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Both genetic factors and environmental factors play an important role in PD pathogenesis and response to treatment. However, PD is clinically heterogeneous and genetically complex, and the exact genetic or environmental causes of this disorder remain unclear. Various approaches for detecting disease-causing genes have recently been made available. In particular, genome-wide association studies (GWAS) have attracted attention for the identification of disease-associated loci of multifactorial disorders. This review introduces GWAS of PD, followed by a discussion about the limitations of GWAS and the major challenges facing geneticists in the post-GWAS era. Alternative strategies to address these challenges are then proposed, such as epigenome-wide association studies (EWAS) and rare variant association studies (RVAS) using next-generation sequencing. To date, however, few reports have described these analyses, and the evidence remains insufficient to confidently identify or exclude rare variants or epigenetic changes in PD. Further analyses are therefore required, using sample sizes in the tens of thousands, extensive functional annotations, and highly targeted hypothesis testing.<\/jats:p>","DOI":"10.1007\/s00702-020-02205-y","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:02:48Z","timestamp":1588996968000},"page":"1517-1526","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genetic and epigenetic analyses of panic disorder in the post-GWAS era"],"prefix":"10.1007","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0636-277X","authenticated-orcid":false,"given":"Yoshiro","family":"Morimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Kurotaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"issue":"4","key":"2205_CR1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.biopsych.2018.09.011","volume":"85","author":"M Abdulkadir","year":"2019","unstructured":"Abdulkadir M, Mathews CA, Scharf JM, Yu D, Tischfield JA, Heiman GA, Hoekstra PJ, Dietrich A (2019) Polygenic risk scores derived from a Tourette syndrome genome-wide association study predict presence of tics in the Avon Longitudinal Study of Parents and Children Cohort. 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