{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:10:23Z","timestamp":1791317423080,"version":"4.3.1"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s00702-021-02325-z","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T02:02:15Z","timestamp":1615514535000},"page":"279-293","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Emergent creativity in frontotemporal dementia"],"prefix":"10.1007","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-7676","authenticated-orcid":false,"given":"Felix","family":"Geser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt A.","family":"Jellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Fellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor K.","family":"Wenning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Yilmazer-Hanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Haybaeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"issue":"8","key":"2325_CR1","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s11910-014-0464-6","volume":"14","author":"LM Acosta","year":"2014","unstructured":"Acosta LM (2014) Creativity and neurological disease. Curr Neurol Neurosci Rep 14:464. https:\/\/doi.org\/10.1007\/s11910-014-0464-6 (PMID: 24938215)","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2325_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/brain\/71.3.229","volume":"71","author":"T Alajouanine","year":"1948","unstructured":"Alajouanine T (1948) Aphasia and artistic realization. Brain 71:229\u2013241. https:\/\/doi.org\/10.1093\/brain\/71.3.229","journal-title":"Brain"},{"key":"2325_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1046\/j.1468-1331.2002.00351.x","volume":"9","author":"L Amaducci","year":"2002","unstructured":"Amaducci L, Grassi E, Boller F (2002) Maurice Ravel and right-hemisphere musical creativity: influence of disease on his last musical works? Eur J Neurol 9:75\u201382. https:\/\/doi.org\/10.1046\/j.1468-1331.2002.00351.x","journal-title":"Eur J Neurol"},{"key":"2325_CR4","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","volume":"351","author":"T Arai","year":"2006","unstructured":"Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y, Oda T (2006) TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 351:602\u2013611. https:\/\/doi.org\/10.1016\/j.bbrc.2006.10.093","journal-title":"Biochem Biophys Res Commun"},{"key":"2325_CR5","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1212\/wnl.57.8.1485","volume":"57","author":"BF Boeve","year":"2001","unstructured":"Boeve BF, Geda YE (2001) Polka music and semantic dementia. Neurology 57:1485. https:\/\/doi.org\/10.1212\/wnl.57.8.1485","journal-title":"Neurology"},{"key":"2325_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neuropsychologia.2016.06.001","volume":"89","author":"C Boutoleau-Bretonni\u00e8re","year":"2016","unstructured":"Boutoleau-Bretonni\u00e8re C, Bretonni\u00e8re C, Evrard C, Rocher L, Mazzietti A, Koenig O, Vercelletto M, Derkinderen P, Thomas-Ant\u00e9rion C (2016) Ugly aesthetic perception associated with emotional changes in experience of art by behavioural variant of frontotemporal dementia patients. Neuropsychologia 89:96\u2013104. https:\/\/doi.org\/10.1016\/j.neuropsychologia.2016.06.001 (PMID: 27265766)","journal-title":"Neuropsychologia"},{"issue":"11","key":"2325_CR7","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","volume":"70","author":"H Braak","year":"2011","unstructured":"Braak H, Thal DR, Ghebremedhin E, Del Tredici K (2011) Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 70:960\u2013969. https:\/\/doi.org\/10.1097\/NEN.0b013e318232a379 (PMID: 22002422)","journal-title":"J Neuropathol Exp Neurol"},{"key":"2325_CR8","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00401-013-1238-y","volume":"127","author":"J Brettschneider","year":"2014","unstructured":"Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ (2014) Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathol 127:423\u2013439. https:\/\/doi.org\/10.1007\/s00401-013-1238-y","journal-title":"Acta Neuropathol"},{"key":"2325_CR9","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1212\/01.WNL.0000052685.09194.39","volume":"60","author":"M Broe","year":"2003","unstructured":"Broe M, Hodges JR, Schofield E, Shepherd CE, Kril JJ, Halliday GM (2003) Staging disease severity in pathologically confirmed cases