{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:58:03Z","timestamp":1789595883389,"version":"build-2803163510"},"reference-count":246,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Society for the Promotion of Research in Experimental Neurology, Vienna, Austria"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s00702-023-02648-z","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T10:02:34Z","timestamp":1683280954000},"page":"1057-1076","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder"],"prefix":"10.1007","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-7649","authenticated-orcid":false,"given":"Kurt A.","family":"Jellinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"2648_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2017.11.005","volume":"97","author":"M Abi Zeid Daou","year":"2018","unstructured":"Abi Zeid Daou M, Boyd BD, Donahue MJ, Albert K, Taylor WD (2018) Anterior-posterior gradient differences in lobar and cingulate cortex cerebral blood flow in late-life depression. J Psychiatr Res 97:1\u20137","journal-title":"J Psychiatr Res"},{"key":"2648_CR2","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jagp.2021.11.011","volume":"30","author":"R Ahmed","year":"2022","unstructured":"Ahmed R, Ryan C, Christman S, Elson D, Bermudez C, Landman BA, Szymkowicz SM, Boyd BD, Kang H, Taylor WD (2022) Structural MRI-based measures of accelerated brain aging do not moderate the acute antidepressant response in late-life depression. Am J Geriatr Psychiatry 30:1015\u20131025","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/0891988713516541","volume":"27","author":"HJ Aizenstein","year":"2014","unstructured":"Aizenstein HJ, Khalaf A, Walker SE, Andreescu C (2014) Magnetic resonance imaging predictors of treatment response in late-life depression. J Geriatr Psychiatry Neurol 27:24\u201332","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"2648_CR4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12916-016-0720-5","volume":"14","author":"HJ Aizenstein","year":"2016","unstructured":"Aizenstein HJ, Baskys A, Boldrini M, Butters MA, Diniz BS, Jaiswal MK, Jellinger KA, Kruglov LS, Meshandin IA, Mijajlovic MD, Niklewski G, Pospos S, Raju K, Richter K, Steffens DC, Taylor WD, Tene O (2016) Vascular depression consensus report\u2014a critical update. BMC Med 14:161","journal-title":"BMC Med"},{"key":"2648_CR5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41398-019-0514-6","volume":"9","author":"GS Alexopoulos","year":"2019","unstructured":"Alexopoulos GS (2019) Mechanisms and treatment of late-life depression. Transl Psychiatry 9:188","journal-title":"Transl Psychiatry"},{"key":"2648_CR6","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/archpsyc.1997.01830220033006","volume":"54","author":"GS Alexopoulos","year":"1997","unstructured":"Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M (1997) \u201cVascular depression\u201d hypothesis. Arch Gen Psychiatry 54:915\u2013922","journal-title":"Arch Gen Psychiatry"},{"key":"2648_CR7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0006-3223(02)01468-3","volume":"52","author":"GS Alexopoulos","year":"2002","unstructured":"Alexopoulos GS, Buckwalter K, Olin J, Martinez R, Wainscott C, Krishnan KR (2002) Comorbidity of late life depression: an opportunity for research on mechanisms and treatment. Biol Psychiatry 52:543\u2013558","journal-title":"Biol Psychiatry"},{"key":"2648_CR8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1176\/appi.ajp.2007.07050744","volume":"165","author":"GS Alexopoulos","year":"2008","unstructured":"Alexopoulos GS, Murphy CF, Gunning-Dixon FM, Latoussakis V, Kanellopoulos D, Klimstra S, Lim KO, Hoptman MJ (2008) Microstructural white matter abnormalities and remission of geriatric depression. Am J Psychiatry 165:238\u2013244","journal-title":"Am J Psychiatry"},{"key":"2648_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5686","author":"IS Almdahl","year":"2022","unstructured":"Almdahl IS, Agartz I, Hugdahl K, Korsnes MS (2022) Brain pathology and cognitive scores prior to onset of late-life depression. Int J Geriatr Psychiatry. https:\/\/doi.org\/10.1002\/gps.5686","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR10","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1017\/S003329170300758X","volume":"33","author":"OP Almeida","year":"2003","unstructured":"Almeida OP, Burton EJ, Ferrier N, McKeith IG, O\u2019Brien JT (2003) Depression with late onset is associated with right frontal lobe atrophy. Psychol Med 33:675\u2013681","journal-title":"Psychol Med"},{"key":"2648_CR11","doi-asserted-by":"crossref","first-page":"110721","DOI":"10.1016\/j.pnpbp.2023.110721","volume":"123","author":"M Amidfar","year":"2023","unstructured":"Amidfar M, Garcez ML, Kim YK (2023) The shared molecular mechanisms underlying aging of the brain, major depressive disorder, and Alzheimer\u2019s disease: the role of circadian rhythm disturbances. Prog Neuropsychopharmacol Biol Psychiatry 123:110721","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2648_CR12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.pscychresns.2013.08.007","volume":"214","author":"C Andreescu","year":"2013","unstructured":"Andreescu C, Tudorascu DL, Butters MA, Tamburo E, Patel M, Price J, Karp JF, Reynolds CF 3rd, Aizenstein H (2013) Resting state functional connectivity and treatment response in late-life depression. Psychiatry Res 214:313\u2013321","journal-title":"Psychiatry Res"},{"key":"2648_CR13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.psc.2013.08.001","volume":"36","author":"R Aziz","year":"2013","unstructured":"Aziz R, Steffens DC (2013) What are the causes of late-life depression? Psychiatr Clin North Am 36:497\u2013516","journal-title":"Psychiatr Clin North Am"},{"key":"2648_CR14","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1002\/alz.12631","volume":"18","author":"GM Babulal","year":"2022","unstructured":"Babulal GM, Zhu Y, Roe CM, Hudson DL, Williams MM, Murphy SA, Doherty J, Johnson AM, Trani JF (2022) The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity. Alzheimers Dement 18:2593\u20132602","journal-title":"Alzheimers Dement"},{"key":"2648_CR15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1001\/archgenpsychiatry.2011.1481","volume":"69","author":"DE Barnes","year":"2012","unstructured":"Barnes DE, Yaffe K, Byers AL, McCormick M, Schaefer C, Whitmer RA (2012) Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia. Arch Gen Psychiatry 69:493\u2013498","journal-title":"Arch Gen Psychiatry"},{"key":"2648_CR16","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1586\/ern.11.88","volume":"11","author":"AT Beekman","year":"2011","unstructured":"Beekman AT (2011) Neuropathological correlates of late-life depression. Expert Rev Neurother 11:947\u2013949","journal-title":"Expert Rev Neurother"},{"key":"2648_CR17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jpsychires.2023.02.003","volume":"160","author":"I Beltran-Najera","year":"2023","unstructured":"Beltran-Najera I, Mustafa A, Warren D, Salling Z, Misiura M, Woods SP, Dotson VM (2023) Elevated frequency and everyday functioning implications of vascular depression in persons with HIV disease. J Psychiatr Res 160:78\u201385","journal-title":"J Psychiatr Res"},{"key":"2648_CR18","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3389\/fnhum.2015.00408","volume":"9","author":"KR Bijanki","year":"2015","unstructured":"Bijanki KR, Matsui JT, Mayberg HS, Magnotta VA, Arndt S, Johnson HJ, Nopoulos P, Paradiso S, McCormick LM, Fiedorowicz JG, Epping EA, Moser DJ (2015) Depressive symptoms related to low fractional anisotropy of white matter underlying the right ventral anterior cingulate in older adults with atherosclerotic vascular disease. Front Hum Neurosci 9:408","journal-title":"Front Hum Neurosci"},{"key":"2648_CR243","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291723000697","author":"M Bl\u00f6chl","year":"2023","unstructured":"Bl\u00f6chl M, Schaare HL, Kumral D, Gaebler M, Nestler S, Villringer A (2023) Vascular risk factors, white matter microstructure, and depressive symptoms: a longitudinal analysis in the UK Biobank. Psychol Med. https:\/\/doi.org\/10.1017\/S0033291723000697","journal-title":"Psychol Med"},{"key":"2648_CR19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3233\/JAD-142955","volume":"46","author":"M Boccia","year":"2015","unstructured":"Boccia M, Acierno M, Piccardi L (2015) Neuroanatomy of Alzheimer\u2019s disease and late-life depression: a coordinate-based meta-analysis of MRI studies. J Alzheimers Dis 46:963\u2013970","journal-title":"J Alzheimers Dis"},{"key":"2648_CR20","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1007\/s10072-022-06068-x","volume":"43","author":"R Botto","year":"2022","unstructured":"Botto R, Callai N, Cermelli A, Causarano L, Rainero I (2022) Anxiety and depression in Alzheimer\u2019s disease: a systematic review of pathogenetic mechanisms and relation to cognitive decline. Neurol Sci 43:4107\u20134124","journal-title":"Neurol Sci"},{"key":"2648_CR21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1503\/jpn.140322","volume":"41","author":"F Bouckaert","year":"2016","unstructured":"Bouckaert F, De Winter FL, Emsell L, Dols A, Rhebergen D, Wampers M, Sunaert S, Stek M, Sienaert P, Vandenbulcke M (2016a) Grey matter volume increase following electroconvulsive therapy in patients with late life depression: a longitudinal MRI study. J Psychiatry Neurosci 41:105\u2013114","journal-title":"J Psychiatry Neurosci"},{"key":"2648_CR22","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1038\/npp.2016.86","volume":"41","author":"F Bouckaert","year":"2016","unstructured":"Bouckaert F, Dols A, Emsell L, De Winter FL, Vansteelandt K, Claes L, Sunaert S, Stek M, Sienaert P, Vandenbulcke M (2016b) Relationship between hippocampal volume, serum BDNF, and depression severity following electroconvulsive