{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:11:44Z","timestamp":1785435104704,"version":"3.56.0"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Collaborative Center for X-Linked Dystonia-Parkinsonism"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>X-Linked Dystonia-Parkinsonism (XDP) is a neurodegenerative disease affecting individuals with ancestry to the island of Panay in the Philippines. In recent years there has been considerable progress at elucidating the genetic basis of XDP and candidate disease mechanisms in patient-derived cellular models, but the neural substrates that give rise to XDP in vivo are still poorly understood. Previous studies of limited XDP postmortem brain samples have reported a selective dropout of medium spiny neurons within the striatum, although neuroimaging of XDP patients has detected additional abnormalities in multiple brain regions beyond the basal ganglia. Given the need to fully define the CNS structures that are affected in this disease, we created a brain bank in Panay to serve as a tissue resource for detailed studies of XDP-related neuropathology. Here we describe this platform, from donor recruitment and consent to tissue collection, processing, and storage, that was assembled within a predominantly rural region of the Philippines with limited access to medical and laboratory facilities. Thirty-six brains from XDP individuals have been collected over an initial 4\u00a0years period. Tissue quality was assessed based on histologic staining of cortex, RNA integrity scores, detection of neuronal transcripts in situ by fluorescent hybridization chain reaction, and western blotting of neuronal and glial proteins. The results indicate that this pipeline preserves tissue integrity to an extent compatible with a range of morphologic, molecular, and biochemical analyses. Thus the algorithms that we developed for working in rural communities may serve as a guide for establishing similar brain banks for other rare diseases in indigenous populations.<\/jats:p>","DOI":"10.1007\/s00702-020-02286-9","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T01:33:19Z","timestamp":1610587999000},"page":"575-587","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Promise and challenges of dystonia brain banking: establishing a human tissue repository for studies of X-Linked Dystonia-Parkinsonism"],"prefix":"10.1007","volume":"128","author":[{"given":"Cara","family":"Fernandez-Cerado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Paul","family":"Legarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Salvie","family":"Velasco-Andrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abegail","family":"Aguil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niecy G.","family":"Ganza-Bautista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Benedict B.","family":"Lagarde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Soria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Dominic G.","family":"Jamora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Acu\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Vanderburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Sapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"DiFiglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela G.","family":"Murcar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Campion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie J.","family":"Ozelius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"Alessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malvindar K.","family":"Singh-Bains","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"Waldvogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L. M.","family":"Faull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Macalintal-Canlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin L.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen B.","family":"Penney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Ang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cid Czarina E.","family":"Diesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3203-6262","authenticated-orcid":false,"given":"D. Cristopher","family":"Bragg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Acu\u00f1a-Sunshine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"2286_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-8935-5_1","volume":"1897","author":"M Abdaljaleel","year":"2019","unstructured":"Abdaljaleel M, Singer EJ, Yong WH (2019) Sustainability in biobanking. Methods Mol Biol 1897:1\u20136. https:\/\/doi.org\/10.1007\/978-1-4939-8935-5_1","journal-title":"Methods Mol Biol"},{"issue":"7","key":"2286_CR2","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nmeth.2483","volume":"10","author":"X