of frontotemporal dementia. Neurology 60:1005\u20131011","journal-title":"Neurology"},{"key":"2325_CR10","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000098464","volume":"57","author":"V Budrys","year":"2007","unstructured":"Budrys V, Skullerud K, Petroska D, Lengveniene J, Kaubrys G (2007) Dementia and art: neuronal intermediate filament inclusion disease and dissolution of artistic creativity. Eur Neurol 57:137\u2013144. https:\/\/doi.org\/10.1159\/000098464","journal-title":"Eur Neurol"},{"key":"2325_CR11","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nrneurol.2010.113","volume":"6","author":"V Buschert","year":"2010","unstructured":"Buschert V, Bokde ALW, Hampel H (2010) Cognitive intervention in Alzheimer disease. Nat Rev Neurol 6:508\u2013517. https:\/\/doi.org\/10.1038\/nrneurol.2010.113","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"2325_CR12","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/j.1468-1331.2011.03546.x","volume":"19","author":"M Canesi","year":"2012","unstructured":"Canesi M, Rusconi ML, Isaias IU, Pezzoli G (2012) Artistic productivity and creative thinking in Parkinson\u2019s disease. Eur J Neurol 19:468\u2013472. https:\/\/doi.org\/10.1111\/j.1468-1331.2011.03546.x","journal-title":"Eur J Neurol"},{"key":"2325_CR13","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3389\/fneur.2017.00534.PMID:29118735;PMCID:PMC5661018","volume":"8","author":"M Canesi","year":"2017","unstructured":"Canesi M, Rusconi ML, Cereda E, Ranghetti A, Cereda V, Moroni F, Pezzoli G (2017) Divergent thinking in Parkinsonism: a case-control study. Front Neurol 8:534. https:\/\/doi.org\/10.3389\/fneur.2017.00534.PMID:29118735;PMCID:PMC5661018","journal-title":"Front Neurol"},{"key":"2325_CR14","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1111\/jocn.12976","volume":"24","author":"Y-S Chang","year":"2015","unstructured":"Chang Y-S, Chu H, Yang C-Y, Tsai JC, Chung MH, Liao YM, Chi MJ, Liu MF, Chou KR (2015) The efficacy of music therapy for people with dementia: a meta-analysis of randomised controlled trials. J Clin Nurs 24:3425\u20133440. https:\/\/doi.org\/10.1111\/jocn.12976","journal-title":"J Clin Nurs"},{"key":"2325_CR15","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1080\/13554794.2014.992915","volume":"21","author":"H Cho","year":"2015","unstructured":"Cho H, Chin J, Suh MK, Kim HJ, Kim YJ, Ye BS, Lee NK, Kim EJ, Seo SW, Na DL (2015) Postmorbid learning of saxophone playing in a patient with frontotemporal dementia. Neurocase 21:767\u2013772. https:\/\/doi.org\/10.1080\/13554794.2014.992915","journal-title":"Neurocase"},{"key":"2325_CR16","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuropsychologia.2015.12.031","volume":"81","author":"MH Cohen","year":"2016","unstructured":"Cohen MH, Carton AM, Hardy CJ, Golden HL, Clark CN, Fletcher PD, Jaisin K,\nMarshall CR, Henley SMD, Rohrer JD, Crutch SJ, Warren JD (2016) Processing emotion from abstract art in frontotemporal lobar degeneration. Neuropsychologia 81:245\u2013254. https:\/\/doi.org\/10.1016\/j.neuropsychologia.2015.12.031 (Epub 2015 Dec 31. PMID: 26748236; PMCID: PMC4749539)","journal-title":"Neuropsychologia"},{"key":"2325_CR17","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1016\/j.neuropsychologia.2010.09.010","volume":"48","author":"LC de Souza","year":"2010","unstructured":"de Souza LC, Volle E, Bertoux M, Czernecki V, Funkiewiez A, Allali G, Leroy B, Sarazin M, Habert MO, Dubois B, Kas A, Levy R (2010) Poor creativity in frontotemporal dementia: a window into the neural bases of the creative mind. Neuropsychologia 48:3733\u20133742. https:\/\/doi.org\/10.1016\/j.neuropsychologia.2010.09.010","journal-title":"Neuropsychologia"},{"key":"2325_CR18","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3389\/fpsyg.2014.00761","volume":"5","author":"LC de Souza","year":"2014","unstructured":"de Souza LC, Guimar\u00e3es HC, Teixeira AL, Caramelli P, Levy R, Dubois B, Volle E (2014) Frontal lobe neurology and the creative mind. Front Psychol 5:761. https:\/\/doi.org\/10.3389\/fpsyg.2014.00761 (PMID:25101029;PMCID:PMC4107958)","journal-title":"Front Psychol"},{"issue":"14","key":"2325_CR19","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1016\/j.neuropsychologia.2006.05.030","volume":"44","author":"V Drago","year":"2006","unstructured":"Drago V, Crucian