{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:02:04Z","timestamp":1785823324346,"version":"3.56.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308449\/2016-9"],"award-info":[{"award-number":["308449\/2016-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308459\/2013-0"],"award-info":[{"award-number":["308459\/2013-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308723\/2013-9"],"award-info":[{"award-number":["308723\/2013-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["481523\/2013-8"],"award-info":[{"award-number":["481523\/2013-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PROESP\/CAPES; #1509\/2009"],"award-info":[{"award-number":["PROESP\/CAPES; #1509\/2009"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES\/MINCyT; #249\/14"],"award-info":[{"award-number":["CAPES\/MINCyT; #249\/14"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","award":["FAPESC\/PRONEX Program\u2014NENASC Project; #1262\/2012-9"],"award-info":[{"award-number":["FAPESC\/PRONEX Program\u2014NENASC Project; #1262\/2012-9"]}],"id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00702-017-1753-4","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T04:57:22Z","timestamp":1499662642000},"page":"1227-1237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test"],"prefix":"10.1007","volume":"124","author":[{"given":"Filipe Marques","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Binder","family":"Neis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Kurrle","family":"Rieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanara V.","family":"Peres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark William","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella A.","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia S.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuella P.","family":"Kaster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-6888","authenticated-orcid":false,"given":"Rodrigo Bainy","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,10]]},"reference":[{"key":"1753_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.psyneuen.2016.04.017","volume":"70","author":"T Ali-Sisto","year":"2016","unstructured":"Ali-Sisto T et al (2016) Purine metabolism is dysregulated in patients with major depressive disorder. Psychoneuroendocrinology 70:25\u201332. doi: 10.1016\/j.psyneuen.2016.04.017","journal-title":"Psychoneuroendocrinology"},{"key":"1753_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.neulet.2005.10.057","volume":"395","author":"RC Almeida","year":"2006","unstructured":"Almeida RC, Souza DG, Soletti RC, Lopez MG, Rodrigues AL, Gabilan NH (2006) Involvement of PKA,MAPK\/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice. Neurosci Lett 395:93\u201397. doi: 10.1016\/j.neulet.2005.10.057","journal-title":"Neurosci Lett"},{"key":"1753_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nature10130","volume":"475","author":"AE Autry","year":"2011","unstructured":"Autry AE et al (2011) NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475:91\u201395. doi: 10.1038\/nature10130","journal-title":"Nature"},{"key":"1753_CR4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1002\/eji.1830150618","volume":"15","author":"J Barankiewicz","year":"1985","unstructured":"Barankiewicz J, Cohen A (1985) Purine nucleotide metabolism in resident and activated rat macrophages in vitro. Eur J Immunol 15:627\u2013631. doi: 10.1002\/eji.1830150618","journal-title":"Eur J Immunol"},{"key":"1753_CR5","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1126\/science.1148045","volume":"318","author":"MM Behrens","year":"2007","unstructured":"Behrens MM, Ali SS, Dao DN, Lucero J, Shekhtman G, Quick KL, Dugan LL (2007) Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science 318:1645\u20131647. doi: 10.1126\/science.1148045","journal-title":"Science"},{"key":"1753_CR6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0079-6123(02)37030-4","volume":"137","author":"LI Benowitz","year":"2002","unstructured":"Benowitz LI, Goldberg DE, Irwin N (2002) Inosine stimulates axon growth in vitro and in the adult CNS. Prog Brain Res 137:389\u2013399","journal-title":"Prog Brain Res"},{"key":"1753_CR7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0006-3223(99)00230-9","volume":"47","author":"RM