{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:46:00Z","timestamp":1792590360302,"version":"4.5.0"},"reference-count":110,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,12,2]],"date-time":"2012-12-02T00:00:00Z","timestamp":1354406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s00702-012-0922-8","type":"journal-article","created":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T11:20:01Z","timestamp":1354360801000},"page":"695-703","source":"Crossref","is-referenced-by-count":53,"title":["Excess iron harms the brain: the syndromes of neurodegeneration with brain iron accumulation (NBIA)"],"prefix":"10.1007","volume":"120","author":[{"given":"Susanne A.","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash P.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,2]]},"reference":[{"key":"922_CR1","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/mds.23095","volume":"25","author":"A Aggarwal","year":"2010","unstructured":"Aggarwal A, Schneider SA, Houlden H et al (2010) Indian-subcontinent NBIA: unusual phenotypes, novel PANK2 mutations, and undetermined genetic forms. Mov Disord 25:1424\u20131431","journal-title":"Mov Disord"},{"key":"922_CR2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3174\/ajnr.A1849","volume":"31","author":"R Awasthi","year":"2010","unstructured":"Awasthi R, Gupta RK, Trivedi R et al (2010) Diffusion tensor MR imaging in children with pantothenate kinase-associated neurodegeneration with brain iron accumulation and their siblings. AJNR Am J Neuroradiol 31:442\u2013447","journal-title":"AJNR Am J Neuroradiol"},{"key":"922_CR3","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1471-4159.2009.06028.x","volume":"109","author":"AG Barbeito","year":"2009","unstructured":"Barbeito AG, Garringer HJ, Baraibar MA et al (2009) Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene. J Neurochem 109:1067\u20131078","journal-title":"J Neurochem"},{"key":"922_CR4","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1002\/mds.22996","volume":"25","author":"MI Behrens","year":"2010","unstructured":"Behrens MI, Bruggemann N, Chana P et al (2010) Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutations. Mov Disord 25:1929\u20131937","journal-title":"Mov Disord"},{"key":"922_CR5","first-page":"5767","volume":"275","author":"J Bras","year":"2008","unstructured":"Bras J, Singleton A, Cookson MR et al (2008) Potential role of ceramide metabolism in Lewy body disease. Eur J Biochem (FEBS) 275:5767\u20135773","journal-title":"Eur J Biochem (FEBS)"},{"issue":"12","key":"922_CR6","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1093\/hmg\/dds089","volume":"21","author":"J Bras","year":"2012","unstructured":"Bras J, Verloes A, Schneider SA et al (2012) Mutation of the Parkinsonism Gene ATP13A2 causes neuronal ceroid-lipofuscinosis. Hum Mol Genet 21(12):2646\u20132650","journal-title":"Hum Mol Genet"},{"key":"922_CR7","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1001\/archneurol.2010.281","volume":"67","author":"N Bruggemann","year":"2010","unstructured":"Bruggemann N, Hagenah J, Reetz K et al (2010) Recessively inherited parkinsonism: effect of ATP13A2 mutations on the clinical and neuroimaging phenotype. Arch Neurol 67:1357\u20131363","journal-title":"Arch Neurol"},{"key":"922_CR8","doi-asserted-by":"crossref","unstructured":"Brunetti D, Dusi S, Morbin M et al. (2012) Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model. Hum Mol Genet (epub ahead of print)","DOI":"10.1093\/hmg\/dds380"},{"key":"922_CR9","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1093\/hmg\/dds229","volume":"21","author":"A Campanella","year":"2012","unstructured":"Campanella A, Privitera D, Guaraldo M et al (2012) Skin fibroblasts from pantothenate kinase-associated neurodegeneration patients show altered cellular oxidative status and have defective iron-handling properties. Hum Mol Genet 21:4049\u20134059","journal-title":"Hum Mol Genet"},{"key":"922_CR10","first-page":"123","volume":"32","author":"G Carlier","year":"1979","unstructured":"Carlier G, Dubru JM (1979) Familial juvenile Parkinsonism. Acta Psychiatr Belg 32:123\u2013127","journal-title":"Acta Psychiatr Belg"},{"key":"922_CR11","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/ana.20457","volume":"57","author":"P Castelnau","year":"2005","unstructured":"Castelnau P, Cif L, Valente EM et al (2005) Pallidal stimulation improves pantothenate kinase-associated neurodegeneration. Ann Neurol 57:738\u2013741","journal-title":"Ann Neurol"},{"key":"922_CR12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/ana.22435","volume":"70","author":"H Catoire","year":"2011","unstructured":"Catoire H et al (2011) Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis. Ann Neurol 70:170\u2013175","journal-title":"Ann Neurol"},{"key":"922_CR13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1055\/s-0031-1285925","volume":"42","author":"L Chiapparini","year":"2011","unstructured":"Chiapparini L, Savoiardo M, D\u2019Arrigo S et al (2011) The \u201ceye-of-the-tiger\u201d sign may be absent in the early stages of classic pantothenate kinase associated neurodegeneration. Neuropediatrics. 