therapy in late-life depression. Neuropsychopharmacology 41:2741\u20132748","journal-title":"Neuropsychopharmacology"},{"key":"2648_CR23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jad.2019.03.055","volume":"251","author":"F Bouckaert","year":"2019","unstructured":"Bouckaert F, Emsell L, Vansteelandt K, De Winter FL, Van den Stock J, Obbels J, Dols A, Stek M, Adamczuk K, Sunaert S, Van Laere K, Sienaert P, Vandenbulcke M (2019) Electroconvulsive therapy response in late-life depression unaffected by age-related brain changes. J Affect Disord 251:114\u2013120","journal-title":"J Affect Disord"},{"key":"2648_CR24","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1016\/j.jamda.2021.09.003","volume":"22","author":"R Briggs","year":"2021","unstructured":"Briggs R, McDowell CP, De Looze C, Kenny RA, Ward M (2021) Depressive symptoms among older adults pre- and post-COVID-19 pandemic. J Am Med Dir Assoc 22:2251\u20132257","journal-title":"J Am Med Dir Assoc"},{"key":"2648_CR25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jad.2012.05.010","volume":"142","author":"D B\u00fcchtemann","year":"2012","unstructured":"B\u00fcchtemann D, Luppa M, Bramesfeld A, Riedel-Heller S (2012) Incidence of late-life depression: a systematic review. J Affect Disord 142:172\u2013179","journal-title":"J Affect Disord"},{"key":"2648_CR26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.31887\/DCNS.2008.10.3\/mabutters","volume":"10","author":"MA Butters","year":"2008","unstructured":"Butters MA, Young JB, Lopez O, Aizenstein HJ, Mulsant BH, Reynolds CF 3rd, DeKosky ST, Becker JT (2008) Pathways linking late-life depression to persistent cognitive impairment and dementia. Dialogues Clin Neurosci 10:345\u2013357","journal-title":"Dialogues Clin Neurosci"},{"key":"2648_CR27","first-page":"236","volume":"8","author":"MS Byun","year":"2016","unstructured":"Byun MS, Choe YM, Sohn BK, Yi D, Han JY, Park J, Choi HJ, Baek H, Lee JH, Kim HJ, Kim YK, Yoon EJ, Sohn CH, Woo JI, Lee DY (2016) Association of cerebral amyloidosis, blood pressure, and neuronal injury with late-life onset depression. Front Aging Neurosci 8:236","journal-title":"Front Aging Neurosci"},{"key":"2648_CR28","doi-asserted-by":"crossref","first-page":"103182","DOI":"10.1016\/j.nicl.2022.103182","volume":"36","author":"N Calarco","year":"2022","unstructured":"Calarco N, Cassidy CM, Selby B, Hawco C, Voineskos AN, Diniz BS, Nikolova YS (2022) Associations between locus coeruleus integrity and diagnosis, age, and cognitive performance in older adults with and without late-life depression: an exploratory study. Neuroimage Clin 36:103182","journal-title":"Neuroimage Clin"},{"key":"2648_CR29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.17219\/acem\/149897","volume":"31","author":"MDP Carrera-Gonz\u00e1lez","year":"2022","unstructured":"Carrera-Gonz\u00e1lez MDP, Cant\u00f3n-Habas V, Rich-Ruiz M (2022) Aging, depression and dementia: the inflammatory process. Adv Clin Exp Med 31:469\u2013473","journal-title":"Adv Clin Exp Med"},{"key":"2648_CR30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/geront\/48.5.593","volume":"48","author":"E Chachamovich","year":"2008","unstructured":"Chachamovich E, Fleck M, Laidlaw K, Power M (2008) Impact of major depression and subsyndromal symptoms on quality of life and attitudes toward aging in an international sample of older adults. Gerontologist 48:593\u2013602","journal-title":"Gerontologist"},{"key":"2648_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2011.01.003","volume":"193","author":"CC Chang","year":"2011","unstructured":"Chang CC, Yu SC, McQuoid DR, Messer DF, Taylor WD, Singh K, Boyd BD, Krishnan KR, MacFall JR, Steffens DC, Payne ME (2011) Reduction of dorsolateral prefrontal cortex gray matter in late-life depression. Psychiatry Res 193:1\u20136","journal-title":"Psychiatry Res"},{"key":"2648_CR32","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/archpsyc.56.3.261","volume":"56","author":"P Chen","year":"1999","unstructured":"Chen P, Ganguli M, Mulsant BH, DeKosky ST (1999) The temporal relationship between depressive symptoms and dementia: a community-based prospective study. Arch Gen Psychiatry 56:261\u2013266","journal-title":"Arch Gen Psychiatry"},{"key":"2648_CR33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1017\/S1041610205002796","volume":"18","author":"PS Chen","year":"2006","unstructured":"Chen PS, McQuoid DR, Payne ME, Steffens DC (2006) White matter and subcortical gray matter lesion volume changes and late-life depression outcome: a 4-year magnetic resonance imaging study. Int Psychogeriatr 18:445\u2013456","journal-title":"Int Psychogeriatr"},{"key":"2648_CR34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jad.2015.04.052","volume":"183","author":"Y Chen","year":"2015","unstructured":"Chen Y, Wang C, Zhu X, Tan Y, Zhong Y (2015) Aberrant connectivity within the default mode network in first-episode, treatment-na\u00efve major depressive disorder. J Affect Disord 183:49\u201356","journal-title":"J Affect Disord"},{"key":"2648_CR35","doi-asserted-by":"crossref","first-page":"153331752110461","DOI":"10.1177\/15333175211046123","volume":"36","author":"Y Cheng","year":"2021","unstructured":"Cheng Y, Sun M, Wang F, Geng X (2021) Identification of hub genes related to Alzheimer\u2019s disease and major depressive disorder. Am J Alzheimers Dis Other Demen 36:15333175211046124","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"2648_CR36","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s00259-019-04379-4","volume":"46","author":"A Chiaravalloti","year":"2019","unstructured":"Chiaravalloti A, Barbagallo G, Martorana A, Castellano AE, Ursini F, Schillaci O (2019) Brain metabolic patterns in patients with suspected non-Alzheimer\u2019s pathophysiology (SNAP) and Alzheimer\u2019s disease (AD): is [(18)F] FDG a specific biomarker in these patients? Eur J Nucl Med Mol Imaging 46:1796\u20131805","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2648_CR37","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jad.2011.04.010","volume":"133","author":"SJ Colloby","year":"2011","unstructured":"Colloby SJ, Firbank MJ, Vasudev A, Parry SW, Thomas AJ, O\u2019Brien JT (2011) Cortical thickness and VBM-DARTEL in late-life depression. J Affect Disord 133:158\u2013164","journal-title":"J Affect Disord"},{"key":"2648_CR38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12888-015-0401-5","volume":"15","author":"HC Comijs","year":"2015","unstructured":"Comijs HC, Nieuwesteeg J, Kok R, van Marwijk HW, van der Mast RC, Naarding P, Voshaar RC, Verhaak P, de Waal MW, Stek ML (2015) The two-year course of late-life depression; results from the Netherlands study of depression in older persons. BMC Psychiatry 15:20","journal-title":"BMC Psychiatry"},{"key":"2648_CR39","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jad.2018.10.358","volume":"245","author":"JL Conde-Sala","year":"2019","unstructured":"Conde-Sala JL, Garre-Olmo J, Calv\u00f3-Perxas L, Turr\u00f3-Garriga O, Vilalta-Franch J (2019) Course of depressive symptoms and associated factors in people aged 65+ in Europe: a two-year follow-up. J Affect Disord 245:440\u2013450","journal-title":"J Affect Disord"},{"key":"2648_CR40","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11920-009-0081-2","volume":"12","author":"EA Crocco","year":"2010","unstructured":"Crocco EA, Castro K, Loewenstein DA (2010) How late-life depression affects cognition: neural mechanisms. Curr Psychiatry Rep 12:34\u201338","journal-title":"Curr Psychiatry Rep"},{"key":"2648_CR41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0165-0327(01)00413-X","volume":"72","author":"P Cuijpers","year":"2002","unstructured":"Cuijpers P, Smit F (2002) Excess mortality in depression: a meta-analysis of community studies. J Affect Disord 72:227\u2013236","journal-title":"J Affect Disord"},{"key":"2648_CR42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jad.2023.02.126","volume":"329","author":"YR Dai","year":"2023","unstructured":"Dai YR, Wu YK, Chen X, Zeng YW, Li K, Li JT, Su YA, Zhu LL, Yan CG, Si TM (2023) Eight-week antidepressant treatment changes intrinsic functional brain topology in first-episode drug-na\u00efve patients with major depressive disorder. J Affect Disord 329:225\u2013234","journal-title":"J Affect Disord"},{"key":"2648_CR43","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1021\/acschemneuro.2c00143","volume":"13","author":"MP Dandekar","year":"2022","unstructured":"Dandekar MP, Palepu MSK, Satti S, Jaiswal Y, Singh AA, Dash SP, Gajula SNR, Sonti R (2022) Multi-strain probiotic formulation reverses maternal separation and chronic unpredictable mild stress-generated anxiety- and depression-like phenotypes by modulating gut microbiome-brain activity in rats. ACS Chem Neurosci 13:1948\u20131965","journal-title":"ACS Chem Neurosci"},{"key":"2648_CR44","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1176\/appi.ajp.2016.16030319","volume":"174","author":"FL De Winter","year":"2017","unstructured":"De Winter FL, Emsell L, Bouckaert F, Claes L, Jain S, Farrar G, Billiet T, Evers S, Van den Stock J, Sienaert P, Obbels J, Sunaert S, Adamczuk K, Vandenberghe R, Van Laere K, Vandenbulcke M (2017) No association of lower hippocampal volume with Alzheimer\u2019s disease pathology in late-life depression. Am J Psychiatry 174:237\u2013245","journal-title":"Am J Psychiatry"},{"key":"2648_CR45","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1161\/STROKEAHA.107.502534","volume":"39","author":"L Delano-Wood","year":"2008","unstructured":"Delano-Wood L, Abeles N, Sacco JM, Wierenga CE, Horne NR, Bozoki A (2008) Regional white matter pathology in mild cognitive impairment: differential influence of lesion type on neuropsychological functioning. Stroke 39:794\u2013799","journal-title":"Stroke"},{"key":"2648_CR46","doi-asserted-by":"crossref","first-page":"864902","DOI":"10.3389\/fpsyt.2022.864902","volume":"13","author":"I