Berman","year":"2000","unstructured":"Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH (2000) Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47:351\u2013354","journal-title":"Biol Psychiatry"},{"key":"1753_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/nrn1846","volume":"7","author":"O Berton","year":"2006","unstructured":"Berton O, Nestler EJ (2006) New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7:137\u2013151. doi: 10.1038\/nrn1846","journal-title":"Nat Rev Neurosci"},{"key":"1753_CR9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.bbr.2012.06.021","volume":"234","author":"LE Bettio","year":"2012","unstructured":"Bettio LE, Cunha MP, Budni J, Pazini FL, Oliveira A, Colla AR, Rodrigues AL (2012) Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K\/mTOR pathways. Behav Brain Res 234:137\u2013148. doi: 10.1016\/j.bbr.2012.06.021","journal-title":"Behav Brain Res"},{"key":"1753_CR10","first-page":"199","volume":"45","author":"HK Chaturvedi","year":"2001","unstructured":"Chaturvedi HK, Bapna JS, Chandra D (2001) Effect of fluvoxamine and N-methyl-d-aspartate receptor antagonists on shock-induced depression in mice. Indian J Physiol Pharmacol 45:199\u2013207","journal-title":"Indian J Physiol Pharmacol"},{"key":"1753_CR11","doi-asserted-by":"publisher","first-page":"9031","DOI":"10.1073\/pnas.132076299","volume":"99","author":"P Chen","year":"2002","unstructured":"Chen P, Goldberg DE, Kolb B, Lanser M, Benowitz LI (2002) Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proc Natl Acad Sci USA 99:9031\u20139036. doi: 10.1073\/pnas.132076299","journal-title":"Proc Natl Acad Sci USA"},{"key":"1753_CR12","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1007\/s11064-016-2056-0","volume":"41","author":"P Cheng","year":"2016","unstructured":"Cheng P et al (2016) Adenosine A1-receptors modulate mTOR signaling to regulate white matter inflammatory lesions induced by chronic cerebral hypoperfusion. Neurochem Res 41:3272\u20133277. doi: 10.1007\/s11064-016-2056-0","journal-title":"Neurochem Res"},{"key":"1753_CR13","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1126\/science.1194313","volume":"329","author":"JF Cryan","year":"2010","unstructured":"Cryan JF, O\u2019Leary OF (2010) Neuroscience. A glutamate pathway to faster-acting antidepressants? Science 329:913\u2013914. doi: 10.1126\/science.1194313","journal-title":"Science"},{"key":"1753_CR14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11302-005-0649-1","volume":"1","author":"RA Cunha","year":"2005","unstructured":"Cunha RA (2005) Neuroprotection by adenosine in the brain: from A(1) receptor activation to A (2A) receptor blockade. Purinergic Signal 1:111\u2013134. doi: 10.1007\/s11302-005-0649-1","journal-title":"Purinergic Signal"},{"key":"1753_CR15","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1016\/j.pnpbp.2008.09.006","volume":"32","author":"MP Cunha","year":"2008","unstructured":"Cunha MP, Machado DG, Bettio LE, Capra JC, Rodrigues AL (2008) Interaction of zinc with antidepressants in the tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry 32:1913\u20131920. doi: 10.1016\/j.pnpbp.2008.09.006","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1753_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9192-4","author":"MP Cunha","year":"2015","unstructured":"Cunha MP et al (2015a) Involvement of PI3K\/Akt signaling pathway and its downstream intracellular targets in the antidepressant-like effect of creatine. Mol Neurobiol. doi: 10.1007\/s12035-015-9192-4","journal-title":"Mol Neurobiol"},{"key":"1753_CR17","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00726-014-1910-0","volume":"47","author":"MP Cunha","year":"2015","unstructured":"Cunha MP et al (2015b) The modulation of NMDA receptors and l-arginine\/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test. Amino Acids 47:795\u2013811. doi: 10.1007\/s00726-014-1910-0","journal-title":"Amino Acids"},{"key":"1753_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-015-9446-7","author":"MP Cunha","year":"2015","unstructured":"Cunha MP, Pazini FL, Rosa JM, Ramos-Hryb AB, Oliveira A, Kaster MP, Rodrigues AL (2015c) Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A and A receptor activation. Purinergic