, Scheinin M (1998a) d-amphetamine and l-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype. Neuroscience 86(3):959\u2013965","journal-title":"Neuroscience"},{"issue":"8","key":"698_CR346","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1523\/JNEUROSCI.18-08-03035.1998","volume":"18","author":"J Sallinen","year":"1998","unstructured":"Sallinen J, Haapalinna A, Viitamaa T, Kobilka BK, Scheinin M (1998b) Adrenergic alpha2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice. J Neurosci 18(8):3035\u20133042","journal-title":"J Neurosci"},{"key":"698_CR1003","doi-asserted-by":"crossref","unstructured":"Samadi P, Gregoire L, Bedard PJ (2004) The opioid agonist morphine decreases the dyskinetic response to dopaminergic agents in parkinsonian monkeys. Neurobiol Dis 16:246\u2013253","DOI":"10.1016\/j.nbd.2004.02.002"},{"key":"698_CR1004","doi-asserted-by":"crossref","unstructured":"Samadi P, Gregoire L, Hadj Tahar A, Di Paolo T, Rouillard C, Bedard PJ (2005) Naltrexone in the short-term decreases antiparkinsonian response to l-Dopa and in the long-term increases dyskinesias in drug-naive parkinsonian monkeys. Neuropharmacology 49:165\u2013173","DOI":"10.1016\/j.neuropharm.2005.02.009"},{"issue":"10","key":"698_CR347","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.tips.2006.08.002","volume":"27","author":"P Samadi","year":"2006","unstructured":"Samadi P, Bedard PJ, Rouillard C (2006) Opioids and motor complications in Parkinson\u2019s disease. Trends Pharmacol Sci 27(10):512\u2013517","journal-title":"Trends Pharmacol Sci"},{"issue":"7","key":"698_CR348","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.neurobiolaging.2007.02.005","volume":"29","author":"P Samadi","year":"2008","unstructured":"Samadi P, Gregoire L, Morissette M, Calon F, Hadj Tahar A, Dridi M, Belanger N, Meltzer LT, Bedard PJ, Di Paolo T (2008) mGluR5 metabotropic glutamate receptors and dyskinesias in MPTP monkeys. Neurobiol Aging 29(7):1040\u20131051","journal-title":"Neurobiol Aging"},{"issue":"3","key":"698_CR349","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/sj.npp.1300826","volume":"31","author":"S Sammut","year":"2006","unstructured":"Sammut S, Dec A, Mitchell D, Linardakis J, Ortiguela M, West AR (2006) Phasic dopaminergic transmission increases NO efflux in the rat dorsal striatum via a neuronal NOS and a dopamine D(1\/5) receptor-dependent mechanism. Neuropsychopharmacology 31(3):493\u2013505","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"698_CR350","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00213-006-0681-z","volume":"191","author":"S Sammut","year":"2007","unstructured":"Sammut S, Bray KE, West AR (2007) Dopamine D2 receptor-dependent modulation of striatal NO synthase activity. Psychopharmacology (Berl) 191(3):793\u2013803","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"698_CR351","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0306-4522(00)00227-X","volume":"99","author":"G Sancesario","year":"2000","unstructured":"Sancesario G, Morello M, Reiner A, Giacomini P, Massa R, Schoen S, Bernardi G (2000) Nitrergic neurons make synapses on dual-input dendritic spines of neurons in the cerebral cortex and the striatum of the rat: implication for a postsynaptic action of nitric oxide. Neuroscience 99(4):627\u2013642","journal-title":"Neuroscience"},{"issue":"1","key":"698_CR352","first-page":"118","volume":"143","author":"R Sandyk","year":"1986","unstructured":"Sandyk R, Snider SR (1986) Naloxone treatment of l-dopa-induced dyskinesias in Parkinson\u2019s disease. Am J Psychiatry 143(1):118","journal-title":"Am J Psychiatry"},{"issue":"5","key":"698_CR353","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/(SICI)1097-4547(19980601)52:5<591::AID-JNR11>3.0.CO;2-5","volume":"52","author":"M Santiago","year":"1998","unstructured":"Santiago M, Matarredona ER, Machado A, Cano J (1998) Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatum. J Neurosci Res 52(5):591\u2013598","journal-title":"J Neurosci Res"},{"issue":"26","key":"698_CR354","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1523\/JNEUROSCI.0852-07.2007","volume":"27","author":"E Santini","year":"2007","unstructured":"Santini E, Valjent E, Usiello A, Carta M, Borgkvist A, Girault JA, Herve