Adiconis","year":"2013","unstructured":"Adiconis X, Borges-Rivera D, Satija R, DeLuca DS, Busby MA, Berlin AM, Sivachenko A, Thompson DA, Wysoker A, Fennell T, Gnirke A, Pochet N, Regev A, Levin JZ (2013) Comparative analysis of RNA sequencing methods for degraded or low-input samples. Nat Methods 10(7):623\u20139. https:\/\/doi.org\/10.1038\/nmeth.2483","journal-title":"Nat Methods"},{"key":"2286_CR3","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.brainresbull.2018.08.014","volume":"145","author":"RO Akinyemi","year":"2019","unstructured":"Akinyemi RO et al (2019) Brain banking in low and middle-income countries: Raison D\u2019etre for the Ibadan Brain Ageing, Dementia And Neurodegeneration (IBADAN) Brain Bank Project. Brain Res Bull 145:136\u2013141. https:\/\/doi.org\/10.1016\/j.brainresbull.2018.08.014","journal-title":"Brain Res Bull"},{"issue":"897\u2013909","key":"2286_CR4","doi-asserted-by":"publisher","first-page":"e821","DOI":"10.1016\/j.cell.2018.02.011","volume":"172","author":"T Aneichyk","year":"2018","unstructured":"Aneichyk T et al (2018) Dissecting the causal mechanism of X-Linked Dystonia-Parkinsonism by integrating genome and transcriptome assembly. Cell 172(897\u2013909):e821. https:\/\/doi.org\/10.1016\/j.cell.2018.02.011","journal-title":"Cell"},{"key":"2286_CR5","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/0896-6273(95)90106-x","volume":"15","author":"N Aronin","year":"1995","unstructured":"Aronin N et al (1995) CAG expansion affects the expression of mutant Huntingtin in the Huntington\u2019s disease brain. Neuron 15:1193\u20131201. https:\/\/doi.org\/10.1016\/0896-6273(95)90106-x","journal-title":"Neuron"},{"key":"2286_CR6","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jocn.2005.06.008","volume":"13","author":"L Azizi","year":"2006","unstructured":"Azizi L, Garrick TM, Harper CG (2006) Brain donation for research: strong support in Australia. J Clin Neurosci 13:449\u2013452. https:\/\/doi.org\/10.1016\/j.jocn.2005.06.008","journal-title":"J Clin Neurosci"},{"key":"2286_CR7","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/00002093-199100530-00005","volume":"5","author":"M Bidaut-Russell","year":"1991","unstructured":"Bidaut-Russell M, Dowd DM, Grossberg GT, Zimny GH (1991) Survey of U.S. Alzheimer Brain Banks: a 1990 directory. Alzheimer Dis Assoc Disord 5:188\u2013193. https:\/\/doi.org\/10.1097\/00002093-199100530-00005","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"2286_CR8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s10561-010-9210-8","volume":"12","author":"AC Birdsill","year":"2011","unstructured":"Birdsill AC, Walker DG, Lue L, Sue LI, Beach TG (2011) Postmortem interval effect on RNA and gene expression in human brain tissue. Cell Tissue Bank 12:311\u2013318. https:\/\/doi.org\/10.1007\/s10561-010-9210-8","journal-title":"Cell Tissue Bank"},{"key":"2286_CR9","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.nicl.2017.10.025","volume":"17","author":"AJ Blood","year":"2018","unstructured":"Blood AJ et al (2018) Increased insula-putamen connectivity in X-linked dystonia-parkinsonism. Neuroimage Clin 17:835\u2013846. https:\/\/doi.org\/10.1016\/j.nicl.2017.10.025","journal-title":"Neuroimage Clin"},{"key":"2286_CR10","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1093\/geront\/gnv683","volume":"57","author":"L Boise","year":"2017","unstructured":"Boise L, Hinton L, Rosen HJ, Ruhl M (2017a) Will my soul go to heaven if they take my brain? Beliefs and worries about brain donation among four ethnic groups. Gerontologist 57:719\u2013734. https:\/\/doi.org\/10.1093\/geront\/gnv683","journal-title":"Gerontologist"},{"key":"2286_CR11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/WAD.0000000000000174","volume":"31","author":"L Boise","year":"2017","unstructured":"Boise L et al (2017b) Willingness to be a brain donor: a survey of research volunteers from 4 racial\/ethnic groups. Alzheimer Dis Assoc Disord 31:135\u2013140. https:\/\/doi.org\/10.1097\/WAD.0000000000000174","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"2286_CR12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1136\/jme.29.3.165","volume":"29","author":"M Boyes","year":"2003","unstructured":"Boyes M, Ward P (2003) Brain donation for schizophrenia research: gift, consent, and meaning. J Med Ethics 29:165\u2013168. https:\/\/doi.org\/10.1136\/jme.29.3.165","journal-title":"J Med Ethics"},{"key":"2286_CR13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1712526114","author":"DC Bragg","year":"2017","unstructured":"Bragg DC et al (2017) Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1. Proc Natl Acad Sci USA. https:\/\/doi.org\/10.1073\/pnas.1712526114","journal-title":"Proc Natl Acad Sci USA"},{"key":"2286_CR14","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1097\/WCO.0000000000000708","volume":"32","author":"DC