Signal. doi: 10.1007\/s11302-015-9446-7","journal-title":"Purinergic Signal"},{"key":"1753_CR19","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1176\/appi.ajp.2011.11010128","volume":"168","author":"MC Denk","year":"2011","unstructured":"Denk MC, Rewerts C, Holsboer F, Erhardt-Lehmann A, Turck CW (2011) Monitoring ketamine treatment response in a depressed patient via peripheral mammalian target of rapamycin activation. Am J Psychiatry 168:751\u2013752. doi: 10.1176\/appi.ajp.2011.11010128","journal-title":"Am J Psychiatry"},{"key":"1753_CR20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.31887\/DCNS.2014.16.1\/rduman","volume":"16","author":"RS Duman","year":"2014","unstructured":"Duman RS (2014) Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections. Dialogues Clin Neurosci 16:11\u201327","journal-title":"Dialogues Clin Neurosci"},{"key":"1753_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.tins.2011.11.004","volume":"35","author":"RS Duman","year":"2012","unstructured":"Duman RS, Voleti B (2012) Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci 35:47\u201356. doi: 10.1016\/j.tins.2011.11.004","journal-title":"Trends Neurosci"},{"key":"1753_CR22","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0306-4530(99)00039-6","volume":"24","author":"S Elgun","year":"1999","unstructured":"Elgun S, Keskinege A, Kumbasar H (1999) Dipeptidyl peptidase IV and adenosine deaminase activity. Decrease in Depression Psychoneuroendocrinol 24:823\u2013832","journal-title":"Decrease in Depression Psychoneuroendocrinol"},{"key":"1753_CR23","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0074-7742(05)63007-3","volume":"63","author":"BB Fredholm","year":"2005","unstructured":"Fredholm BB, Chen JF, Cunha RA, Svenningsson P, Vaugeois JM (2005) Adenosine and brain function. Int Rev Neurobiol 63:191\u2013270. doi: 10.1016\/S0074-7742(05)63007-3","journal-title":"Int Rev Neurobiol"},{"key":"1753_CR24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.pbb.2011.09.001","volume":"100","author":"M Ganzella","year":"2011","unstructured":"Ganzella M, Faraco RB, Almeida RF, Fernandes VF, Souza DO (2011) Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors. Pharmacol Biochem Behav 100:271\u2013274. doi: 10.1016\/j.pbb.2011.09.001","journal-title":"Pharmacol Biochem Behav"},{"key":"1753_CR25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0014-2999(02)02301-4","volume":"451","author":"Z Gerevich","year":"2002","unstructured":"Gerevich Z, Wirkner K, Illes P (2002) Adenosine A2A receptors inhibit the N-methyl-d-aspartate component of excitatory synaptic currents in rat striatal neurons. Eur J Pharmacol 451:161\u2013164","journal-title":"Eur J Pharmacol"},{"key":"1753_CR26","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1007\/s11064-013-1150-9","volume":"38","author":"FM Goncalves","year":"2013","unstructured":"Goncalves FM et al (2013) Vatairea macrocarpa lectin (VML) induces depressive-like behavior and expression of neuroinflammatory markers in mice. Neurochem Res 38:2375\u20132384. doi: 10.1007\/s11064-013-1150-9","journal-title":"Neurochem Res"},{"key":"1753_CR27","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-016-9551-2","author":"FM Goncalves","year":"2016","unstructured":"Goncalves FM et al (2016) Signaling pathways underlying the antidepressant-like effect of inosine in mice. Purinergic Signal. doi: 10.1007\/s11302-016-9551-2","journal-title":"Purinergic Signal"},{"key":"1753_CR28","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.euroneuro.2011.08.008","volume":"21","author":"A Gustavsson","year":"2011","unstructured":"Gustavsson A et al (2011) Cost of disorders of the brain in Europe. 