D, Greengard P, Fisone G (2007) Critical involvement of cAMP\/DARPP-32 and extracellular signal-regulated protein kinase signaling in l-DOPA-induced dyskinesia. J Neurosci 27(26):6995\u20137005","journal-title":"J Neurosci"},{"issue":"3","key":"698_CR355","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1471-4159.2008.05831.x","volume":"108","author":"E Santini","year":"2009","unstructured":"Santini E, Alcacer C, Cacciatore S, Heiman M, Herve D, Greengard P, Girault JA, Valjent E, Fisone G (2009) l-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice. J Neurochem 108(3):621\u2013633","journal-title":"J Neurochem"},{"key":"698_CR356","doi-asserted-by":"crossref","first-page":"e12322","DOI":"10.1371\/journal.pone.0012322","volume":"5","author":"E Santini","year":"2010","unstructured":"Santini E, Sgambato-Faure V, Li Q, Savasta M, Dovero S, Fisone G, Bezard E (2010) Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in l-DOPA-induced dyskinesia. PLoS One 5:e12322","journal-title":"PLoS One"},{"issue":"8","key":"698_CR357","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/mds.10464","volume":"18","author":"JM Savola","year":"2003","unstructured":"Savola JM, Hill M, Engstrom M, Merivuori H, Wurster S, McGuire SG, Fox SH, Crossman AR, Brotchie JM (2003) Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson\u2019s disease. Mov Disord 18(8):872\u2013883","journal-title":"Mov Disord"},{"key":"698_CR358","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1517\/14656566.2010.511612","volume":"11","author":"AH Schapira","year":"2010","unstructured":"Schapira AH (2010) Safinamide in the treatment of Parkinson\u2019s disease. Expert Opin Pharmacother 11:2261\u20132268","journal-title":"Expert Opin Pharmacother"},{"issue":"2","key":"698_CR359","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3940(93)90244-F","volume":"158","author":"SN Schiffmann","year":"1993","unstructured":"Schiffmann SN, Vanderhaeghen JJ (1993) Age-related loss of mRNA encoding adenosine A2 receptor in the rat striatum. Neurosci Lett 158(2):121\u2013124","journal-title":"Neurosci Lett"},{"issue":"3","key":"698_CR360","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1471-4159.1991.tb08257.x","volume":"57","author":"SN Schiffmann","year":"1991","unstructured":"Schiffmann SN, Jacobs O, Vanderhaeghen JJ (1991) Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study. J Neurochem 57(3):1062\u20131067","journal-title":"J Neurochem"},{"issue":"5","key":"698_CR361","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pneurobio.2007.05.001","volume":"83","author":"SN Schiffmann","year":"2007","unstructured":"Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferre S (2007) Adenosine A2A receptors and basal ganglia physiology. Prog Neurobiol 83(5):277\u2013292","journal-title":"Prog Neurobiol"},{"issue":"11","key":"698_CR362","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0165-6147(00)01805-8","volume":"22","author":"E Schlicker","year":"2001","unstructured":"Schlicker E, Kathmann M (2001) Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol Sci 22(11):565\u2013572","journal-title":"Trends Pharmacol Sci"},{"key":"698_CR363","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01244933","volume":"93","author":"E Schlicker","year":"1993","unstructured":"Schlicker E, Fink K, Detzner M, Gothert M (1993) Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J Neural Transm Gen Sect 93:1\u201310","journal-title":"J Neural Transm Gen Sect"},{"issue":"4","key":"698_CR364","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1474-4422(06)70411-2","volume":"5","author":"A Schrag","year":"2006","unstructured":"Schrag A, Schott JM (2006) Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism. Lancet Neurol 5(4):355\u2013363","journal-title":"Lancet Neurol"},{"issue":"6","key":"698_CR365","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/mds.870130605","volume":"13","author":"A Schrag","year":"1998","unstructured":"Schrag A, Ben-Shlomo Y, Brown R, Marsden CD, Quinn N (1998) Young-onset Parkinson\u2019s disease revisited\u2014clinical features, natural history, and mortality. Mov Disord 13(6):885\u2013894","journal-title":"Mov Disord"},{"key":"698_CR366","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/ana.410210418","volume":"21","author":"P