{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:33:40Z","timestamp":1790688820505,"version":"4.1.0"},"reference-count":121,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP-136871"],"award-info":[{"award-number":["MOP-136871"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162103"],"award-info":[{"award-number":["PJT-162103"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017033","name":"Quebec Pain Research Network","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100017033","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["30851"],"award-info":[{"award-number":["30851"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s00702-020-02172-4","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T16:03:46Z","timestamp":1584547426000},"page":"661-672","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Alleviating pain with delta opioid receptor agonists: evidence from experimental models"],"prefix":"10.1007","volume":"127","author":[{"given":"Sophie","family":"Berthiaume","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Blais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-8863","authenticated-orcid":false,"given":"Louis","family":"Gendron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"2172_CR1","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1097\/ALN.0b013e318238bba6","volume":"115","author":"R Al-Hasani","year":"2011","unstructured":"Al-Hasani R, Bruchas MR (2011) Molecular mechanisms of opioid receptor-dependent signaling and behavior. Anesthesiology 115:1363\u20131381. https:\/\/doi.org\/10.1097\/ALN.0b013e318238bba6","journal-title":"Anesthesiology"},{"key":"2172_CR2","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1523\/JNEUROSCI.3734-11.2012","volume":"32","author":"N Audet","year":"2012","unstructured":"Audet N et al (2012) Differential association of receptor-Gbetagamma complexes with beta-arrestin2 determines recycling bias and potential for tolerance of delta opioid receptor agonists. J Neurosci 32:4827\u20134840. https:\/\/doi.org\/10.1523\/JNEUROSCI.3734-11.2012","journal-title":"J Neurosci"},{"key":"2172_CR3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00210-005-0013-6","volume":"372","author":"A Baamonde","year":"2005","unstructured":"Baamonde A, Lastra A, Juarez L, Garcia V, Hidalgo A, Menendez L (2005) Effects of the local administration of selective mu-, delta-and kappa-opioid receptor agonists on osteosarcoma-induced hyperalgesia Naunyn Schmiedebergs. Arch Pharmacol 372:213\u2013219. https:\/\/doi.org\/10.1007\/s00210-005-0013-6","journal-title":"Arch Pharmacol"},{"key":"2172_CR4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.coph.2004.08.012","volume":"5","author":"CP Bailey","year":"2005","unstructured":"Bailey CP, Connor M (2005) Opioids: cellular mechanisms of tolerance and physical dependence. Curr Opin Pharmacol 5:60\u201368. https:\/\/doi.org\/10.1016\/j.coph.2004.08.012","journal-title":"Curr Opin Pharmacol"},{"key":"2172_CR5","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.neuron.2014.01.044","volume":"81","author":"R Bardoni","year":"2014","unstructured":"Bardoni R et al (2014) Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron 81:1312\u20131327. https:\/\/doi.org\/10.1016\/j.neuron.2014.01.044","journal-title":"Neuron"},{"key":"2172_CR6","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1016\/s0968-0896(01)00017-7","volume":"9","author":"DR Barn","year":"2001","unstructured":"Barn DR, Caulfield WL, Cottney J, McGurk K, Morphy JR, Rankovic Z, Roberts B (2001) Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand. Bioorg Med Chem 9:2609\u20132624. https:\/\/doi.org\/10.1016\/s0968-0896(01)00017-7","journal-title":"Bioorg Med Chem"},{"key":"2172_CR7","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G, Julius D (2009) Cellular and molecular mechanisms of pain. Cell 139:267\u2013284. https:\/\/doi.org\/10.1016\/j.cell.2009.09.028","journal-title":"Cell"},{"key":"2172_CR8","doi-asserted-by":"publisher","first-page":"13068","DOI":"10.1523\/JNEUROSCI.1817-11.2011","volume":"31","author":"H Beaudry","year":"2011","unstructured":"Beaudry H, Dubois D, Gendron L (2011) Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli. J Neurosci 31:13068\u201313077. https:\/\/doi.org\/10.1523\/JNEUROSCI.1817-11.2011","journal-title":"J Neurosci"},{"key":"2172_CR9","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1111\/ejn.12829","volume":"41","author":"H Beaudry","year":"2015","unstructured":"Beaudry H, Gendron L, Moron JA (2015a) Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain. Eur J Neurosci 41:901\u2013907. https:\/\/doi.org\/10.1111\/ejn.12829","journal-title":"Eur J Neurosci"},{"key":"2172_CR10","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1111\/bph.13088","volume":"172","author":"H Beaudry","year":"2015","unstructured":"Beaudry H, Mercier-Blais AA, Delaygue C, Lavoie C, Parent JL, Neugebauer W, Gendron L (2015b) Regulation of mu and delta opioid receptor functions: involvement of cyclin-dependent kinase 5. Br J Pharmacol 172:2573\u20132587. https:\/\/doi.org\/10.1111\/bph.13088","journal-title":"Br J Pharmacol"},{"key":"2172_CR11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.neuroscience.2009.03.053","volume":"161","author":"H Beaudry","year":"2009","unstructured":"Beaudry H, Proteau-Gagne A, Li S, Dory Y, Chavkin C, Gendron L (2009) Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents. Neuroscience 161:381\u2013391. https:\/\/doi.org\/10.1016\/j.neuroscience.2009.03.053","journal-title":"Neuroscience"},{"key":"2172_CR12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.20471\/acc.2019.58.s1.05","volume":"58","author":"I Bicanic","year":"2019","unstructured":"Bicanic I, Hladnik A, Dzaja D, Petanjek Z (2019) The anatomy of orofacial innervation. Acta Clin Croat 58:35\u201342. https:\/\/doi.org\/10.20471\/acc.2019.58.s1.05","journal-title":"Acta Clin Croat"},{"key":"2172_CR13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s11916-009-0048-3","volume":"13","author":"ME