{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:36:13Z","timestamp":1782722173216,"version":"3.54.5"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV-14-0547"],"award-info":[{"award-number":["APVV-14-0547"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003194","name":"Agent\u00fara Ministerstva \u0161kolstva, vedy, v\u00fdskumu a \u0161portu SR","doi-asserted-by":"publisher","award":["26240220008"],"award-info":[{"award-number":["26240220008"]}],"id":[{"id":"10.13039\/501100003194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003194","name":"Agent\u00fara Ministerstva \u0161kolstva, vedy, v\u00fdskumu a \u0161portu SR","doi-asserted-by":"publisher","award":["26240220046"],"award-info":[{"award-number":["26240220046"]}],"id":[{"id":"10.13039\/501100003194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s00702-018-1883-3","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T11:39:59Z","timestamp":1524742799000},"page":"1013-1025","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cerebrovascular inflammation is associated with tau pathology in Guam parkinsonism dementia"],"prefix":"10.1007","volume":"125","author":[{"given":"Petra","family":"Majerova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph M.","family":"Garruto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3223-8705","authenticated-orcid":false,"given":"Andrej","family":"Kovac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"1883_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.matbio.2015.03.005","volume":"44\u201346","author":"V Arpino","year":"2015","unstructured":"Arpino V, Brock M, Gill SE (2015) The role of TIMPs in regulation of extracellular matrix proteolysis. Matrix Biol 44\u201346:247\u2013254. \n                    https:\/\/doi.org\/10.1016\/j.matbio.2015.03.005","journal-title":"Matrix Biol"},{"key":"1883_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40478-015-0186-2","volume":"3","author":"LJ Blair","year":"2015","unstructured":"Blair LJ, Frauen HD, Zhang B, Nordhues BA, Bijan S, Lin YC, Zamudio F, Hernandez LD, Sabbagh JJ, Selenica ML, Dickey CA (2015) Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy. Acta Neuropathol Commun 3:8. \n                    https:\/\/doi.org\/10.1186\/s40478-015-0186-2","journal-title":"Acta Neuropathol Commun"},{"issue":"Suppl 2","key":"1883_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3109\/17482960903286009","volume":"10","author":"WG Bradley","year":"2009","unstructured":"Bradley WG, Mash DC (2009) Beyond Guam: the cyanobacteria\/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases. Amyotroph Lateral Scler 10(Suppl 2):7\u201320. \n                    https:\/\/doi.org\/10.3109\/17482960903286009","journal-title":"Amyotroph Lateral Scler"},{"key":"1883_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/BF00294173","volume":"87","author":"L Buee","year":"1994","unstructured":"Buee L, Hof PR, Bouras C, Delacourte A, Perl DP, Morrison JH, Fillit HM (1994) Pathological alterations of the cerebral microvasculature in Alzheimer\u2019s disease and related dementing disorders. Acta Neuropathol 87:469\u2013480","journal-title":"Acta Neuropathol"},{"key":"1883_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1749-6632.1997.tb48457.x","volume":"826","author":"L Buee","year":"1997","unstructured":"Buee L, Hof PR, Delacourte A (1997) Brain microvascular changes in Alzheimer\u2019s disease and other dementias. Ann N Y Acad Sci 826:7\u201324","journal-title":"Ann N Y Acad Sci"},{"key":"1883_CR6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1159\/000334916","volume":"10","author":"A Carrano","year":"2012","unstructured":"Carrano A, Hoozemans JJ, van der Vies SM, van Horssen J, de Vries HE, Rozemuller AJ (2012) Neuroinflammation and blood\u2013brain barrier changes in capillary amyloid angiopathy. Neurodegener Dis 10:329\u2013331. \n                    https:\/\/doi.org\/10.1159\/000334916","journal-title":"Neurodegener Dis"},{"issue":"Suppl 2","key":"1883_CR7","doi-asserted-by":"publisher","first-page":"II6","DOI":"10.1007\/BF03161076","volume":"246","author":"DW