Seeman","year":"1987","unstructured":"Seeman P, Guttman M (1987) Dopamine receptor elevation in denervated tissues. Ann Neurol 21:412\u2013415","journal-title":"Ann Neurol"},{"issue":"2","key":"698_CR367","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/mds.10312","volume":"18","author":"G Segovia","year":"2003","unstructured":"Segovia G, Mora F, Crossman AR, Brotchie JM (2003) Effects of CB1 cannabinoid receptor modulating compounds on the hyperkinesia induced by high-dose levodopa in the reserpine-treated rat model of Parkinson\u2019s disease. Mov Disord 18(2):138\u2013149","journal-title":"Mov Disord"},{"issue":"3","key":"698_CR368","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0361-9230(00)00358-0","volume":"53","author":"H Sershen","year":"2000","unstructured":"Sershen H, Hashim A, Lajtha A (2000) Serotonin-mediated striatal dopamine release involves the dopamine uptake site and the serotonin receptor. Brain Res Bull 53(3):353\u2013357","journal-title":"Brain Res Bull"},{"issue":"1","key":"698_CR369","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0022-3565(25)12244-1","volume":"276","author":"K Shiosaki","year":"1996","unstructured":"Shiosaki K, Jenner P, Asin KE, Britton DR, Lin CW, Michaelides M, Smith L, Bianchi B, Didomenico S, Hodges L, Hong Y, Mahan L, Mikusa J, Miller T, Nikkel A, Stashko M, Witte D, Williams M (1996) ABT-431: the diacetyl prodrug of A-86929, a potent and selective dopamine D1 receptor agonist: in vitro characterization and effects in animal models of Parkinson\u2019s disease. J Pharmacol Exp Ther 276(1):150\u2013160","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"698_CR370","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/exnr.2001.7854","volume":"174","author":"MA Silverdale","year":"2002","unstructured":"Silverdale MA, Crossman AR, Brotchie JM (2002) Striatal AMPA receptor binding is unaltered in the MPTP-lesioned macaque model of Parkinson\u2019s disease and dyskinesia. Exp Neurol 174(1):21\u201328","journal-title":"Exp Neurol"},{"key":"698_CR371","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0166-2236(90)90106-K","volume":"13","author":"AD Smith","year":"1990","unstructured":"Smith AD, Bolam JP (1990) The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones. Trends Neurosci 13:259\u2013265","journal-title":"Trends Neurosci"},{"key":"698_CR372","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/mds.10200","volume":"17","author":"LA Smith","year":"2002","unstructured":"Smith LA, Tel BC, Jackson MJ, Hansard MJ, Braceras R, Bonhomme C, Chezaubernard C, Del Signore S, Rose S, Jenner P (2002) Repeated administration of piribedil induces less dyskinesia than l-dopa in MPTP-treated common marmosets: a behavioural and biochemical investigation. Mov Disord 17:887\u2013901","journal-title":"Mov Disord"},{"issue":"3","key":"698_CR373","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/01.WNF.0000220818.71231.DF","volume":"29","author":"LA Smith","year":"2006","unstructured":"Smith LA, Jackson MJ, Johnston L, Kuoppamaki M, Rose S, Al-Barghouthy G, Del Signore S, Jenner P (2006) Switching from levodopa to the long-acting dopamine D2\/D3 agonist piribedil reduces the expression of dyskinesia while maintaining effective motor activity in MPTP-treated primates. Clin Neuropharmacol 29(3):112\u2013125","journal-title":"Clin Neuropharmacol"},{"issue":"Pt 4","key":"698_CR374","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/brain\/awl028","volume":"129","author":"V Sossi","year":"2006","unstructured":"Sossi V, de la Fuente-Fernandez R, Schulzer M, Adams J, Stoessl J (2006) Age-related differences in levodopa dynamics in Parkinson\u2019s: implications for motor complications. Brain 129(Pt 4):1050\u20131058","journal-title":"Brain"},{"issue":"Suppl 3","key":"698_CR375","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/S1353-8020(09)70784-9","volume":"15","author":"F Stocchi","year":"2009","unstructured":"Stocchi F (2009) The therapeutic concept of continuous dopaminergic stimulation (CDS) in the treatment of Parkinson\u2019s disease. Parkinsonism Relat Disord 15(Suppl 3):S68\u2013S71","journal-title":"Parkinsonism Relat