{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:04:25Z","timestamp":1781658265987,"version":"3.54.5"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006009","name":"Celal Bayar \u00dcniversitesi","doi-asserted-by":"publisher","award":["2018-225"],"award-info":[{"award-number":["2018-225"]}],"id":[{"id":"10.13039\/501100006009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00702-020-02234-7","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T12:04:06Z","timestamp":1595333046000},"page":"1419-1426","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Examination of plasma zonulin levels in bipolar I disorder: a case\u2013control study with follow-up"],"prefix":"10.1007","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-7394","authenticated-orcid":false,"given":"Orkun","family":"Ayd\u0131n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"Kocaba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"Sarand\u00f6l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"Ta\u015ftan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece","family":"Onur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fen","family":"Esen-Danac\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"2234_CR1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3389\/fpsyt.2018.00730","volume":"9","author":"E Aizawa","year":"2019","unstructured":"Aizawa E, Tsuji H, Asahara T, Takahashi T, Teraishi T, Yoshida S et al (2019) Bifidobacterium and Lactobacillus counts in the gut microbiota of patients with bipolar disorder and healthy controls. Front Psychiatry 9:730","journal-title":"Front Psychiatry"},{"issue":"1","key":"2234_CR2","doi-asserted-by":"crossref","first-page":"e0210728","DOI":"10.1371\/journal.pone.0210728","volume":"14","author":"M Ajamian","year":"2019","unstructured":"Ajamian M, Steer D, Rosella G, Gibson PR (2019) Serum zonulin as a marker of intestinal mucosal barrier function: may not be what it seems. PLoS ONE 14(1):e0210728","journal-title":"PLoS ONE"},{"issue":"2","key":"2234_CR3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/comp.2001.19756","volume":"42","author":"A Akdemir","year":"2001","unstructured":"Akdemir A, T\u00fcrk\u00e7apar MH, \u00d6rsel SD, Demirergi N, Dag I, \u00d6zbay MH (2001) Reliability and validity of the Turkish version of the Hamilton Depression Rating Scale. Compr Psychiatry 42(2):161\u2013165","journal-title":"Compr Psychiatry"},{"key":"2234_CR4","doi-asserted-by":"crossref","unstructured":"Barbaro MR, Cremon C, Caio G, Bellacosa L, De Giorgio R, Volta U et al (2014) Increased zonulin serum levels and correlation with symptoms in non-celiac gluten sensitivity and irritable bowel syndrome with diarrhea. Proc UEG Week","DOI":"10.1016\/S0016-5085(15)30192-X"},{"key":"2234_CR5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.schres.2019.07.006","volume":"211","author":"GS Barber","year":"2019","unstructured":"Barber GS, Sturgeon C, Fasano A, Cascella NG, Eaton WW, McMahon RP, Kelly DL (2019) Elevated zonulin, a measure of tight-junction permeability, may be implicated in schizophrenia. Schizophr Res 211:111\u2013112","journal-title":"Schizophr Res"},{"issue":"19","key":"2234_CR6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00535-008-2266-6","volume":"44","author":"I Bjarnason","year":"2009","unstructured":"Bjarnason I, Takeuchi K (2009) Intestinal permeability in the pathogenesis of NSAID-induced enteropathy. J Gastroenterol 44(19):23\u201329","journal-title":"J Gastroenterol"},{"issue":"2","key":"2234_CR7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.18231\/j.tjp.2019.022","volume":"5","author":"S Chandran","year":"2019","unstructured":"Chandran S, Manohari SM, Raman V (2019) The gut\u2013brain connection: a qualitative review of the conceptualisation and implications of the gut\u2013brain\u2013microbiome axis. Telangana J Psychiatry 5(2):94","journal-title":"Telangana J Psychiatry"},{"issue":"4","key":"2234_CR8","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/MPG.0b013e3181dcc4a5","volume":"51","author":"L de Magistris","year":"2010","unstructured":"de Magistris L, Familiari V, Pascotto A, Sapone A, Frolli A, Iardino P et al (2010) Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr 51(4):418\u2013424","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2234_CR9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbi.2016.12.010","volume":"62","author":"F Dickerson","year":"2017","unstructured":"Dickerson F, Severance E, Yolken R (2017) The microbiome, immunity, and schizophrenia and bipolar disorder. Brain Behav Immun 62:46\u201352","journal-title":"Brain Behav Immun"},{"issue":"4","key":"2234_CR10","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/00365520500235334","volume":"41","author":"S Drago","year":"2006","unstructured":"Drago S, El Asmar R, Di Pierro M, Grazia Clemente M, Sapone ATA, Thakar M et al (2006) Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol 41(4):408\u2013419","journal-title":"Scand J Gastroenterol"},{"key":"2234_CR11","doi-asserted-by":"publisher","DOI":"10.5080\/u23431","author":"M Elbir","year":"2019","unstructured":"Elbir M, Alp Topba\u015f \u00d6, Bayad S, Kocaba\u015f T, Z\u00fclkif Topak O, \u00c7etin \u015e et al (2019) Adaptation and reliability of the structured clinical interview for DSM-5-disorders\u2014clinician version (SCID-5\/CV) to the Turkish language. Turk Psikiyatri Dergisi. https:\/\/doi.org\/10.5080\/u23431","journal-title":"Turk Psikiyatri Dergisi"},{"issue":"7","key":"2234_CR12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/1028415X.2017.1313569","volume":"21","author":"C Erg\u00fcn","year":"2018","unstructured":"Erg\u00fcn C, Urhan M, Ayer A (2018) A review on the relationship between gluten and schizophrenia: is gluten the cause? Nutr Neurosci 21(7):455\u2013466","journal-title":"Nutr Neurosci"},{"key":"2234_CR13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jpeds.2017.04.004","volume":"188","author":"E Esnafoglu","year":"2017","unstructured":"Esnafoglu E, C\u0131rr\u0131k S, Ayy\u0131ld\u0131z SN, Erdil A, Ert\u00fcrk EY, Dagl\u0131 A, Noyan T (2017) Increased serum zonulin levels as an intestinal permeability marker in autistic subjects. J Pediatr 188:240\u2013244","journal-title":"J Pediatr"},{"issue":"1","key":"2234_CR14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1749-6632.2012.06538.x","volume":"1258","author":"A Fasano","year":"2012","unstructured":"Fasano A (2012) Zonulin, regulation of tight junctions, and autoimmune diseases. Ann N Y Acad Sci 1258(1):25","journal-title":"Ann N Y Acad Sci"},{"key":"2234_CR15","doi-asserted-by":"crossref","unstructured":"Fasano, A. (2020). All disease begins in the (leaky) gut: Role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases. F1000Research, 9.","DOI":"10.12688\/f1000research.20510.1"},{"key":"2234_CR16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpeds.2017.05.038","volume":"188","author":"A Fasano","year":"2017","unstructured":"Fasano A, Hill I (2017) Serum zonulin, gut permeability, and the pathogenesis of autism spectrum disorders: Cause, effect, or an epiphenomenon? The Journal of pediatrics 188:15\u201317","journal-title":"The Journal of pediatrics"},{"issue":"1","key":"2234_CR17","first-page":"17","volume":"12","author":"G Fond","year":"2016","unstructured":"Fond G (2016) Microbiote intestinal: un r\u00f4le potentiel dans les troubles psychiatriques majeurs. M\u00e9decine 12(1):17\u201321","journal-title":"M\u00e9decine"},{"issue":"1","key":"2234_CR18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","volume":"23","author":"M Hamilton","year":"1960","unstructured":"Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23(1):56","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"2234_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-56847-4","volume":"10","author":"A Horvath","year":"2020","unstructured":"Horvath A, Leber B, Feldbacher N, Steinwender M, Komarova I, Rainer F et al (2020) The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study. Scientific reports 10(1):1\u201310","journal-title":"Scientific reports"},{"key":"2234_CR20","doi-asserted-by":"crossref","unstructured":"I\u015f\u0131k, \u00dc., Aydo\u011fan Av\u015far, P., Aktepe, E., Do\u011fu\u00e7, D. K., K\u0131l\u0131\u00e7, F., & B\u00fcy\u00fckbayram, H. \u0130. (2020). Serum zonulin and claudin-5 levels in children with obsessive\u2013compulsive disorder. Nordic Journal of Psychiatry, 1\u20136.","DOI":"10.1080\/13651501.2020.1801754"},{"key":"2234_CR21","unstructured":"Karada\u011f, F., Oral, T., Yalcin, F. A., & Erten, E. (2002). Reliability and validity of Turkish translation of young mania rating scale. Turk psikiyatri dergisi= Turkish journal of psychiatry, 13(2), 107\u2013114."