Dickson","year":"1999","unstructured":"Dickson DW (1999) Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. J Neurol 246(Suppl 2):II6\u2013II15","journal-title":"J Neurol"},{"key":"1883_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0165-5728(02)00114-5","volume":"128","author":"JB Dietrich","year":"2002","unstructured":"Dietrich JB (2002) The adhesion molecule ICAM-1 and its regulation in relation with the blood\u2013brain barrier. J Neuroimmunol 128:58\u201368","journal-title":"J Neuroimmunol"},{"key":"1883_CR9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/00005072-199702000-00004","volume":"56","author":"PL DiPatre","year":"1997","unstructured":"DiPatre PL, Gelman BB (1997) Microglial cell activation in aging and Alzheimer disease: partial linkage with neurofibrillary tangle burden in the hippocampus. J Neuropathol Exp Neurol 56:143\u2013149","journal-title":"J Neuropathol Exp Neurol"},{"key":"1883_CR10","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s004010000195","volume":"100","author":"E Farkas","year":"2000","unstructured":"Farkas E, De Jong GI, de Vos RA, Jansen Steur EN, Luiten PG (2000) Pathological features of cerebral cortical capillaries are doubled in Alzheimer\u2019s disease and Parkinson\u2019s disease. Acta Neuropathol 100:395\u2013402","journal-title":"Acta Neuropathol"},{"key":"1883_CR11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/NEN.0000000000000030","volume":"73","author":"I Ferrer","year":"2014","unstructured":"Ferrer I et al (2014) Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression. J Neuropathol Exp Neurol 73:81\u201397. \n                    https:\/\/doi.org\/10.1097\/NEN.0000000000000030","journal-title":"J Neuropathol Exp Neurol"},{"key":"1883_CR12","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/S0002-9440(10)61119-4","volume":"160","author":"MS Forman","year":"2002","unstructured":"Forman MS, Schmidt ML, Kasturi S, Perl DP, Lee VM, Trojanowski JQ (2002) Tau and alpha-synuclein pathology in amygdala of Parkinsonism\u2013dementia complex patients of Guam. Am J Pathol 160:1725\u20131731","journal-title":"Am J Pathol"},{"key":"1883_CR13","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1523\/JNEUROSCI.0081-05.2005","volume":"25","author":"MS Forman","year":"2005","unstructured":"Forman MS, Lal D, Zhang B, Dabir DV, Swanson E, Lee VM, Trojanowski JQ (2005) Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. J Neurosci 25:3539\u20133550. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.0081-05.2005","journal-title":"J Neurosci"},{"key":"1883_CR14","first-page":"347","volume":"12","author":"RM Garruto","year":"1991","unstructured":"Garruto RM (1991) Pacific paradigms of environmentally-induced neurological disorders: clinical, epidemiological and molecular perspectives. Neurotoxicology 12:347\u2013377","journal-title":"Neurotoxicology"},{"key":"1883_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1212\/WNL.35.2.193","volume":"35","author":"RM Garruto","year":"1985","unstructured":"Garruto RM, Yanagihara R, Gajdusek DC (1985) Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism\u2013dementia on Guam. Neurology 35:193\u2013198","journal-title":"Neurology"},{"key":"1883_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/archneur.1962.04210030065009","volume":"7","author":"A Hirano","year":"1962","unstructured":"Hirano A, Zimmerman HM (1962) Alzheimer\u2019s neurofibrillary changes. A topographic study. Arch Neurol 7:227\u2013242","journal-title":"Arch Neurol"},{"key":"1883_CR17","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/brain\/84.4.642","volume":"84","author":"A Hirano","year":"1961","unstructured":"Hirano A, Kurland LT, Krooth RS, Lessell S (1961a) Parkinsonism\u2013dementia complex, an endemic disease on the island of Guam. I. Clinical features. Brain 84:642\u2013661","journal-title":"Brain"},{"key":"1883_CR18","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1093\/brain\/84.4.662","volume":"84","author":"A