42:159\u2013162","journal-title":"Neuropediatrics."},{"issue":"7","key":"922_CR14","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/mds.23514","volume":"26","author":"HF Chien","year":"2011","unstructured":"Chien HF, Bonifati V, Barbosa ER (2011) ATP13A2-related neurodegeneration (PARK9) without evidence of brain iron accumulation. Mov Disord 26(7):1364\u20131365","journal-title":"Mov Disord"},{"key":"922_CR15","unstructured":"Chinnery PF (1993) Neuroferritinopathy. In: Pagon RA, Bird TD, Dolan CR, Stephens K (eds) GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle, 1993\u20132005"},{"key":"922_CR16","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1136\/jmg.40.5.e69","volume":"40","author":"PF Chinnery","year":"2003","unstructured":"Chinnery PF, Curtis AR, Fey C et al (2003) Neuroferritinopathy in a French family with late onset dominant dystonia. J Med Genet 40:e69","journal-title":"J Med Genet"},{"key":"922_CR17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/brain\/awl319","volume":"130","author":"PF Chinnery","year":"2007","unstructured":"Chinnery PF, Crompton DE, Birchall D et al (2007) Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation. Brain 130:110\u2013119","journal-title":"Brain"},{"key":"922_CR18","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1476-511X-10-84","volume":"10","author":"P Dan","year":"2011","unstructured":"Dan P, Edvardson S, Bielawski J et al (2011) 2-Hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase. Lipids Health Dis 10:84","journal-title":"Lipids Health Dis"},{"key":"922_CR19","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1136\/jnnp.53.12.1063","volume":"53","author":"AG Volder De","year":"1990","unstructured":"De Volder AG, Cirelli S, de Barsy T et al (1990) Neuronal ceroid-lipofuscinosis: preferential metabolic alterations in thalamus and posterior association cortex demonstrated by PET. J Neurol Neurosurg Psychiatry 53:1063\u20131067","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"922_CR20","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.4161\/auto.21011","volume":"8","author":"B Dehay","year":"2012","unstructured":"Dehay B, Martinez-Vicente M, Ramirez A et al (2012) Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove. Autophagy 8:1389\u20131391","journal-title":"Autophagy"},{"issue":"4","key":"922_CR21","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/jmri.22884","volume":"35","author":"RF Delgado","year":"2011","unstructured":"Delgado RF, Sanchez PR, Speckter H et al (2011) Missense PANK2 mutation without \u201cEye of the tiger\u201d sign: MR findings in a large group of patients with pantothenate kinase-associated neurodegeneration (PKAN). J Magn Reson Imaging 35(4):788\u2013794","journal-title":"J Magn Reson Imaging"},{"key":"922_CR22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neulet.2010.05.025","volume":"479","author":"X Deng","year":"2010","unstructured":"Deng X, Vidal R, Englander EW (2010) Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy. Neurosci Lett 479:44\u201348","journal-title":"Neurosci Lett"},{"issue":"11","key":"922_CR23","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1007\/s00415-012-6521-7","volume":"259","author":"M Deschauer","year":"2012","unstructured":"Deschauer M, Gaul C, Behrmann C et al (2012) C19orf12 mutations in neurodegeneration with brain iron accumulation mimicking juvenile amyotrophic lateral sclerosis. J Neurol 259(11):2434\u20132439","journal-title":"J Neurol"},{"key":"922_CR24","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1093\/brain\/awn274","volume":"132","author":"D Devos","year":"2009","unstructured":"Devos D, Tchofo PJ, Vuillaume I et al (2009) Clinical features and natural history of neuroferritinopathy caused by the 458dupA FTL mutation. Brain 132:e109","journal-title":"Brain"},{"key":"922_CR25","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/cmmi.1482","volume":"7","author":"M Dezortova","year":"2012","unstructured":"Dezortova M, Herynek V, Krssak M et al (2012) Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients. Contrast Media Mol Imaging 7:509\u2013515","journal-title":"Contrast Media Mol Imaging"},{"key":"922_CR26","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1212\/01.wnl.0000260963.08711.08","volume":"68","author":"A Fonzo Di","year":"2007","unstructured":"Di Fonzo A, Chien HF, Socal M et al (2007) ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease. Neurology. 68:1557\u20131562","journal-title":"Neurology."