Demchenko","year":"2022","unstructured":"Demchenko I, Tassone VK, Kennedy SH, Dunlop K, Bhat V (2022) Intrinsic connectivity networks of glutamate-mediated antidepressant response: a neuroimaging review. Front Psychiatry 13:864902","journal-title":"Front Psychiatry"},{"key":"2648_CR47","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopsych.2011.04.014","volume":"70","author":"T den Heijer","year":"2011","unstructured":"den Heijer T, Tiemeier H, Luijendijk HJ, van der Lijn F, Koudstaal PJ, Hofman A, Breteler MM (2011) A study of the bidirectional association between hippocampal volume on magnetic resonance imaging and depression in the elderly. Biol Psychiatry 70:191\u2013197","journal-title":"Biol Psychiatry"},{"key":"2648_CR48","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1192\/bjp.bp.112.118307","volume":"202","author":"BS Diniz","year":"2013","unstructured":"Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds CF 3rd (2013) Late-life depression and risk of vascular dementia and Alzheimer\u2019s disease: systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry 202:329\u2013335","journal-title":"Br J Psychiatry"},{"key":"2648_CR49","first-page":"e12129","volume":"7","author":"BS Diniz","year":"2021","unstructured":"Diniz BS, Vieira EM, Mendes-Silva AP, Bowie CR, Butters MA, Fischer CE, Flint A, Herrmann N, Kennedy J, Lanct\u00f4t KL, Mah L, Pollock BG, Mulsant BH, Rajji TK (2021) Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults. Alzheimers Dement 7:e12129","journal-title":"Alzheimers Dement"},{"key":"2648_CR50","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11920-012-0279-6","volume":"14","author":"BM Disabato","year":"2012","unstructured":"Disabato BM, Sheline YI (2012) Biological basis of late life depression. Curr Psychiatry Rep 14:273\u2013279","journal-title":"Curr Psychiatry Rep"},{"key":"2648_CR51","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1600-0447.2006.00770.x","volume":"113","author":"JK Djernes","year":"2006","unstructured":"Djernes JK (2006) Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand 113:372\u2013387","journal-title":"Acta Psychiatr Scand"},{"key":"2648_CR52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jpsychires.2017.08.002","volume":"95","author":"K Droppa","year":"2017","unstructured":"Droppa K, Karim HT, Tudorascu DL, Karp JF, Reynolds CF 3rd, Aizenstein HJ, Butters MA (2017) Association between change in brain gray matter volume, cognition, and depression severity: pre- and post- antidepressant pharmacotherapy for late-life depression. J Psychiatr Res 95:129\u2013134","journal-title":"J Psychiatr Res"},{"key":"2648_CR53","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jad.2023.02.129","volume":"330","author":"Y Du","year":"2023","unstructured":"Du Y, Yu J, Liu M, Qiu Q, Fang Y, Zhao L, Wei W, Wang J, Lin X, Yan F, Li X (2023) The relationship between depressive symptoms and cognitive function in Alzheimer\u2019s disease: the mediating effect of amygdala functional connectivity and radiomic features. J Affect Disord 330:101\u2013109","journal-title":"J Affect Disord"},{"key":"2648_CR54","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1176\/appi.ajp.2016.16050518","volume":"174","author":"BW Dunlop","year":"2017","unstructured":"Dunlop BW, Rajendra JK, Craighead WE, Kelley ME, McGrath CL, Choi KS, Kinkead B, Nemeroff CB, Mayberg HS (2017) Functional connectivity of the subcallosal cingulate cortex and differential outcomes to treatment with cognitive-behavioral therapy or antidepressant medication for major depressive disorder. Am J Psychiatry 174:533\u2013545","journal-title":"Am J Psychiatry"},{"key":"2648_CR55","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biopsych.2021.04.012","volume":"90","author":"JP Empana","year":"2021","unstructured":"Empana JP, Boutouyrie P, Lemogne C, Jouven X, van Sloten TT (2021) Microvascular contribution to late-onset depression: mechanisms, current evidence, association with other brain diseases, and therapeutic perspectives. Biol Psychiatry 90:214\u2013225","journal-title":"Biol Psychiatry"},{"key":"2648_CR56","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jad.2015.09.011","volume":"189","author":"HA Eyre","year":"2016","unstructured":"Eyre HA, Yang H, Leaver AM, Van Dyk K, Siddarth P, Cyr NS, Narr K, Ercoli L, Baune BT, Lavretsky H (2016) Altered resting-state functional connectivity in late-life depression: a cross-sectional study. J Affect Disord 189:126\u2013133","journal-title":"J Affect Disord"},{"key":"2648_CR57","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jad.2022.11.006","volume":"322","author":"M Felez-Nobrega","year":"2023","unstructured":"Felez-Nobrega M, Werneck AO, El Fatouhi D, de Luca K, Islam SMS, Franzese F (2023) Device-based physical activity and late-life depressive symptoms: an analysis of influential factors using share data. J Affect Disord 322:267\u2013272","journal-title":"J Affect Disord"},{"key":"2648_CR58","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/mp.2015.168","volume":"21","author":"JC Felger","year":"2016","unstructured":"Felger JC, Li Z, Haroon E, Woolwine BJ, Jung MY, Hu X, Miller AH (2016) Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Mol Psychiatry 21:1358\u20131365","journal-title":"Mol Psychiatry"},{"key":"2648_CR59","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3758\/s13415-017-0544-6","volume":"17","author":"J Ferri","year":"2017","unstructured":"Ferri J, Eisendrath SJ, Fryer SL, Gillung E, Roach BJ, Mathalon DH (2017) Blunted amygdala activity is associated with depression severity in treatment-resistant depression. Cogn Affect Behav Neurosci 17:1221\u20131231","journal-title":"Cogn Affect Behav Neurosci"},{"key":"2648_CR60","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1192\/bjp.bp.111.098897","volume":"201","author":"MJ Firbank","year":"2012","unstructured":"Firbank MJ, Teodorczuk A, van der Flier WM, Gouw AA, Wallin A, Erkinjuntti T, Inzitari D, Wahlund LO, Pantoni L, Poggesi A, Pracucci G, Langhorne P, O\u2019Brien JT (2012) Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study. Br J Psychiatry 201:40\u201345","journal-title":"Br J Psychiatry"},{"key":"2648_CR61","doi-asserted-by":"crossref","first-page":"45611","DOI":"10.4088\/JCP.22m14469","volume":"84","author":"H Galfalvy","year":"2023","unstructured":"Galfalvy H, Sz\u00fccs A, Chang YW, Buerke M, Szanto K (2023) Long-term suicidal ideation profiles in late-life depression and their association with suicide attempt or death by suicide. J Clin Psychiatry 84:22m14469","journal-title":"J Clin Psychiatry"},{"key":"2648_CR62","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/archpsyc.63.2.153","volume":"63","author":"M Ganguli","year":"2006","unstructured":"Ganguli M, Du Y, Dodge HH, Ratcliff GG, Chang CC (2006) Depressive symptoms and cognitive decline in late life: a prospective epidemiological study. Arch Gen Psychiatry 63:153\u2013160","journal-title":"Arch Gen Psychiatry"},{"key":"2648_CR63","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1212\/01.wnl.0000308937.30473.d1","volume":"70","author":"MI Geerlings","year":"2008","unstructured":"Geerlings MI, den Heijer T, Koudstaal PJ, Hofman A, Breteler MM (2008) History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease. Neurology 70:1258\u20131264","journal-title":"Neurology"},{"key":"2648_CR64","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jad.2021.05.096","volume":"292","author":"AF Geraets","year":"2021","unstructured":"Geraets AF, K\u00f6hler S, Jansen JF, Eussen SJ, Stehouwer CD, Schaper NC, Wesselius A, Verhey FR, Schram MT (2021a) The association of markers of cerebral small vessel disease and brain atrophy with incidence and course of depressive symptoms\u2014the Maastricht study. J Affect Disord 292:439\u2013447","journal-title":"J Affect Disord"},{"key":"2648_CR65","first-page":"1","volume":"52","author":"AFJ Geraets","year":"2021","unstructured":"Geraets AFJ, Schram MT, Jansen JFA, Koster A, Dagnelie PC, van Greevenbroek MMJ, Stehouwer CDA, Verhey FRJ, K\u00f6hler S (2021b) The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study. Psychol Med 52:1\u201310","journal-title":"Psychol Med"},{"key":"2648_CR66","doi-asserted-by":"publisher","first-page":"19","DOI":"10.20517\/22574-21209.22021.20102","volume":"6","author":"AFJ Geraets","year":"2022","unstructured":"Geraets AFJ, K\u00f6hler S, Schram MT (2022) Vascular and metabolic risk factors of late-life depression. Vessel plus 6:19. https:\/\/doi.org\/10.20517\/22574-21209.22021.20102","journal-title":"Vessel plus"},{"key":"2648_CR67","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.3390\/ijerph20042975","volume":"20","author":"SK Gerhards","year":"2023","unstructured":"Gerhards SK, Luppa M, R\u00f6hr S, Pabst A, Bauer A, Frankh\u00e4nel T, D\u00f6ring J, Escales C, Z\u00f6llinger IR, Oey A, Brettschneider C, Wiese B, Hoffmann W, Gensichen J, K\u00f6nig HH, Frese T, Thyrian JR, Kaduszkiewicz H, Riedel-Heller SG (2023) Depression and anxiety in old age during the COVID-19 pandemic: a comparative study of individuals at cardiovascular risk and the general population. Int J Environ Res Public Health 20:2975","journal-title":"Int J Environ Res Public Health"},{"key":"2648_CR68","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neurobiolaging.2021.09.025","volume":"111","author":"L Gerritsen","year":"2022","unstructured":"Gerritsen L, Sigurdsson S, Jonsson PV, Gudnason V, Launer LJ, Geerlings MI (2022) Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik Study. Neurobiol Aging 111:14\u201323","journal-title":"Neurobiol Aging"},{"key":"2648_CR69","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.regg.2021.10.002","volume":"57","author":"A Gonz\u00e1lez Hern\u00e1ndez","year":"2022","unstructured":"Gonz\u00e1lez Hern\u00e1ndez A, Rodr\u00edguez Quintero AM, Bonilla Santos J (2022) Depression and its relationship