Disord"},{"key":"698_CR376","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1212\/WNL.67.7_suppl_2.S24","volume":"67","author":"F Stocchi","year":"2006","unstructured":"Stocchi F, Vacca L, Grassini P, De Pandis MF, Battaglia G, Cattaneo C, Fariello RG (2006) Symptom relief in Parkinson disease by safinamide: Biochemical and clinical evidence of efficacy beyond MAO-B inhibition. Neurology 67:S24\u2013S29","journal-title":"Neurology"},{"issue":"Suppl 3","key":"698_CR377","doi-asserted-by":"crossref","first-page":"S599","DOI":"10.1002\/mds.22052","volume":"23","author":"F Stocchi","year":"2008","unstructured":"Stocchi F, Tagliati M, Olanow CW (2008) Treatment of levodopa-induced motor complications. Mov Disord 23(Suppl 3):S599\u2013S612","journal-title":"Mov Disord"},{"key":"698_CR378","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.expneurol.2009.07.011","volume":"219","author":"KA Stockwell","year":"2009","unstructured":"Stockwell KA, Scheller D, Rose S, Jackson MJ, Tayarani-Binazir K, Iravani MM, Smith LA, Olanow CW, Jenner P (2009) Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction. Exp Neurol 219:533\u2013542","journal-title":"Exp Neurol"},{"issue":"1","key":"698_CR379","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.expneurol.2009.10.004","volume":"221","author":"KA Stockwell","year":"2010","unstructured":"Stockwell KA, Scheller DK, Smith LA, Rose S, Iravani MM, Jackson MJ, Jenner P (2010) Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or l-DOPA in MPTP-treated common marmosets. Exp Neurol 221(1):79\u201385","journal-title":"Exp Neurol"},{"issue":"5839","key":"698_CR380","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/294366a0","volume":"294","author":"JC Stoof","year":"1981","unstructured":"Stoof JC, Kebabian JW (1981) Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum. Nature 294(5839):366\u2013368","journal-title":"Nature"},{"issue":"2","key":"698_CR381","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0169-328X(98)00157-0","volume":"59","author":"PC Suen","year":"1998","unstructured":"Suen PC, Wu K, Xu JL, Lin SY, Levine ES, Black IB (1998) NMDA receptor subunits in the postsynaptic density of rat brain: expression and phosphorylation by endogenous protein kinases. Brain Res Mol Brain Res 59(2):215\u2013228","journal-title":"Brain Res Mol Brain Res"},{"issue":"5","key":"698_CR382","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tins.2007.03.008","volume":"30","author":"DJ Surmeier","year":"2007","unstructured":"Surmeier DJ, Ding J, Day M, Wang Z, Shen W (2007) D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. Trends Neurosci 30(5):228\u2013235","journal-title":"Trends Neurosci"},{"key":"698_CR383","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(95)00064-W","volume":"675","author":"T Suzuki","year":"1995","unstructured":"Suzuki T, Takamori K, Misawa M, Onodera K (1995) Effects of the histaminergic system on the morphine-induced conditioned place preference in mice. Brain Res 675:195\u2013202","journal-title":"Brain Res"},{"issue":"2","key":"698_CR384","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/(SICI)1096-9861(19980921)399:2<229::AID-CNE6>3.0.CO;2-2","volume":"399","author":"P Svenningsson","year":"1998","unstructured":"Svenningsson P, Le Moine C, Aubert I, Burbaud P, Fredholm BB, Bloch B (1998) Cellular distribution of adenosine A2A receptor mRNA in the primate striatum. J Comp Neurol 399(2):229\u2013240","journal-title":"J Comp Neurol"},{"issue":"4","key":"698_CR385","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/cne.901630406","volume":"163","author":"LW Swanson","year":"1975","unstructured":"Swanson LW, Hartman BK (1975) The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker. J Comp Neurol 163(4):467\u2013505","journal-title":"J Comp Neurol"},{"key":"698_CR386","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0006-8993(86)90992-3","volume":"364","author":"H Takagi","year":"1986","unstructured":"Takagi H, Morishima Y, Matsuyama T, Hayashi H, Watanabe T, Wada H (1986) Histaminergic axons in the neostriatum and cerebral cortex of the rat: a correlated light and electron microscopic immunocytochemical study using histidine decarboxylase as a marker. Brain Res 364:114\u2013123","journal-title":"Brain