Bragg","year":"2019","unstructured":"Bragg DC, Sharma N, Ozelius LJ (2019) X-linked dystonia-parkinsonism: recent advances. Curr Opin Neurol 32:604\u2013609. https:\/\/doi.org\/10.1097\/WCO.0000000000000708","journal-title":"Curr Opin Neurol"},{"key":"2286_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.parkreldis.2016.07.012","volume":"31","author":"N Bruggemann","year":"2016","unstructured":"Bruggemann N et al (2016) Neuroanatomical changes extend beyond striatal atrophy in X-linked dystonia parkinsonism. Parkinsonism Relat Disord 31:91\u201397. https:\/\/doi.org\/10.1016\/j.parkreldis.2016.07.012","journal-title":"Parkinsonism Relat Disord"},{"key":"2286_CR16","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1111\/ene.13256","volume":"24","author":"N Bruggemann","year":"2017","unstructured":"Bruggemann N et al (2017) Striatal dysfunction in X-linked dystonia-parkinsonism is associated with disease progression. Eur J Neurol 24:680\u2013686. https:\/\/doi.org\/10.1111\/ene.13256","journal-title":"Eur J Neurol"},{"key":"2286_CR17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s10561-020-09819-2","volume":"21","author":"RJW Chan","year":"2020","unstructured":"Chan RJW et al (2020) Patient attitudes towards brain donation across both neurodegenerative and non-neurodegenerative neurological disorders. Cell Tissue Bank 21:265\u2013277. https:\/\/doi.org\/10.1007\/s10561-020-09819-2","journal-title":"Cell Tissue Bank"},{"key":"2286_CR18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fmed.2017.00084","volume":"4","author":"C Chan-On","year":"2017","unstructured":"Chan-On C, Sarwal MM (2017) A comprehensive analysis of the current status and unmet needs in kidney transplantation in Southeast Asia. Front Med 4:84. https:\/\/doi.org\/10.3389\/fmed.2017.00084","journal-title":"Front Med"},{"issue":"9","key":"2286_CR19","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1101\/gr.189621.115","volume":"25","author":"M Cieslik","year":"2015","unstructured":"Cieslik M, Chugh R, Wu YM, Wu M, Brennan C, Lonigro R, Su F, Wang R, Siddiqui J, Mehra R, Cao X, Lucas D, Chinnaiyan AM, Robinson D (2015) The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing. Genome Res 25(9):1372\u201381. https:\/\/doi.org\/10.1101\/gr.189621.115","journal-title":"Genome Res"},{"key":"2286_CR20","first-page":"1","volume":"39","author":"FF Cruz-Sanchez","year":"1993","unstructured":"Cruz-Sanchez FF, Tolosa E (1993) The need of a consensus for brain banking. J Neural Transm Suppl 39:1\u20134","journal-title":"J Neural Transm Suppl"},{"key":"2286_CR21","first-page":"215","volume":"39","author":"FF Cruz-Sanchez","year":"1993","unstructured":"Cruz-Sanchez FF, Moral A, de Belleroche J, Rossi ML (1993) Amyotrophic lateral sclerosis brain banking: a proposal to standardize protocols and neuropathological diagnostic criteria. J Neural Transm Suppl 39:215\u2013222","journal-title":"J Neural Transm Suppl"},{"key":"2286_CR22","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.transproceed.2012.01.100","volume":"44","author":"RA Danguilan","year":"2012","unstructured":"Danguilan RA, De Belen-Uriarte R, Jorge SL, Lesaca RJ, Amarillo ML, Ampil RS, Ona ET (2012) National survey of Filipinos on acceptance of incentivized organ donation. Transplant Proc 44:839\u2013842. https:\/\/doi.org\/10.1016\/j.transproceed.2012.01.100","journal-title":"Transplant Proc"},{"key":"2286_CR23","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1001\/jamaneurol.2014.56","volume":"71","author":"A Domingo","year":"2014","unstructured":"Domingo A et al (2014) Woman with x-linked recessive dystonia-parkinsonism: clue to the epidemiology of parkinsonism in Filipino women? JAMA Neurol 71:1177\u20131180. https:\/\/doi.org\/10.1001\/jamaneurol.2014.56","journal-title":"JAMA Neurol"},{"key":"2286_CR24","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1080\/08870446.2012.669480","volume":"27","author":"V Eatough","year":"2012","unstructured":"Eatough V, Shaw K, Lees A (2012) Banking on brains: insights of brain donor relatives and friends from an experiential perspective. Psychol Health 27:1271\u20131290. https:\/\/doi.org\/10.1080\/08870446.2012.669480","journal-title":"Psychol Health"},{"key":"2286_CR25","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/mds.10271","volume":"17","author":"VG Evidente","year":"2002","unstructured":"Evidente VG et al (2002) Phenomenology of \u201cLubag\u201d or X-linked dystonia-parkinsonism. Mov Disord 17:1271\u20131277. https:\/\/doi.org\/10.1002\/mds.10271","journal-title":"Mov Disord"},{"key":"2286_CR26","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1001\/archneur.61.12.1956","volume":"61","author":"VG Evidente","year":"2004","unstructured":"Evidente