with mild cognitive impairment and Alzheimer disease: a review study. Rev Esp Geriatr Gerontol 57:118\u2013128","journal-title":"Rev Esp Geriatr Gerontol"},{"key":"2648_CR70","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1017\/S0033291796004576","volume":"27","author":"BS Greenwald","year":"1997","unstructured":"Greenwald BS, Kramer-Ginsberg E, Bogerts B, Ashtari M, Aupperle P, Wu H, Allen L, Zeman D, Patel M (1997) Qualitative magnetic resonance imaging findings in geriatric depression. Possible link between later-onset depression and Alzheimer\u2019s disease? Psychol Med 27:421\u2013431","journal-title":"Psychol Med"},{"key":"2648_CR71","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1186\/s12888-022-04450-9","volume":"22","author":"Z Guo","year":"2022","unstructured":"Guo Z, Liu K, Li J, Zhu H, Chen B, Liu X (2022) Disrupted topological organization of functional brain networks in Alzheimer\u2019s disease patients with depressive symptoms. BMC Psychiatry 22:810","journal-title":"BMC Psychiatry"},{"key":"2648_CR72","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.biopsych.2015.02.037","volume":"79","author":"A Gyurak","year":"2016","unstructured":"Gyurak A, Patenaude B, Korgaonkar MS, Grieve SM, Williams LM, Etkin A (2016) Frontoparietal activation during response inhibition predicts remission to antidepressants in patients with major depression. Biol Psychiatry 79:274\u2013281","journal-title":"Biol Psychiatry"},{"key":"2648_CR73","doi-asserted-by":"crossref","first-page":"821866","DOI":"10.3389\/fnagi.2022.821866","volume":"14","author":"A Hakim","year":"2022","unstructured":"Hakim A (2022) Perspectives on the complex links between depression and dementia. Front Aging Neurosci 14:821866","journal-title":"Front Aging Neurosci"},{"key":"2648_CR74","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biopsych.2021.11.025","volume":"92","author":"NV Harerimana","year":"2022","unstructured":"Harerimana NV, Liu Y, Gerasimov ES, Duong D, Beach TG, Reiman EM, Schneider JA, Boyle P, Lori A, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Wingo TS, Wingo AP (2022) Genetic evidence supporting a causal role of depression in Alzheimer\u2019s disease. Biol Psychiatry 92:25\u201333","journal-title":"Biol Psychiatry"},{"key":"2648_CR75","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/gps.4489","volume":"32","author":"KD Harrington","year":"2017","unstructured":"Harrington KD, Gould E, Lim YY, Ames D, Pietrzak RH, Rembach A, Rainey-Smith S, Martins RN, Salvado O, Villemagne VL, Rowe CC, Masters CL, Maruff P (2017) Amyloid burden and incident depressive symptoms in cognitively normal older adults. Int J Geriatr Psychiatry 32:455\u2013463","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR76","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.jagp.2021.01.004","volume":"29","author":"X He","year":"2021","unstructured":"He X, Pueraro E, Kim Y, Garcia CM, Maas B, Choi J, Egglefield DA, Schiff S, Sneed JR, Brown PJ, Brickman AM, Roose SP, Rutherford BR (2021) Association of white matter integrity with executive function and antidepressant treatment outcome in patients with late-life depression. Am J Geriatr Psychiatry 29:1188\u20131198","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR77","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nn.4113","volume":"18","author":"GE Hodes","year":"2015","unstructured":"Hodes GE, Kana V, Menard C, Merad M, Russo SJ (2015) Neuroimmune mechanisms of depression. Nat Neurosci 18:1386\u20131393","journal-title":"Nat Neurosci"},{"key":"2648_CR78","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jad.2020.12.049","volume":"281","author":"WSW Hyung","year":"2021","unstructured":"Hyung WSW, Kang J, Kim J, Lee S, Youn H, Ham BJ, Han C, Suh S, Han CE, Jeong HG (2021) Cerebral amyloid accumulation is associated with distinct structural and functional alterations in the brain of depressed elders with mild cognitive impairment. J Affect Disord 281:459\u2013466","journal-title":"J Affect Disord"},{"key":"2648_CR79","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000519453","volume":"50","author":"S Invernizzi","year":"2021","unstructured":"Invernizzi S, Simoes Loureiro I, Kandana Arachchige KG, Lefebvre L (2021) Late-life depression, cognitive impairment, and relationship with Alzheimer\u2019s disease. Dement Geriatr Cogn Disord 50:414\u2013424","journal-title":"Dement Geriatr Cogn Disord"},{"key":"2648_CR80","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2217\/nmt.14.5","volume":"4","author":"Z Ismail","year":"2014","unstructured":"Ismail Z, Malick A, Smith EE, Schweizer T, Fischer C (2014) Depression versus dementia: is this construct still relevant? Neurodegener Dis Manag 4:119\u2013126","journal-title":"Neurodegener Dis Manag"},{"key":"2648_CR81","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00702-012-0945-1","volume":"120","author":"KA Jellinger","year":"2013","unstructured":"Jellinger KA (2013) Organic bases of late-life depression: a critical update. J Neural Transm 120:1109\u20131125","journal-title":"J Neural Transm"},{"key":"2648_CR82","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3390\/ijms23010308","volume":"23","author":"KA Jellinger","year":"2021","unstructured":"Jellinger KA (2021) Pathomechanisms of vascular depression in older adults. Int J Mol Sci 23:308","journal-title":"Int J Mol Sci"},{"key":"2648_CR83","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3390\/ijms23010308","volume":"23","author":"KA Jellinger","year":"2022","unstructured":"Jellinger KA (2022a) Pathomechanisms of vascular depression in older adults. Int J Mol Sci 23:308","journal-title":"Int J Mol Sci"},{"key":"2648_CR84","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00702-022-02521-5","volume":"129","author":"KA Jellinger","year":"2022","unstructured":"Jellinger KA (2022b) The enigma of vascular depression in old age: a critical update. J Neural Transm 129:961\u2013976","journal-title":"J Neural Transm"},{"key":"2648_CR85","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jad.2022.11.089","volume":"323","author":"M Ji","year":"2023","unstructured":"Ji M, Sun Y, Zhou J, Li X, Wei H, Wang Z (2023) Comparative effectiveness and acceptability of psychotherapies for late-life depression: A systematic review and network meta-analysis. J Affect Disord 323:409\u2013416","journal-title":"J Affect Disord"},{"key":"2648_CR86","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamapsychiatry.2015.0071","volume":"72","author":"RH Kaiser","year":"2015","unstructured":"Kaiser RH, Andrews-Hanna JR, Wager TD, Pizzagalli DA (2015) Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity. JAMA Psychiat 72:603\u2013611","journal-title":"JAMA Psychiat"},{"key":"2648_CR87","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/ph13050092","volume":"13","author":"HO Kalkman","year":"2020","unstructured":"Kalkman HO (2020) The association between vascular inflammation and depressive disorder. Causality, biomarkers and targeted treatment. Pharmaceuticals 13:92","journal-title":"Pharmaceuticals"},{"key":"2648_CR88","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/mp.2016.55","volume":"22","author":"HT Karim","year":"2017","unstructured":"Karim HT, Andreescu C, Tudorascu D, Smagula SF, Butters MA, Karp JF, Reynolds C, Aizenstein HJ (2017) Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters. Mol Psychiatry 22:450\u2013457","journal-title":"Mol Psychiatry"},{"key":"2648_CR89","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.nicl.2018.06.006","volume":"19","author":"HT Karim","year":"2018","unstructured":"Karim HT, Wang M, Andreescu C, Tudorascu D, Butters MA, Karp JF, Reynolds CF 3rd, Aizenstein HJ (2018) Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression. Neuroimage Clin 19:831\u2013839","journal-title":"Neuroimage Clin"},{"key":"2648_CR90","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/archpsyc.60.9.897","volume":"60","author":"WJ Katon","year":"2003","unstructured":"Katon WJ, Lin E, Russo J, Unutzer J (2003) Increased medical costs of a population-based sample of depressed elderly patients. Arch Gen Psychiatry 60:897\u2013903","journal-title":"Arch Gen Psychiatry"},{"key":"2648_CR91","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/JGP.0b013e3181cabd0e","volume":"18","author":"ER Kenny","year":"2010","unstructured":"Kenny ER, O\u2019Brien JT, Cousins DA, Richardson J, Thomas AJ, Firbank MJ, Blamire AM (2010) Functional connectivity in late-life depression using resting-state functional magnetic resonance imaging. Am J Geriatr Psychiatry 18:643\u2013651","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR92","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jagp.2013.06.003","volume":"22","author":"AA Khundakar","year":"2014","unstructured":"Khundakar AA, Thomas AJ (2014) Cellular morphometry in late-life depression: a review of postmortem studies. Am J Geriatr Psychiatry 22:122\u2013132","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR93","doi-asserted-by":"crossref","first-page":"110010","DOI":"10.1016\/j.pnpbp.2020.110010","volume":"104","author":"YK Kim","year":"2021","unstructured":"Kim YK, Han KM (2021) Neural substrates for late-life depression: a selective review of structural neuroimaging studies. Prog Neuropsychopharmacol Biol Psychiatry 104:110010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2648_CR94","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3233\/JAD-180394","volume":"65","author":"Y Kim","year":"2018","unstructured":"Kim Y, Jang H, Kim SJ, Cho SH, Kim SE, Kim ST, Kim HJ, Moon SH, Ewers M, Im K, Kwon H, Na DL, Seo SW (2018) Vascular effects on depressive symptoms in cognitive impairment. J Alzheimers Dis 65:597\u2013605","journal-title":"J Alzheimers Dis"},{"key":"2648_CR95","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5809","author":"D Kim","year":"2022","unstructured":"Kim D, Kiss A, Bronskill SE, Lanct\u00f4t KL, Herrmann N, Gallagher D (2022) Association between depression, gender and Alzheimer\u2019s neuropathology in older adults without dementia. Int J Geriatr Psychiatry. https:\/\/doi.org\/10.1002\/gps.5809","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR96","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/brain\/awad067","volume":"146","author":"J Klingbeil","year":"2023","unstructured":"Klingbeil J, Saur D (2023) Localization of depressive symptoms based on focal brain lesions: adding \u201cresilience\u201d to \u201crisk.