},{"issue":"9","key":"2234_CR22","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.4088\/JCP.09m05874yel","volume":"72","author":"DE Kemp","year":"2011","unstructured":"Kemp DE, Johnson E, Wang WV, Tohen M, Calabrese JR (2011) Clinical utility of early improvement to predict response or remission in acute mania: focus on olanzapine and risperidone. The Journal of clinical psychiatry 72(9):1236\u20131241","journal-title":"The Journal of clinical psychiatry"},{"key":"2234_CR23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jad.2020.01.117","volume":"266","author":"F K\u0131l\u0131\u00e7","year":"2020","unstructured":"K\u0131l\u0131\u00e7 F, I\u015f\u0131k \u00dc, Demirda\u015f A, Do\u011fu\u00e7 DK, Bozkurt M (2020) Serum zonulin and claudin-5 levels in patients with bipolar disorder. J Affect Disord 266:37\u201342","journal-title":"J Affect Disord"},{"issue":"10","key":"2234_CR24","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1038\/ajg.2012.211","volume":"107","author":"DA Leffler","year":"2012","unstructured":"Leffler DA, Kelly CP, Abdallah HZ, Colatrella AM, Harris LA, Leon F et al (2012) A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge. The American journal of gastroenterology 107(10):1554","journal-title":"The American journal of gastroenterology"},{"issue":"1","key":"2234_CR25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1046\/j.1471-4159.2000.0740320.x","volume":"74","author":"R Lu","year":"2000","unstructured":"Lu R, Wang W, Uzzau S, Vigorito R, Zielke HR, Fasano A (2000) Affinity purification and partial characterization of the zonulin\/zonula occludens toxin (Zot) receptor from human brain. J Neurochem 74(1):320\u2013326","journal-title":"J Neurochem"},{"issue":"1","key":"2234_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-1781(01)00298-0","volume":"104","author":"M Maes","year":"2001","unstructured":"Maes M, Delanghe J, Chiavetto LB, Bignotti S, Tura G-B, Pioli R et al (2001) Haptoglobin polymorphism and schizophrenia: genetic variation on chromosome 16. Psychiatry Res 104(1):1\u20139","journal-title":"Psychiatry Res"},{"issue":"10","key":"2234_CR27","doi-asserted-by":"crossref","first-page":"7056","DOI":"10.1007\/s12035-019-1578-2","volume":"56","author":"M Maes","year":"2019","unstructured":"Maes M, Sirivichayakul S, Kanchanatawan B, Vodjani A (2019) Upregulation of the intestinal paracellular pathway with breakdown of tight and adherens junctions in deficit schizophrenia. Mol Neurobiol 56(10):7056\u20137073","journal-title":"Mol Neurobiol"},{"issue":"9","key":"2234_CR28","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1586\/ern.12.98","volume":"12","author":"RK McNamara","year":"2012","unstructured":"McNamara RK, Lotrich FE (2012) Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target? Expert Rev Neurother 12(9):1143\u20131161","journal-title":"Expert Rev Neurother"},{"issue":"8","key":"2234_CR29","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1007\/s00394-018-1784-0","volume":"57","author":"S M\u00f6rkl","year":"2018","unstructured":"M\u00f6rkl S, Lackner S, Meinitzer A, Mangge H, Lehofer M, Halwachs B et al (2018) Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women. Eur J Nutr 57(8):2985\u20132997","journal-title":"Eur J Nutr"},{"key":"2234_CR30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpsychires.2018.01.013","volume":"99","author":"TT Nguyen","year":"2018","unstructured":"Nguyen TT, Kosciolek T, Eyler LT, Knight R, Jeste DV (2018) Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder. J Psychiatr Res 99:50\u201361","journal-title":"J Psychiatr Res"},{"issue":"4","key":"2234_CR31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3892\/br.2017.865","volume":"6","author":"B Ohlsson","year":"2017","unstructured":"Ohlsson B, Roth B, Larsson E, H\u00f6glund P (2017) Calprotectin in serum and zonulin in serum and feces are elevated after introduction of a