{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:27:43Z","timestamp":1791239263280,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00702-019-02134-5","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T18:02:54Z","timestamp":1578592974000},"page":"339-346","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["MicroRNA-425-5p promotes tau phosphorylation and cell apoptosis in Alzheimer\u2019s disease by targeting heat shock protein B8"],"prefix":"10.1007","volume":"127","author":[{"given":"Jiao","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanpeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"2134_CR1","doi-asserted-by":"publisher","first-page":"14645","DOI":"10.1523\/JNEUROSCI.1327-13.2013","volume":"33","author":"S Absalon","year":"2013","unstructured":"Absalon S, Kochanek DM, Raghavan V, Krichevsky AM (2013) MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci 33:14645\u201314659","journal-title":"J Neurosci"},{"key":"2134_CR2","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.15252\/embj.201387576","volume":"33","author":"J Banzhaf-Strathmann","year":"2014","unstructured":"Banzhaf-Strathmann J et al (2014) MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease. EMBO J. 33:1667\u20131680","journal-title":"EMBO J"},{"key":"2134_CR3","doi-asserted-by":"publisher","first-page":"958","DOI":"10.4161\/auto.6.7.13042","volume":"6","author":"V Crippa","year":"2010","unstructured":"Crippa V et al (2010a) A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases. Autophagy 6:958\u2013960. https:\/\/doi.org\/10.4161\/auto.6.7.13042","journal-title":"Autophagy"},{"key":"2134_CR4","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.1093\/hmg\/ddq257","volume":"19","author":"V Crippa","year":"2010","unstructured":"Crippa V et al (2010b) The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Hum Mol Genet 19:3440\u20133456. https:\/\/doi.org\/10.1093\/hmg\/ddq257","journal-title":"Hum Mol Genet"},{"key":"2134_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.nbd.2012.01.003","volume":"46","author":"C Delay","year":"2012","unstructured":"Delay C, Mandemakers W, H\u00e9bert SS (2012) MicroRNAs in Alzheimer's disease. Neurobiol Dis 46:285\u2013290","journal-title":"Neurobiol Dis"},{"key":"2134_CR6","doi-asserted-by":"crossref","first-page":"31745","DOI":"10.18632\/oncotarget.15958","volume":"8","author":"F Fang","year":"2017","unstructured":"Fang F, Song T, Zhang T, Cui Y, Zhang G, Xiong Q (2017) MiR-425-5p promotes invasion and metastasis of hepatocellular carcinoma cells through SCAI-mediated dysregulation of multiple signaling pathways. Oncotarget 8:31745","journal-title":"Oncotarget"},{"key":"2134_CR7","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1096\/fj.06-5911fje","volume":"20","author":"JM Fontaine","year":"2006","unstructured":"Fontaine JM, Sun X, Hoppe AD, Simon S, Vicart P, Welsh MJ, Benndorf R (2006) Abnormal small heat shock protein interactions involving neuropathy-associated HSP22 (HSPB8) mutants. FASEB J 20:2168\u20132170. https:\/\/doi.org\/10.1096\/fj.06-5911fje","journal-title":"FASEB J"},{"key":"2134_CR8","doi-asserted-by":"publisher","first-page":"14820","DOI":"10.1523\/JNEUROSCI.3883-11.2011","volume":"31","author":"H Geekiyanage","year":"2011","unstructured":"Geekiyanage H, Chan C (2011) MicroRNA-137\/181c regulates serine palmitoyltransferase and in turn amyloid \u03b2, novel targets in sporadic Alzheimer's disease. J Neurosci 31:14820\u201314830","journal-title":"J Neurosci"},{"key":"2134_CR9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.expneurol.2011.11.026","volume":"235","author":"H Geekiyanage","year":"2012","unstructured":"Geekiyanage H, Jicha GA, Nelson PT, Chan C (2012) Blood serum miRNA: non-invasive biomarkers for Alzheimer's disease. Exp Neurol 235:491\u2013496","journal-title":"Exp Neurol"},{"key":"2134_CR10","doi-asserted-by":"publisher","first-page":"6252","DOI":"10.18632\/oncotarget.2193","volume":"5","author":"MA Hamouda","year":"2014","unstructured":"Hamouda MA et al (2014) The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells. Oncotarget 5:6252\u20136266. https:\/\/doi.org\/10.18632\/oncotarget.2193","journal-title":"Oncotarget"},{"key":"2134_CR11","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"JA Hardy","year":"1992","unstructured":"Hardy JA, Higgins GA (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256:184\u2013186","journal-title":"Science"},{"key":"2134_CR12","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1093\/hmg\/ddq234","volume":"19","author":"J Irobi","year":"2010","unstructured":"Irobi J et al (2010) Mutant HSPB8 causes motor neuron-specific neurite degeneration. Hum Mol Genet 19:3254\u20133265","journal-title":"Hum Mol Genet"},{"key":"2134_CR13","doi-asserted-by":"crossref","first-page":"94172","DOI":"10.18632\/oncotarget.21613","volume":"8","author":"B Jiang","year":"2017","unstructured":"Jiang B et al (2017) MicroRNA-126a-5p enhances myocardial ischemia-reperfusion injury through suppressing Hspb8 expression. Oncotarget 8:94172","journal-title":"Oncotarget"},{"key":"2134_CR14","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1001\/archneur.1985.04060100083029","volume":"42","author":"ZS