Res"},{"key":"698_CR387","doi-asserted-by":"crossref","first-page":"7647","DOI":"10.1073\/pnas.81.23.7647","volume":"81","author":"N Takeda","year":"1984","unstructured":"Takeda N, Inagaki S, Shiosaka S, Taguchi Y, Oertel WH, Tohyama M, Watanabe T, Wada H (1984) Immunohistochemical evidence for the coexistence of histidine decarboxylase-like and glutamate decarboxylase-like immunoreactivities in nerve cells of the magnocellular nucleus of the posterior hypothalamus of rats. Proc Natl Acad Sci USA 81:7647\u20137650","journal-title":"Proc Natl Acad Sci USA"},{"key":"698_CR1007","doi-asserted-by":"crossref","unstructured":"Tani Y, Ogata A, Koyama M, Inoue T (2010) Effects of piclozotan (SUN N4057), a partial serotonin 1A receptor agonist, on motor complications induced by repeated administration of levodopa in parkinsonian rats. Eur J Pharmacol 649:218\u2013223","DOI":"10.1016\/j.ejphar.2010.09.013"},{"issue":"6","key":"698_CR388","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.neuropharm.2005.12.004","volume":"50","author":"JL Taylor","year":"2006","unstructured":"Taylor JL, Bishop C, Ullrich T, Rice KC, Walker PD (2006) Serotonin 2A receptor antagonist treatment reduces dopamine D1 receptor-mediated rotational behavior but not l-DOPA-induced abnormal involuntary movements in the unilateral dopamine-depleted rat. Neuropharmacology 50(6):761\u2013768","journal-title":"Neuropharmacology"},{"issue":"4","key":"698_CR389","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0306-4522(02)00535-3","volume":"115","author":"BC Tel","year":"2002","unstructured":"Tel BC, Zeng BY, Cannizzaro C, Pearce RK, Rose S, Jenner P (2002) Alterations in striatal neuropeptide mRNA produced by repeated administration of l-DOPA, ropinirole or bromocriptine correlate with dyskinesia induction in MPTP-treated common marmosets. Neuroscience 115(4):1047\u20131058","journal-title":"Neuroscience"},{"issue":"8","key":"698_CR390","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1074\/jbc.272.8.5157","volume":"272","author":"WG Tingley","year":"1997","unstructured":"Tingley WG, Ehlers MD, Kameyama K, Doherty C, Ptak JB, Riley CT, Huganir RL (1997) Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-d-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J Biol Chem 272(8):5157\u20135166","journal-title":"J Biol Chem"},{"issue":"2","key":"698_CR391","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ana.1099","volume":"50","author":"DM Togasaki","year":"2001","unstructured":"Togasaki DM, Tan L, Protell P, Di Monte DA, Quik M, Langston JW (2001) Levodopa induces dyskinesias in normal squirrel monkeys. Ann Neurol 50(2):254\u2013257","journal-title":"Ann Neurol"},{"issue":"3","key":"698_CR392","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neuropharm.2004.10.009","volume":"48","author":"DM Togasaki","year":"2005","unstructured":"Togasaki DM, Protell P, Tan LC, Langston JW, Di Monte DA, Quik M (2005) Dyskinesias in normal squirrel monkeys induced by nomifensine and levodopa. Neuropharmacology 48(3):398\u2013405","journal-title":"Neuropharmacology"},{"key":"698_CR393","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.parkreldis.2004.11.003","volume":"11","author":"B Tousi","year":"2005","unstructured":"Tousi B, Subramanian T (2005) The effect of levetiracetam on levodopa induced dyskinesia in patients with Parkinson\u2019s disease. Parkinsonism Relat Disord 11:333\u2013334","journal-title":"Parkinsonism Relat Disord"},{"issue":"4","key":"698_CR394","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1046\/j.1471-4159.2000.0751664.x","volume":"75","author":"L Trabace","year":"2000","unstructured":"Trabace L, Kendrick KM (2000) Nitric oxide can differentially modulate striatal neurotransmitter concentrations via soluble guanylate cyclase and peroxynitrite formation. J Neurochem 75(4):1664\u20131674","journal-title":"J Neurochem"},{"issue":"2","key":"698_CR395","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1001\/archneur.1982.00510140054014","volume":"39","author":"M Trabucchi","year":"1982","unstructured":"Trabucchi M, Bassi S, Frattola L (1982) Effect of naloxone on the \u201con\u2013off\u201d syndrome in patients receiving long-term levodopa therapy. Arch Neurol 39(2):120\u2013121","journal-title":"Arch