Bigal","year":"2009","unstructured":"Bigal ME, Lipton RB (2009) Overuse of acute migraine medications and migraine chronification. Curr Pain Headache Rep 13:301\u2013307. https:\/\/doi.org\/10.1007\/s11916-009-0048-3","journal-title":"Curr Pain Headache Rep"},{"key":"2172_CR14","first-page":"491","volume":"277","author":"EJ Bilsky","year":"1996","unstructured":"Bilsky EJ, Bernstein RN, Hruby VJ, Rothman RB, Lai J, Porreca F (1996a) Characterization of antinociception to opioid receptor selective agonists after antisense oligodeoxynucleotide-mediated \"knock-down\" of opioid receptor in vivo. J Pharmacol Exp Ther 277:491\u2013501","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR15","first-page":"359","volume":"273","author":"EJ Bilsky","year":"1995","unstructured":"Bilsky EJ et al (1995) SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J Pharmacol Exp Ther 273:359\u2013366","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/s0304-3940(96)13262-6","volume":"220","author":"EJ Bilsky","year":"1996","unstructured":"Bilsky EJ, Wang T, Lai J, Porreca F (1996b) Selective blockade of peripheral delta opioid agonist induced antinociception by intrathecal administration of delta receptor antisense oligodeoxynucleotide. Neurosci Lett 220:155\u2013158. https:\/\/doi.org\/10.1016\/s0304-3940(96)13262-6","journal-title":"Neurosci Lett"},{"key":"2172_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2019.170223","author":"RJ Bodnar","year":"2019","unstructured":"Bodnar RJ (2019) Endogenous opiates and behavior: 2017. Peptides. https:\/\/doi.org\/10.1016\/j.peptides.2019.170223","journal-title":"Peptides"},{"key":"2172_CR18","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1016\/j.celrep.2016.07.084","volume":"16","author":"AD Brackley","year":"2016","unstructured":"Brackley AD, Gomez R, Akopian AN, Henry MA, Jeske NA (2016) GRK2 constitutively governs peripheral delta opioid receptor activity. Cell Rep 16:2686\u20132698. https:\/\/doi.org\/10.1016\/j.celrep.2016.07.084","journal-title":"Cell Rep"},{"key":"2172_CR19","doi-asserted-by":"publisher","first-page":"8762","DOI":"10.1074\/jbc.M117.776799","volume":"292","author":"AD Brackley","year":"2017","unstructured":"Brackley AD, Sarrami S, Gomez R, Guerrero KA, Jeske NA (2017) Identification of a signaling cascade that maintains constitutive delta-opioid receptor incompetence in peripheral sensory neurons. J Biol Chem 292:8762\u20138772. https:\/\/doi.org\/10.1074\/jbc.M117.776799","journal-title":"J Biol Chem"},{"key":"2172_CR20","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.pain.2006.01.032","volume":"122","author":"J Brainin-Mattos","year":"2006","unstructured":"Brainin-Mattos J, Smith ND, Malkmus S, Rew Y, Goodman M, Taulane J, Yaksh TL (2006) Cancer-related bone pain is attenuated by a systemically available delta-opioid receptor agonist. Pain 122:174\u2013181. https:\/\/doi.org\/10.1016\/j.pain.2006.01.032","journal-title":"Pain"},{"key":"2172_CR21","first-page":"939","volume":"296","author":"MR Brandt","year":"2001","unstructured":"Brandt MR, Furness MS, Mello NK, Rice KC, Negus SS (2001) Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity. J Pharmacol Exp Ther 296:939\u2013946","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR22","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s00213-002-1179-y","volume":"164","author":"DC Broom","year":"2002","unstructured":"Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH (2002a) Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats. Psychopharmacology 164:42\u201348","journal-title":"Psychopharmacology"},{"key":"2172_CR23","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/S0893-133X(01)00413-4","volume":"26","author":"DC Broom","year":"2002","unstructured":"Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH (2002b) Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology 26:744\u2013755","journal-title":"Neuropsychopharmacology"},{"key":"2172_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1254\/jjp.90.1","volume":"90","author":"DC Broom","year":"2002","unstructured":"Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH (2002c) Behavioral effects of delta-opioid receptor agonists: potential antidepressants? Jpn J Pharmacol 90:1\u20136","journal-title":"Jpn J Pharmacol"},{"key":"2172_CR25","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1124\/jpet.102.036525","volume":"303","author":"DC Broom","year":"2002","unstructured":"Broom DC, Nitsche JF, Pintar JE, Rice KC, Woods JH, Traynor JR (2002d) Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice. J Pharmacol Exp Ther 303:723\u2013729","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1526-4610.2011.02050.x","volume":"52","author":"DC Buse","year":"2012","unstructured":"Buse DC, Pearlman SH, Reed ML, Serrano D, Ng-Mak DS, Lipton RB (2012) Opioid use and dependence among persons with migraine: results of the AMPP study. Headache 52:18\u201336. https:\/\/doi.org\/10.1111\/j.1526-4610.2011.02050.x","journal-title":"Headache"},{"key":"2172_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.tips.2006.11.003","volume":"28","author":"CM Cahill","year":"2007","unstructured":"Cahill CM, Holdridge SV, Morinville A (2007) Trafficking of delta-opioid receptors and other G-protein-coupled receptors: implications for pain and analgesia. Trends Pharmacol Sci 28:23\u201331. https:\/\/doi.org\/10.1016\/j.tips.2006.11.003","journal-title":"Trends Pharmacol Sci"},{"key":"2172_CR28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/cne.1370","volume":"440","author":"CM Cahill","year":"2001","unstructured":"Cahill CM, McClellan KA, Morinville A, Hoffert C, Hubatsch D, O'Donnell D, Beaudet A (2001a) Immunohistochemical distribution of delta opioid receptors in the rat central nervous system: evidence for somatodendritic labeling and antigen-specific cellular compartmentalization. J Comp Neurol 440:65\u201384. https:\/\/doi.org\/10.1002\/cne.1370","journal-title":"J Comp