2010 Eur Neuropsychopharmacol 21:718\u2013779. doi: 10.1016\/j.euroneuro.2011.08.008","journal-title":"2010 Eur Neuropsychopharmacol"},{"key":"1753_CR29","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.biopsych.2007.03.017","volume":"62","author":"K Hashimoto","year":"2007","unstructured":"Hashimoto K, Sawa A, Iyo M (2007) Increased levels of glutamate in brains from patients with mood disorders. Biol Psychiatry 62:1310\u20131316. doi: 10.1016\/j.biopsych.2007.03.017","journal-title":"Biol Psychiatry"},{"key":"1753_CR30","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4049\/jimmunol.164.2.1013","volume":"164","author":"G Hasko","year":"2000","unstructured":"Hasko G et al (2000) Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol 164:1013\u20131019","journal-title":"J Immunol"},{"key":"1753_CR31","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.tips.2004.01.006","volume":"25","author":"G Hasko","year":"2004","unstructured":"Hasko G, Sitkovsky MV, Szabo C (2004) Immunomodulatory and neuroprotective effects of inosine. Trends Pharmacol Sci 25:152\u2013157. doi: 10.1016\/j.tips.2004.01.006","journal-title":"Trends Pharmacol Sci"},{"key":"1753_CR32","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1046\/j.1471-4159.1996.67052051.x","volume":"67","author":"SE Haun","year":"1996","unstructured":"Haun SE, Segeleon JE, Trapp VL, Clotz MA, Horrocks LA (1996) Inosine mediates the protective effect of adenosine in rat astrocyte cultures subjected to combined glucose\u2013oxygen deprivation. J Neurochem 67:2051\u20132059","journal-title":"J Neurochem"},{"key":"1753_CR33","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.pnpbp.2011.05.010","volume":"35","author":"CS Jernigan","year":"2011","unstructured":"Jernigan CS, Goswami DB, Austin MC, Iyo AH, Chandran A, Stockmeier CA, Karolewicz B (2011) The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 35:1774\u20131779. doi: 10.1016\/j.pnpbp.2011.05.010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1753_CR34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2003.10.040","volume":"355","author":"MP Kaster","year":"2004","unstructured":"Kaster MP, Rosa AO, Rosso MM, Goulart EC, Santos AR, Rodrigues AL (2004) Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors. Neurosci Lett 355:21\u201324","journal-title":"Neurosci Lett"},{"key":"1753_CR35","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.neuropharm.2011.08.018","volume":"62","author":"MP Kaster","year":"2011","unstructured":"Kaster MP, Gadotti VM, Calixto JB, Santos AR, Rodrigues AL (2011) Depressive-like behavior induced by tumor necrosis factor-alpha in mice. Neuropharmacology 62:419\u2013426. doi: 10.1016\/j.neuropharm.2011.08.018","journal-title":"Neuropharmacology"},{"key":"1753_CR36","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S1734-1140(12)70865-4","volume":"64","author":"MP Kaster","year":"2012","unstructured":"Kaster MP, Machado DG, Santos AR, Rodrigues AL (2012) Involvement of NMDA receptors in the antidepressant-like action of adenosine. Pharmacol Rep 64:706\u2013713","journal-title":"Pharmacol Rep"},{"key":"1753_CR37","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s11302-013-9361-8","volume":"9","author":"MP Kaster","year":"2013","unstructured":"Kaster MP, Budni J, Gazal M, Cunha MP, Santos AR, Rodrigues AL (2013) The antidepressant-like effect of inosine in the FST is associated with both adenosine A1 and A 2A receptors. Purinergic Signal 9:481\u2013486. doi: 10.1007\/s11302-013-9361-8","journal-title":"Purinergic Signal"},{"key":"1753_CR38","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ejphar.2015.12.029","volume":"771","author":"MP Kaster","year":"2016","unstructured":"Kaster MP, Moretti M, Cunha MP, Rodrigues AL (2016) Novel approaches for the management of depressive disorders. Eur J Pharmacol 771:236\u2013240. doi: 10.1016\/j.ejphar.2015.12.029","journal-title":"Eur J Pharmacol"},{"key":"1753_CR39","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1001\/archpsyc.62.6.617","volume":"62","author":"RC Kessler","year":"2005","unstructured":"Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:617\u2013627. doi: 10.1001\/archpsyc.62.6.617","journal-title":"Arch Gen Psychiatry"},{"key":"1753_CR40","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyu033","author":"AE Lepack","year":"2014","unstructured":"Lepack AE, Fuchikami M, Dwyer JM, Banasr M, Duman RS (2014) BDNF release is required for the behavioral actions of ketamine. Int J Neuropsychopharmacol. doi: 10.1093\/ijnp\/pyu033","journal-title":"Int J Neuropsychopharmacol"},{"key":"1753_CR41","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1126\/science.1190287","volume":"329","author":"N Li","year":"2010","unstructured":"Li N et al (2010) mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329:959\u2013964. doi: 