},{"key":"922_CR27","doi-asserted-by":"crossref","first-page":"E1251","DOI":"10.1002\/humu.21205","volume":"31","author":"KJ Dick","year":"2010","unstructured":"Dick KJ, Eckhardt M, Paisan-Ruiz C et al (2010) Mutation of FA2H underlies a complicated form of hereditary spastic paraplegia (SPG35). Hum Mutat 31:E1251\u2013E1260","journal-title":"Hum Mutat"},{"key":"922_CR28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jns.2009.11.008","volume":"290","author":"H Doi","year":"2010","unstructured":"Doi H, Koyano S, Miyatake S et al (2010) Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2: clinical features and (99 m) Tc-ECD brain perfusion SPECT findings. J Neurol Sci 290:172\u2013176","journal-title":"J Neurol Sci"},{"key":"922_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2011.12.054","volume":"46","author":"P Dusek","year":"2012","unstructured":"Dusek P, Jankovic J, Weidong L (2012) Iron dysregulation in movement disorders. Neurobiol Dis 46:1\u201318","journal-title":"Neurobiol Dis"},{"key":"922_CR30","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ajhg.2008.10.010","volume":"83","author":"S Edvardson","year":"2008","unstructured":"Edvardson S, Hama H, Shaag A et al (2008) Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia. Am J Hum Genet 83:643\u2013648","journal-title":"Am J Hum Genet"},{"issue":"Pt 4","key":"922_CR31","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/brain\/110.4.993","volume":"110","author":"D Eidelberg","year":"1987","unstructured":"Eidelberg D, Sotrel A, Joachim C et al (1987) Adult onset Hallervorden-Spatz disease with neurofibrillary pathology. A discrete clinicopathological entity. Brain 110(Pt 4):993\u20131013","journal-title":"Brain"},{"issue":"3","key":"922_CR32","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.nbd.2011.02.009","volume":"42","author":"FH Farias","year":"2011","unstructured":"Farias FH, Zeng R, Johnson GS et al (2011) A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan terriers. Neurobiol Dis 42(3):468\u2013474","journal-title":"Neurobiol Dis"},{"key":"922_CR33","doi-asserted-by":"crossref","unstructured":"Fermin-Delgado R, Roa-Sanchez P, Speckter H et al. (2012) Involvement of globus pallidus and midbrain nuclei in pantothenate kinase-associated neurodegeneration: measurement of T2 and T2* Time. Clin Neuroradiol (epub ahead of print)","DOI":"10.1007\/s00062-011-0127-9"},{"key":"922_CR34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1056\/NEJMra1004967","volume":"366","author":"RE Fleming","year":"2012","unstructured":"Fleming RE, Ponka P (2012) Iron overload in human disease. N Engl J Med 366:348\u2013359","journal-title":"N Engl J Med"},{"key":"922_CR35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0002-9440(10)64548-8","volume":"157","author":"JE Galvin","year":"2000","unstructured":"Galvin JE, Giasson B, Hurtig HI et al (2000) Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. Am J Pathol 157:361\u2013368","journal-title":"Am J Pathol"},{"issue":"10","key":"922_CR36","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1469-8749.2011.03993.x","volume":"53","author":"C Garone","year":"2011","unstructured":"Garone C, Pippucci T, Cordelli DM et al (2011a) FA2H-related disorders: a novel c.270\u00a0+\u00a03A\u00a0>\u00a0T splice-site mutation leads to a complex neurodegenerative phenotype. Dev Med Child Neurol 53(10):958\u2013961","journal-title":"Dev Med Child Neurol"},{"key":"922_CR37","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1469-8749.2011.03993.x","volume":"53","author":"C Garone","year":"2011","unstructured":"Garone C, Pippucci T, Cordelli DM et al (2011b) FA2H-related disorders: a novel c.270\u00a0+\u00a03A\u00a0>\u00a0T splice-site mutation leads to a complex neurodegenerative phenotype. Dev Med Child Neurol 53:958\u2013961","journal-title":"Dev Med Child Neurol"},{"key":"922_CR38","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1440-1789.2008.00901.x","volume":"28","author":"LF Gonzalez-Cuyar","year":"2008","unstructured":"Gonzalez-Cuyar LF, Perry G, Miyajima H et al (2008) Redox active iron accumulation in aceruloplasminemia. Neuropathology. 28:466\u2013471","journal-title":"Neuropathology."},{"key":"922_CR39","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/mds.23586","volume":"26","author":"F Grandas","year":"2011","unstructured":"Grandas F, Fernandez-Carballal C, Guzman-de-Villoria J et al (2011) Treatment of a dystonic storm with pallidal stimulation in a patient with PANK2 mutation. Mov Disord 26:921\u2013922","journal-title":"Mov Disord"},{"issue":"2","key":"922_CR40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/jmg.2008.061929","volume":"46","author":"A Gregory","year":"2009","unstructured":"Gregory A, Hayflick S (2009) Clinical and genetic delineation of neurodegeneration with brain iron accumulation. J Med Genet 46(2):73\u201380","journal-title":"J Med Genet"},{"key":"922_CR41","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1212\/01.wnl.0000327094.67726.28","volume":"71","author":"A Gregory","year":"2008","unstructured":"Gregory A, Westaway SK, Holm IE et al (2008) Neurodegeneration associated