Neurol"},{"issue":"29","key":"698_CR396","doi-asserted-by":"crossref","first-page":"13159","DOI":"10.1073\/pnas.1003432107","volume":"107","author":"A Ulusoy","year":"2010","unstructured":"Ulusoy A, Sahin G, Kirik D (2010) Presynaptic dopaminergic compartment determines the susceptibility to l-DOPA-induced dyskinesia in rats. Proc Natl Acad Sci USA 107(29):13159\u201313164","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"698_CR397","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1096\/fj.04-3010fje","volume":"19","author":"M Stelt van der","year":"2005","unstructured":"van der Stelt M, Fox SH, Hill M, Crossman AR, Petrosino S, Di Marzo V, Brotchie JM (2005) A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson\u2019s disease. FASEB J 19(9):1140\u20131142","journal-title":"FASEB J"},{"issue":"5","key":"698_CR398","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1212\/WNL.50.5.1323","volume":"50","author":"L Verhagen Metman","year":"1998","unstructured":"Verhagen Metman L, Del Dotto P, van den Munckhof P, Fang J, Mouradian MM, Chase TN (1998) Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson\u2019s disease. Neurology 50(5):1323\u20131326","journal-title":"Neurology"},{"issue":"4","key":"698_CR399","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0306-4522(92)90184-4","volume":"46","author":"SR Vincent","year":"1992","unstructured":"Vincent SR, Kimura H (1992) Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46(4):755\u2013784","journal-title":"Neuroscience"},{"key":"698_CR400","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0306-4522(97)00010-9","volume":"80","author":"ML Vizuete","year":"1997","unstructured":"Vizuete ML, Traiffort E, Bouthenet ML, Ruat M, Souil E, Tardivel-Lacombe J, Schwartz JC (1997) Detailed mapping of the histamine H2 receptor and its gene transcripts in guinea-pig brain. Neuroscience 80:321\u2013343","journal-title":"Neuroscience"},{"issue":"6","key":"698_CR401","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00429-008-0178-0","volume":"212","author":"BA Vogt","year":"2008","unstructured":"Vogt BA, Hof PR, Friedman DP, Sikes RW, Vogt LJ (2008) Norepinephrinergic afferents and cytology of the macaque monkey midline, mediodorsal, and intralaminar thalamic nuclei. Brain Struct Funct 212(6):465\u2013479","journal-title":"Brain Struct Funct"},{"issue":"12","key":"698_CR402","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S1474-4422(09)70287-X","volume":"8","author":"V Voon","year":"2009","unstructured":"Voon V, Fernagut PO, Wickens J, Baunez C, Rodriguez M, Pavon N, Juncos JL, Obeso JA, Bezard E (2009) Chronic dopaminergic stimulation in Parkinson\u2019s disease: from dyskinesias to impulse control disorders. Lancet Neurol 8(12):1140\u20131149","journal-title":"Lancet Neurol"},{"key":"698_CR403","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0166-2236(91)90034-R","volume":"14","author":"H Wada","year":"1991","unstructured":"Wada H, Inagaki N, Yamatodani A, Watanabe T (1991) Is the histaminergic neuron system a regulatory center for whole-brain activity? Trends Neurosci 14:415\u2013418","journal-title":"Trends Neurosci"},{"issue":"6","key":"698_CR404","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.brainresbull.2010.01.009","volume":"81","author":"S Walsh","year":"2010","unstructured":"Walsh S, Mnich K, Mackie K, Gorman AM, Finn DP, Dowd E (2010) Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson\u2019s disease in the rat. Brain Res Bull 81(6):543\u2013548","journal-title":"Brain Res Bull"},{"issue":"6477","key":"698_CR405","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/369233a0","volume":"369","author":"YT Wang","year":"1994","unstructured":"Wang YT, Salter MW (1994) Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369(6477):233\u2013235","journal-title":"Nature"},{"issue":"1","key":"698_CR406","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/(SICI)1096-9861(19990913)412:1<132::AID-CNE10>3.0.CO;2-B","volume":"412","author":"H Wang","year":"1999","unstructured":"Wang H, Gracy KN, Pickel VM (1999) Mu-opioid and NMDA-type glutamate receptors are often colocalized in spiny neurons within patches of the caudate-putamen nucleus. J Comp Neurol 412(1):132\u2013146","journal-title":"J Comp