10.1126\/science.1190287","journal-title":"Science"},{"key":"1753_CR42","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","volume":"69","author":"N Li","year":"2011","unstructured":"Li N et al (2011) Glutamate N-methyl-d-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry 69:754\u2013761. doi: 10.1016\/j.biopsych.2010.12.015","journal-title":"Biol Psychiatry"},{"key":"1753_CR43","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.neuint.2015.05.003","volume":"87","author":"MW Lopes","year":"2015","unstructured":"Lopes MW et al (2015) Region-specific alterations of AMPA receptor phosphorylation and signaling pathways in the pilocarpine model of epilepsy. Neurochem Int 87:22\u201333. doi: 10.1016\/j.neuint.2015.05.003","journal-title":"Neurochem Int"},{"key":"1753_CR44","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.euroneuro.2012.05.005","volume":"23","author":"FK Ludka","year":"2012","unstructured":"Ludka FK, Zomkowski AD, Cunha MP, Dal-Cim T, Zeni AL, Rodrigues AL, Tasca CI (2012) Acute atorvastatin treatment exerts antidepressant-like effect in mice via the l-arginine-nitric oxide-cyclic guanosine monophosphate pathway and increases BDNF levels. Eur Neuropsychopharmacol 23:400\u2013412. doi: 10.1016\/j.euroneuro.2012.05.005","journal-title":"Eur Neuropsychopharmacol"},{"key":"1753_CR45","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.euroneuro.2012.05.005","volume":"23","author":"FK Ludka","year":"2013","unstructured":"Ludka FK, Zomkowski AD, Cunha MP, Dal-Cim T, Zeni AL, Rodrigues AL, Tasca CI (2013) Acute atorvastatin treatment exerts antidepressant-like effect in mice via the l-arginine-nitric oxide-cyclic guanosine monophosphate pathway and increases BDNF levels. Eur Neuropsychopharmacol 23:400\u2013412. doi: 10.1016\/j.euroneuro.2012.05.005","journal-title":"Eur Neuropsychopharmacol"},{"key":"1753_CR46","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s11302-012-9327-2","volume":"9","author":"SJ Macedo-Junior","year":"2012","unstructured":"Macedo-Junior SJ, Nascimento FP, Luiz-Cerutti M, Santos AR (2012) Role of pertussis toxin-sensitive G-protein, K+ channels, and voltage-gated Ca2+ channels in the antinociceptive effect of inosine. Purinergic Signal 9:51\u201358. doi: 10.1007\/s11302-012-9327-2","journal-title":"Purinergic Signal"},{"key":"1753_CR47","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.pharmthera.2009.02.010","volume":"123","author":"R Machado-Vieira","year":"2009","unstructured":"Machado-Vieira R, Salvadore G, Diazgranados N, Zarate CA Jr (2009) Ketamine and the next generation of antidepressants with a rapid onset of action. Pharmacol Ther 123:143\u2013150. doi: 10.1016\/j.pharmthera.2009.02.010","journal-title":"Pharmacol Ther"},{"key":"1753_CR48","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1089\/acm.2008.0513","volume":"15","author":"CE Markowitz","year":"2009","unstructured":"Markowitz CE, Spitsin S, Zimmerman V, Jacobs D, Udupa JK, Hooper DC, Koprowski H (2009) The treatment of multiple sclerosis with inosine. J Altern Complement Med 15:619\u2013625. doi: 10.1089\/acm.2008.0513","journal-title":"J Altern Complement Med"},{"key":"1753_CR49","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jpsychires.2013.10.014","volume":"48","author":"M Moretti","year":"2013","unstructured":"Moretti M, Budni J, Freitas AE, Rosa PB, Rodrigues AL (2013) Antidepressant-like effect of ascorbic acid is associated with the modulation of mammalian target of rapamycin pathway. J Psychiatr Res 48:16\u201324. doi: 10.1016\/j.jpsychires.2013.10.014","journal-title":"J Psychiatr Res"},{"key":"1753_CR50","doi-asserted-by":"publisher","first-page":"4199","DOI":"10.1038\/srep04199","volume":"4","author":"J Muto","year":"2014","unstructured":"Muto J et al (2014) Oral administration of inosine produces antidepressant-like effects in mice. Sci Rep 4:4199. doi: 10.1038\/srep04199","journal-title":"Sci Rep"},{"key":"1753_CR51","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1124\/jpet.110.166058","volume":"334","author":"FP Nascimento","year":"2010","unstructured":"Nascimento FP et al (2010) Inosine reduces pain-related behavior in mice: involvement of adenosine A1 and A2A receptor subtypes and protein kinase C pathways. J Pharmacol Exp Ther 334:590\u2013598. doi: 10.1124\/jpet.110.166058","journal-title":"J