\u201d Brain 146:1238\u20131239","journal-title":"Brain"},{"key":"2648_CR97","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/JAD-148006","volume":"45","author":"AM Koenig","year":"2015","unstructured":"Koenig AM, DeLozier IJ, Zmuda MD, Marron MM, Begley AE, Anderson SJ, Reynolds CF 3rd, Arnold SE, Becker JT, Butters MA (2015) Neuropsychological functioning in the acute and remitted States of late-life depression. J Alzheimers Dis 45:175\u2013185","journal-title":"J Alzheimers Dis"},{"key":"2648_CR98","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1017\/S0033291709990833","volume":"40","author":"S K\u00f6hler","year":"2010","unstructured":"K\u00f6hler S, Thomas AJ, Barnett NA, O\u2019Brien JT (2010) The pattern and course of cognitive impairment in late-life depression. Psychol Med 40:591\u2013602","journal-title":"Psychol Med"},{"key":"2648_CR99","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.3390\/ijms22147421","volume":"22","author":"CY Kuo","year":"2021","unstructured":"Kuo CY, Lin CH, Lane HY (2021) Molecular basis of late-life depression. Int J Mol Sci 22:7421","journal-title":"Int J Mol Sci"},{"key":"2648_CR100","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jad.2020.05.020","volume":"274","author":"JK Kuring","year":"2020","unstructured":"Kuring JK, Mathias JL, Ward L (2020) Risk of dementia in persons who have previously experienced clinically-significant depression, anxiety, or PTSD: a systematic review and meta-analysis. J Affect Disord 274:247\u2013261","journal-title":"J Affect Disord"},{"key":"2648_CR101","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/gps.4204","volume":"30","author":"P Laborde-Lahoz","year":"2015","unstructured":"Laborde-Lahoz P, El-Gabalawy R, Kinley J, Kirwin PD, Sareen J, Pietrzak RH (2015) Subsyndromal depression among older adults in the USA: prevalence, comorbidity, and risk for new-onset psychiatric disorders in late life. Int J Geriatr Psychiatry 30:677\u2013685","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR102","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/0898264308321002","volume":"20","author":"K Ladin","year":"2008","unstructured":"Ladin K (2008) Risk of late-life depression across 10 European Union countries: deconstructing the education effect. J Aging Health 20:653\u2013670","journal-title":"J Aging Health"},{"key":"2648_CR103","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41398-019-0424-7","volume":"9","author":"KT Laird","year":"2019","unstructured":"Laird KT, Krause B, Funes C, Lavretsky H (2019) Psychobiological factors of resilience and depression in late life. Transl Psychiatry 9:88","journal-title":"Transl Psychiatry"},{"key":"2648_CR104","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.neuropsychologia.2013.05.004","volume":"51","author":"M Lamar","year":"2013","unstructured":"Lamar M, Charlton RA, Ajilore O, Zhang A, Yang S, Barrick TR, Rhodes E, Kumar A (2013) Prefrontal vulnerabilities and whole brain connectivity in aging and depression. Neuropsychologia 51:1463\u20131470","journal-title":"Neuropsychologia"},{"key":"2648_CR105","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000492489","volume":"46","author":"M Lauriola","year":"2018","unstructured":"Lauriola M, Mangiacotti A, D\u2019Onofrio G, Cascavilla L, Paris F, Ciccone F, Greco M, Paroni G, Seripa D, Greco A (2018) Late-life depression versus amnestic mild cognitive impairment: Alzheimer\u2019s disease incidence in 4 years of follow-up. Dement Geriatr Cogn Disord 46:140\u2013153","journal-title":"Dement Geriatr Cogn Disord"},{"key":"2648_CR106","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0006-3223(03)00063-5","volume":"54","author":"SH Lee","year":"2003","unstructured":"Lee SH, Payne ME, Steffens DC, McQuoid DR, Lai TJ, Provenzale JM, Krishnan KR (2003) Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression. Biol Psychiatry 54:529\u2013533","journal-title":"Biol Psychiatry"},{"key":"2648_CR107","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1038\/s41598-021-83739-3","volume":"11","author":"S Lee","year":"2021","unstructured":"Lee S, Kim D, Youn H, Hyung WSW, Suh S, Kaiser M, Han CE, Jeong HG (2021) Brain network analysis reveals that amyloidopathy affects comorbid cognitive dysfunction in older adults with depression. Sci Rep 11:4299","journal-title":"Sci Rep"},{"key":"2648_CR108","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpsychires.2016.12.011","volume":"87","author":"W Li","year":"2017","unstructured":"Li W, Wang Y, Ward BD, Antuono PG, Li SJ, Goveas JS (2017) Intrinsic inter-network brain dysfunction correlates with symptom dimensions in late-life depression. J Psychiatr Res 87:71\u201380","journal-title":"J Psychiatr Res"},{"key":"2648_CR109","doi-asserted-by":"crossref","first-page":"841461","DOI":"10.3389\/fpsyt.2022.841461","volume":"13","author":"H Li","year":"2022","unstructured":"Li H, Yan W, Wang Q, Liu L, Lin X, Zhu X, Su S, Sun W, Sui M, Bao Y, Lu L, Deng J, Sun X (2022) Mindfulness-based cognitive therapy regulates brain connectivity in patients with late-life depression. Front Psychiatry 13:841461","journal-title":"Front Psychiatry"},{"key":"2648_CR110","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/s41380-020-0798-1","volume":"25","author":"J Licinio","year":"2020","unstructured":"Licinio J, Wong ML (2020) Advances in depression research: second special issue, 2020, with highlights on biological mechanisms, clinical features, co-morbidity, genetics, imaging, and treatment. Mol Psychiatry 25:1356\u20131360","journal-title":"Mol Psychiatry"},{"key":"2648_CR111","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fpsyt.2020.00249","volume":"11","author":"C Lin","year":"2020","unstructured":"Lin C, Huang CM, Fan YT, Liu HL, Chen YL, Aizenstein HJ, Lee TM, Lee SH (2020) Cognitive reserve moderates effects of white matter hyperintensity on depressive symptoms and cognitive function in late-life depression. Front Psychiatry 11:249","journal-title":"Front Psychiatry"},{"key":"2648_CR112","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11682-022-00748-0","volume":"17","author":"C Lin","year":"2023","unstructured":"Lin C, Lee SH, Huang CM, Chen GY, Chang W, Liu HL, Ng SH, Lee TM, Wu SC (2023) Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample entropy analysis from resting-state fMRI. Brain Imaging Behav 17:125\u2013135","journal-title":"Brain Imaging Behav"},{"key":"2648_CR113","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fphar.2020.00279","volume":"11","author":"C Linnemann","year":"2020","unstructured":"Linnemann C, Lang UE (2020) Pathways connecting late-life depression and dementia. Front Pharmacol 11:279","journal-title":"Front Pharmacol"},{"key":"2648_CR114","doi-asserted-by":"crossref","first-page":"1001447","DOI":"10.3389\/fnagi.2022.1001447","volume":"14","author":"W Liu","year":"2022","unstructured":"Liu W, Li H, Lin X, Li P, Zhu X, Su S, Shi J, Lu L, Deng J, Sun X (2022) Blunted superior temporal gyrus activity to negative emotional expression after mindfulness-based cognitive therapy for late-life depression. Front Aging Neurosci 14:1001447","journal-title":"Front Aging Neurosci"},{"key":"2648_CR115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/gps.328","volume":"16","author":"AJ Lloyd","year":"2001","unstructured":"Lloyd AJ, Grace JB, Jaros E, Perry RH, Fairbairn AF, Swann AG, O\u2019Brien JT, McKeith IG (2001) Depression in late life, cognitive decline and white matter pathology in two clinico-pathologically investigated cases. Int J Geriatr Psychiatry 16:281\u2013287","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR116","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jad.2020.06.072","volume":"276","author":"Z Long","year":"2020","unstructured":"Long Z, Du L, Zhao J, Wu S, Zheng Q, Lei X (2020) Prediction on treatment improvement in depression with resting state connectivity: a coordinate-based meta-analysis. J Affect Disord 276:62\u201368","journal-title":"J Affect Disord"},{"key":"2648_CR117","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1001\/archpsyc.65.12.1394","volume":"65","author":"HJ Luijendijk","year":"2008","unstructured":"Luijendijk HJ, van den Berg JF, Dekker MJ, van Tuijl HR, Otte W, Smit F, Hofman A, Stricker BH, Tiemeier H (2008) Incidence and recurrence of late-life depression. Arch Gen Psychiatry 65:1394\u20131401","journal-title":"Arch Gen Psychiatry"},{"key":"2648_CR118","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41398-022-01883-4","volume":"12","author":"ET Luning Prak","year":"2022","unstructured":"Luning Prak ET, Brooks T, Makhoul W, Beer JC, Zhao L, Girelli T, Skarke C, Sheline YI (2022) No increase in inflammation in late-life major depression screened to exclude physical illness. Transl Psychiatry 12:118","journal-title":"Transl Psychiatry"},{"key":"2648_CR119","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41398-019-0560-0","volume":"9","author":"DM Lydon-Staley","year":"2019","unstructured":"Lydon-Staley DM, Kuehner C, Zamoscik V, Huffziger S, Kirsch P, Bassett DS (2019) Repetitive negative thinking in daily life and functional connectivity among default mode, fronto-parietal, and salience networks. Transl Psychiatry 9:234","journal-title":"Transl Psychiatry"},{"key":"2648_CR120","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1176\/appi.psy.47.5.435","volume":"47","author":"JM