Neurol"},{"key":"2172_CR29","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0304-3959(02)00333-0","volume":"101","author":"CM Cahill","year":"2003","unstructured":"Cahill CM, Morinville A, Hoffert C, O'Donnell D, Beaudet A (2003) Up-regulation and trafficking of delta opioid receptor in a model of chronic inflammation: implications for pain control. Pain 101:199\u2013208","journal-title":"Pain"},{"key":"2172_CR30","doi-asserted-by":"publisher","first-page":"7598","DOI":"10.1523\/JNEUROSCI.21-19-07598.2001","volume":"21","author":"CM Cahill","year":"2001","unstructured":"Cahill CM, Morinville A, Lee MC, Vincent JP, Collier B, Beaudet A (2001b) Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception. J Neurosci 21:7598\u20137607","journal-title":"J Neurosci"},{"key":"2172_CR31","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1007\/s00018-017-2732-5","volume":"75","author":"I Charfi","year":"2018","unstructured":"Charfi I, Abdallah K, Gendron L, Pineyro G (2018) Delta opioid receptors recycle to the membrane after sorting to the degradation path. Cell Mol Life Sci 75:2257\u20132271. https:\/\/doi.org\/10.1007\/s00018-017-2732-5","journal-title":"Cell Mol Life Sci"},{"key":"2172_CR32","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/WCO.0000000000000311","volume":"29","author":"A Charles","year":"2016","unstructured":"Charles A, Pradhan AA (2016) Delta-opioid receptors as targets for migraine therapy. Curr Opin Neurol 29:314\u2013319. https:\/\/doi.org\/10.1097\/WCO.0000000000000311","journal-title":"Curr Opin Neurol"},{"key":"2172_CR33","doi-asserted-by":"publisher","first-page":"5976","DOI":"10.1523\/JNEUROSCI.15-09-05976.1995","volume":"15","author":"PY Cheng","year":"1995","unstructured":"Cheng PY et al (1995) Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of delta-opioid receptor within both enkephalin- and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord. J Neurosci 15:5976\u20135988","journal-title":"J Neurosci"},{"key":"2172_CR34","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pharmthera.2013.06.003","volume":"140","author":"PCS Chung","year":"2013","unstructured":"Chung PCS, Kieffer BL (2013) Delta opioid receptors in brain function and diseases. Pharmacol Ther 140:112\u2013120. https:\/\/doi.org\/10.1016\/j.pharmthera.2013.06.003","journal-title":"Pharmacol Ther"},{"key":"2172_CR35","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.bbr.2014.10.029","volume":"278","author":"PC Chung","year":"2015","unstructured":"Chung PC et al (2015) Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures. Behav Brain Res 278:429\u2013434. https:\/\/doi.org\/10.1016\/j.bbr.2014.10.029","journal-title":"Behav Brain Res"},{"key":"2172_CR36","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/00001756-199312000-00041","volume":"5","author":"RJ Dado","year":"1993","unstructured":"Dado RJ, Law PY, Loh HH, Elde R (1993) Immunofluorescent identification of a delta (delta)-opioid receptor on primary afferent nerve terminals. NeuroReport 5:341\u2013344","journal-title":"NeuroReport"},{"key":"2172_CR37","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1177\/0333102417714032","volume":"38","author":"R Dallel","year":"2018","unstructured":"Dallel R, Descheemaeker A, Luccarini P (2018) Recurrent administration of the nitric oxide donor, isosorbide dinitrate, induces a persistent cephalic cutaneous hypersensitivity: a model for migraine progression. Cephalalgia 38:776\u2013785. https:\/\/doi.org\/10.1177\/0333102417714032","journal-title":"Cephalalgia"},{"key":"2172_CR38","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0006-8993(93)90509-L","volume":"611","author":"JA Desmeules","year":"1993","unstructured":"Desmeules JA, Kayser V, Gacel G, Guilbaud G, Roques BP (1993) The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine. Brain Res 611:243\u2013248","journal-title":"Brain Res"},{"key":"2172_CR39","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1111\/j.1460-9568.2010.07466.x","volume":"32","author":"D Dubois","year":"2010","unstructured":"Dubois D, Gendron L (2010) Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice. Eur J Neurosci 32:1921\u20131929. https:\/\/doi.org\/10.1111\/j.1460-9568.2010.07466.x","journal-title":"Eur J Neurosci"},{"key":"2172_CR40","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00429-014-0717-9","volume":"220","author":"E Erbs","year":"2015","unstructured":"Erbs E et al (2015) A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Struct Funct 220:677\u2013702. https:\/\/doi.org\/10.1007\/s00429-014-0717-9","journal-title":"Brain Struct Funct"},{"key":"2172_CR41","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/76061","volume":"25","author":"D Filliol","year":"2000","unstructured":"Filliol D et al (2000) Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet 25:195\u2013200. https:\/\/doi.org\/10.1038\/76061","journal-title":"Nat Genet"},{"key":"2172_CR42","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1038\/sj.bjp.0703248","volume":"129","author":"GL Fraser","year":"2000","unstructured":"Fraser GL, Gaudreau GA, Clarke PB, Menard DP, Perkins MN (2000a) Antihyperalgesic effects of delta opioid agonists in a rat model of chronic inflammation. Br J Pharmacol 129:1668\u20131672. https:\/\/doi.org\/10.1038\/sj.bjp.0703248","journal-title":"Br J Pharmacol"},{"key":"2172_CR43","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1124\/mol.57.4.725","volume":"57","author":"GL Fraser","year":"2000","unstructured":"Fraser GL, Holmgren J, Clarke PB, Wahlestedt C (2000b) Antisense inhibition of delta-opioid receptor gene function in vivo by peptide nucleic acids. Mol Pharmacol 57:725\u2013731. https:\/\/doi.org\/10.1124\/mol.57.4.725","journal-title":"Mol Pharmacol"},{"key":"2172_CR44","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1742-7843.2005.pto_07.x","volume":"97","author":"EL Gallantine","year":"2005","unstructured":"Gallantine EL, Meert TF (2005) A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80. Basic Clin Pharmacol Toxicol 