GP, Foster PS, Cheong J, Finney GR, Pisani F, Heilman KM (2006a) Lewy body dementia and creativity: case report. Neuropsychologia 44:3011\u20133015. https:\/\/doi.org\/10.1016\/j.neuropsychologia.2006.05.030","journal-title":"Neuropsychologia"},{"key":"2325_CR20","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1212\/01.wnl.0000238439.77764.da","volume":"67","author":"V Drago","year":"2006","unstructured":"Drago V, Foster PS, Trifiletti D, FitzGerald DB, Kluger BM, Crucian GP, Heilman KM (2006b) What\u2019s inside the art? The influence of frontotemporal dementia in art production. Neurology 67:1285\u20131287. https:\/\/doi.org\/10.1212\/01.wnl.0000238439.77764.da","journal-title":"Neurology"},{"issue":"1\u20132","key":"2325_CR21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jns.2009.03.001","volume":"281","author":"V Drago","year":"2009","unstructured":"Drago V, Foster PS, Okun MS, Cosentino FI, Conigliaro R, Haq I, Sudhyadhom A, Skidmore FM, Heilman KM (2009a) Turning off artistic ability: the influence of left DBS in art production. J Neurol Sci 281:116\u2013121. https:\/\/doi.org\/10.1016\/j.jns.2009.03.001","journal-title":"J Neurol Sci"},{"issue":"1\u20132","key":"2325_CR22","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jns.2008.09.026","volume":"276","author":"V Drago","year":"2009","unstructured":"Drago V, Foster PS, Skidmore FM, Heilman KM (2009b) Creativity in Parkinson\u2019s disease as a function of right versus left hemibody onset. J Neurol Sci 276:179\u2013183. https:\/\/doi.org\/10.1016\/j.jns.2008.09.026 (PMID: 18952243)","journal-title":"J Neurol Sci"},{"issue":"Pt 6","key":"2325_CR23","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1093\/brain\/120.6.1027","volume":"120","author":"T Edwards-Lee","year":"1997","unstructured":"Edwards-Lee T, Miller BL, Benson DF, Cummings JL, Russell GL, Boone K, Mena I (1997) The temporal variant of frontotemporal dementia. Brain 120:1027\u20131040. https:\/\/doi.org\/10.1093\/brain\/120.6.1027","journal-title":"Brain"},{"key":"2325_CR24","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1001\/jama.2017.19501","volume":"319","author":"MG Erkkinen","year":"2018","unstructured":"Erkkinen MG, Z\u00fa\u00f1iga RG, Pardo CC, Miller BL, Miller ZA (2018) Artistic renaissance in frontotemporal dementia. JAMA 319:1304\u20131306. https:\/\/doi.org\/10.1001\/jama.2017.19501","journal-title":"JAMA"},{"key":"2325_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/WNN.0b013e31802b6c1f","volume":"20","author":"GR Finney","year":"2007","unstructured":"Finney GR, Heilman KM (2007) Artwork before and after onset of progressive nonfluent aphasia. Cogn Behav Neurol 20:7\u201310. https:\/\/doi.org\/10.1097\/WNN.0b013e31802b6c1f","journal-title":"Cogn Behav Neurol"},{"key":"2325_CR26","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1212\/wnl.55.12.1935","volume":"55","author":"C Geroldi","year":"2000","unstructured":"Geroldi C, Metitieri T, Binetti G, Zanetti O, Trabucchi M, Frisoni GB (2000) Pop music and frontotemporal dementia. Neurology 55:1935\u20131936. https:\/\/doi.org\/10.1212\/wnl.55.12.1935","journal-title":"Neurology"},{"key":"2325_CR27","unstructured":"Geser F, Lee VM-Y, Trojanowski J. Frontotemporal dementias (2007) In: Rosenberg RN, DiMauro S, Paulson H, Ptacek L, Nestler E (eds) The molecular and genetic basis of neurological and psychiatric disease, 4th edn. Lippincott Williams & Wilkins, Wolters Kluwer, Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Sydney, Tokyo, pp 330\u2013338"},{"key":"2325_CR28","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s00415-009-5069-7","volume":"256","author":"F Geser","year":"2009","unstructured":"Geser F, Martinez-Lage M, Kwong LK, Lee VM, Trojanowski JQ (2009a) Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases. J Neurol 256:1205\u20131214. https:\/\/doi.org\/10.1007\/s00415-009-5069-7","journal-title":"J Neurol"},{"key":"2325_CR29","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1001\/archneurol.2008.558","volume":"66","author":"F Geser","year":"2009","unstructured":"Geser F, Martinez-Lage M, Robinson J, Uryu K, Neumann M, Brandmeir NJ, Xie SX, Kwong LK, Elman L, McCluskey L, Clark CM, Malunda J, Miller BL, Zimmerman EA, Qian J, Van Deerlin V, Grossman M, Lee VM, Trojanowski JQ (2009b) Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Arch Neurol 