with genetic defects in phospholipase A(2). Neurology 71:1402\u20131409","journal-title":"Neurology"},{"issue":"8","key":"922_CR42","first-page":"1843","volume":"33","author":"A Gruenewald","year":"2012","unstructured":"Gruenewald A, Arns B, Seibler P et al (2012) ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome. Neurobiol Aging 33(8):1843","journal-title":"Neurobiol Aging"},{"key":"922_CR43","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/s00330-004-2553-4","volume":"15","author":"M Hajek","year":"2005","unstructured":"Hajek M, Adamovicova M, Herynek V et al (2005) MR relaxometry and 1H MR spectroscopy for the determination of iron and metabolite concentrations in PKAN patients. Eur Radiol 15:1060\u20131068","journal-title":"Eur Radiol"},{"key":"922_CR44","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/ana.20771","volume":"59","author":"MB Hartig","year":"2006","unstructured":"Hartig MB, Hortnagel K, Garavaglia B et al (2006) Genotypic and phenotypic spectrum of PANK2 mutations in patients with neurodegeneration with brain iron accumulation. Ann Neurol 59:248\u2013256","journal-title":"Ann Neurol"},{"key":"922_CR45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ajhg.2011.09.007","volume":"89","author":"MB Hartig","year":"2011","unstructured":"Hartig MB, Iuso A, Haack T et al (2011) Absence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation. Am J Hum Genet 89:543\u2013550","journal-title":"Am J Hum Genet"},{"issue":"1","key":"922_CR46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbadis.2006.09.011","volume":"1772","author":"D Hautot","year":"2006","unstructured":"Hautot D, Pankhurst QA, Morris CM et al (2006) Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients. Biochim Biophys Acta 1772(1):21\u201325","journal-title":"Biochim Biophys Acta"},{"key":"922_CR47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.spen.2006.08.007","volume":"13","author":"SJ Hayflick","year":"2006","unstructured":"Hayflick SJ (2006) Neurodegeneration with brain iron accumulation: from genes to pathogenesis. Semin Pediatr Neurol. 13:182\u2013185","journal-title":"Semin Pediatr Neurol."},{"key":"922_CR48","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0887-8994(01)00296-X","volume":"25","author":"SJ Hayflick","year":"2001","unstructured":"Hayflick SJ, Penzien JM, Michl W et al (2001) Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome. Pediatr Neurol 25:166\u2013169","journal-title":"Pediatr Neurol"},{"key":"922_CR49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa020817","volume":"348","author":"SJ Hayflick","year":"2003","unstructured":"Hayflick SJ, Westaway SK, Levinson B et al (2003) Genetic, clinical, and radiographic delineation of Hallervorden-Spatz syndrome. N Engl J Med 348:33\u201340","journal-title":"N Engl J Med"},{"key":"922_CR50","first-page":"1230","volume":"27","author":"SJ Hayflick","year":"2006","unstructured":"Hayflick SJ, Hartman M, Coryell J et al (2006) Brain MRI in neurodegeneration with brain iron accumulation with and without PANK2 mutations. AJNR Am J Neuroradiol 27:1230\u20131233","journal-title":"AJNR Am J Neuroradiol"},{"key":"922_CR51","doi-asserted-by":"crossref","unstructured":"Horvath R, Holinski-Feder E, Neeve V et al.(2012) A new phenotype of brain iron accumulation with dystonia, optic atrophy and peripheral neuropathy. Mov Disord (in press)","DOI":"10.1002\/mds.24980"},{"key":"922_CR52","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.humpath.2011.05.016","volume":"43","author":"K Kaneko","year":"2012","unstructured":"Kaneko K, Hineno A, Yoshida K et al (2012) Extensive brain pathology in a patient with aceruloplasminemia with a prolonged duration of illness. Hum Pathol 43:451\u2013456","journal-title":"Hum Pathol"},{"key":"922_CR53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10048-011-0310-9","volume":"13","author":"MJ Keogh","year":"2012","unstructured":"Keogh MJ, Jonas P, Coulthard A et al (2012) Neuroferritinopathy: a new inborn error of iron metabolism. Neurogenetics 13:93\u201396","journal-title":"Neurogenetics"},{"issue":"5","key":"922_CR54","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00415-011-6294-4","volume":"259","author":"VS Kostic","year":"2011","unstructured":"Kostic VS, Svetel M, Mijajlovic M et al (2011) Transcranial sonography in pantothenate kinase-associated neurodegeneration. J Neurol 259(5):959\u2013964","journal-title":"J Neurol"},{"key":"922_CR55","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1523\/JNEUROSCI.4265-04.2005","volume":"25","author":"PT Kotzbauer","year":"2005","unstructured":"Kotzbauer PT, Truax AC, Trojanowski JQ et al (2005) Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2. J Neurosci 25:689\u2013698","journal-title":"J Neurosci"},{"key":"922_CR56","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1002\/mds.21166","volume":"21","author":"M Krause","year":"2006","unstructured":"Krause M, Fogel