Lyness","year":"2006","unstructured":"Lyness JM, Niculescu A, Tu X, Reynolds CF 3rd, Caine ED (2006) The relationship of medical comorbidity and depression in older, primary care patients. Psychosomatics 47:435\u2013439","journal-title":"Psychosomatics"},{"key":"2648_CR121","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0006-3223(00)01113-6","volume":"49","author":"JR MacFall","year":"2001","unstructured":"MacFall JR, Payne ME, Provenzale JE, Krishnan KR (2001) Medial orbital frontal lesions in late-onset depression. Biol Psychiatry 49:803\u2013806","journal-title":"Biol Psychiatry"},{"key":"2648_CR122","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/sj.npp.1300986","volume":"31","author":"JR MacFall","year":"2006","unstructured":"MacFall JR, Taylor WD, Rex DE, Pieper S, Payne ME, McQuoid DR, Steffens DC, Kikinis R, Toga AW, Krishnan KR (2006) Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN). Neuropsychopharmacology 31:1500\u20131507","journal-title":"Neuropsychopharmacology"},{"key":"2648_CR123","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jagp.2013.01.013","volume":"21","author":"RS Mackin","year":"2013","unstructured":"Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW (2013) Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response. Am J Geriatr Psychiatry 21:794\u2013802","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR124","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.biopsych.2020.06.017","volume":"89","author":"RS Mackin","year":"2021","unstructured":"Mackin RS, Insel PS, Landau S, Bickford D, Morin R, Rhodes E, Tosun D, Rosen HJ, Butters M, Aisen P, Raman R, Saykin A, Toga A, Jack C Jr, Koeppe R, Weiner MW, Nelson C (2021) Late-life depression is associated with reduced cortical amyloid burden: findings from the Alzheimer\u2019s Disease Neuroimaging Initiative Depression Project. Biol Psychiatry 89:757\u2013765","journal-title":"Biol Psychiatry"},{"key":"2648_CR125","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/mp.2010.80","volume":"16","author":"G MacQueen","year":"2011","unstructured":"MacQueen G, Frodl T (2011) The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research? Mol Psychiatry 16:252\u2013264","journal-title":"Mol Psychiatry"},{"key":"2648_CR126","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jagp.2015.12.003","volume":"24","author":"N Mahgoub","year":"2016","unstructured":"Mahgoub N, Alexopoulos GS (2016) Amyloid hypothesis: is there a role for antiamyloid treatment in late-life depression? Am J Geriatr Psychiatry 24:239\u2013247","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR127","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jad.2022.04.081","volume":"308","author":"A Maier","year":"2022","unstructured":"Maier A, Durrant-Finn C, Pabst A, L\u00f6bner M, Eisele M, Brettschneider C, Heser K, Kleineidam L, Weyerer S, Werle J, Pentzek M, Fuchs A, Weeg D, M\u00f6sch E, Wiese B, Oey A, van den Bussche H, K\u00f6nig HH, Wagner M, Maier W, Riedel-Heller SG, Scherer M, Luppa M (2022) Incidence and risk factors of depressive symptoms in the highest age groups and competing mortality risk. Evidence from the AgeCoDe-AqeQualiDe prospective cohort study. J Affect Disord 308:494\u2013501","journal-title":"J Affect Disord"},{"key":"2648_CR128","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/arclin\/acac083","volume":"38","author":"KJ Manning","year":"2023","unstructured":"Manning KJ, Wu R, McQuoid DR, Steffens DC, Potter GG (2023) Reliable cognitive decline in late-life major depression. Arch Clin Neuropsychol 38:247\u2013257","journal-title":"Arch Clin Neuropsychol"},{"key":"2648_CR129","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jagp.2013.10.001","volume":"23","author":"CM Marano","year":"2015","unstructured":"Marano CM, Workman CI, Lyman CH, Munro CA, Kraut MA, Smith GS (2015) Structural imaging in late-life depression: association with mood and cognitive responses to antidepressant treatment. Am J Geriatr Psychiatry 23:4\u201312","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jagp.2022.08.003","volume":"31","author":"E Mastrobattista","year":"2023","unstructured":"Mastrobattista E, Lenze EJ, Reynolds CF, Mulsant BH, Wetherell J, Wu GF, Blumberger DM, Karp JF, Butters MA, Mendes-Silva AP, Vieira EL, Tseng G, Diniz BS (2023) Late-life depression is associated with increased levels of GDF-15, a pro-aging mitokine. Am J Geriatr Psychiatry 31:1\u20139","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR131","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/gps.4435","volume":"31","author":"ST McCutcheon","year":"2016","unstructured":"McCutcheon ST, Han D, Troncoso J, Koliatsos VE, Albert M, Lyketsos CG, Leoutsakos JS (2016) Clinicopathological correlates of depression in early Alzheimer\u2019s disease in the NACC. Int J Geriatr Psychiatry 31:1301\u20131311","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR132","first-page":"41","volume":"34","author":"MC McKinnon","year":"2009","unstructured":"McKinnon MC, Yucel K, Nazarov A, MacQueen GM (2009) A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 34:41\u201354","journal-title":"J Psychiatry Neurosci"},{"key":"2648_CR133","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpsychires.2015.10.010","volume":"72","author":"A Medina","year":"2016","unstructured":"Medina A, Watson SJ, Bunney W Jr, Myers RM, Schatzberg A, Barchas J, Akil H, Thompson RC (2016) Evidence for alterations of the glial syncytial function in major depressive disorder. J Psychiatr Res 72:15\u201321","journal-title":"J Psychiatr Res"},{"key":"2648_CR134","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jagp.2016.07.017","volume":"24","author":"AP Mendes-Silva","year":"2016","unstructured":"Mendes-Silva AP, Pereira KS, Tolentino-Araujo GT, Nicolau Ede S, Silva-Ferreira CM, Teixeira AL, Diniz BS (2016) Shared biologic pathways between Alzheimer disease and major depression: a systematic review of microRNA expression studies. Am J Geriatr Psychiatry 24:903\u2013912","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR135","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/B978-0-12-822290-4.00012-8","volume":"183","author":"MF Mendez","year":"2021","unstructured":"Mendez MF (2021) Degenerative dementias: Alterations of emotions and mood disorders. Handb Clin Neurol 183:261\u2013281","journal-title":"Handb Clin Neurol"},{"key":"2648_CR136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00406-022-01549-8","volume":"273","author":"HJ M\u00f6ller","year":"2023","unstructured":"M\u00f6ller HJ, Falkai P (2023) Is the serotonin hypothesis\/theory of depression still relevant? Methodological reflections motivated by a recently published umbrella review. Eur Arch Psychiatry Clin Neurosci 273:1\u20133","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2648_CR137","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01661-0","author":"J Moncrieff","year":"2022","unstructured":"Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA (2022) The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-022-01661-0","journal-title":"Mol Psychiatry"},{"key":"2648_CR138","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3389\/fphar.2019.00483","volume":"10","author":"MG Morgese","year":"2019","unstructured":"Morgese MG, Trabace L (2019) Monoaminergic system modulation in depression and Alzheimer\u2019s disease: a new standpoint? Front Pharmacol 10:483","journal-title":"Front Pharmacol"},{"key":"2648_CR139","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4088\/JCP.08m04265","volume":"70","author":"N Mossaheb","year":"2009","unstructured":"Mossaheb N, Weissgram S, Zehetmayer S, Jungwirth S, Rainer M, Tragl KH, Fischer P (2009) Late-onset depression in elderly subjects from the Vienna Transdanube Aging (VITA) study. J Clin Psychiatry 70:500\u2013508","journal-title":"J Clin Psychiatry"},{"key":"2648_CR140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.archger.2015.10.004","volume":"63","author":"A Murray","year":"2016","unstructured":"Murray A, McNeil C, Salarirad S, Deary I, Phillips L, Whalley L, Staff R (2016) Brain hyperintensity location determines outcome in the triad of impaired cognition, physical health and depressive symptoms: a cohort study in late life. Arch Gerontol Geriatr 63:49\u201354","journal-title":"Arch Gerontol Geriatr"},{"key":"2648_CR141","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pneurobio.2012.05.009","volume":"98","author":"SL Naismith","year":"2012","unstructured":"Naismith SL, Norrie LM, Mowszowski L, Hickie IB (2012) The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features. Prog Neurobiol 98:99\u2013143","journal-title":"Prog Neurobiol"},{"key":"2648_CR142","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3233\/JAD-180276","volume":"64","author":"H Ni","year":"2018","unstructured":"Ni H, Xu M, Zhan GL, Fan Y, Zhou H, Jiang HY, Lu WH, Tan L, Zhang DF, Yao YG, Zhang C (2018) The GWAS risk genes for depression may be actively involved in Alzheimer\u2019s disease. J Alzheimers Dis 64:1149\u20131161","journal-title":"J Alzheimers Dis"},{"key":"2648_CR143","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3233\/JAD-148004","volume":"47","author":"F Novais","year":"2015","unstructured":"Novais F, Starkstein S (2015) Phenomenology of depression in Alzheimer\u2019s disease. J Alzheimers Dis 47:845\u2013855","journal-title":"J Alzheimers Dis"},{"key":"2648_CR144","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/gps.4649","volume":"33","author":"PV Nunes","year":"2018","unstructured":"Nunes PV, Suemoto CK, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Farfel JM, de Oliveira KC, Grinberg LT, da Costa NR, Nascimento CF, Salmasi F, Kim HK, Young LT, Jacob-Filho W, Lafer B (2018) Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study. Int J Geriatr Psychiatry 33:14\u201320","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neurobiolaging.2022.05.007","volume":"117","author":"PV