66:180\u2013189. https:\/\/doi.org\/10.1001\/archneurol.2008.558","journal-title":"Arch Neurol"},{"issue":"10","key":"2325_CR30","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1001\/archneurol.2010.254","volume":"67","author":"F Geser","year":"2010","unstructured":"Geser F, Robinson JL, Malunda JA, Xie SX, Clark CM, Kwong LK, Moberg PJ, Moore EM, Van Deerlin VM, Lee VM, Arnold SE, Trojanowski JQ (2010) Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness. Arch Neurol 67:1238\u20131250. https:\/\/doi.org\/10.1001\/archneurol.2010.254 (PMID:20937952;PMCID:PMC3050578)","journal-title":"Arch Neurol"},{"key":"2325_CR31","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.pneurobio.2011.08.011","volume":"95","author":"F Geser","year":"2011","unstructured":"Geser F, Prvulovic D, O\u2019Dwyer L, Hardiman O, Bede P, Bokde AL, Trojanowski JQ, Hampel H (2011a) On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia. Prog Neurobiol 95:649\u2013662. https:\/\/doi.org\/10.1016\/j.pneurobio.2011.08.011","journal-title":"Prog Neurobiol"},{"issue":"4","key":"2325_CR32","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1365-2990.2010.01136.x","volume":"37","author":"F Geser","year":"2011","unstructured":"Geser F, Malunda JA, Hurtig HI, Duda JE, Wenning GK, Gilman S, Low PA, Lee VM, Trojanowski JQ (2011b) TDP-43 pathology occurs infrequently in multiple system atrophy. Neuropathol Appl Neurobiol 37:358\u2013365. https:\/\/doi.org\/10.1111\/j.1365-2990.2010.01136.x (PMID:20942898;PMCID:PMC3030620)","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2325_CR33","unstructured":"Geser F, Hermle L, Egan PJ, Brettschneider J, Mitrovics TCG (2016) Amyotrophic lateral sclerosis with atrophy of the amygdala. Pract Neurol July\/August 38\u201341"},{"issue":"8","key":"2325_CR34","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s00702-020-02213-y","volume":"127","author":"F Geser","year":"2020","unstructured":"Geser F, Fellner L, Haybaeck J, Wenning GK (2020) Development of neurodegeneration in amyotrophic lateral sclerosis: from up or down? J Neural Transm (Vienna) 127:1097\u20131105. https:\/\/doi.org\/10.1007\/s00702-020-02213-y (Epub 2020 Jun 4 PMID: 32500222)","journal-title":"J Neural Transm (Vienna)"},{"key":"2325_CR35","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1136\/pgmj.2005.034348","volume":"81","author":"N Gordon","year":"2005","unstructured":"Gordon N (2005) Unexpected development of artistic talents. Postgrad Med J 81:753\u2013755. https:\/\/doi.org\/10.1136\/pgmj.2005.034348","journal-title":"Postgrad Med J"},{"key":"2325_CR36","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.neuropsychologia.2008.10.015","volume":"47","author":"HAC Green","year":"2009","unstructured":"Green HAC, Patterson K (2009) Jigsaws-a preserved ability in semantic dementia. Neuropsychologia 47:569\u2013576. https:\/\/doi.org\/10.1016\/j.neuropsychologia.2008.10.015","journal-title":"Neuropsychologia"},{"key":"2325_CR37","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/gps.3975","volume":"29","author":"C Gretton","year":"2014","unstructured":"Gretton C, Ffytche DH (2014) Art and the brain: a view from dementia. Int J Geriatr Psychiatry 29:111\u2013126. https:\/\/doi.org\/10.1002\/gps.3975","journal-title":"Int J Geriatr Psychiatry"},{"key":"2325_CR38","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1136\/jnnp.2008.153130","volume":"80","author":"JC Hailstone","year":"2009","unstructured":"Hailstone JC, Omar R, Warren JD (2009) Relatively preserved knowledge of music in semantic dementia. J Neurol Neurosurg Psychiatry 80:808\u2013809. https:\/\/doi.org\/10.1136\/jnnp.2008.153130","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"2325_CR39","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1037\/a0031734","volume":"7","author":"AR Halpern","year":"2013","unstructured":"Halpern AR, O\u2019Connor MG (2013) Stability of art preference in frontotemporal dementia. Psychol Aesthet Creat Arts 7:95\u201399. https:\/\/doi.org\/10.1037\/a0031734","journal-title":"Psychol Aesthet Creat Arts"},{"key":"2325_CR40","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1111\/psyg.12437","volume":"19","author":"A Hamauchi","year":"2019","unstructured":"Hamauchi A, Hidaka Y, Kitamura I, Yatabe Y, Hashimoto M, Yonehara T, Fukuhara R, Ikeda M (2019) Emergence of artistic talent in