W, Tronnier V et al (2006) Long-term benefit to pallidal deep brain stimulation in a case of dystonia secondary to pantothenate kinase-associated neurodegeneration. Mov Disord 21:2255\u20132257","journal-title":"Mov Disord"},{"key":"922_CR57","unstructured":"Kruer M, Gregory A, Hogarth P, Hayflick S (2009) Static encephalopathy of childhood with neurodegeneration in adulthood (SENDA syndrome): a novel neurodegneration with brain iron accumulation (NBIA) phenotype. (oral correspondence). Ref Type: Abstract"},{"issue":"5","key":"922_CR58","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/ana.22122","volume":"68","author":"MC Kruer","year":"2010","unstructured":"Kruer MC, Paisan-Ruiz C, Boddaert N et al (2010) Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA). Ann Neurol 68(5):611\u2013618","journal-title":"Ann Neurol"},{"key":"922_CR59","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/brain\/awr042","volume":"134","author":"MC Kruer","year":"2011","unstructured":"Kruer MC, Hiken M, Gregory A et al (2011) Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration. Brain. 134:947\u2013958","journal-title":"Brain."},{"key":"922_CR60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neulet.2012.06.036","volume":"523","author":"MC Kruer","year":"2012","unstructured":"Kruer MC, Paudel R, Wagoner W et al (2012) Analysis of ATP13A2 in large neurodegeneration with brain iron accumulation (NBIA) and dystonia-parkinsonism cohorts. Neurosci Lett 523:35\u201338","journal-title":"Neurosci Lett"},{"issue":"3","key":"922_CR61","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/mds.22435","volume":"24","author":"A Kubota","year":"2008","unstructured":"Kubota A, Hida A, Ichikawa Y et al (2008) A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: Description of clinical features and implications for genotype-phenotype correlations. Mov Disord 24(3):441\u2013445","journal-title":"Mov Disord"},{"issue":"Suppl 1","key":"922_CR62","doi-asserted-by":"crossref","first-page":"I47","DOI":"10.1007\/s00415-003-1110-2","volume":"250","author":"A Kupsch","year":"2003","unstructured":"Kupsch A, Kuehn A, Klaffke S et al (2003) Deep brain stimulation in dystonia. J Neurol 250(Suppl 1):I47\u2013I52","journal-title":"J Neurol"},{"key":"922_CR63","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1212\/01.wnl.0000310986.48286.8e","volume":"70","author":"MA Kurian","year":"2008","unstructured":"Kurian MA, Morgan NV, MacPherson L et al (2008) Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN). Neurology 70:1623\u20131629","journal-title":"Neurology"},{"key":"922_CR64","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/ncpneuro0356","volume":"3","author":"M Levy","year":"2007","unstructured":"Levy M, Turtzo C, Llinas RH (2007) Superficial siderosis: a case report and review of the literature. Nat Clin Pract Neurol 3:54\u201358","journal-title":"Nat Clin Pract Neurol"},{"key":"922_CR65","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00702-010-0518-0","volume":"118","author":"X Li","year":"2011","unstructured":"Li X, Jankovic J (2011) Iron chelation and neuroprotection in neurodegenerative diseases. J Neural Transm 118:473\u2013477","journal-title":"J Neural Transm"},{"issue":"2","key":"922_CR66","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejpn.2011.07.009","volume":"16","author":"J Liman","year":"2011","unstructured":"Liman J, Wellmer A, Rostasy K et al (2011) Transcranial ultrasound in neurodegeneration with brain iron accumulation (NBIA). Eur J Paediatr Neurol 16(2):175\u2013178","journal-title":"Eur J Paediatr Neurol"},{"key":"922_CR67","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3109\/00207454.2010.542843","volume":"121","author":"CM Mak","year":"2011","unstructured":"Mak CM, Sheng B, Lee HH et al (2011) Young-onset parkinsonism in a Hong Kong Chinese man with adult-onset Hallervorden-Spatz syndrome. Int J Neurosci 121:224\u2013227","journal-title":"Int J Neurosci"},{"key":"922_CR68","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2353\/ajpath.2008.070823","volume":"172","author":"I Malik","year":"2008","unstructured":"Malik I, Turk J, Mancuso DJ et al (2008) Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Am J Pathol 172:406\u2013416","journal-title":"Am J Pathol"},{"key":"922_CR69","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/mds.20282","volume":"20","author":"C Marelli","year":"2005","unstructured":"Marelli C, Piacentini S, Garavaglia B et al (2005) Clinical and neuropsychological correlates in two brothers with pantothenate kinase-associated neurodegeneration. Mov Disord 20:208\u2013212","journal-title":"Mov Disord"},{"key":"922_CR70","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1212\/01.wnl.0000310985.40011.d6","volume":"70","author":"A McNeill","year":"2008","unstructured":"McNeill A, Birchall D, Hayflick SJ et al (2008a) T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation. Neurology 70:1614\u20131619","journal-title":"Neurology"},{"key":"922_CR71","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000148691","volume":"60","author":"A McNeill","year":"2008","unstructured":"McNeill A, Pandolfo M, Kuhn J et al (2008b) The neurological presentation of ceruloplasmin gene mutations. Eur Neurol 60:200\u2013205","journal-title":"Eur Neurol"},{"key":"922_CR72","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1212\/01.wnl.0000310985.40011.d6","volume":"70","author":"A McNeill","year":"2008","unstructured":"McNeill A, Birchall D, Hayflick SJ et al (2008c) T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation. Neurology. 