Khachaturian","year":"1985","unstructured":"Khachaturian ZS (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42:1097\u20131105","journal-title":"Arch Neurol"},{"key":"2134_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/bs.pmbts.2016.12.013","volume":"146","author":"S Kumar","year":"2017","unstructured":"Kumar S, Vijayan M, Bhatti JS, Reddy PH (2017) Chapter three-microRNAs as peripheral biomarkers in aging and age-related diseases. Prog Mol Biol Transl Sci 146:47\u201394","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2134_CR16","doi-asserted-by":"publisher","first-page":"e3420","DOI":"10.1371\/journal.pone.0003420","volume":"3","author":"M Lu","year":"2008","unstructured":"Lu M, Zhang Q, Deng M, Miao J, Guo Y, Gao W, Cui Q (2008) An analysis of human microRNA and disease associations. PLoS ONE 3:e3420","journal-title":"PLoS ONE"},{"key":"2134_CR17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neulet.2017.09.043","volume":"661","author":"X Ma","year":"2017","unstructured":"Ma X, Liu L, Meng J (2017) MicroRNA-125b promotes neurons cell apoptosis and Tau phosphorylation in Alzheimer\u2019s disease. Neurosci Lett 661:57\u201362","journal-title":"Neurosci Lett"},{"key":"2134_CR18","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/j.1750-3639.2007.00120.x","volume":"18","author":"PT Nelson","year":"2008","unstructured":"Nelson PT, Wang WX, Rajeev BW (2008) MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol 18:130\u2013138","journal-title":"Brain Pathol"},{"key":"2134_CR19","doi-asserted-by":"publisher","first-page":"e8898","DOI":"10.1371\/journal.pone.0008898","volume":"5","author":"J Nunez-Iglesias","year":"2010","unstructured":"Nunez-Iglesias J, Liu C-C, Morgan TE, Finch CE, Zhou XJ (2010) Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS ONE 5:e8898","journal-title":"PLoS ONE"},{"key":"2134_CR20","doi-asserted-by":"publisher","first-page":"e11070","DOI":"10.1371\/journal.pone.0011070","volume":"5","author":"N Schonrock","year":"2010","unstructured":"Schonrock N, Ke YD, Humphreys D, Staufenbiel M, Ittner LM, Preiss T, G\u00f6tz J (2010) Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-\u03b2. PLoS ONE 5:e11070","journal-title":"PLoS ONE"},{"key":"2134_CR21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1177\/0004563216649377","volume":"54","author":"L Sun","year":"2017","unstructured":"Sun L, Jiang R, Li J, Wang B, Ma C, Lv Y, Mu N (2017) MicoRNA-425-5p is a potential prognostic biomarker for cervical cancer. Ann Clin Biochem 54:127\u2013133","journal-title":"Ann Clin Biochem"},{"key":"2134_CR22","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.brainresbull.2009.08.006","volume":"80","author":"X Wang","year":"2009","unstructured":"Wang X et al (2009) miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull 80:268\u2013273","journal-title":"Brain Res Bull"},{"key":"2134_CR23","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3233\/JAD-2011-101779","volume":"24","author":"G Yu","year":"2011","unstructured":"Yu G, Li Y, Tian Q, Liu R, Wang Q, Wang J-Z, Wang X (2011) Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells. J Alzheimer's Dis 24:525\u2013535","journal-title":"J Alzheimer's Dis"},{"key":"2134_CR24","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.3892\/etm.2015.2318","volume":"9","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Li Y, Fan L, Zhao Q, Tan B, Li Z, Zang A (2015) microRNA-425-5p is upregulated in human gastric cancer and contributes to invasion and metastasis in vitro and in vivo. Exp Therap Med 9:1617\u20131622","journal-title":"Exp Therap Med"},{"key":"2134_CR25","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/jcmm.12742","volume":"20","author":"Y Zhang","year":"2016","unstructured":"Zhang Y et al (2016) Micro RNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10. J Cell Mol Med 20:360\u2013369","journal-title":"J Cell Mol Med"},{"key":"2134_CR26","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.brainresbull.2012.05.018","volume":"88","author":"H-C Zhu","year":"2012","unstructured":"Zhu H-C, Wang L-M, Wang M, Song B, Tan S, Teng J-F, Duan D-X (2012) MicroRNA-195 downregulates Alzheimer's disease amyloid-\u03b2 production by targeting BACE1. Brain Res Bull 88:596\u2013601","journal-title":"Brain Res Bull"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-019-02134-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00702-019-02134-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-019-02134-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T01:02:24Z","timestamp":1610067744000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00702-019-02134-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,9]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["2134"],"URL":"https:\/\/doi.org\/10.1007\/s00702-019-02134-5","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,9]]},"assertion":[{"value":"10 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was obtained from the Ethics Committee of Qingdao Mental Health Center (No. QMHC2015021156673). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}