progressive nonfluent aphasia: a case report. Psychogeriatrics 19:601\u2013604. https:\/\/doi.org\/10.1111\/psyg.12437","journal-title":"Psychogeriatrics"},{"issue":"Suppl 1","key":"2325_CR41","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/jnc.13668.PMID:27502124;PMCID:PMC6680357","volume":"138","author":"EM Hock","year":"2016","unstructured":"Hock EM, Polymenidou M (2016) Prion-like propagation as a pathogenic principle in frontotemporal dementia. J Neurochem 138:163\u2013183. https:\/\/doi.org\/10.1111\/jnc.13668.PMID:27502124;PMCID:PMC6680357","journal-title":"J Neurochem"},{"issue":"Suppl 1","key":"2325_CR42","doi-asserted-by":"publisher","first-page":"S96","DOI":"10.1017\/cjn.2016.25","volume":"43","author":"DB Hogan","year":"2016","unstructured":"Hogan DB, Jett\u00e9 N, Fiest KM, Roberts JI, Pearson D, Smith EE, Roach P, Kirk A, Pringsheim T, Maxwell CJ (2016) The prevalence and incidence of frontotemporal dementia: a systematic review. Can J Neurol Sci 43:S96\u2013S109. https:\/\/doi.org\/10.1017\/cjn.2016.25","journal-title":"Can J Neurol Sci"},{"issue":"2","key":"2325_CR43","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/ana.24559","volume":"79","author":"DJ Irwin","year":"2016","unstructured":"Irwin DJ, Brettschneider J, McMillan CT et al (2016) Deep clinical and neuropathological phenotyping of Pick disease. Ann Neurol 79(2):272\u2013287. https:\/\/doi.org\/10.1002\/ana.24559 (Epub 2015 Dec 25. PMID: 26583316; PMCID: PMC4755803)","journal-title":"Ann Neurol"},{"key":"2325_CR44","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/WNN.0b013e31821de326","volume":"24","author":"JK Johnson","year":"2011","unstructured":"Johnson JK, Chang C-C, Brambati SM, Migliaccio R, Gorno-Tempini ML, Miller BL, Janata P (2011) Music recognition in frontotemporal lobar degeneration and Alzheimer disease. Cogn Behav Neurol 24:74\u201384. https:\/\/doi.org\/10.1097\/WNN.0b013e31821de326","journal-title":"Cogn Behav Neurol"},{"issue":"Pt 5","key":"2325_CR45","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1093\/brain\/119.5.1775","volume":"119","author":"N Kapur","year":"1996","unstructured":"Kapur N (1996) Paradoxical functional facilitation in brain-behaviour research. A critical review. Brain 119:1775\u20131790. https:\/\/doi.org\/10.1093\/brain\/119.5.1775","journal-title":"Brain"},{"key":"2325_CR46","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.clineuro.2011.11.010","volume":"114","author":"H Kearney","year":"2012","unstructured":"Kearney H, O\u2019Dowd S, Murray B, Kavanagh E, O\u2019Connell M, Lynch T (2012) Re-emergence of artistic traits in a patient with frontotemporal dementia. Clin Neurol Neurosurg 114:417\u2013420. https:\/\/doi.org\/10.1016\/j.clineuro.2011.11.010 (Epub 2011 Dec 9. PMID: 22169065)","journal-title":"Clin Neurol Neurosurg"},{"key":"2325_CR47","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/mds.10360","volume":"18","author":"G Kleiner-Fisman","year":"2003","unstructured":"Kleiner-Fisman G, Black SE, Lang AE (2003) Neurodegenerative disease and the evolution of art: the effects of presumed corticobasal degeneration in a professional artist. Mov Disord 18:294\u2013302. https:\/\/doi.org\/10.1002\/mds.10360","journal-title":"Mov Disord"},{"key":"2325_CR48","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9528-0","author":"JJ Kril","year":"2011","unstructured":"Kril JJ, Halliday GM (2011) Pathological staging of frontotemporal lobar degeneration. J Mol Neurosci. https:\/\/doi.org\/10.1007\/s12031-011-9528-0","journal-title":"J Mol Neurosci"},{"key":"2325_CR49","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/nan.12250","volume":"41","author":"T Lashley","year":"2015","unstructured":"Lashley T, Rohrer JD, Mead S, Revesz T (2015) Review: an update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations. Neuropathol Appl Neurobiol 41:858\u2013881. https:\/\/doi.org\/10.1111\/nan.12250","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2325_CR50","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3109\/17482968.2011.639376","volume":"13","author":"P Lillo","year":"2012","unstructured":"Lillo P, Savage S, Mioshi E, Kiernan MC, Hodges JR (2012) Amyotrophic lateral sclerosis and frontotemporal dementia: a behavioural and cognitive continuum. Amyotroph Lateral Scler 13:102\u2013109. https:\/\/doi.org\/10.3109\/17482968.2011.639376","journal-title":"Amyotroph