97:39\u201351. https:\/\/doi.org\/10.1111\/j.1742-7843.2005.pto_07.x","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2172_CR45","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1111\/j.1460-9568.2008.06223.x","volume":"27","author":"C Gaveriaux-Ruff","year":"2008","unstructured":"Gaveriaux-Ruff C, Karchewski LA, Hever X, Matifas A, Kieffer BL (2008) Inflammatory pain is enhanced in delta opioid receptor-knockout mice. Eur J Neurosci 27:2558\u20132567. https:\/\/doi.org\/10.1111\/j.1460-9568.2008.06223.x","journal-title":"Eur J Neurosci"},{"key":"2172_CR46","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/FBP.0b013e32834a1f2c","volume":"22","author":"C Gaveriaux-Ruff","year":"2011","unstructured":"Gaveriaux-Ruff C, Kieffer BL (2011) Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches. Behav Pharmacol 22:405\u2013414. https:\/\/doi.org\/10.1097\/FBP.0b013e32834a1f2c","journal-title":"Behav Pharmacol"},{"key":"2172_CR47","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1124\/pr.114.008979","volume":"68","author":"L Gendron","year":"2016","unstructured":"Gendron L, Cahill CM, von Zastrow M, Schiller PW, Pineyro G (2016) Molecular pharmacology of delta-opioid receptors. Pharmacol Rev 68:631\u2013700. https:\/\/doi.org\/10.1124\/pr.114.008979","journal-title":"Pharmacol Rev"},{"key":"2172_CR48","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.neuroscience.2006.08.077","volume":"144","author":"L Gendron","year":"2007","unstructured":"Gendron L et al (2007a) Morphine priming in rats with chronic inflammation reveals a dichotomy between antihyperalgesic and antinociceptive properties of deltorphin. Neuroscience 144:263\u2013274. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.08.077","journal-title":"Neuroscience"},{"key":"2172_CR49","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1523\/JNEUROSCI.3598-05.2006","volume":"26","author":"L Gendron","year":"2006","unstructured":"Gendron L, Lucido AL, Mennicken F, O'Donnell D, Vincent JP, Stroh T, Beaudet A (2006) Morphine and pain-related stimuli enhance cell surface availability of somatic delta-opioid receptors in rat dorsal root ganglia. J Neurosci 26:953\u2013962. https:\/\/doi.org\/10.1523\/JNEUROSCI.3598-05.2006","journal-title":"J Neurosci"},{"key":"2172_CR50","doi-asserted-by":"publisher","DOI":"10.1111\/bph.2015.172.issue-2","author":"L Gendron","year":"2015","unstructured":"Gendron L, Mittal N, Beaudry H, Walwyn W (2015) Recent advances on the \u03b4 opioid receptor: from trafficking to function. Br J Pharmacol. https:\/\/doi.org\/10.1111\/bph.2015.172.issue-2","journal-title":"Br J Pharmacol"},{"key":"2172_CR51","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.neuroscience.2007.09.060","volume":"150","author":"L Gendron","year":"2007","unstructured":"Gendron L, Pintar JE, Chavkin C (2007b) Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia. Neuroscience 150:807\u2013817. https:\/\/doi.org\/10.1016\/j.neuroscience.2007.09.060","journal-title":"Neuroscience"},{"key":"2172_CR52","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.semarthrit.2008.11.005","volume":"40","author":"DL Goldenberg","year":"2010","unstructured":"Goldenberg DL (2010a) The interface of pain and mood disturbances in the rheumatic diseases. Semin Arthritis Rheum 40:15\u201331. https:\/\/doi.org\/10.1016\/j.semarthrit.2008.11.005","journal-title":"Semin Arthritis Rheum"},{"key":"2172_CR53","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.amjmed.2010.01.014","volume":"123","author":"DL Goldenberg","year":"2010","unstructured":"Goldenberg DL (2010b) Pain\/Depression dyad: a key to a better understanding and treatment of functional somatic syndromes. Am J Med 123:675\u2013682. https:\/\/doi.org\/10.1016\/j.amjmed.2010.01.014","journal-title":"Am J Med"},{"key":"2172_CR54","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.cell.2005.06.010","volume":"122","author":"JS Guan","year":"2005","unstructured":"Guan JS et al (2005) Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell 122:619\u2013631. https:\/\/doi.org\/10.1016\/j.cell.2005.06.010","journal-title":"Cell"},{"key":"2172_CR55","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1523\/JNEUROSCI.4585-04.2005","volume":"25","author":"SP Hack","year":"2005","unstructured":"Hack SP, Bagley EE, Chieng BC, Christie MJ (2005) Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. J Neurosci 25:3192\u20133198","journal-title":"J Neurosci"},{"key":"2172_CR56","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00210-009-0436-6","volume":"380","author":"A Hervera","year":"2009","unstructured":"Hervera A, Leanez S, Negrete R, Pol O (2009) The peripheral administration of a nitric oxide donor potentiates the local antinociceptive effects of a DOR agonist during chronic inflammatory pain in mice. Naunyn Schmiedebergs Arch Pharmacol 380:345\u2013352. https:\/\/doi.org\/10.1007\/s00210-009-0436-6","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2172_CR57","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.ejpain.2006.10.008","volume":"11","author":"SV Holdridge","year":"2007","unstructured":"Holdridge SV, Cahill CM (2007) Spinal administration of a delta opioid receptor agonist attenuates hyperalgesia and allodynia in a rat model of neuropathic pain. Eur J Pain 11:685\u2013693. https:\/\/doi.org\/10.1016\/j.ejpain.2006.10.008","journal-title":"Eur J Pain"},{"key":"2172_CR58","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S0306-4522(00)00110-X","volume":"98","author":"P Honore","year":"2000","unstructured":"Honore P et al (2000) Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience 98:585\u2013598","journal-title":"Neuroscience"},{"key":"2172_CR59","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1124\/mol.118.114637","volume":"95","author":"NA Jeske","year":"2019","unstructured":"Jeske NA (2019) Dynamic opioid receptor regulation in the periphery. Mol Pharmacol 95:463\u2013467. https:\/\/doi.org\/10.1124\/mol.118.114637","journal-title":"Mol