Hirano","year":"1961","unstructured":"Hirano A, Malamud N, Kurland LT (1961b) Parkinsonism\u2013dementia complex, an endemic disease on the island of Guam. II. Pathological features. Brain 84:662\u2013679","journal-title":"Brain"},{"key":"1883_CR19","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1016\/j.ajpath.2011.06.025","volume":"179","author":"T Jaworski","year":"2011","unstructured":"Jaworski T et al (2011) Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. Am J Pathol 179:2001\u20132015. \n                    https:\/\/doi.org\/10.1016\/j.ajpath.2011.06.025","journal-title":"Am J Pathol"},{"key":"1883_CR20","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0006-8993(95)01250-8","volume":"705","author":"RN Kalaria","year":"1995","unstructured":"Kalaria RN, Pax AB (1995) Increased collagen content of cerebral microvessels in Alzheimer\u2019s disease. Brain Res 705:349\u2013352","journal-title":"Brain Res"},{"key":"1883_CR21","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3233\/JAD-2009-1197","volume":"18","author":"A Kovac","year":"2009","unstructured":"Kovac A, Zilkova M, Deli MA, Zilka N, Novak M (2009) Human truncated tau is using a different mechanism from amyloid-beta to damage the blood\u2013brain barrier. J Alzheimers Dis 18:897\u2013906. \n                    https:\/\/doi.org\/10.3233\/JAD-2009-1197","journal-title":"J Alzheimers Dis"},{"key":"1883_CR22","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.4049\/jimmunol.1100216","volume":"187","author":"A Kovac","year":"2011","unstructured":"Kovac A, Zilka N, Kazmerova Z, Cente M, Zilkova M, Novak M (2011) Misfolded truncated protein tau induces innate immune response via MAPK pathway. J Immunol 187:2732\u20132739. \n                    https:\/\/doi.org\/10.4049\/jimmunol.1100216","journal-title":"J Immunol"},{"key":"1883_CR23","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","volume":"24","author":"VM Lee","year":"2001","unstructured":"Lee VM, Goedert M, Trojanowski JQ (2001) Neurodegenerative tauopathies. Annu Rev Neurosci 24:1121\u20131159. \n                    https:\/\/doi.org\/10.1146\/annurev.neuro.24.1.1121","journal-title":"Annu Rev Neurosci"},{"key":"1883_CR24","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1742-2094-7-56","volume":"7","author":"DC Lee","year":"2010","unstructured":"Lee DC et al (2010) LPS-induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. J Neuroinflammation 7:56. \n                    https:\/\/doi.org\/10.1186\/1742-2094-7-56","journal-title":"J Neuroinflammation"},{"key":"1883_CR25","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.arcmed.2010.03.007","volume":"41","author":"RB Maccioni","year":"2010","unstructured":"Maccioni RB, Farias G, Morales I, Navarrete L (2010) The revitalized tau hypothesis on Alzheimer\u2019s disease. Arch Med Res 41:226\u2013231. \n                    https:\/\/doi.org\/10.1016\/j.arcmed.2010.03.007","journal-title":"Arch Med Res"},{"key":"1883_CR26","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s004010050477","volume":"91","author":"R Mena","year":"1996","unstructured":"Mena R, Edwards PC, Harrington CR, Mukaetova-Ladinska EB, Wischik CM (1996) Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer\u2019s disease. Acta Neuropathol 91:633\u2013641","journal-title":"Acta Neuropathol"},{"key":"1883_CR27","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170203143336","author":"A Michalicova","year":"2017","unstructured":"Michalicova A, Banks WA, Legath J, Kovac A (2017) Tauopathies\u2014focus on changes at the neurovascular unit. Curr Alzheimer Res. \n                    https:\/\/doi.org\/10.2174\/1567205014666170203143336","journal-title":"Curr Alzheimer Res"},{"key":"1883_CR28","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4103\/0019-5545.44908","volume":"51","author":"E Mohandas","year":"2009","unstructured":"Mohandas E, Rajmohan V, Raghunath B (2009) Neurobiology of Alzheimer\u2019s disease. Indian J Psychiatry 51:55\u201361. \n                    https:\/\/doi.org\/10.4103\/0019-5545.44908","journal-title":"Indian J