Lateral Scler"},{"key":"2325_CR51","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1080\/13554790802633213","volume":"15","author":"A Liu","year":"2009","unstructured":"Liu A, Werner K, Roy S, Trojanowski JQ, Morgan-Kane U, Miller BL, Rankin KP (2009) A case study of an emerging visual artist with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Neurocase 15:235\u2013247. https:\/\/doi.org\/10.1080\/13554790802633213","journal-title":"Neurocase"},{"key":"2325_CR52","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1159\/000085608","volume-title":"Neurological disorders in famous artists","author":"K Maurer","year":"2005","unstructured":"Maurer K, Prvulovic D (2005) Carolus Horn\u2014when the images in the brain decay. Evidence of backward-development of visual and cognitive functions in Alzheimer\u2019s disease. In: Bogousslavsky J, Boller F (eds) Neurological disorders in famous artists. Karger, Basel, pp 101\u2013111"},{"key":"2325_CR53","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1212\/01.wnl.0000064164.02891.12","volume":"60","author":"JC Mell","year":"2003","unstructured":"Mell JC, Howard SM, Miller BL (2003) Art and the brain: the influence of frontotemporal dementia on an accomplished artist. Neurology 60:1707\u20131710. https:\/\/doi.org\/10.1212\/01.wnl.0000064164.02891.12","journal-title":"Neurology"},{"key":"2325_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mehy.2004.03.002","volume":"63","author":"MF Mendez","year":"2004","unstructured":"Mendez MF (2004) Dementia as a window to the neurology of art. Med Hypotheses 63:1\u20137. https:\/\/doi.org\/10.1016\/j.mehy.2004.03.002","journal-title":"Med Hypotheses"},{"key":"2325_CR55","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1076\/neur.9.1.44.14375","volume":"9","author":"MF Mendez","year":"2003","unstructured":"Mendez MF, Perryman KM (2003) Disrupted facial empathy in drawings from artists with frontotemporal dementia. Neurocase 9:44\u201350. https:\/\/doi.org\/10.1076\/neur.9.1.44.14375","journal-title":"Neurocase"},{"key":"2325_CR56","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1159\/000151697","volume":"60","author":"A Midorikawa","year":"2008","unstructured":"Midorikawa A, Fukutake T, Kawamura M (2008) Dementia and painting in patients from different cultural backgrounds. Eur Neurol 60:224\u2013229. https:\/\/doi.org\/10.1159\/000151697","journal-title":"Eur Neurol"},{"key":"2325_CR57","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1001\/archneur.61.6.842","volume":"61","author":"BL Miller","year":"2004","unstructured":"Miller BL, Hou CE (2004) Portraits of artists: emergence of visual creativity in dementia. Arch Neurol 61:842\u2013844. https:\/\/doi.org\/10.1001\/archneur.61.6.842","journal-title":"Arch Neurol"},{"key":"2325_CR58","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/B978-0-444-63287-6.00005-1","volume":"204","author":"ZA Miller","year":"2013","unstructured":"Miller ZA, Miller BL (2013) Artistic creativity and dementia. Prog Brain Res 204:99\u2013112. https:\/\/doi.org\/10.1016\/B978-0-444-63287-6.00005-1","journal-title":"Prog Brain Res"},{"key":"2325_CR59","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1016\/s0140-6736(05)65881-3","volume":"348","author":"BL Miller","year":"1996","unstructured":"Miller BL, Ponton M, Benson DF, Cummings JL, Mena I (1996) Enhanced artistic creativity with temporal lobe degeneration. Lancet 348:1744\u20131745. https:\/\/doi.org\/10.1016\/s0140-6736(05)65881-3","journal-title":"Lancet"},{"key":"2325_CR60","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1212\/WNL.51.4.978","volume":"51","author":"BL Miller","year":"1998","unstructured":"Miller BL, Cummings J, Mishkin F, Boone K, Prince F, Ponton M, Cotman C (1998) Emergence of artistic talent in frontotemporal dementia. Neurology 51:978\u2013982","journal-title":"Neurology"},{"key":"2325_CR61","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1192\/bjp.176.5.458","volume":"176","author":"BL Miller","year":"2000","unstructured":"Miller BL, Boone K, Cummings JL, Read SL, Mishkin F (2000) Functional correlates of musical and visual ability in frontotemporal dementia. Br J Psychiatry 176:458\u2013463. https:\/\/doi.org\/10.1192\/bjp.176.5.458","journal-title":"Br J