70:1614\u20131619","journal-title":"Neurology."},{"key":"922_CR73","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejpn.2008.01.006","volume":"13","author":"MA Mikati","year":"2009","unstructured":"Mikati MA, Yehya A, Darwish H et al (2009) Deep brain stimulation as a mode of treatment of early onset pantothenate kinase-associated neurodegeneration. Eur J Paediatr Neurol 13:61\u201364","journal-title":"Eur J Paediatr Neurol"},{"key":"922_CR74","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/ng1826","volume":"38","author":"NV Morgan","year":"2006","unstructured":"Morgan NV, Westaway SK, Morton JE et al (2006) PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron. Nat Genet 38:752\u2013754","journal-title":"Nat Genet"},{"key":"922_CR75","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1600-0404.1994.tb02645.x","volume":"89","author":"AS Najim al-Din","year":"1994","unstructured":"Najim al-Din AS, Wriekat A, Mubaidin A et al (1994) Pallido-pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor-Rakeb syndrome. Acta Neurol Scand 89:347\u2013352","journal-title":"Acta Neurol Scand"},{"key":"922_CR76","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s004010000224","volume":"100","author":"M Neumann","year":"2000","unstructured":"Neumann M, Adler S, Schluter O et al (2000) Alpha-synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies. Acta Neuropathol 100:568\u2013574","journal-title":"Acta Neuropathol"},{"key":"922_CR77","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1365-2990.2006.00710.x","volume":"32","author":"T Oide","year":"2006","unstructured":"Oide T, Yoshida K, Kaneko K et al (2006) Iron overload and antioxidative role of perivascular astrocytes in aceruloplasminemia. Neuropathol Appl Neurobiol 32:170\u2013176","journal-title":"Neuropathol Appl Neurobiol"},{"key":"922_CR78","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1002\/mds.23299","volume":"25","author":"WG Ondo","year":"2010","unstructured":"Ondo WG, Adam OR, Jankovic J et al (2010) Dramatic response of facial stereotype\/tic to tetrabenazine in the first reported cases of neuroferritinopathy in the United States. Mov Disord 25:2470\u20132472","journal-title":"Mov Disord"},{"key":"922_CR79","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/mds.21580","volume":"22","author":"JL Ostrem","year":"2007","unstructured":"Ostrem JL, Marks WJ Jr, Volz MM et al (2007) Pallidal deep brain stimulation in patients with cranial-cervical dystonia (Meige syndrome). Mov Disord 22:1885\u20131891","journal-title":"Mov Disord"},{"key":"922_CR80","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ana.21415","volume":"65","author":"C Paisan-Ruiz","year":"2009","unstructured":"Paisan-Ruiz C, Bhatia KP, Li A et al (2009) Characterization of PLA2G6 as a locus for dystonia-parkinsonism. Ann Neurol 65:19\u201323","journal-title":"Ann Neurol"},{"issue":"4","key":"922_CR81","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.neurobiolaging.2010.05.009","volume":"33","author":"C Paisan-Ruiz","year":"2010","unstructured":"Paisan-Ruiz C, Li A, Schneider SA et al (2010a) Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations. Neurobiol Aging 33(4):814\u2013823","journal-title":"Neurobiol Aging"},{"key":"922_CR82","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/mds.23221","volume":"25","author":"C Paisan-Ruiz","year":"2010","unstructured":"Paisan-Ruiz C, Guevara R, Federoff M et al (2010b) Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations. Mov Disord 25:1791\u20131800","journal-title":"Mov Disord"},{"issue":"8","key":"922_CR83","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/humu.21527","volume":"32","author":"JS Park","year":"2011","unstructured":"Park JS, Mehta P, Cooper AA et al (2011) Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset Parkinsonism. Hum Mutat 32(8):956\u2013964","journal-title":"Hum Mutat"},{"key":"922_CR84","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/ejhg.2011.222","volume":"20","author":"TM Pierson","year":"2012","unstructured":"Pierson TM, Simeonov DR, Sincan M et al (2012) Exome sequencing and SNP analysis detect novel compound heterozygosity in fatty acid hydroxylase-associated neurodegeneration. Eur J Hum Genet 20:476\u2013479","journal-title":"Eur J Hum