diet with lower carbohydrate content and higher fiber, fat and protein contents. Biomedical reports 6(4):411\u2013422","journal-title":"Biomedical reports"},{"key":"2234_CR32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.comppsych.2018.10.006","volume":"87","author":"G \u00d6zyurt","year":"2018","unstructured":"\u00d6zyurt G, \u00d6zt\u00fcrk Y, Appak Y\u00c7, Arslan FD, Baran M, Karakoyun \u0130 et al (2018) Increased zonulin is associated with hyperactivity and social dysfunctions in children with attention deficit hyperactivity disorder. Compr Psychiatry 87:138\u2013142","journal-title":"Compr Psychiatry"},{"issue":"15","key":"2234_CR33","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jpsychires.2010.03.006","volume":"44","author":"M Riedel","year":"2010","unstructured":"Riedel M, M\u00f6ller H-J, Obermeier M, Schennach-Wolff R, Bauer M, Adli M et al (2010) Response and remission criteria in major depression\u2013a validation of current practice. J Psychiatr Res 44(15):1063\u20131068","journal-title":"J Psychiatr Res"},{"key":"2234_CR34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pnpbp.2014.01.013","volume":"53","author":"JD Rosenblat","year":"2014","unstructured":"Rosenblat JD, Cha DS, Mansur RB, McIntyre RS (2014) Inflamed moods: a review of the interactions between inflammation and mood disorders. Prog Neuropsychopharmacol Biol Psychiatry 53:23\u201334","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2234_CR35","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fpsyt.2017.00104","volume":"8","author":"LM Rowland","year":"2017","unstructured":"Rowland LM, Demyanovich HK, Wijtenburg SA, Eaton WW, Rodriguez K, Gaston F et al (2017) Antigliadin antibodies (AGA IgG) are related to neurochemistry in schizophrenia. Frontiers in psychiatry 8:104","journal-title":"Frontiers in psychiatry"},{"key":"2234_CR36","doi-asserted-by":"crossref","unstructured":"Scheffler, L., Crane, A., Heyne, H., T\u00f6njes, A., Schleinitz, D., Ihling, C. H., et al. (2018). Widely used commercial ELISA does not detect preHP-2, but recognizes properdin as a potential second member of the zonulin family. bioRxiv, 157578.","DOI":"10.1101\/157578"},{"key":"2234_CR37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pharmthera.2018.05.005","volume":"189","author":"EG Severance","year":"2018","unstructured":"Severance EG, Dickerson FB, Yolken RH (2018) Autoimmune phenotypes in schizophrenia reveal novel treatment targets. Pharmacol Ther 189:184\u2013198","journal-title":"Pharmacol Ther"},{"issue":"2","key":"2234_CR38","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s12640-019-00126-7","volume":"37","author":"D Simeonova","year":"2020","unstructured":"Simeonova D, Stoyanov D, Leunis J, Carvalho AF, Kubera M, Murdjeva M, Maes M (2020) Increased Serum Immunoglobulin Responses to Gut Commensal Gram-Negative Bacteria in Unipolar Major Depression and Bipolar Disorder Type 1, Especially When Melancholia Is Present. Neurotox Res 37(2):338\u2013348","journal-title":"Neurotox Res"},{"issue":"5","key":"2234_CR39","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00213-018-5102-6","volume":"236","author":"K Skonieczna-\u017bydecka","year":"2019","unstructured":"Skonieczna-\u017bydecka K, \u0141oniewski I, Misera A, Stachowska E, Maciejewska D, Marlicz W, Galling B (2019) Second-generation antipsychotics and metabolism alterations: a systematic review of the role of the gut microbiome. Psychopharmacology 236(5):1491\u20131512","journal-title":"Psychopharmacology"},{"issue":"8","key":"2234_CR40","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1136\/gutjnl-2017-314759","volume":"67","author":"BR Stevens","year":"2018","unstructured":"Stevens BR, Goel R, Seungbum K, Richards EM, Holbert RC, Pepine CJ, Raizada MK (2018) Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression. Gut 67(8):1555\u20131557","journal-title":"Gut"},{"issue":"4","key":"2234_CR41","doi-asserted-by":"crossref","first-page":"e1251384","DOI":"10.1080\/21688370.2016.1251384","volume":"4","author":"C Sturgeon","year":"2016","unstructured":"Sturgeon C, Fasano A (2016) Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. Tissue barriers 4(4):e1251384","journal-title":"Tissue