Nunes","year":"2022","unstructured":"Nunes PV, Suemoto CK, Rodriguez RD, Paraizo Leite RE, Nascimento C, Pasqualucci CA, Nitrini R, Jacob-Filho W, Grinberg LT, Lafer B (2022) Neuropathology of depression in non-demented older adults: a large postmortem study of 741 individuals. Neurobiol Aging 117:107\u2013116","journal-title":"Neurobiol Aging"},{"key":"2648_CR146","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41386-021-00973-z","volume":"47","author":"LE Oberlin","year":"2022","unstructured":"Oberlin LE, Respino M, Victoria L, Abreu L, Hoptman MJ, Alexopoulos GS, Gunning FM (2022) Late-life depression accentuates cognitive weaknesses in older adults with small vessel disease. Neuropsychopharmacology 47:580\u2013587","journal-title":"Neuropsychopharmacology"},{"key":"2648_CR147","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0006-3223(00)00944-6","volume":"49","author":"J O'Brien","year":"2001","unstructured":"O\u2019Brien J, Thomas A, Ballard C, Brown A, Ferrier N, Jaros E, Perry R (2001) Cognitive impairment in depression is not associated with neuropathologic evidence of increased vascular or Alzheimer-type pathology. Biol Psychiatry 49:130\u2013136","journal-title":"Biol Psychiatry"},{"key":"2648_CR148","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3233\/ADR-220052","volume":"6","author":"S Ochi","year":"2022","unstructured":"Ochi S, Mori T, Iga JI, Ueno SI (2022) Prevalence of comorbid dementia in late-life depression and bipolar disorder: a retrospective inpatient study. J Alzheimers Dis Rep 6:589\u2013598","journal-title":"J Alzheimers Dis Rep"},{"key":"2648_CR149","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.comppsych.2010.10.016","volume":"52","author":"I Ohanna","year":"2011","unstructured":"Ohanna I, Golander H, Barak Y (2011) Does late onset depression predispose to dementia? A retrospective, case-controlled study. Compr Psychiatry 52:659\u2013661","journal-title":"Compr Psychiatry"},{"key":"2648_CR150","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jad.2022.09.127","volume":"320","author":"M Orhan","year":"2023","unstructured":"Orhan M, Schouws S, van Oppen P, Stek M, Naarding P, Rhebergen D, Dols A, Korten N (2023) Cognitive functioning in late life affective disorders: Comparing older adults with bipolar disorder, late life depression and healthy controls. J Affect Disord 320:468\u2013473","journal-title":"J Affect Disord"},{"key":"2648_CR151","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/0891988720901783","volume":"34","author":"ML Oudega","year":"2021","unstructured":"Oudega ML, Siddiqui A, Wattjes MP, Barkhof F, Kate MT, Muller M, Bouckaert F, Vandenbulcke M, De Winter FL, Sienaert P, Stek ML, Comijs HC, Korten NCM, Emsell L, Eikelenboom P, Rhebergen D, van Exel E, Dols A (2021) Are apathy and depressive symptoms related to vascular white matter hyperintensities in severe late life depression? J Geriatr Psychiatry Neurol 34:21\u201328","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"2648_CR152","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","volume":"63","author":"RL Ownby","year":"2006","unstructured":"Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D (2006) Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 63:530\u2013538","journal-title":"Arch Gen Psychiatry"},{"key":"2648_CR244","doi-asserted-by":"publisher","DOI":"10.1017\/S003329172200112X","author":"F \u00d6zel","year":"2022","unstructured":"\u00d6zel F, Hilal S, de Feijter M, van der Velpen I, Direk N, Ikram MA, Vernooij MW, Luik AI (2022) Associations of neuroimaging markers with depressive symptoms over time in middle-aged and elderly persons. Psychol Med. https:\/\/doi.org\/10.1017\/S003329172200112X","journal-title":"Psychol Med"},{"key":"2648_CR153","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.biopsych.2019.07.023","volume":"86","author":"JL Padmanabhan","year":"2019","unstructured":"Padmanabhan JL, Cooke D, Joutsa J, Siddiqi SH, Ferguson M, Darby RR, Soussand L, Horn A, Kim NY, Voss JL, Naidech AM, Brodtmann A, Egorova N, Gozzi S, Phan TG, Corbetta M, Grafman J, Fox MD (2019) A human depression circuit derived from focal brain lesions. Biol Psychiatry 86:749\u2013758","journal-title":"Biol Psychiatry"},{"key":"2648_CR154","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jad.2022.03.035","volume":"306","author":"Y Pang","year":"2022","unstructured":"Pang Y, Wei Q, Zhao S, Li N, Li Z, Lu F, Pang J, Zhang R, Wang K, Chu C, Tian Y, Wang J (2022) Enhanced default mode network functional connectivity links with electroconvulsive therapy response in major depressive disorder. J Affect Disord 306:47\u201354","journal-title":"J Affect Disord"},{"key":"2648_CR155","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1192\/j.eurpsy.2020.34","volume":"63","author":"SP Pantazatos","year":"2020","unstructured":"Pantazatos SP, Yttredahl A, Rubin-Falcone H, Kishon R, Oquendo MA, John Mann J, Miller JM (2020) Depression-related anterior cingulate prefrontal resting state connectivity normalizes following cognitive behavioral therapy. Eur Psychiatry 63:e37","journal-title":"Eur Psychiatry"},{"key":"2648_CR156","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/JGP.0b013e3181b0fa13","volume":"18","author":"F Panza","year":"2010","unstructured":"Panza F, Frisardi V, Capurso C, D\u2019Introno A, Colacicco AM, Imbimbo BP, Santamato A, Vendemiale G, Seripa D, Pilotto A, Capurso A, Solfrizzi V (2010) Late-life depression, mild cognitive impairment, and dementia: possible continuum? Am J Geriatr Psychiatry 18:98\u2013116","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR157","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1017\/S1041610212000828","volume":"24","author":"MB Paradise","year":"2012","unstructured":"Paradise MB, Naismith SL, Norrie LM, Graeber MB, Hickie IB (2012) The role of glia in late-life depression. Int Psychogeriatr 24:1878\u20131890","journal-title":"Int Psychogeriatr"},{"key":"2648_CR158","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jad.2017.12.101","volume":"229","author":"S Perin","year":"2018","unstructured":"Perin S, Harrington KD, Lim YY, Ellis K, Ames D, Pietrzak RH, Schembri A, Rainey-Smith S, Salvado O, Laws SM, Martins RN, Villemagne VL, Rowe CC, Masters CL, Maruff P (2018) Amyloid burden and incident depressive symptoms in preclinical Alzheimer\u2019s disease. J Affect Disord 229:269\u2013274","journal-title":"J Affect Disord"},{"key":"2648_CR159","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrneurol.2015.10","volume":"11","author":"ND Prins","year":"2015","unstructured":"Prins ND, Scheltens P (2015) White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol 11:157\u2013165","journal-title":"Nat Rev Neurol"},{"key":"2648_CR160","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s12916-022-02678-6","volume":"20","author":"S Qi","year":"2022","unstructured":"Qi S, Calhoun VD, Zhang D, Miller J, Deng ZD, Narr KL, Sheline Y, McClintock SM, Jiang R, Yang X, Upston J, Jones T, Sui J, Abbott CC (2022) Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder. BMC Med 20:477","journal-title":"BMC Med"},{"key":"2648_CR161","doi-asserted-by":"crossref","first-page":"e2253668","DOI":"10.1001\/jamanetworkopen.2022.53668","volume":"6","author":"X Qiu","year":"2023","unstructured":"Qiu X, Shi L, Kubzansky LD, Wei Y, Castro E, Li H, Weisskopf MG, Schwartz JD (2023) Association of long-term exposure to air pollution with late-life depression in older adults in the US. JAMA Netw Open 6:e2253668","journal-title":"JAMA Netw Open"},{"key":"2648_CR162","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1080\/13548506.2020.1859563","volume":"27","author":"A Rajtar-Zembaty","year":"2022","unstructured":"Rajtar-Zembaty A, Rajtar-Zembaty J, Olszewska K, Epa R, Chrobak AA, Starowicz-Filip A, Betkowska-Korpala B (2022) Comparison of cognitive functioning of elders with late-life depression and patients with and without a history of depressive episodes: a cross-sectional study. Psychol Health Med 27:1227\u20131233","journal-title":"Psychol Health Med"},{"key":"2648_CR163","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3389\/fnins.2020.00253","volume":"14","author":"N Rashidi-Ranjbar","year":"2020","unstructured":"Rashidi-Ranjbar N, Miranda D, Butters MA, Mulsant BH, Voineskos AN (2020) Evidence for structural and functional alterations of frontal-executive and corticolimbic circuits in late-life depression and relationship to mild cognitive impairment and dementia: a systematic review. Front Neurosci 14:253","journal-title":"Front Neurosci"},{"key":"2648_CR164","doi-asserted-by":"crossref","first-page":"101852","DOI":"10.1016\/j.nicl.2019.101852","volume":"23","author":"M Respino","year":"2019","unstructured":"Respino M, Jaywant A, Kuceyeski A, Victoria LW, Hoptman MJ, Scult MA, Sankin L, Pimontel M, Liston C, Belvederi Murri M, Alexopoulos GS, Gunning FM (2019) The impact of white matter hyperintensities on the structural connectome in late-life depression: relationship to executive functions. Neuroimage Clin 23:101852","journal-title":"Neuroimage Clin"},{"key":"2648_CR165","doi-asserted-by":"crossref","first-page":"e80049","DOI":"10.1371\/journal.pone.0080049","volume":"8","author":"SR Ribeiz","year":"2013","unstructured":"Ribeiz SR, Duran F, Oliveira MC, Bezerra D, Castro CC, Steffens DC, Busatto Filho G, Bottino CM (2013) Structural brain changes as biomarkers and outcome predictors in patients with late-life depression: a cross-sectional and prospective study. PLoS ONE 8:e80049","journal-title":"PLoS ONE"},{"key":"2648_CR166","first-page":"190","volume":"29","author":"P Riederer","year":"2022","unstructured":"Riederer P (2022) Umbrella-Review zur Serotonin-Theorie der Depression: Kritik aus neurobiochemischer Sicht. Psychopharmakotherapie 29:190\u2013191","journal-title":"Psychopharmakotherapie"},{"key":"2648_CR167","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/gps.5470","volume":"36","author":"AC