VG, Nolte D, Niemann S, Advincula J, Mayo MC, Natividad FF, M\u00fcller U (2004) Phenotypic and molecular analyses of X-linked dystonia-parkinsonism (\u201clubag\u201d) in women. Arch Neurol 61:1956\u20131959. https:\/\/doi.org\/10.1001\/archneur.61.12.1956","journal-title":"Arch Neurol"},{"key":"2286_CR27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/nen.0b013e31802c3e7d","volume":"66","author":"I Ferrer","year":"2007","unstructured":"Ferrer I et al (2007) Brain protein preservation largely depends on the postmortem storage temperature: implications for study of proteins in human neurologic diseases and management of brain banks: a BrainNet Europe Study. J Neuropathol Exp Neurol 66:35\u201346. https:\/\/doi.org\/10.1097\/nen.0b013e31802c3e7d","journal-title":"J Neuropathol Exp Neurol"},{"key":"2286_CR28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10561-008-9077-0","volume":"9","author":"I Ferrer","year":"2008","unstructured":"Ferrer I, Martinez A, Boluda S, Parchi P, Barrachina M (2008) Brain banks: benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies. Cell Tissue Bank 9:181\u2013194. https:\/\/doi.org\/10.1007\/s10561-008-9077-0","journal-title":"Cell Tissue Bank"},{"key":"2286_CR29","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s10561-014-9465-6","volume":"16","author":"MK Fonseca","year":"2015","unstructured":"Fonseca MK et al (2015) Assessing families\u2019 and patients\u2019 attitudes toward brain donation for research purposes in a Brazilian population sample. Cell Tissue Bank 16:287\u2013294. https:\/\/doi.org\/10.1007\/s10561-014-9465-6","journal-title":"Cell Tissue Bank"},{"key":"2286_CR30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/B978-0-444-63639-3.00004-9","volume":"150","author":"M Freund","year":"2018","unstructured":"Freund M, Taylor A, Ng C, Little AR (2018) The NIH NeuroBioBank: creating opportunities for human brain research. Handb Clin Neurol 150:41\u201348. https:\/\/doi.org\/10.1016\/B978-0-444-63639-3.00004-9","journal-title":"Handb Clin Neurol"},{"key":"2286_CR31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/ana.20513","volume":"58","author":"S Goto","year":"2005","unstructured":"Goto S et al (2005) Functional anatomy of the basal ganglia in X-linked recessive dystonia-parkinsonism. Ann Neurol 58:7\u201317. https:\/\/doi.org\/10.1002\/ana.20513","journal-title":"Ann Neurol"},{"key":"2286_CR32","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/brain\/awt084","volume":"136","author":"S Goto","year":"2013","unstructured":"Goto S et al (2013) Defects in the striatal neuropeptide Y system in X-linked dystonia-parkinsonism. Brain 136:1555\u20131567. https:\/\/doi.org\/10.1093\/brain\/awt084","journal-title":"Brain"},{"key":"2286_CR33","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1093\/brain\/awy222","volume":"141","author":"H Hanssen","year":"2018","unstructured":"Hanssen H et al (2018) Basal ganglia and cerebellar pathology in X-linked dystonia-parkinsonism. Brain 141:2995\u20133008. https:\/\/doi.org\/10.1093\/brain\/awy222","journal-title":"Brain"},{"key":"2286_CR34","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1111\/j.1365-2648.2012.06099.x","volume":"69","author":"C Harris","year":"2013","unstructured":"Harris C, Kiger A, Counsell C (2013) Attitudes to brain donation for Parkinson\u2019s research and how to ask: a qualitative study with suggested guidelines for practice. J Adv Nurs 69:1096\u20131108. https:\/\/doi.org\/10.1111\/j.1365-2648.2012.06099.x","journal-title":"J Adv Nurs"},{"key":"2286_CR35","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0304-3940(95)12102-a","volume":"200","author":"PJ Harrison","year":"1995","unstructured":"Harrison PJ, Heath PR, Eastwood SL, Burnet PW, McDonald B, Pearson RC (1995) The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins. Neurosci Lett 200:151\u2013154. https:\/\/doi.org\/10.1016\/0304-3940(95)12102-a","journal-title":"Neurosci Lett"},{"key":"2286_CR36","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1242\/dmm.022590","volume":"9","author":"N Ito","year":"2016","unstructured":"Ito N et al (2016) Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells. Dis Model Mech 9:451\u2013462. https:\/\/doi.org\/10.1242\/dmm.022590","journal-title":"Dis Model Mech"},{"key":"2286_CR37","doi-asserted-by":"publisher","first-page":"e42823","DOI":"10.1371\/journal.pone.0042823","volume":"7","author":"W Kamphuis","year":"2012","unstructured":"Kamphuis W et al (2012) GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease. PLoS ONE 7:e42823. https:\/\/doi.org\/10.1371\/journal.pone.0042823","journal-title":"PLoS ONE"},{"key":"2286_CR38","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1093\/schbul\/17.4.593","volume":"17","author":"DG Kirch","year":"1991","unstructured":"Kirch