Pharmacol Exp Ther"},{"key":"1753_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8815-5","author":"FP Nascimento","year":"2014","unstructured":"Nascimento FP et al (2014) Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Mol Neurobiol. doi: 10.1007\/s12035-014-8815-5","journal-title":"Mol Neurobiol"},{"key":"1753_CR53","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.pbb.2014.12.009","volume":"130","author":"VB Neis","year":"2015","unstructured":"Neis VB, Moretti M, Manosso LM, Lopes MW, Leal RB, Rodrigues AL (2015) Agmatine enhances antidepressant potency of MK-801 and conventional antidepressants in mice. Pharmacol Biochem Behav 130:9\u201314. doi: 10.1016\/j.pbb.2014.12.009","journal-title":"Pharmacol Biochem Behav"},{"key":"1753_CR54","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.pbb.2016.10.004","volume":"150\u2013151","author":"VB Neis","year":"2016","unstructured":"Neis VB et al (2016a) Acute agmatine administration, similar to ketamine, reverses depressive-like behavior induced by chronic unpredictable stress in mice. Pharmacol Biochem Behav 150\u2013151:108\u2013114. doi: 10.1016\/j.pbb.2016.10.004","journal-title":"Pharmacol Biochem Behav"},{"key":"1753_CR55","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.euroneuro.2016.03.009","volume":"26","author":"VB Neis","year":"2016","unstructured":"Neis VB et al (2016b) Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling. Eur Neuropsychopharmacol 26:959\u2013971. doi: 10.1016\/j.euroneuro.2016.03.009","journal-title":"Eur Neuropsychopharmacol"},{"key":"1753_CR56","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0006-8993(95)00057-W","volume":"675","author":"G Nowak","year":"1995","unstructured":"Nowak G, Ordway GA, Paul IA (1995) Alterations in the N-methyl-d-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Res 675:157\u2013164","journal-title":"Brain Res"},{"key":"1753_CR57","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1468-1331.2011.03590.x","volume":"19","author":"J Olesen","year":"2012","unstructured":"Olesen J, Gustavsson A, Svensson M, Wittchen HU, Jonsson B, group Cs, European Brain C (2012) The economic cost of brain disorders in Europe. Eur J Neurol 19:155\u2013162. doi: 10.1111\/j.1468-1331.2011.03590.x","journal-title":"Eur J Neurol"},{"key":"1753_CR58","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/mp.2015.92","volume":"20","author":"GI Papakostas","year":"2016","unstructured":"Papakostas GI, Ionescu DF (2016) Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder. Mol Psychiatry 20:1142\u20131150. doi: 10.1038\/mp.2015.92","journal-title":"Mol Psychiatry"},{"key":"1753_CR59","doi-asserted-by":"publisher","first-page":"6818","DOI":"10.1007\/s12035-015-9580-9","volume":"53","author":"FL Pazini","year":"2016","unstructured":"Pazini FL, Cunha MP, Rosa JM, Colla AR, Lieberknecht V, Oliveira A, Rodrigues AL (2016) Creatine, similar to ketamine, counteracts depressive-like behavior induced by corticosterone via PI3\/Akt\/mTOR pathway. Mol Neurobiol 53:6818\u20136834. doi: 10.1007\/s12035-015-9580-9","journal-title":"Mol Neurobiol"},{"key":"1753_CR60","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neuro.2015.07.005","volume":"50","author":"TV Peres","year":"2015","unstructured":"Peres TV et al (2015) Developmental exposure to manganese induces lasting motor and cognitive impairment in rats. Neurotoxicology 50:28\u201337. doi: 10.1016\/j.neuro.2015.07.005","journal-title":"Neurotoxicology"},{"key":"1753_CR61","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0003-2697(77)90043-4","volume":"83","author":"GLA Peterson","year":"1977","unstructured":"Peterson GLA et al (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83:346\u2013356","journal-title":"Anal Biochem"},{"key":"1753_CR62","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-0773.1996.tb00259.x","volume":"79","author":"AL Rodrigues","year":"1996","unstructured":"Rodrigues AL, Rocha JB, Mello CF, Souza DO (1996) Effect of perinatal lead exposure on rat behaviour in open-field and two-way avoidance tasks. Pharmacol Toxicol 79:150\u2013156","journal-title":"Pharmacol Toxicol"},{"key":"1753_CR63","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.biopsych.2006.11.011","volume":"61","author":"R Sattler","year":"2007","unstructured":"Sattler