barriers"},{"key":"2234_CR42","doi-asserted-by":"crossref","unstructured":"Tatucu-Babet, O., Forsyth, A., Owen, E., Navarro-Perez, D., Radcliffe, J., Benheim, D., et al. (2020). Serum zonulin measured by enzyme-linked immunosorbent assay may not be a reliable marker of small intestinal permeability in healthy adults. Nutrition Research.","DOI":"10.1016\/j.nutres.2020.05.003"},{"issue":"39","key":"2234_CR43","doi-asserted-by":"crossref","first-page":"16799","DOI":"10.1073\/pnas.0906773106","volume":"106","author":"A Tripathi","year":"2009","unstructured":"Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS et al (2009) Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci 106(39):16799\u201316804","journal-title":"Proc Natl Acad Sci"},{"key":"2234_CR44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1749-6632.2009.04037.x","volume":"1165","author":"J Visser","year":"2009","unstructured":"Visser J, Rozing J, Sapone A, Lammers K, Fasano A (2009) Tight junctions, intestinal permeability, and autoimmunity celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci 1165:195","journal-title":"Ann N Y Acad Sci"},{"issue":"31","key":"2234_CR45","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.3748\/wjg.v23.i31.5669","volume":"23","author":"A Vojdani","year":"2017","unstructured":"Vojdani A, Vojdani E, Kharrazian D (2017) Fluctuation of zonulin levels in blood vs stability of antibodies. World J Gastroenterol 23(31):5669","journal-title":"World J Gastroenterol"},{"issue":"1","key":"2234_CR46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00726-005-0292-8","volume":"32","author":"C Wan","year":"2007","unstructured":"Wan C, La Y, Zhu H, Yang Y, Jiang L, Chen Y et al (2007) Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene. Amino Acids 32(1):101\u2013108","journal-title":"Amino Acids"},{"issue":"24","key":"2234_CR47","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1242\/jcs.113.24.4435","volume":"113","author":"W Wang","year":"2000","unstructured":"Wang W, Uzzau S, Goldblum SE, Fasano A (2000) Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci 113(24):4435\u20134440","journal-title":"J Cell Sci"},{"issue":"8","key":"2234_CR48","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1073\/pnas.0500178102","volume":"102","author":"T Watts","year":"2005","unstructured":"Watts T, Berti I, Sapone A, Gerarduzzi T, Not T, Zielke R, Fasano A (2005) Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci 102(8):2916\u20132921","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"2234_CR49","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","volume":"133","author":"RC Young","year":"1978","unstructured":"Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. The British journal of psychiatry 133(5):429\u2013435","journal-title":"The British journal of psychiatry"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-020-02234-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00702-020-02234-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-020-02234-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T23:52:09Z","timestamp":1626825129000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00702-020-02234-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["2234"],"URL":"https:\/\/doi.org\/10.1007\/s00702-020-02234-7","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,21]]},"assertion":[{"value":"23 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants"}},{"value":"The study was approved by the Ethics Committee for Clinical Studies of the Celal Bayar University (Application no: 33803, Decision no: 35\/30.07.2018) and required permissions were obtained from the administrative units of Uluda\u011f University Medical School.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants provided written informed consent; additional approvals were collected from the patients\u2019 guardians.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All participants provided written informed consent; additional approvals were collected from the patients\u2019 guardians.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors agreed and they gave their consent for publishing.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}