Pharmacol"},{"key":"2172_CR60","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.pain.2006.08.003","volume":"127","author":"N Kabli","year":"2007","unstructured":"Kabli N, Cahill CM (2007) Anti-allodynic effects of peripheral delta opioid receptors in neuropathic pain. Pain 127:84\u201393. https:\/\/doi.org\/10.1016\/j.pain.2006.08.003","journal-title":"Pain"},{"key":"2172_CR61","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0014-2999(97)00157-X","volume":"326","author":"J Kamei","year":"1997","unstructured":"Kamei J, Kashiwazaki T, Hitosugi H, Nagase H (1997a) The role of spinal delta1-opioid receptors in inhibiting the formalin-induced nociceptive response in diabetic mice. Eur J Pharmacol 326:31\u201336","journal-title":"Eur J Pharmacol"},{"key":"2172_CR62","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0014-2999(97)00085-X","volume":"322","author":"J Kamei","year":"1997","unstructured":"Kamei J et al (1997b) Supraspinal delta 1-opioid receptor-mediated antinociceptive properties of (-)-TAN-67 in diabetic mice. Eur J Pharmacol 322:27\u201330","journal-title":"Eur J Pharmacol"},{"key":"2172_CR63","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0301-0082(02)00008-4","volume":"66","author":"BL Kieffer","year":"2002","unstructured":"Kieffer BL, Gaveriaux-Ruff C (2002) Exploring the opioid system by gene knockout. Prog Neurobiol 66:285\u2013306","journal-title":"Prog Neurobiol"},{"key":"2172_CR64","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1038\/nn.2407","volume":"12","author":"T King","year":"2009","unstructured":"King T et al (2009) Unmasking the tonic-aversive state in neuropathic pain. Nat Neurosci 12:1364\u20131366. https:\/\/doi.org\/10.1038\/nn.2407","journal-title":"Nat Neurosci"},{"key":"2172_CR65","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1124\/jpet.113.206573","volume":"347","author":"M Kouchek","year":"2013","unstructured":"Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q (2013) Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. J Pharmacol Exp Ther 347:258\u2013264. https:\/\/doi.org\/10.1124\/jpet.113.206573","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR66","unstructured":"Le Bars D, Villanueva L, Bouhassira D, Willer JC (1992) Diffuse noxious inhibitory controls (DNIC) in animals and in man. Patol Fiziol Eksp Ter, 55\u201365"},{"key":"2172_CR67","doi-asserted-by":"publisher","first-page":"5893","DOI":"10.1021\/jm8008986","volume":"51","author":"B Le Bourdonnec","year":"2008","unstructured":"Le Bourdonnec B et al (2008) Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N, N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859). J Med Chem 51:5893\u20135896. https:\/\/doi.org\/10.1021\/jm8008986","journal-title":"J Med Chem"},{"key":"2172_CR68","doi-asserted-by":"publisher","first-page":"5685","DOI":"10.1021\/jm900773n","volume":"52","author":"B Le Bourdonnec","year":"2009","unstructured":"Le Bourdonnec B et al (2009) Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N, N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). J Med Chem 52:5685\u20135702. https:\/\/doi.org\/10.1021\/jm900773n","journal-title":"J Med Chem"},{"key":"2172_CR69","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1385\/JMN:25:3:207","volume":"25","author":"AL Lucido","year":"2005","unstructured":"Lucido AL, Morinville A, Gendron L, Stroh T, Beaudet A (2005) Prolonged morphine treatment selectively increases membrane recruitment of delta-opioid receptors in mouse basal ganglia. J Mol Neurosci 25:207\u2013214. https:\/\/doi.org\/10.1385\/JMN:25:3:207","journal-title":"J Mol Neurosci"},{"key":"2172_CR70","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/0166-2236(95)93946-U","volume":"18","author":"A Mansour","year":"1995","unstructured":"Mansour A, Fox CA, Akil H, Watson SJ (1995) Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci 18:22\u201329","journal-title":"Trends Neurosci"},{"key":"2172_CR71","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/cne.903500307","volume":"350","author":"A Mansour","year":"1994","unstructured":"Mansour A, Fox CA, Burke S, Meng F, Thompson RC, Akil H, Watson SJ (1994) Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. J Comp Neurol 350:412\u2013438. https:\/\/doi.org\/10.1002\/cne.903500307","journal-title":"J Comp Neurol"},{"key":"2172_CR72","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1016\/S0140-6736(99)03528-X","volume":"353","author":"H McQuay","year":"1999","unstructured":"McQuay H (1999) Opioids in pain management. Lancet 353:2229\u20132232. https:\/\/doi.org\/10.1016\/S0140-6736(99)03528-X","journal-title":"Lancet"},{"key":"2172_CR73","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/cne.10839","volume":"465","author":"F Mennicken","year":"2003","unstructured":"Mennicken F, Zhang J, Hoffert C, Ahmad S, Beaudet A, O'Donnell D (2003) Phylogenetic changes in the expression of delta opioid receptors in spinal cord and dorsal root ganglia. J Comp Neurol 465:349\u2013360. https:\/\/doi.org\/10.1002\/cne.10839","journal-title":"J Comp Neurol"},{"key":"2172_CR74","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0014-2999(01)00814-7","volume":"415","author":"J Mika","year":"2001","unstructured":"Mika J, Przewlocki R, Przewlocka B (2001) The role of delta-opioid receptor subtypes in neuropathic pain. Eur J Pharmacol 415:31\u201337","journal-title":"Eur J Pharmacol"},{"key":"2172_CR75","doi-asserted-by":"publisher","first-page":"5549","DOI":"10.1523\/JNEUROSCI.2719-03.2004","volume":"24","author":"A Morinville","year":"2004","unstructured":"Morinville A et al (2004) Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord. J Neurosci 24:5549\u20135559. https:\/\/doi.org\/10.1523\/JNEUROSCI.2719-03.2004","journal-title":"J Neurosci"},{"key":"2172_CR76","doi-asserted-by":"publisher","first-page":"4888","DOI":"10.1523\/JNEUROSCI.23-12-04888.2003","volume":"23","author":"A Morinville","year":"2003","unstructured":"Morinville A, Cahill CM, Esdaile MJ, Aibak H, Collier B, Kieffer BL, Beaudet A (2003) Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice. J Neurosci 23:4888\u20134898","journal-title":"J Neurosci"},{"key":"2172_CR77","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1177\/0333102418777507","volume":"39","author":"LS Moye","year":"2019","unstructured":"Moye LS, Novack ML, Tipton AF, Krishnan H, Pandey SC, Pradhan AA (2019a) The development of a mouse model of mTBI-induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target. Cephalalgia 39:77\u201390. https:\/\/doi.org\/10.1177\/0333102418777507","journal-title":"Cephalalgia"},{"key":"2172_CR78","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuropharm.2018.12.017","volume":"148","author":"LS Moye","year":"2019","unstructured":"Moye LS, Tipton AF, Dripps I, Sheets Z, Crombie A, Violin JD, Pradhan AA (2019b) Delta opioid receptor agonists are effective for multiple types of headache disorders. Neuropharmacology 148:77\u201386. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.12.017","journal-title":"Neuropharmacology"},{"key":"2172_CR79","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1111\/j.1460-9568.2006.04569.x","volume":"23","author":"X Nadal","year":"2006","unstructured":"Nadal X, Banos JE, Kieffer BL, Maldonado R (2006) Neuropathic pain is enhanced in delta-opioid receptor knockout mice. Eur J Neurosci 23:830\u2013834","journal-title":"Eur J Neurosci"},{"key":"2172_CR80","first-page":"362","volume":"286","author":"SS Negus","year":"1998","unstructured":"Negus SS, Gatch MB, Mello NK, Zhang X, Rice K (1998) Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. J Pharmacol Exp Ther 286:362\u2013375","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR81","doi-asserted-by":"publisher","first-page":"11703","DOI":"10.1523\/JNEUROSCI.1631-13.2013","volume":"33","author":"A Normandin","year":"2013","unstructured":"Normandin A, Luccarini P, Molat JL, Gendron L, Dallel R (2013) Spinal mu and delta opioids inhibit both thermal and mechanical pain in rats. J Neurosci 33:11703\u201311714. https:\/\/doi.org\/10.1523\/JNEUROSCI.1631-13.2013","journal-title":"J Neurosci"},{"key":"2172_CR82","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.pain.2008.12.006","volume":"141","author":"I Obara","year":"2009","unstructured":"Obara I, Parkitna JR, Korostynski M, Makuch W, Kaminska D, Przewlocka B, Przewlocki R (2009) Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain. Pain 141:283\u2013291. https:\/\/doi.org\/10.1016\/j.pain.2008.12.006","journal-title":"Pain"},{"key":"2172_CR83","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.neuroscience.2011.03.052","volume":"183","author":"V Otis","year":"2011","unstructured":"Otis V, Sarret P, Gendron L (2011) Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience 183:221\u2013229. https:\/\/doi.org\/10.1016\/j.neuroscience.2011.03.052","journal-title":"Neuroscience"},{"key":"2172_CR84","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/cne.903260206","volume":"326","author":"F Pasquini","year":"1992","unstructured":"Pasquini F, Bochet P, Garbay-Jaureguiberry C, Roques BP, Rossier J, Beaudet A (1992) Electron microscopic localization of photoaffinity-labelled delta opioid receptors in the neostriatum of the rat. J Comp Neurol 326:229\u2013244. https:\/\/doi.org\/10.1002\/cne.903260206","journal-title":"J Comp Neurol"},{"key":"2172_CR85","doi-asserted-by":"publisher","first-page":"8825","DOI":"10.1523\/JNEUROSCI.0160-05.2005","volume":"25","author":"AM Patwardhan","year":"2005","unstructured":"Patwardhan AM, Berg KA, Akopain AN, Jeske NA, Gamper N, Clarke WP, Hargreaves KM (2005) Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors. J Neurosci 25:8825\u20138832. https:\/\/doi.org\/10.1523\/JNEUROSCI.0160-05.2005","journal-title":"J Neurosci"},{"key":"2172_CR86","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.pain.2006.05.007","volume":"125","author":"AM Patwardhan","year":"2006","unstructured":"Patwardhan AM, Diogenes A, Berg KA, Fehrenbacher JC, Clarke WP, Akopian AN, Hargreaves KM (2006) PAR-2 agonists activate trigeminal nociceptors and induce functional competence in the delta opioid receptor. Pain 125:114\u2013124. https:\/\/doi.org\/10.1016\/j.pain.2006.05.007","journal-title":"Pain"},{"key":"2172_CR87","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1124\/jpet.103.055590","volume":"307","author":"P Petrillo","year":"2003","unstructured":"Petrillo P et al (2003) Evidence for a selective role of the delta-opioid agonist [8R-(4bS*,8aalpha,8abeta, 12bbeta)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoli ne hydrochloride (SB-235863) in blocking hyperalgesia associated with inflammatory and neuropathic pain responses. J Pharmacol Exp Ther 307:1079\u20131089. https:\/\/doi.org\/10.1124\/jpet.103.055590","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR88","doi-asserted-by":"publisher","first-page":"10762","DOI":"10.1523\/JNEUROSCI.0123-13.2013","volume":"33","author":"L Pettinger","year":"2013","unstructured":"Pettinger L, Gigout S, Linley JE, Gamper N (2013) Bradykinin controls pool size of sensory neurons expressing functional delta-opioid receptors. J Neurosci 33:10762\u201310771. https:\/\/doi.org\/10.1523\/JNEUROSCI.0123-13.2013","journal-title":"J Neurosci"},{"key":"2172_CR89","first-page":"341","volume":"230","author":"F Porreca","year":"1984","unstructured":"Porreca F, Mosberg HI, Hurst R, Hruby VJ, Burks TF (1984) Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse. J Pharmacol Exp Ther 230:341\u2013348","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR90","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1744-8069-9-8","volume":"9","author":"A Pradhan","year":"2013","unstructured":"Pradhan A, Smith M, McGuire B, Evans C, Walwyn W (2013a) Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels. Mol Pain 9:8. https:\/\/doi.org\/10.1186\/1744-8069-9-8","journal-title":"Mol Pain"},{"key":"2172_CR91","doi-asserted-by":"publisher","first-page":"3541","DOI":"10.1523\/JNEUROSCI.4124-15.2016","volume":"36","author":"AA Pradhan","year":"2016","unstructured":"Pradhan AA et al (2016) Agonist-specific recruitment of arrestin isoforms differentially modify delta opioid receptor function. J Neurosci 36:3541\u20133551. https:\/\/doi.org\/10.1523\/JNEUROSCI.4124-15.2016","journal-title":"J Neurosci"},{"key":"2172_CR92","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.neuroscience.2006.04.021","volume":"141","author":"AA Pradhan","year":"2006","unstructured":"Pradhan AA, Siau C, Constantin A, Clarke PB (2006) Chronic morphine administration results in tolerance to delta opioid receptor-mediated antinociception. Neuroscience 141:947\u2013954","journal-title":"Neuroscience"},{"key":"2172_CR93","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.pain.2013.10.004","volume":"155","author":"AA Pradhan","year":"2014","unstructured":"Pradhan AA, Smith ML, McGuire B, Tarash I, Evans CJ, Charles A (2014) Characterization of a novel model of chronic migraine. Pain 155:269\u2013274. https:\/\/doi.org\/10.1016\/j.pain.2013.10.004","journal-title":"Pain"},{"key":"2172_CR94","doi-asserted-by":"publisher","first-page":"797","DOI":"10.4111\/kju.2013.54.11.797","volume":"54","author":"MR Pradhan","year":"2013","unstructured":"Pradhan MR, Ranjan P, Rao RN, Chipde SS, Pradhan K, Kapoor R (2013b) Inflammatory myofibroblastic tumor of the urinary bladder managed by laparoscopic partial cystectomy Korean. J Urol 54:797\u2013800. https:\/\/doi.org\/10.4111\/kju.2013.54.11.797","journal-title":"J Urol"},{"key":"2172_CR95","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0014-2999(99)00813-4","volume":"387","author":"C Qiu","year":"2000","unstructured":"Qiu C, Sora I, Ren K, Uhl G, Dubner R (2000) Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice. Eur J Pharmacol 387:163\u2013169","journal-title":"Eur J Pharmacol"},{"key":"2172_CR96","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/cne.21982","volume":"513","author":"MS Riedl","year":"2009","unstructured":"Riedl MS et al (2009) Coexpression of alpha 2A-adrenergic and delta-opioid receptors in substance P-containing terminals in rat dorsal horn. J Comp Neurol 513:385\u2013398","journal-title":"J Comp Neurol"},{"key":"2172_CR97","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0006-8993(94)91155-x","volume":"665","author":"GC Rossi","year":"1994","unstructured":"Rossi GC, Pasternak GW, Bodnar RJ (1994) Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medulla. Brain Res 665:85\u201393. https:\/\/doi.org\/10.1016\/0006-8993(94)91155-x","journal-title":"Brain Res"},{"key":"2172_CR98","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ejphar.2008.11.028","volume":"602","author":"MP Rowan","year":"2009","unstructured":"Rowan MP, Ruparel NB, Patwardhan AM, Berg KA, Clarke WP, Hargreaves KM (2009) Peripheral delta opioid receptors require priming for functional competence in vivo. Eur J Pharmacol 602:283\u2013287. https:\/\/doi.org\/10.1016\/j.ejphar.2008.11.028","journal-title":"Eur J Pharmacol"},{"key":"2172_CR99","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bbr.2011.04.041","volume":"223","author":"A Saitoh","year":"2011","unstructured":"Saitoh A et al (2011) The novel delta opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions. Behav Brain Res 223:271\u2013279","journal-title":"Behav Brain Res"},{"key":"2172_CR100","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.neuroscience.2011.05.062","volume":"190","author":"JL Saloman","year":"2011","unstructured":"Saloman JL, Niu KY, Ro JY (2011) Activation of peripheral delta-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats. Neuroscience 190:379\u2013385. https:\/\/doi.org\/10.1016\/j.neuroscience.2011.05.062","journal-title":"Neuroscience"},{"key":"2172_CR101","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.cell.2009.04.019","volume":"137","author":"G Scherrer","year":"2009","unstructured":"Scherrer G et al (2009) Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell 137:1148\u20131159. https:\/\/doi.org\/10.1016\/j.cell.2009.04.019","journal-title":"Cell"},{"key":"2172_CR102","doi-asserted-by":"publisher","first-page":"9691","DOI":"10.1073\/pnas.0603359103","volume":"103","author":"G Scherrer","year":"2006","unstructured":"Scherrer G et al (2006) Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci USA 103:9691\u20139696. https:\/\/doi.org\/10.1073\/pnas.0603359103","journal-title":"Proc Natl Acad Sci USA"},{"key":"2172_CR103","doi-asserted-by":"publisher","first-page":"13538","DOI":"10.1523\/JNEUROSCI.4013-12.2013","volume":"33","author":"DJ Schuster","year":"2013","unstructured":"Schuster DJ, Kitto KF, Overland AC, Messing RO, Stone LS, Fairbanks CA, Wilcox GL (2013) Protein kinase Cepsilon is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs. J Neurosci 33:13538\u201313546. https:\/\/doi.org\/10.1523\/JNEUROSCI.4013-12.2013","journal-title":"J Neurosci"},{"key":"2172_CR104","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1091\/mbc.E18-05-0292","volume":"30","author":"DJ Shiwarski","year":"2019","unstructured":"Shiwarski DJ, Crilly SE, Dates A, Puthenveedu MA (2019) Dual RXR motifs regulate nerve growth factor-mediated intracellular retention of the delta opioid receptor. Mol Biol Cell 30:680\u2013690. https:\/\/doi.org\/10.1091\/mbc.E18-05-0292","journal-title":"Mol Biol Cell"},{"key":"2172_CR105","doi-asserted-by":"publisher","first-page":"589","DOI":"10.2147\/JPR.S55782","volume":"7","author":"HS Smith","year":"2014","unstructured":"Smith HS, Peppin JF (2014) Toward a systematic approach to opioid rotation. J Pain Res 7:589\u2013608. https:\/\/doi.org\/10.2147\/JPR.S55782","journal-title":"J Pain Res"},{"key":"2172_CR106","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1097\/00001756-200005150-00012","volume":"11","author":"JH Sohn","year":"2000","unstructured":"Sohn JH, Lee BH, Park SH, Ryu JW, Kim BO, Park YG (2000) Microinjection of opiates into the periaqueductal gray matter attenuates neuropathic pain symptoms in rats. NeuroReport 11:1413\u20131416","journal-title":"NeuroReport"},{"key":"2172_CR107","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/13543784.2017.1275562","volume":"26","author":"V