R, Rothstein JD (2007) Targeting an old mechanism in a new disease-protection of glutamatergic dysfunction in depression. Biol Psychiatry 61:137\u2013138. doi: 10.1016\/j.biopsych.2006.11.011","journal-title":"Biol Psychiatry"},{"key":"1753_CR64","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1001\/jamaneurol.2013.5528","volume":"71","author":"MA Schwarzschild","year":"2013","unstructured":"Schwarzschild MA et al (2013) Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol 71:141\u2013150. doi: 10.1001\/jamaneurol.2013.5528","journal-title":"JAMA Neurol"},{"key":"1753_CR65","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1161\/01.STR.0000155747.15679.04","volume":"36","author":"H Shen","year":"2005","unstructured":"Shen H, Chen GJ, Harvey BK, Bickford PC, Wang Y (2005) Inosine reduces ischemic brain injury in rats. Stroke 36:654\u2013659. doi: 10.1161\/01.STR.0000155747.15679.04","journal-title":"Stroke"},{"key":"1753_CR66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-2999(99)00330-1","volume":"375","author":"P Skolnick","year":"1999","unstructured":"Skolnick P (1999) Antidepressants for the new millennium. Eur J Pharmacol 375:31\u201340","journal-title":"Eur J Pharmacol"},{"key":"1753_CR67","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","volume":"85","author":"L Steru","year":"1985","unstructured":"Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367\u2013370","journal-title":"Psychopharmacology"},{"key":"1753_CR68","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S2215-0366(15)00505-2","volume":"3","author":"D Vigo","year":"2016","unstructured":"Vigo D, Thornicroft G, Atun R (2016) Estimating the true global burden of mental illness. Lancet Psychiatry 3:171\u2013178. doi: 10.1016\/S2215-0366(15)00505-2","journal-title":"Lancet Psychiatry"},{"key":"1753_CR69","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.cellsig.2016.02.010","volume":"28","author":"AA Welihinda","year":"2016","unstructured":"Welihinda AA, Kaur M, Greene K, Zhai Y, Amento EP (2016) The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal 28:552\u2013560. doi: 10.1016\/j.cellsig.2016.02.010","journal-title":"Cell Signal"},{"key":"1753_CR70","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0304-3940(03)00151-4","volume":"341","author":"MM Wu","year":"2003","unstructured":"Wu MM, You SW, Hou B, Jiao XY, Li YY, Ju G (2003) Effects of inosine on axonal regeneration of axotomized retinal ganglion cells in adult rats. Neurosci Lett 341:84\u201386","journal-title":"Neurosci Lett"},{"key":"1753_CR71","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","volume":"63","author":"CA Zarate Jr","year":"2006","unstructured":"Zarate CA Jr et al (2006) A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63:856\u2013864. doi: 10.1001\/archpsyc.63.8.856","journal-title":"Arch Gen Psychiatry"},{"key":"1753_CR72","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.euroneuro.2010.07.011","volume":"20","author":"AD Zomkowski","year":"2010","unstructured":"Zomkowski AD, Engel D, Gabilan NH, Rodrigues AL (2010) Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test. Eur Neuropsychopharmacol 20:793\u2013801. doi: 10.1016\/j.euroneuro.2010.07.011","journal-title":"Eur Neuropsychopharmacol"},{"key":"1753_CR73","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.pbb.2012.09.011","volume":"103","author":"AD Zomkowski","year":"2012","unstructured":"Zomkowski AD, Engel D, Cunha MP, Gabilan NH, Rodrigues AL (2012) The role of the NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of duloxetine in the forced swimming test. Pharmacol Biochem Behav 103:408\u2013417. doi: 10.1016\/j.pbb.2012.09.011","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00702-017-1753-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-017-1753-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-017-1753-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:23:43Z","timestamp":1659201823000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00702-017-1753-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,10]]},"references-count":73,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["1753"],"URL":"https:\/\/doi.org\/10.1007\/s00702-017-1753-4","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,10]]}}}