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Alterations within the raphe mesencephalic nucleus in the brain have been reported not only in patients with major depression but in patients with depressive symptoms accompanying several neurodegenerative disorders. The aim of the study was to assess the echogenicity of the nucleus raphe and other basal ganglia in patients with Huntington\u2019s disease (HD). TCS was performed in 127 HD patients participating in observational studies (Registry\/Enroll-HD) in the Institute of Psychiatry and Neurology (Warsaw, Poland). Raphe hypoechogenicity was found in 78% of HD patients with current symptoms of depression (according to DSM-IV criteria), 57% of patients with a previous history of depression, and 56.8% patients who lacked signs or history of depression. Patients with hypoechogenic raphe reported significantly higher depression as measured on the BDI (15.6\u2009\u00b1\u20091.7) as compared to patients with normal echogenicity (9.5\u2009\u00b1\u20091.2), (<jats:italic>p<\/jats:italic>\u2009=\u20090.023). The diameter of the third ventricle was negatively correlated with Mini-Mental State Examination (MMSE) (rho \u2212 0.37) and total functional capacity (TFC) scores (rho \u2212 0.26). Hyperechogenic substantia nigra was visualized in 66,4% patients with HD and the degree of hyperechogenicity was correlated with the total motor score (TMS) (rho \u2212 0.38). Changes in echogenicity of the basal ganglia are related to both depressive and motor symptoms among patients with HD.<\/jats:p>","DOI":"10.1007\/s00702-020-02187-x","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T14:02:40Z","timestamp":1586786560000},"page":"1047-1055","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Alterations in transcranial sonography among Huntington\u2019s disease patients with psychiatric symptoms"],"prefix":"10.1007","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0531-9558","authenticated-orcid":false,"given":"Grzegorz","family":"Witkowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Jachinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Stepniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Ziora-Jakutowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina","family":"Sienkiewicz-Jarosz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,13]]},"reference":[{"key":"2187_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0272-7358(88)90050-5","volume":"8","author":"AT Beck","year":"1988","unstructured":"Beck AT, Steer RA, Garbin MG (1988) Psychometric properties of the Beck Depression Inventory twenty-five years of evaluation. 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The authors also confirm that the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Authors declare that informed consents for participation in Registry study were obtained from all participants. Moreover, informed consents for transcranial ulltrasonographic examination were also obtained from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Authors declare that consent for publication of blinded data was a part of informed consents obtained from participants.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}