Neurol"},{"key":"698_CR407","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(84)90811-4","volume":"295","author":"T Watanabe","year":"1984","unstructured":"Watanabe T, Taguchi Y, Shiosaka S, Tanaka J, Kubota H, Terano Y, Tohyama M, Wada H (1984) Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker. Brain Res 295:13\u201325","journal-title":"Brain Res"},{"issue":"7","key":"698_CR408","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.biopsych.2006.11.032","volume":"62","author":"JE Westin","year":"2007","unstructured":"Westin JE, Vercammen L, Strome EM, Konradi C, Cenci MA (2007) Spatiotemporal pattern of striatal ERK1\/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors. Biol Psychiatry 62(7):800\u2013810","journal-title":"Biol Psychiatry"},{"key":"698_CR409","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-211-45295-0_5","volume":"70","author":"T Wichmann","year":"2006","unstructured":"Wichmann T, DeLong MR (2006) Basal ganglia discharge abnormalities in Parkinson\u2019s disease. J Neural Transm Suppl 70:21\u201325","journal-title":"J Neural Transm Suppl"},{"issue":"1","key":"698_CR411","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1152\/physrev.2001.81.1.299","volume":"81","author":"JT Williams","year":"2001","unstructured":"Williams JT, Christie MJ, Manzoni O (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81(1):299\u2013343","journal-title":"Physiol Rev"},{"issue":"5568","key":"698_CR412","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1063545","volume":"296","author":"RI Wilson","year":"2002","unstructured":"Wilson RI, Nicoll RA (2002) Endocannabinoid signaling in the brain. Science 296(5568):678\u2013682","journal-title":"Science"},{"issue":"10","key":"698_CR413","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/mds.23034","volume":"25","author":"E Wolf","year":"2010","unstructured":"Wolf E, Seppi K, Katzenschlager R, Hochschorner G, Ransmayr G, Schwingenschuh P, Ott E, Kloiber I, Haubenberger D, Auff E, Poewe W (2010) Long-term antidyskinetic efficacy of amantadine in Parkinson\u2019s disease. Mov Disord 25(10):1357\u20131363","journal-title":"Mov Disord"},{"key":"698_CR414","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00702-010-0472-x","volume":"117","author":"M Wolz","year":"2010","unstructured":"Wolz M, Lohle M, Strecker K, Schwanebeck U, Schneider C, Reichmann H, Grahlert X, Schwarz J, Storch A (2010) Levetiracetam for levodopa-induced dyskinesia in Parkinson\u2019s disease: a randomized, double-blind, placebo-controlled trial. J Neural Transm 117:1279\u20131286","journal-title":"J Neural Transm"},{"issue":"1","key":"698_CR415","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0168-0102(95)90023-3","volume":"23","author":"PT Wong","year":"1995","unstructured":"Wong PT, Feng H, Teo WL (1995) Interaction of the dopaminergic and serotonergic systems in the rat striatum: effects of selective antagonists and uptake inhibitors. Neurosci Res 23(1):115\u2013119","journal-title":"Neurosci Res"},{"issue":"52","key":"698_CR416","doi-asserted-by":"crossref","first-page":"13548","DOI":"10.1523\/JNEUROSCI.3554-06.2006","volume":"26","author":"D Xiao","year":"2006","unstructured":"Xiao D, Bastia E, Xu YH, Benn CL, Cha JH, Peterson TS, Chen JF, Schwarzschild MA (2006) Forebrain adenosine A2A receptors contribute to l-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice. J Neurosci 26(52):13548\u201313555","journal-title":"J Neurosci"},{"key":"698_CR417","doi-asserted-by":"crossref","unstructured":"Yanovsky Y, Li S, Klyuch BP, Yao Q, Blandina P, Passani MB, Lin JS, Haas HL, Sergeeva OA (2011) l-Dopa activates histaminergic neurons. J Physiol 589:1349\u20131366","DOI":"10.1113\/jphysiol.2010.203257"},{"issue":"5300","key":"698_CR418","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.275.5300.674","volume":"275","author":"XM Yu","year":"1997","unstructured":"Yu XM, Askalan R, Keil GJ 2nd, Salter MW (1997) NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science 275(5300):674\u2013678","journal-title":"Science"},{"issue":"1\u20132","key":"698_CR419","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0006-8993(96)00489-1","volume":"731","author":"K Zavitsanou","year":"1996","unstructured":"Zavitsanou K, Mitsacos A, Giompres P, Kouvelas ED (1996) Changes in [3H]AMPA and [3H]kainate