DG, Wagman AM, Goldman-Rakic PS (1991) Commentary: the acquisition and use of human brain tissue in neuropsychiatric research. Schizophr Bull 17:593\u2013596. https:\/\/doi.org\/10.1093\/schbul\/17.4.593","journal-title":"Schizophr Bull"},{"key":"2286_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/B978-0-12-802395-2.00002-X","volume":"145","author":"N Klioueva","year":"2017","unstructured":"Klioueva N, Bovenberg J, Huitinga I (2017) Banking brain tissue for research. Handb Clin Neurol 145:9\u201312. https:\/\/doi.org\/10.1016\/B978-0-12-802395-2.00002-X","journal-title":"Handb Clin Neurol"},{"key":"2286_CR40","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/B978-0-444-63639-3.00005-0","volume":"150","author":"NM Klioueva","year":"2018","unstructured":"Klioueva NM, Rademaker MC, Huitinga I (2018) Design of a European code of conduct for brain banking. Handb Clin Neurol 150:51\u201381. https:\/\/doi.org\/10.1016\/B978-0-444-63639-3.00005-0","journal-title":"Handb Clin Neurol"},{"key":"2286_CR41","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00414-011-0578-1","volume":"125","author":"A Koppelkamm","year":"2011","unstructured":"Koppelkamm A, Vennemann B, Lutz-Bonengel S, Fracasso T, Vennemann M (2011) RNA integrity in post-mortem samples: influencing parameters and implications on RT-qPCR assays. Int J Leg Med 125:573\u2013580. https:\/\/doi.org\/10.1007\/s00414-011-0578-1","journal-title":"Int J Leg Med"},{"key":"2286_CR42","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/nrn2535","volume":"10","author":"H Kretzschmar","year":"2009","unstructured":"Kretzschmar H (2009) Brain banking: opportunities, challenges and meaning for the future. Nat Rev Neurosci 10:70\u201378. https:\/\/doi.org\/10.1038\/nrn2535","journal-title":"Nat Rev Neurosci"},{"key":"2286_CR43","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.parkreldis.2010.12.009","volume":"17","author":"T Kuhta","year":"2011","unstructured":"Kuhta T, Zadikoff C, Simuni T, Martel A, Williams K, Videnovic A (2011) Brain donation\u2013what do patients with movement disorders know and how do they feel about it? Parkinsonism Relat Disord 17:204\u2013207. https:\/\/doi.org\/10.1016\/j.parkreldis.2010.12.009","journal-title":"Parkinsonism Relat Disord"},{"key":"2286_CR44","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/geront\/gnq063","volume":"51","author":"S Lambe","year":"2011","unstructured":"Lambe S, Cantwell N, Islam F, Horvath K, Jefferson AL (2011) Perceptions, knowledge, incentives, and barriers of brain donation among African American elders enrolled in an Alzheimer\u2019s research program. Gerontologist 51:28\u201338. https:\/\/doi.org\/10.1093\/geront\/gnq063","journal-title":"Gerontologist"},{"key":"2286_CR45","first-page":"137","volume":"14","author":"LV Lee","year":"1976","unstructured":"Lee LV, Pascasio FM, Fuentes FD, Viterbo GH (1976) Torsion dystonia in Panay, Philippines. Adv Neurol 14:137\u2013151","journal-title":"Adv Neurol"},{"key":"2286_CR46","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S1353-8020(02)00042-1","volume":"9","author":"LV Lee","year":"2002","unstructured":"Lee LV et al (2002) The natural history of sex-linked recessive dystonia parkinsonism of Panay, Philippines (XDP). Parkinsonism Relat Disord 9:29\u201338","journal-title":"Parkinsonism Relat Disord"},{"key":"2286_CR47","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s10561-019-09786-3","volume":"20","author":"MP Lin","year":"2019","unstructured":"Lin MP, Jowsey T, Curtis MA (2019) Why people donate their brain to science: a systematic review. Cell Tissue Bank 20:447\u2013466. https:\/\/doi.org\/10.1007\/s10561-019-09786-3","journal-title":"Cell Tissue Bank"},{"key":"2286_CR48","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1086\/512129","volume":"80","author":"S Makino","year":"2007","unstructured":"Makino S et al (2007) Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism. Am J Hum Genet 80:393\u2013406. https:\/\/doi.org\/10.1086\/512129","journal-title":"Am J Hum Genet"},{"key":"2286_CR49","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fnana.2014.00048","volume":"8","author":"V Martinez-Cerdeno","year":"2014","unstructured":"Martinez-Cerdeno V, Noctor SC (2014) Cajal, Retzius, and Cajal-Retzius cells. Front Neuroanat 8:48. https:\/\/doi.org\/10.3389\/fnana.2014.00048","journal-title":"Front Neuroanat"},{"key":"2286_CR50","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/01.wco.0000084222.82329.f2","volume":"16","author":"DD Murphy","year":"2003","unstructured":"Murphy DD, Ravina B (2003) Brain banking for neurodegenerative diseases. Curr Opin Neurol 16:459\u2013463. https:\/\/doi.org\/10.1097\/01.wco.0000084222.82329.f2","journal-title":"Curr Opin Neurol"},{"issue":"Suppl 1","key":"2286_CR51","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3109\/00207454.2010.526729","volume":"121","author":"PM Pasco","year":"2011","unstructured":"Pasco PM et al (2011) Understanding XDP through imaging, pathology, and genetics. Int J Neurosci 121(Suppl 1):12\u201317. https:\/\/doi.org\/10.3109\/00207454.2010.526729","journal-title":"Int J Neurosci"},{"key":"2286_CR52","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1365-2990.2012.01298.x","volume":"38","author":"R Paudel","year":"2012","unstructured":"Paudel R, Hardy J, Revesz T, Holton JL, Houlden H (2012) Review: genetics and neuropathology of primary pure dystonia. Neuropathol Appl Neurobiol 38:520\u2013534. https:\/\/doi.org\/10.1111\/j.1365-2990.2012.01298.