Genet"},{"key":"922_CR85","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/glia.21172","volume":"59","author":"KA Potter","year":"2011","unstructured":"Potter KA, Kern MJ, Fullbright G et al (2011) Central nervous system dysfunction in a mouse model of Fa2h deficiency. Glia 59:1009\u20131021","journal-title":"Glia"},{"key":"922_CR86","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ng1884","volume":"38","author":"A Ramirez","year":"2006","unstructured":"Ramirez A, Heimbach A, Grundemann J et al (2006) Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat Genet 38:1184\u20131191","journal-title":"Nat Genet"},{"key":"922_CR87","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0022-510X(00)00337-3","volume":"177","author":"Y Saito","year":"2000","unstructured":"Saito Y, Kawai M, Inoue K et al (2000) Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. J Neurol Sci 177:48\u201359","journal-title":"J Neurol Sci"},{"key":"922_CR88","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/ana.22211","volume":"68","author":"SA Schneider","year":"2010","unstructured":"Schneider SA, Bhatia KP (2010) Three faces of the same gene: fA2H links neurodegeneration with brain iron accumulation, leukodystrophies, and hereditary spastic paraplegias. Ann Neurol 68:575\u2013577","journal-title":"Ann Neurol"},{"key":"922_CR89","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/jnnp.2008.169953","volume":"80","author":"SA Schneider","year":"2009","unstructured":"Schneider SA, Hardy J, Bhatia KP (2009) Iron accumulation in syndromes of neurodegeneration with brain accumulation\u2014causative or consequential? J Neurol Neurosurg Psychiatry 80:589\u2013590","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"922_CR90","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/mds.22947","volume":"25","author":"SA Schneider","year":"2010","unstructured":"Schneider SA, Paisan-Ruiz C, Quinn NP et al (2010) ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation. Mov Disord 25:979\u2013984","journal-title":"Mov Disord"},{"key":"922_CR91","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/mds.23971","volume":"27","author":"SA Schneider","year":"2012","unstructured":"Schneider SA, Hardy J, Bhatia KP (2012) Syndromes of neurodegeneration with brain iron accumulation (NBIA): an update on clinical presentations, histological and genetic underpinnings, and treatment considerations. Mov Disord 27:42\u201353","journal-title":"Mov Disord"},{"key":"922_CR92","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3988\/jcn.2009.5.4.192","volume":"5","author":"JH Seo","year":"2009","unstructured":"Seo JH, Song SK, Lee PH (2009) A Novel PANK2 mutation in a patient with atypical pantothenate-kinase-associated neurodegeneration presenting with adult-onset Parkinsonism. J Clin Neurol 5:192\u2013194","journal-title":"J Clin Neurol"},{"issue":"Suppl 1","key":"922_CR94","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1468-1331.2010.03060.x","volume":"17","author":"JD Speelman","year":"2010","unstructured":"Speelman JD, Contarino MF, Schuurman PR et al (2010) Deep brain stimulation for dystonia: patient selection and outcomes. Eur J Neurol 17(Suppl 1):102\u2013106","journal-title":"Eur J Neurol"},{"key":"922_CR95","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.nurt.2007.05.006","volume":"4","author":"J Stankiewicz","year":"2007","unstructured":"Stankiewicz J, Panter SS, Neema M et al (2007) Iron in chronic brain disorders: imaging and neurotherapeutic implications. Neurotherapeutics 4:371\u2013386","journal-title":"Neurotherapeutics"},{"key":"922_CR96","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/jmri.22031","volume":"31","author":"J Szumowski","year":"2010","unstructured":"Szumowski J, Bas E, Gaarder K et al (2010) Measurement of brain iron distribution in Hallevorden-Spatz syndrome. J Magn Reson Imaging 31:482\u2013489","journal-title":"J Magn Reson Imaging"},{"key":"922_CR97","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/mds.10650","volume":"19","author":"M Thomas","year":"2004","unstructured":"Thomas M, Hayflick SJ, Jankovic J (2004) Clinical heterogeneity of neurodegeneration with brain iron accumulation (Hallervorden-Spatz syndrome) and pantothenate kinase-associated neurodegeneration. Mov Disord 19:36\u201342","journal-title":"Mov Disord"},{"key":"922_CR98","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/brain\/awq022","volume":"133","author":"L Timmermann","year":"2010","unstructured":"Timmermann L, Pauls KA, Wieland K et al (2010) Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulation. Brain 133:701\u2013712","journal-title":"Brain"},{"key":"922_CR99","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF00690197","volume":"68","author":"FM Tome","year":"1985","unstructured":"Tome FM, Brunet P, Fardeau M et al (1985) Familial disorder of the central and peripheral nervous systems with particular cytoplasmic lamellated inclusions in