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Latest research findings suggest the body mass index (BMI) to play a role in antidepressant treatment response in general. Our study aims to examine whether adiposity-related parameters such as BMI, glucose homeostasis, or serum lipids are associated with remission to electroconvulsive therapy (ECT). A pilot study (PS, <jats:italic>n<\/jats:italic>\u2009=\u20099) and a glucose study (GS, <jats:italic>n<\/jats:italic>\u2009=\u200929) were conducted. Blood was withdrawn directly before and 15\u00a0min (GS) as well as 1\u00a0h (PS) after the first ECT and directly before the last one (usually an ECT series comprised up to twelve sessions). BMI was associated with remission in the PS (remitters: <jats:italic>M<\/jats:italic>\u2009=\u200928, SD\u2009=\u20092.5; non-remitters: <jats:italic>M<\/jats:italic>\u2009=\u200922, SD\u2009=\u20092.08; <jats:italic>t<\/jats:italic>(7)\u2009=\u20093.325, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>d<\/jats:italic>\u2009=\u20090.24) but not in the GS or when pooled together. Glucose and insulin levels increased significantly after a single ECT session (GS: glucose: <jats:italic>F<\/jats:italic> (2,25.66)\u2009=\u200939.04, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; insulin: PS: <jats:italic>F<\/jats:italic> (2,83)\u2009=\u200925.8, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; GS: <jats:italic>F<\/jats:italic> (2,25.87)\u2009=\u20093.97, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) but no chronic effect was detectable. Serum lipids were neither significantly altered after a single ECT session nor during a whole course of ECT. There was no difference between remitters and non-remitters in insulin, glucose, or serum lipid levels. Our study is lacking the differentiation between abdominal and peripheral fat distribution, and the sample size is small. Unexpectedly, BMI, glucose homeostasis, and lipid serum levels did not differ in patients remitting during ECT. In contrast to recently published studies, we cannot confirm the hypothesis that BMI may have an impact on ECT response.<\/jats:p>","DOI":"10.1007\/s00702-022-02475-8","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T08:02:44Z","timestamp":1645776164000},"page":"331-341","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Electroconvulsive therapy and adiposity-related parameters in treatment-resistant depressed patients"],"prefix":"10.1007","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2368-1235","authenticated-orcid":false,"given":"Hannah Benedictine","family":"Maier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Moschny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sermin","family":"Toto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Schlatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian K.","family":"Eberlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai G.","family":"Kahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bleich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Neyazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Frieling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"2475_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jad.2015.09.037","volume":"189","author":"SS Aksay","year":"2016","unstructured":"Aksay SS, Bumb JM, Janke C, Biemann R, Borucki K, Lederbogen F, Deuschle M, Sartorius A, Kranaster L (2016) Serum lipid profile changes after successful treatment with electroconvulsive therapy in major depression: a prospective pilot trial. 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CP, NM, CS, JK, WS, SB declare no conflict of interest. ST is a member of the advisory board for Otsuka and Janssen-Cilag and has received speaker\u2019s honoraria from Janssen-Cilag, Lundbeck\/Otsuka and Servier. CE has received honoraria for talks and advisory board activities from Recordati Pharma. KGK received speaker honoraria by EliLilly, Takeda, Schwabe, Trommsdorff, Ferrer, Janssen, Alexion, Servier and Otsuka. He received unrestricted research grants by Servier and Ferrer. AN received lecture fees from Novartis and Merck. HF received speaker\u2019s honararia and served as advisor for Recordati Pharma GmbH and Janssen-Cilag Gmbh.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}