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2286_CR53","doi-asserted-by":"publisher","first-page":"105032","DOI":"10.1016\/j.nbd.2020.105032","volume":"144","author":"T Petrozziello","year":"2020","unstructured":"Petrozziello T et al (2020) Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex. Neurobiol Dis 144:105032. https:\/\/doi.org\/10.1016\/j.nbd.2020.105032","journal-title":"Neurobiol Dis"},{"key":"2286_CR54","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/s0169-328x(03)00337-1","volume":"118","author":"P Preece","year":"2003","unstructured":"Preece P, Cairns NJ (2003) Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance. Mol Brain Res 118:60\u201371. https:\/\/doi.org\/10.1016\/s0169-328x(03)00337-1","journal-title":"Mol Brain Res"},{"key":"2286_CR55","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/B978-0-444-63639-3.00007-4","volume":"150","author":"SHM Rademaker","year":"2018","unstructured":"Rademaker SHM, Huitinga I (2018) A new viewpoint: running a nonprofit brain bank as a business. Handb Clin Neurol 150:93\u2013101. https:\/\/doi.org\/10.1016\/B978-0-444-63639-3.00007-4","journal-title":"Handb Clin Neurol"},{"key":"2286_CR56","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/B978-0-444-63639-3.00008-6","volume":"150","author":"EPC Ramirez","year":"2018","unstructured":"Ramirez EPC, Keller CE, Vonsattel JP (2018) The New York Brain Bank of Columbia University: practical highlights of 35 years of experience. Handb Clin Neurol 150:105\u2013118. https:\/\/doi.org\/10.1016\/B978-0-444-63639-3.00008-6","journal-title":"Handb Clin Neurol"},{"key":"2286_CR57","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10561-007-9055-y","volume":"9","author":"R Ravid","year":"2008","unstructured":"Ravid R (2008) Standard operating procedures, ethical and legal regulations in BTB (Brain\/Tissue\/Bio) banking: what is still missing? Cell Tissue Bank 9:121\u2013137. https:\/\/doi.org\/10.1007\/s10561-007-9055-y","journal-title":"Cell Tissue Bank"},{"key":"2286_CR58","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1111\/j.1742-4658.2012.08518.x","volume":"279","author":"R Ravid","year":"2012","unstructured":"Ravid R, Ferrer I (2012) Brain banks as key part of biochemical and molecular studies on cerebral cortex involvement in Parkinson\u2019s disease. FEBS J 279:1167\u20131176. https:\/\/doi.org\/10.1111\/j.1742-4658.2012.08518.x","journal-title":"FEBS J"},{"key":"2286_CR59","first-page":"207","volume":"39","author":"GP Reynolds","year":"1993","unstructured":"Reynolds GP, Pearson SJ (1993) Neurochemical-clinical correlates in Huntington\u2019s disease\u2013applications of brain banking techniques. J Neural Transm Suppl 39:207\u2013214","journal-title":"J Neural Transm Suppl"},{"key":"2286_CR60","doi-asserted-by":"publisher","first-page":"104950","DOI":"10.1016\/j.nbd.2020.104950","volume":"141","author":"E Sapp","year":"2020","unstructured":"Sapp E, Seeley C, Iuliano M, Weisman E, Vodicka P, DiFiglia M, Kegel-Gleason KB (2020) Protein changes in synaptosomes of Huntington\u2019s disease knock-in mice are dependent on age and brain region. Neurobiol Dis 141:104950. https:\/\/doi.org\/10.1016\/j.nbd.2020.104950","journal-title":"Neurobiol Dis"},{"key":"2286_CR61","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1093\/geront\/41.6.716","volume":"41","author":"FA Schmitt","year":"2001","unstructured":"Schmitt FA, Wetherby MM, Wekstein DR, Dearth CM, Markesbery WR (2001) Brain donation in normal aging: procedures, motivations, and donor characteristics from the Biologically Resilient Adults in Neurological Studies (BRAiNS) Project. Gerontologist 41:716\u2013722. https:\/\/doi.org\/10.1093\/geront\/41.6.716","journal-title":"Gerontologist"},{"issue":"1","key":"2286_CR62","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1186\/s12864-017-3827-y","volume":"18","author":"S Schuierer","year":"2017","unstructured":"Schuierer S, Carbone W, Knehr J, Petitjean V, Fernandez A, Sultan M, Roma G (2017) A comprehensive assessment of RNA-seq protocols for degraded and low quantity samples. BMC