Psychiatry"},{"issue":"1","key":"2325_CR62","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/nan.12526","volume":"45","author":"M Neumann","year":"2019","unstructured":"Neumann M, Mackenzie IRA (2019) Review: neuropathology of non-tau frontotemporal lobar degeneration. Neuropathol Appl Neurobiol 45:19\u201340. https:\/\/doi.org\/10.1111\/nan.12526 (PMID: 30357887)","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2325_CR63","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1126\/science.1134108","volume":"314","author":"M Neumann","year":"2006","unstructured":"Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314:130\u2013133","journal-title":"Science"},{"issue":"2","key":"2325_CR64","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ncl.2017.01.008","volume":"35","author":"NT Olney","year":"2017","unstructured":"Olney NT, Spina S, Miller BL (2017) Frontotemporal dementia. Neurol Clin 35:339\u2013374. https:\/\/doi.org\/10.1016\/j.ncl.2017.01.008 (PMID:28410663;PMCID:PMC5472209)","journal-title":"Neurol Clin"},{"key":"2325_CR65","doi-asserted-by":"publisher","unstructured":"Orth M, Trimble MR (2006). Friedrich Nietzsche\u2019s mental illness\u2014general paralysis of the insane vs. frontotemporal dementia. Acta Psychiatr Scand 114:439\u201344. https:\/\/doi.org\/10.1111\/j.1600-0447.2006.00827.x (PMID: 17087793)","DOI":"10.1111\/j.1600-0447.2006.00827.x"},{"issue":"6","key":"2325_CR66","first-page":"RA134","volume":"9","author":"A Otte","year":"2003","unstructured":"Otte A, De Bondt P, Van De Wiele C, Audenaert K, Dierckx R (2003) The exceptional brain of Maurice Ravel. Med Sci Monit 9:RA134\u2013RA139 (PMID: 12824964)","journal-title":"Med Sci Monit"},{"key":"2325_CR67","doi-asserted-by":"publisher","unstructured":"Palmiero M, Di Giacomo D, Passafiume D (2012) Creativity and dementia: a review. Cogn Process. 2012;13:193\u2013209. https:\/\/doi.org\/10.1007\/s10339-012-0439-y. (PMID: 22438178)","DOI":"10.1007\/s10339-012-0439-y"},{"key":"2325_CR68","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/13554790802269976","volume":"14","author":"A Postiglione","year":"2008","unstructured":"Postiglione A, Milan G, Pappat\u00e0 S, De Falco C, Lamenza F, Schiattarella V, Gallotta G, Sorrentino P, Striano S (2008) Fronto-temporal dementia presenting as Geschwind\u2019s syndrome. Neurocase 14:264\u2013270. https:\/\/doi.org\/10.1080\/13554790802269976","journal-title":"Neurocase"},{"issue":"1","key":"2325_CR69","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/WNN.0b013e31803141dd","volume":"20","author":"KP Rankin","year":"2007","unstructured":"Rankin KP, Liu AA, Howard S, Slama H, Hou CE, Shuster K, Miller BL (2007) A case-controlled study of altered visual art production in Alzheimer\u2019s and FTLD. Cogn Behav Neurol 20:48\u201361. https:\/\/doi.org\/10.1097\/WNN.0b013e31803141dd (PMID:17356345;PMCID:PMC2651227)","journal-title":"Cogn Behav Neurol"},{"issue":"Suppl 3","key":"2325_CR70","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/pl00014170","volume":"249","author":"B Reisberg","year":"1999","unstructured":"Reisberg B, Franssen EH, Hasan SM, Monteiro I, Boksay I, Souren LE, Kenowsky S, Auer SR, Elahi S, Kluger A (1999) Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer\u2019s and other dementing processes. Eur Arch Psychiatry Clin Neurosci 249:28\u201336. https:\/\/doi.org\/10.1007\/pl00014170","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2325_CR71","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/brain\/awg085","volume":"126","author":"E Schofield","year":"2003","unstructured":"Schofield E, Kersaitis C, Shepherd CE, Kril JJ, Halliday GM (2003) Severity of gliosis in Pick\u2019s disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders. Brain 126:827\u2013840. https:\/\/doi.org\/10.1093\/brain\/awg085","journal-title":"Brain"},{"issue":"6","key":"2325_CR72","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1002\/mds.1239","volume":"16","author":"A Schrag","year":"2001","unstructured":"Schrag A, Trimble M (2001) Poetic talent unmasked by treatment of Parkinson\u2019s disease. Mov Disord 16:1175\u20131176. https:\/\/doi.org\/10.1002\/mds.1239 (PMID:11748756)","journal-title":"Mov Disord"},{"key":"2325_CR73","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/brain\/awm270","volume":"131","author":"WW Seeley","year":"2008","unstructured":"Seeley WW, Matthews BR, Crawford