peripheral nerves, muscle satellite cells, and blood capillaries. Acta Neuropathol 68:209\u2013217","journal-title":"Acta Neuropathol"},{"issue":"11","key":"922_CR100","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1111\/j.1468-1331.2012.03838.x","volume":"19","author":"A Tonelli","year":"2012","unstructured":"Tonelli A, D\u2019Angelo MG, Arrigoni F et al (2012) Atypical adult onset complicated spastic paraparesis with thin corpus callosum in two patients carrying a novel FA2H mutation. Eur J Neurol 19(11):e127\u2013e129","journal-title":"Eur J Neurol"},{"key":"922_CR101","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1093\/hmg\/dds206","volume":"21","author":"M Usenovic","year":"2012","unstructured":"Usenovic M, Knight AL, Ray A et al (2012) Identification of novel ATP13A2 interactors and their role in alpha-synuclein misfolding and toxicity. Hum Mol Genet 21:3785\u20133794","journal-title":"Hum Mol Genet"},{"key":"922_CR102","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/jnen\/63.4.363","volume":"63","author":"R Vidal","year":"2004","unstructured":"Vidal R, Ghetti B, Takao M et al (2004) Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene. J Neuropathol Exp Neurol 63:363\u2013380","journal-title":"J Neuropathol Exp Neurol"},{"key":"922_CR103","unstructured":"Vinters H, Farrell M, Mischel P et al. (1998) Diagnostic neuropathology. New York, NY, USA: Marcel Dekker Incorporated: 502"},{"key":"922_CR104","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s004010050049","volume":"99","author":"K Wakabayashi","year":"2000","unstructured":"Wakabayashi K, Fukushima T, Koide R et al (2000) Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disease) with diffuse neurofibrillary and lewy body pathology. Acta Neuropathol 99:331\u2013336","journal-title":"Acta Neuropathol"},{"key":"922_CR105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/1531-8249(199907)46:1<123::AID-ANA19>3.0.CO;2-H","volume":"46","author":"D Waldvogel","year":"1999","unstructured":"Waldvogel D, van GP, Hallett M (1999) Increased iron in the dentate nucleus of patients with Friedrich\u2019s ataxia. Ann Neurol 46:123\u2013125","journal-title":"Ann Neurol"},{"key":"922_CR106","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/mds.20511","volume":"20","author":"DR Williams","year":"2005","unstructured":"Williams DR, Hadeed A (2005) al Din AS et al. Kufor Rakeb disease: autosomal recessive, levodopa-responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementia. Mov Disord 20:1264\u20131271","journal-title":"Mov Disord"},{"key":"922_CR107","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ana.410110403","volume":"11","author":"K Williamson","year":"1982","unstructured":"Williamson K, Sima AA, Curry B et al (1982) Neuroaxonal dystrophy in young adults: a clinicopathological study of two unrelated cases. Ann Neurol 11:335\u2013343","journal-title":"Ann Neurol"},{"key":"922_CR108","doi-asserted-by":"crossref","first-page":"e1002304","DOI":"10.1371\/journal.pgen.1002304","volume":"7","author":"A Wohlke","year":"2011","unstructured":"Wohlke A, Philipp U, Bock P et al (2011) A one base pair deletion in the canine ATP13A2 gene causes exon skipping and late-onset neuronal ceroid lipofuscinosis in the Tibetan terrier. PLoS Genet 7:e1002304","journal-title":"PLoS Genet"},{"key":"922_CR109","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0022-510X(00)00295-1","volume":"175","author":"K Yoshida","year":"2000","unstructured":"Yoshida K, Kaneko K, Miyajima H et al (2000) Increased lipid peroxidation in the brains of aceruloplasminemia patients. J Neurol Sci 175:91\u201395","journal-title":"J Neurol Sci"},{"key":"922_CR110","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.nbd.2009.09.024","volume":"37","author":"W Zhu","year":"2010","unstructured":"Zhu W, Li X, Luo F et al (2010) Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration. Neurobiol Dis 37:307\u2013313","journal-title":"Neurobiol Dis"},{"key":"922_CR111","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1523\/JNEUROSCI.0458-08.2008","volume":"28","author":"I Zoller","year":"2008","unstructured":"Zoller I, Meixner M, Hartmann D et al (2008) Absence of 2-hydroxylated Sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration. J Neurosci 28:9741\u20139754","journal-title":"J Neurosci"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-012-0922-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00702-012-0922-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-012-0922-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T09:03:36Z","timestamp":1562403816000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00702-012-0922-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,2]]},"references-count":110,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["922"],"URL":"https:\/\/doi.org\/10.1007\/s00702-012-0922-8","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,2]]}}}