Spahn","year":"2017","unstructured":"Spahn V, Stein C (2017) Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development. Expert Opin Investig Drugs 26:155\u2013160. https:\/\/doi.org\/10.1080\/13543784.2017.1275562","journal-title":"Expert Opin Investig Drugs"},{"key":"2172_CR108","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.mcn.2016.12.005","volume":"79","author":"E St-Louis","year":"2017","unstructured":"St-Louis E et al (2017) Involvement of the coatomer protein complex I in the intracellular traffic of the delta opioid receptor. Mol Cell Neurosci 79:53\u201363. https:\/\/doi.org\/10.1016\/j.mcn.2016.12.005","journal-title":"Mol Cell Neurosci"},{"key":"2172_CR109","first-page":"1269","volume":"248","author":"C Stein","year":"1989","unstructured":"Stein C, Millan MJ, Shippenberg TS, Peter K, Herz A (1989) Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors. J Pharmacol Exp Ther 248:1269\u20131275","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR110","first-page":"701","volume":"268","author":"PE Stewart","year":"1994","unstructured":"Stewart PE, Hammond DL (1994) Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat. J Pharmacol Exp Ther 268:701\u2013708","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR111","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s10194-016-0696-8","volume":"17","author":"K Thorlund","year":"2016","unstructured":"Thorlund K et al (2016) Risk of medication overuse headache across classes of treatments for acute migraine. J Headache Pain 17:107. https:\/\/doi.org\/10.1186\/s10194-016-0696-8","journal-title":"J Headache Pain"},{"key":"2172_CR112","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.3881","volume":"18","author":"D Usoskin","year":"2015","unstructured":"Usoskin D et al (2015) Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci 18:145\u2013153. https:\/\/doi.org\/10.1038\/nn.3881","journal-title":"Nat Neurosci"},{"key":"2172_CR113","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1111\/bph.14353","volume":"175","author":"A Vicente-Sanchez","year":"2018","unstructured":"Vicente-Sanchez A, Dripps IJ, Tipton AF, Akbari H, Akbari A, Jutkiewicz EM, Pradhan AA (2018) Tolerance to high-internalizing delta opioid receptor agonist is critically mediated by arrestin 2. Br J Pharmacol 175:3050\u20133059. https:\/\/doi.org\/10.1111\/bph.14353","journal-title":"Br J Pharmacol"},{"key":"2172_CR114","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1523\/JNEUROSCI.0415-09.2009","volume":"29","author":"WY Xie","year":"2009","unstructured":"Xie WY, He Y, Yang YR, Li YF, Kang K, Xing BM, Wang Y (2009) Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance. J Neurosci 29:3551\u20133564. https:\/\/doi.org\/10.1523\/JNEUROSCI.0415-09.2009","journal-title":"J Neurosci"},{"key":"2172_CR115","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082164","author":"MF Yam","year":"2018","unstructured":"Yam MF, Loh YC, Tan CS, Khadijah Adam S, Abdul Manan N, Basir R (2018) General pathways of pain sensation and the major neurotransmitters involved in pain regulation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19082164","journal-title":"Int J Mol Sci"},{"key":"2172_CR116","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.jpain.2012.01.006","volume":"13","author":"Y Ye","year":"2012","unstructured":"Ye Y, Dang D, Viet CT, Dolan JC, Schmidt BL (2012) Analgesia targeting IB4-positive neurons in cancer-induced mechanical hypersensitivity. J Pain 13:524\u2013531. https:\/\/doi.org\/10.1016\/j.jpain.2012.01.006","journal-title":"J Pain"},{"key":"2172_CR117","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/S0306-4522(97)00341-2","volume":"82","author":"X Zhang","year":"1998","unstructured":"Zhang X, Bao L, Arvidsson U, Elde R, Hokfelt T (1998) Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: evidence for association with the membrane of large dense-core vesicles. Neuroscience 82:1225\u20131242","journal-title":"Neuroscience"},{"key":"2172_CR118","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.pneurobio.2009.10.011","volume":"90","author":"X Zhang","year":"2010","unstructured":"Zhang X, Bao L, Ma GQ (2010) Sorting of neuropeptides and neuropeptide receptors into secretory pathways. Prog Neurobiol 90:276\u2013283. https:\/\/doi.org\/10.1016\/j.pneurobio.2009.10.011","journal-title":"Prog Neurobiol"},{"key":"2172_CR119","first-page":"1000","volume":"286","author":"L Zhou","year":"1998","unstructured":"Zhou L, Zhang Q, Stein C, Schafer M (1998) Contribution of opioid receptors on primary afferent versus sympathetic neurons to peripheral opioid analgesia. J Pharmacol Exp Ther 286:1000\u20131006","journal-title":"J Pharmacol Exp Ther"},{"key":"2172_CR120","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1523\/JNEUROSCI.18-07-02538.1998","volume":"18","author":"Y Zhu","year":"1998","unstructured":"Zhu Y, Hsu MS, Pintar JE (1998) Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse. J Neurosci 18:2538\u20132549","journal-title":"J Neurosci"},{"key":"2172_CR121","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0896-6273(00)80836-3","volume":"24","author":"Y Zhu","year":"1999","unstructured":"Zhu Y et al (1999) Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron 24:243\u2013252","journal-title":"Neuron"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-020-02172-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00702-020-02172-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-020-02172-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:42:07Z","timestamp":1616028127000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00702-020-02172-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":121,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["2172"],"URL":"https:\/\/doi.org\/10.1007\/s00702-020-02172-4","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,18]]},"assertion":[{"value":"19 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}