Genomics 18(1):442. https:\/\/doi.org\/10.1186\/s12864-017-3827-y","journal-title":"BMC Genomics"},{"key":"2286_CR63","doi-asserted-by":"publisher","first-page":"4496","DOI":"10.7150\/jca.26769","volume":"9","author":"M Sereika","year":"2018","unstructured":"Sereika M, Urbanaviciute R, Tamasauskas A, Skiriute D, Vaitkiene P (2018) GFAP expression is influenced by astrocytoma grade and rs2070935 polymorphism. J Cancer 9:4496\u20134502. https:\/\/doi.org\/10.7150\/jca.26769","journal-title":"J Cancer"},{"key":"2286_CR64","doi-asserted-by":"publisher","first-page":"569","DOI":"10.7916\/d8-j6sx-b156","volume":"9","author":"N Sharma","year":"2019","unstructured":"Sharma N (2019) Neuropathology of dystonia. Tremor Other Hyperkinetic Mov 9:569. https:\/\/doi.org\/10.7916\/d8-j6sx-b156","journal-title":"Tremor Other Hyperkinetic Mov"},{"key":"2286_CR65","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s12264-018-0326-3","volume":"35","author":"CE Shepherd","year":"2019","unstructured":"Shepherd CE, Alvendia H, Halliday GM (2019) Brain banking for research into neurodegenerative disorders and ageing. Neurosci Bull 35:283\u2013288. https:\/\/doi.org\/10.1007\/s12264-018-0326-3","journal-title":"Neurosci Bull"},{"key":"2286_CR66","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jneumeth.2004.04.020","volume":"139","author":"LK Siew","year":"2004","unstructured":"Siew LK, Love S, Dawbarn D, Wilcock GK, Allen SJ (2004) Measurement of pre- and post-synaptic proteins in cerebral cortex: effects of post-mortem delay. J Neurosci Methods 139:153\u2013159. https:\/\/doi.org\/10.1016\/j.jneumeth.2004.04.020","journal-title":"J Neurosci Methods"},{"key":"2286_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2006.09.025","volume":"1123","author":"AD Stan","year":"2006","unstructured":"Stan AD, Ghose S, Gao XM, Roberts RC, Lewis-Amezcua K, Hatanpaa KJ, Tamminga CA (2006) Human postmortem tissue: what quality markers matter? Brain Res 1123:1\u201311. https:\/\/doi.org\/10.1016\/j.brainres.2006.09.025","journal-title":"Brain Res"},{"key":"2286_CR68","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.nbd.2011.01.012","volume":"42","author":"DG Standaert","year":"2011","unstructured":"Standaert DG (2011) Update on the pathology of dystonia. Neurobiol Dis 42:148\u2013151. https:\/\/doi.org\/10.1016\/j.nbd.2011.01.012","journal-title":"Neurobiol Dis"},{"key":"2286_CR69","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/ageing\/27.5.623","volume":"27","author":"M Stevens","year":"1998","unstructured":"Stevens M (1998) Factors influencing decisions about donation of the brain for research purposes. Age Ageing 27:623\u2013629. https:\/\/doi.org\/10.1093\/ageing\/27.5.623","journal-title":"Age Ageing"},{"key":"2286_CR70","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1056\/nejm198901053200118","volume":"320","author":"EG Stopa","year":"1989","unstructured":"Stopa EG, Bird ED (1989) Brain donation. N Engl J Med 320:62\u201363. https:\/\/doi.org\/10.1056\/nejm198901053200118","journal-title":"N Engl J Med"},{"key":"2286_CR71","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.biopsych.2003.10.013","volume":"55","author":"H Tomita","year":"2004","unstructured":"Tomita H et al (2004) Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biol Psychiatry 55:346\u2013352. https:\/\/doi.org\/10.1016\/j.biopsych.2003.10.013","journal-title":"Biol Psychiatry"},{"key":"2286_CR72","first-page":"255","volume":"91","author":"WW Tourtellotte","year":"1970","unstructured":"Tourtellotte WW (1970) Avant-propos: a human specimen bank and a brain biopsier. Riv Patol Nerv Ment 91:255\u2013262","journal-title":"Riv Patol Nerv Ment"},{"key":"2286_CR73","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s10561-018-9720-3","volume":"19","author":"D Trujillo Diaz","year":"2018","unstructured":"Trujillo Diaz D, Hernandez NC, Cortes EP, Faust PL, Vonsattel JPG, Louis ED (2018) Banking brains: a pre-mortem \u201chow to\u201d guide to successful donation. Cell Tissue Bank 19:473\u2013488. https:\/\/doi.org\/10.1007\/s10561-018-9720-3","journal-title":"Cell Tissue Bank"},{"key":"2286_CR74","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10561-008-9079-y","volume":"9","author":"JP Vonsattel","year":"2008","unstructured":"Vonsattel JP, Amaya Mdel P, Cortes EP, Mancevska K, Keller CE (2008a) Twenty-first century brain banking: practical prerequisites and lessons from the past: the experience of New York Brain Bank, Taub Institute, Columbia University. Cell Tissue Bank 9:247\u2013258. https:\/\/doi.org\/10.1007\/s10561-008-9079-y","journal-title":"Cell Tissue Bank"},{"key":"2286_CR75","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00401-007-0311-9","volume":"115","author":"JP Vonsattel","year":"2008","unstructured":"Vonsattel JP, Del