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To define non-motor and motor profiles and their respective impact on HRQoL in CD patients using the newly validated Dystonia Non-Motor Symptoms Questionnaire (DNMSQuest). In an observational prospective multicentre case\u2013control study, we enrolled 61 patients with CD and 61 age- and sex-matched healthy controls (HC) comparing demographic data, motor and non-motor symptoms and HRQoL measurements. 95% CD patients reported at least one NMS. Mean total NMS score was significantly higher in CD patients (5.62\u2009\u00b1\u20093.33) than in HC (1.74\u2009\u00b1\u20091.52;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Pain, insomnia and stigma were the most prevalent NMS and HRQoL was significantly impaired in CD patients compared to HC. There was strong correlation of NMS burden with HRQoL (CDQ-24:\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.72, EQ-5D:\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u2212\u00a00.59;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in CD patients. Regression analysis between HRQoL and NMS suggested that emotional well-being (standardized beta\u2009=\u2009\u2212\u00a00.352) and pain (standardized beta\u2009=\u2009\u2212\u00a00.291) had a major impact on HRQoL while, in contrast motor severity had no significant impact in this model. Most NMS with the exception of pain, stigma and ADL did not correlate with motor severity. NMS are highly prevalent in CD patients and occur independent of age, sex, disease duration, duration of botulinum neurotoxin therapy and socio-economic status. Specific NMS such as emotional well-being and pain have a major impact on HRQoL and are more relevant than motor severity.\n                  <\/jats:p>","DOI":"10.1007\/s00702-020-02274-z","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T09:02:50Z","timestamp":1604480570000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Emotional well-being and pain could be a greater determinant of quality of life compared to motor severity in cervical dystonia"],"prefix":"10.1007","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-6518","authenticated-orcid":false,"given":"Lisa","family":"Klingelhoefer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sauerbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Untucht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Wienecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00f6n\u00fcl","family":"Mammadova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Falkenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Gregor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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Robert Untucht: reports a grant from the Stiftung Hochschulmedizin (medical university foundation) Dresden and travel costs to a conference by Merz Pharma (Frankfurt, Germany). Bj\u00f6rn Falkenburger: received payment for consultations, talks or articles from Desitin, UCB, Thieme; research support from Deutsche Forschungsgemeinschaft and Merz. K. Ray Chaudhuri: Advisory board: AbbVie, UCB, GKC, Bial, Cynapsus, Novartis, Lobsor, Stada, Medtronic, Zambon, Profile, Sunovion, Roche, Therevance, Scion, Britannia. Honoraria for lectures: AbbVie, Britannia, UCB, Mundipharma, Zambon, Novartis, Boeringer Ingelheim. Grants (Investigator Initiated): Britania, AbbVie, UCB, GKC, Bial. Aacdemic grants: EU (Horizon 2020), IMI EU, Parkinson\u2019s UK, NIHR, PDNMG, NPF, MRC, Kirby Laing Foundation, Wellcome Trust. Heinz Reichmann: was acting on Advisory Boards, gave lectures and received research grants from Abbott, Abbvie, Bayer Health Care, Bial, Boehringer\/Ingelheim, Brittania, Cephalon, Desitin, GSK, Lundbeck, Medtronic, Merck-Serono, Novartis, Orion, Pfizer, TEVA, UCB Pharma, Valeant, Zambon, and Kyowa. Maximilian Kaiser, Anna Sauerbier, Miriam Wienecke, K\u00f6n\u00fcl Mammadova, Olaf Gregor: None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Obtained and described under methods.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Obtained and described under methods.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have approved the publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}