RK, Gorno-Tempini ML, Foti D, Mackenzie IR, Miller BL (2008) Unravelling Bol\u00e9ro: progressive aphasia, transmodal creativity and the right posterior neocortex. Brain 131:39\u201349. https:\/\/doi.org\/10.1093\/brain\/awm270","journal-title":"Brain"},{"issue":"10","key":"2325_CR74","doi-asserted-by":"publisher","first-page":"841","DOI":"10.2165\/11640070-000000000-00000","volume":"26","author":"RE Seltman","year":"2012","unstructured":"Seltman RE, Matthews BR (2012) Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management. CNS Drugs 26:841\u2013870. https:\/\/doi.org\/10.2165\/11640070-000000000-00000 (PMID: 22950490)","journal-title":"CNS Drugs"},{"key":"2325_CR75","first-page":"91","volume-title":"Fronto-temporal lobar degeneration: fronto-temporal dementia, progressive aphasia, semantic dementia","author":"JS Snowden","year":"1996","unstructured":"Snowden JS, Neary D, Mann DM (1996) Semantic dementia. In: Snowden JS, Neary D, Mann DMA (eds) Fronto-temporal lobar degeneration: fronto-temporal dementia, progressive aphasia, semantic dementia. Churchill Livingstone, New York, Edinburgh, London, Madrid, Melbourne, San Francisco, Tokyo, pp 91\u2013114"},{"key":"2325_CR76","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1212\/01.wnl.0000035637.48621.68","volume":"59","author":"C Thomas Ant\u00e9rion","year":"2002","unstructured":"Thomas Ant\u00e9rion C, Honor\u00e9-Masson S, Dirson S, Laurent B (2002) Lonely cowboy\u2019s thoughts. Neurology 59:1812\u20131813. https:\/\/doi.org\/10.1212\/01.wnl.0000035637.48621.68","journal-title":"Neurology"},{"key":"2325_CR77","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1001\/archneur.1986.00520100078018","volume":"43","author":"RM Torack","year":"1986","unstructured":"Torack RM, Morris JC (1986) Mesolimbocortical dementia. A clinicopathologic case study of a putative disorder. Arch Neurol 43:1074\u20131078. https:\/\/doi.org\/10.1001\/archneur.1986.00520100078018","journal-title":"Arch Neurol"},{"key":"2325_CR78","doi-asserted-by":"publisher","first-page":"CD003477","DOI":"10.1002\/14651858.CD003477.pub4","volume":"7","author":"JT van der Steen","year":"2018","unstructured":"van der Steen JT, Smaling HJ, van der Wouden JC, Bruinsma MS, Scholten RJ, Vink AC (2018) Music-based therapeutic interventions for people with dementia. Cochrane Database Syst Rev 7:CD003477. https:\/\/doi.org\/10.1002\/14651858.CD003477.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"2325_CR79","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cortex.2017.06.003","volume":"94","author":"L Veronelli","year":"2017","unstructured":"Veronelli L, Makaretz SJ, Quimby M, Dickerson BC, Collins JA (2017) Geschwind Syndrome in frontotemporal lobar degeneration: Neuroanatomical and neuropsychological features over 9 years. Cortex 94:27\u201338. https:\/\/doi.org\/10.1016\/j.cortex.2017.06.003","journal-title":"Cortex"},{"key":"2325_CR80","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1001\/archneurol.2010.364","volume":"68","author":"J Weinstein","year":"2011","unstructured":"Weinstein J, Koenig P, Gunawardena D, McMillan C, Bonner M, Grossman M (2011) Preserved musical semantic memory in semantic dementia. Arch Neurol 68:248\u2013250. https:\/\/doi.org\/10.1001\/archneurol.2010.364","journal-title":"Arch Neurol"},{"key":"2325_CR81","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/13554794.2013.860179","volume":"21","author":"TQ Wu","year":"2015","unstructured":"Wu TQ, Miller ZA, Adhimoolam B, Zackey DD, Khan BK, Ketelle R, Rankin KP, Miller BL (2015) Verbal creativity in semantic variant primary progressive aphasia. Neurocase 21:73\u201378. https:\/\/doi.org\/10.1080\/13554794.2013.860179","journal-title":"Neurocase"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-021-02325-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00702-021-02325-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-021-02325-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T07:03:44Z","timestamp":1615964624000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00702-021-02325-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":81,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["2325"],"URL":"https:\/\/doi.org\/10.1007\/s00702-021-02325-z","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"11 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}