binding in rat caudate-putamen and nucleus accumbens after 6-hydroxydopamine lesions of the medial forebrain bundle: an autoradiographic study. Brain Res 731(1\u20132):132\u2013140","journal-title":"Brain Res"},{"issue":"2","key":"698_CR420","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3940(99)00762-4","volume":"276","author":"BY Zeng","year":"1999","unstructured":"Zeng BY, Dass B, Owen A, Rose S, Cannizzaro C, Tel BC, Jenner P (1999) Chronic l-DOPA treatment increases striatal cannabinoid CB1 receptor mRNA expression in 6-hydroxydopamine-lesioned rats. Neurosci Lett 276(2):71\u201374","journal-title":"Neurosci Lett"},{"issue":"3","key":"698_CR421","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1046\/j.1460-9568.2000.00988.x","volume":"12","author":"BY Zeng","year":"2000","unstructured":"Zeng BY, Pearce RK, MacKenzie GM, Jenner P (2000) Alterations in preproenkephalin and adenosine-2a receptor mRNA, but not preprotachykinin mRNA correlate with occurrence of dyskinesia in normal monkeys chronically treated with l-DOPA. Eur J Neurosci 12(3):1096\u20131104","journal-title":"Eur J Neurosci"},{"issue":"3","key":"698_CR422","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.nbd.2010.08.004","volume":"40","author":"BY Zeng","year":"2010","unstructured":"Zeng BY, Iravani MM, Jackson MJ, Rose S, Parent A, Jenner P (2010) Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia. Neurobiol Dis 40(3):599\u2013607","journal-title":"Neurobiol Dis"},{"key":"698_CR423","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/mds.20563","volume":"20","author":"TA Zesiewicz","year":"2005","unstructured":"Zesiewicz TA, Sullivan KL, Maldonado JL, Tatum WO, Hauser RA (2005) Open-label pilot study of levetiracetam (Keppra) for the treatment of levodopa-induced dyskinesias in Parkinson\u2019s disease. Mov Disord 20:1205\u20131209","journal-title":"Mov Disord"},{"issue":"3","key":"698_CR424","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/S0022-3565(24)38271-0","volume":"289","author":"W Zhang","year":"1999","unstructured":"Zhang W, Klimek V, Farley JT, Zhu MY, Ordway GA (1999) Alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine. J Pharmacol Exp Ther 289(3):1286\u20131292","journal-title":"J Pharmacol Exp Ther"},{"issue":"1\u20132","key":"698_CR425","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.physbeh.2007.05.033","volume":"92","author":"X Zhang","year":"2007","unstructured":"Zhang X, Andren PE, Svenningsson P (2007) Changes on 5-HT2 receptor mRNAs in striatum and subthalamic nucleus in Parkinson\u2019s disease model. Physiol Behav 92(1\u20132):29\u201333","journal-title":"Physiol Behav"},{"issue":"1","key":"698_CR426","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0006-8993(91)90553-8","volume":"556","author":"FC Zhou","year":"1991","unstructured":"Zhou FC, Bledsoe S, Murphy J (1991) Serotonergic sprouting is induced by dopamine-lesion in substantia nigra of adult rat brain. Brain Res 556(1):108\u2013116","journal-title":"Brain Res"},{"issue":"16","key":"698_CR427","doi-asserted-by":"crossref","first-page":"RC91","DOI":"10.1523\/JNEUROSCI.20-16-j0001.2000","volume":"20","author":"X Zhuang","year":"2000","unstructured":"Zhuang X, Belluscio L, Hen R (2000) G(olf)alpha mediates dopamine D1 receptor signaling. J Neurosci 20(16):RC91","journal-title":"J Neurosci"},{"issue":"10","key":"698_CR428","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1073\/pnas.96.10.5780","volume":"96","author":"A Zimmer","year":"1999","unstructured":"Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, Bonner TI (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA 96(10):5780\u20135785","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-011-0698-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00702-011-0698-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-011-0698-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T12:36:30Z","timestamp":1741523790000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00702-011-0698-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,1]]},"references-count":432,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["698"],"URL":"https:\/\/doi.org\/10.1007\/s00702-011-0698-2","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,1]]}}}