Amaya MP, Keller CE (2008b) Twenty-first century brain banking. Processing brains for research: the Columbia University methods. Acta Neuropathol 115:509\u2013532. https:\/\/doi.org\/10.1007\/s00401-007-0311-9","journal-title":"Acta Neuropathol"},{"key":"2286_CR76","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1038\/nprot.2006.354","volume":"1","author":"HJ Waldvogel","year":"2006","unstructured":"Waldvogel HJ, Curtis MA, Baer K, Rees MI, Faull RL (2006) Immunohistochemical staining of post-mortem adult human brain sections. Nat Protoc 1:2719\u20132732. https:\/\/doi.org\/10.1038\/nprot.2006.354","journal-title":"Nat Protoc"},{"key":"2286_CR77","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10561-008-9068-1","volume":"9","author":"HJ Waldvogel","year":"2008","unstructured":"Waldvogel HJ, Bullock JY, Synek BJ, Curtis MA, van Roon-Mom WM, Faull RL (2008) The collection and processing of human brain tissue for research. Cell Tissue Bank 9:169\u2013179. https:\/\/doi.org\/10.1007\/s10561-008-9068-1","journal-title":"Cell Tissue Bank"},{"key":"2286_CR78","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/mds.870080328","volume":"8","author":"CH Waters","year":"1993","unstructured":"Waters CH et al (1993) Neuropathology of lubag (X-linked dystonia parkinsonism). Mov Disord 8:387\u2013390. https:\/\/doi.org\/10.1002\/mds.870080328","journal-title":"Mov Disord"},{"key":"2286_CR79","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jneumeth.2007.06.001","volume":"165","author":"S Weis","year":"2007","unstructured":"Weis S, Llenos IC, Dulay JR, Elashoff M, Martinez-Murillo F, Miller CL (2007) Quality control for microarray analysis of human brain samples: the impact of postmortem factors. RNA characteristics, and histopathology. J Neurosci Methods 165:198\u2013209. https:\/\/doi.org\/10.1016\/j.jneumeth.2007.06.001","journal-title":"J Neurosci Methods"},{"key":"2286_CR80","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/mds.25369","volume":"28","author":"A Westenberger","year":"2013","unstructured":"Westenberger A et al (2013) X-linked dystonia-parkinsonism manifesting in a female patient due to atypical turner syndrome. Mov Disord 28:675\u2013678. https:\/\/doi.org\/10.1002\/mds.25369","journal-title":"Mov Disord"},{"key":"2286_CR81","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25488","author":"A Westenberger","year":"2019","unstructured":"Westenberger A et al (2019) A hexanucleotide repeat modifies expressivity of X-linked dystonia-parkinsonism. Ann Neurol. https:\/\/doi.org\/10.1002\/ana.25488","journal-title":"Ann Neurol"},{"key":"2286_CR82","first-page":"341","volume":"78","author":"KC Wilhelmsen","year":"1998","unstructured":"Wilhelmsen KC et al (1998) Molecular genetic analysis of Lubag. Adv Neurol 78:341\u2013348","journal-title":"Adv Neurol"},{"key":"2286_CR83","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/B978-0-444-63639-3.00006-2","volume":"150","author":"HR Zielke","year":"2018","unstructured":"Zielke HR, Mash DC (2018) A review of brain biorepository management and operations. Handb Clin Neurol 150:83\u201392. https:\/\/doi.org\/10.1016\/B978-0-444-63639-3.00006-2","journal-title":"Handb Clin Neurol"},{"key":"2286_CR84","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4137\/BMI.S9873","volume":"7","author":"JS Zoltewicz","year":"2012","unstructured":"Zoltewicz JS, Scharf D, Yang B, Chawla A, Newsom KJ, Fang L (2012) Characterization of antibodies that detect human GFAP after traumatic brain injury. Biomark Insights 7:71\u201379. https:\/\/doi.org\/10.4137\/BMI.S9873","journal-title":"Biomark Insights"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-020-02286-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00702-020-02286-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-020-02286-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T02:05:24Z","timestamp":1620266724000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00702-020-02286-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,13]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["2286"],"URL":"https:\/\/doi.org\/10.1007\/s00702-020-02286-9","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,13]]},"assertion":[{"value":"24 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts or competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The work was approved by Institutional Review Boards at Makati Medical Center (Manila, Philippines) and Massachusetts General Hospital (Boston, MA, USA) as described in the text.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All tissue donors and\/or next of kin provided informed consent, as indicated in the text.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have provided consent for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}