Psychiatry"},{"key":"1883_CR29","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1097\/00005072-199703000-00010","volume":"56","author":"K Oyanagi","year":"1997","unstructured":"Oyanagi K, Makifuchi T, Ohtoh T, Chen KM, Gajdusek DC, Chase TN (1997) Distinct pathological features of the gallyas- and tau-positive glia in the Parkinsonism\u2013dementia complex and amyotrophic lateral sclerosis of Guam. J Neuropathol Exp Neurol 56:308\u2013316","journal-title":"J Neuropathol Exp Neurol"},{"key":"1883_CR30","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/0006-8993(95)01257-5","volume":"707","author":"C Schwab","year":"1996","unstructured":"Schwab C, Steele JC, McGeer PL (1996) Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins. Brain Res 707:196\u2013205","journal-title":"Brain Res"},{"key":"1883_CR31","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/j.ajpath.2011.05.047","volume":"179","author":"A Serrano-Pozo","year":"2011","unstructured":"Serrano-Pozo A, Mielke ML, Gomez-Isla T, Betensky RA, Growdon JH, Frosch MP, Hyman BT (2011) Reactive glia not only associates with plaques but also parallels tangles in Alzheimer\u2019s disease. Am J Pathol 179:1373\u20131384. \n                    https:\/\/doi.org\/10.1016\/j.ajpath.2011.05.047","journal-title":"Am J Pathol"},{"key":"1883_CR32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0304-3940(00)01037-5","volume":"285","author":"LG Sheffield","year":"2000","unstructured":"Sheffield LG, Marquis JG, Berman NE (2000) Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer\u2019s disease. Neurosci Lett 285:165\u2013168","journal-title":"Neurosci Lett"},{"key":"1883_CR33","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.neuron.2012.02.006","volume":"73","author":"C Soto","year":"2012","unstructured":"Soto C (2012) In vivo spreading of tau pathology. Neuron 73:621\u2013623. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2012.02.006","journal-title":"Neuron"},{"key":"1883_CR34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/00001756-200301200-00017","volume":"14","author":"L Vechterova","year":"2003","unstructured":"Vechterova L, Kontsekova E, Zilka N, Ferencik M, Ravid R, Novak M (2003) DC11: a novel monoclonal antibody revealing Alzheimer\u2019s disease-specific tau epitope. NeuroReport 14:87\u201391. \n                    https:\/\/doi.org\/10.1097\/01.wnr.0000053064.88427.50","journal-title":"NeuroReport"},{"key":"1883_CR35","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jneuroim.2006.12.003","volume":"184","author":"D Wong","year":"2007","unstructured":"Wong D, Prameya R, Dorovini-Zis K (2007) Adhesion and migration of polymorphonuclear leukocytes across human brain microvessel endothelial cells are differentially regulated by endothelial cell adhesion molecules and modulate monolayer permeability. J Neuroimmunol 184:136\u2013148. \n                    https:\/\/doi.org\/10.1016\/j.jneuroim.2006.12.003","journal-title":"J Neuroimmunol"},{"key":"1883_CR36","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jneuroim.2009.01.013","volume":"209","author":"N Zilka","year":"2009","unstructured":"Zilka N, Stozicka Z, Kovac A, Pilipcinec E, Bugos O, Novak M (2009) Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy. J Neuroimmunol 209:16\u201325. \n                    https:\/\/doi.org\/10.1016\/j.jneuroim.2009.01.013","journal-title":"J Neuroimmunol"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00702-018-1883-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-018-1883-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-018-1883-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T19:44:52Z","timestamp":1556221492000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00702-018-1883-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,26]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["1883"],"URL":"https:\/\/doi.org\/10.1007\/s00702-018-1883-3","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,26]]},"assertion":[{"value":"7 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}