Robinson","year":"2021","unstructured":"Robinson AC, Roncaroli F, Davidson YS, Minshull J, Heal C, Montaldi D, Payton A, Horan MA, Pendleton N, Mann DMA (2021) Mid to late-life scores of depression in the cognitively healthy are associated with cognitive status and Alzheimer\u2019s disease pathology at death. Int J Geriatr Psychiatry 36:713\u2013721","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR168","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/acps.13513","volume":"147","author":"G Roebuck","year":"2023","unstructured":"Roebuck G, Lotfaliany M, Agustini B, Forbes M, Mohebbi M, McNeil J, Woods RL, Reid CM, Nelson MR, Shah RC, Ryan J, Newman AB, Owen A, Freak-Poli R, Stocks N, Berk M (2023) The effect of depressive symptoms on disability-free survival in healthy older adults: a prospective cohort study. Acta Psychiatr Scand 147:92\u2013104","journal-title":"Acta Psychiatr Scand"},{"key":"2648_CR169","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4329\/wjr.v12.i5.48","volume":"12","author":"SN Rushia","year":"2020","unstructured":"Rushia SN, Shehab AAS, Motter JN, Egglefield DA, Schiff S, Sneed JR, Garcon E (2020) Vascular depression for radiology: a review of the construct, methodology, and diagnosis. World J Radiol 12:48\u201367","journal-title":"World J Radiol"},{"key":"2648_CR170","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s11682-021-00494-9","volume":"16","author":"A Saberi","year":"2022","unstructured":"Saberi A, Mohammadi E, Zarei M, Eickhoff SB, Tahmasian M (2022) Structural and functional neuroimaging of late-life depression: a coordinate-based meta-analysis. Brain Imaging Behav 16:518\u2013531","journal-title":"Brain Imaging Behav"},{"key":"2648_CR171","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jad.2020.09.062","volume":"278","author":"NM Saldanha","year":"2021","unstructured":"Saldanha NM, Suemoto CK, Rodriguez RD, Leite REP, Nascimento C, Ferreti-Rebustini R, da Silva MM, Pasqualucci CA, Nitrini R, Jacob-Filho W, Lafer B, Grinberg LT, Nunes PV (2021) Beta-amyloid pathology is not associated with depression in a large community sample autopsy study. J Affect Disord 278:372\u2013381","journal-title":"J Affect Disord"},{"key":"2648_CR172","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3389\/fpsyg.2019.01241","volume":"10","author":"KI Salo","year":"2019","unstructured":"Salo KI, Scharfen J, Wilden ID, Schubotz RI, Holling H (2019) Confining the concept of vascular depression to late-onset depression: a meta-analysis of MRI-defined hyperintensity burden in major depressive disorder and bipolar disorder. Front Psychol 10:1241","journal-title":"Front Psychol"},{"key":"2648_CR173","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1365-2990.2010.01101.x","volume":"36","author":"M Santos","year":"2010","unstructured":"Santos M, Gold G, Kovari E, Herrmann FR, Hof PR, Bouras C, Giannakopoulos P (2010) Neuropathological analysis of lacunes and microvascular lesions in late-onset depression. Neuropathol Appl Neurobiol 36:661\u2013672","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2648_CR174","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/acps.13065","volume":"140","author":"A Saricicek Aydogan","year":"2019","unstructured":"Saricicek Aydogan A, Oztekin E, Esen ME, Dusmez S, Gelal F, Besiroglu L, Zorlu N (2019) Cortical thickening in remitters compared to non-remitters with major depressive disorder following 8-week antidepressant treatment. Acta Psychiatr Scand 140:217\u2013226","journal-title":"Acta Psychiatr Scand"},{"key":"2648_CR175","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S2215-0366(18)30166-4","volume":"5","author":"R Schaakxs","year":"2018","unstructured":"Schaakxs R, Comijs HC, Lamers F, Kok RM, Beekman ATF, Penninx B (2018) Associations between age and the course of major depressive disorder: a 2-year longitudinal cohort study. Lancet Psychiatry 5:581\u2013590","journal-title":"Lancet Psychiatry"},{"key":"2648_CR176","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/15622970109027497","volume":"2","author":"I Schweitzer","year":"2001","unstructured":"Schweitzer I, Tuckwell V, Ames D, O\u2019Brien J (2001) Structural neuroimaging studies in late-life depression: a review. World J Biol Psychiatry 2:83\u201388","journal-title":"World J Biol Psychiatry"},{"key":"2648_CR177","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s44220-023-00033-z","volume":"1","author":"J Seitz-Holland","year":"2023","unstructured":"Seitz-Holland J, Mulsant BH, Reynolds CF III, Blumberger DM, Karp JF, Butters MA, Mendes-Silva AP, Vieira EL, Tseng G, Lenze EJ, Diniz BS (2023) Major depression, physical health and molecular senescence markers abnormalities. Nat Mental Health 1:200\u2013209","journal-title":"Nat Mental Health"},{"key":"2648_CR245","unstructured":"Sekhon S, Patel J, Sapra A (2021) Late Onset Depression. In: StatPearls, 2021\/09\/18 Edition. StatPearls Publishing, Treasure Island. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551507\/"},{"key":"2648_CR178","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jagp.2012.10.019","volume":"21","author":"CE Sexton","year":"2013","unstructured":"Sexton CE, Mackay CE, Ebmeier KP (2013) A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. Am J Geriatr Psychiatry 21:184\u2013195","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR179","first-page":"905","volume":"7","author":"R Shao","year":"2022","unstructured":"Shao R, Gao M, Lin C, Huang CM, Liu HL, Toh CH, Wu C, Tsai YF, Qi D, Lee SH, Lee TMC (2022) Multimodal neural evidence on the corticostriatal underpinning of suicidality in late-life depression. Biol Psychiatry Cogn Neurosci Neuroimaging 7:905\u2013915","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"2648_CR180","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.biopsych.2019.06.011","volume":"86","author":"X Shen","year":"2019","unstructured":"Shen X, Adams MJ, Ritakari TE, Cox SR, McIntosh AM, Whalley HC (2019) White matter microstructure and its relation to longitudinal measures of depressive symptoms in mid- and late life. Biol Psychiatry 86:759\u2013768","journal-title":"Biol Psychiatry"},{"key":"2648_CR181","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1017\/S1041610217001879","volume":"30","author":"N Siafarikas","year":"2018","unstructured":"Siafarikas N, Selbaek G, Fladby T, \u0160altyte Benth J, Auning E, Aarsland D (2018) Frequency and subgroups of neuropsychiatric symptoms in mild cognitive impairment and different stages of dementia in Alzheimer\u2019s disease. Int Psychogeriatr 30:103\u2013113","journal-title":"Int Psychogeriatr"},{"key":"2648_CR182","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/s41562-021-01161-1","volume":"5","author":"SH Siddiqi","year":"2021","unstructured":"Siddiqi SH, Schaper F, Horn A, Hsu J, Padmanabhan JL, Brodtmann A, Cash RFH, Corbetta M, Choi KS, Dougherty DD, Egorova N, Fitzgerald PB, George MS, Gozzi SA, Irmen F, Kuhn AA, Johnson KA, Naidech AM, Pascual-Leone A, Phan TG, Rouhl RPW, Taylor SF, Voss JL, Zalesky A, Grafman JH, Mayberg HS, Fox MD (2021) Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease. Nat Hum Behav 5:1707\u20131716","journal-title":"Nat Hum Behav"},{"key":"2648_CR183","doi-asserted-by":"crossref","first-page":"e5858","DOI":"10.1002\/gps.5858","volume":"38","author":"LI Sinclair","year":"2023","unstructured":"Sinclair LI, Ballard CG (2023) Persistent depressive symptoms are associated with frontal regional atrophy in patients with Alzheimer\u2019s disease. Int J Geriatr Psychiatry 38:e5858","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR184","doi-asserted-by":"crossref","first-page":"108447","DOI":"10.1016\/j.neuropharm.2021.108447","volume":"194","author":"GS Smith","year":"2021","unstructured":"Smith GS, Kuwabara H, Gould NF, Nassery N, Savonenko A, Joo JH, Bigos KL, Kraut M, Brasic J, Holt DP, Hall AW, Mathews WB, Dannals RF, Nandi A, Workman CI (2021a) Molecular imaging of the serotonin transporter availability and occupancy by antidepressant treatment in late-life depression. Neuropharmacology 194:108447","journal-title":"Neuropharmacology"},{"key":"2648_CR185","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neurobiolaging.2021.01.002","volume":"101","author":"GS Smith","year":"2021","unstructured":"Smith GS, Kuwabara H, Nandi A, Gould NF, Nassery N, Savonenko A, Joo JH, Kraut M, Brasic J, Holt DP, Hall AW, Mathews WB, Dannals RF, Avramopoulos D, Workman CI (2021b) Molecular imaging of beta-amyloid deposition in late-life depression. Neurobiol Aging 101:85\u201393","journal-title":"Neurobiol Aging"},{"key":"2648_CR186","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41398-021-01539-9","volume":"11","author":"GS Smith","year":"2021","unstructured":"Smith GS, Workman CI, Protas H, Su Y, Savonenko A, Kuwabara H, Gould NF, Kraut M, Joo JH, Nandi A, Avramopoulos D, Reiman EM, Chen K (2021c) Positron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares. Transl Psychiatry 11:473","journal-title":"Transl Psychiatry"},{"key":"2648_CR187","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000335497","volume":"2","author":"H Soennesyn","year":"2012","unstructured":"Soennesyn H, Oppedal K, Greve OJ, Fritze F, Auestad BH, Nore SP, Beyer MK, Aarsland D (2012) White matter hyperintensities and the course of depressive symptoms in elderly people with mild dementia. Dement Geriatr Cogn Dis Extra 2:97\u2013111","journal-title":"Dement Geriatr Cogn Dis Extra"},{"key":"2648_CR188","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1017\/S1041610211001141","volume":"24","author":"HI Solhaug","year":"2012","unstructured":"Solhaug HI, Romuld EB, Romild U, Stordal E (2012) Increased prevalence of depression in cohorts of the elderly: an 11-year follow-up in the general population\u2014the HUNT study. Int Psychogeriatr 24:151\u2013158","journal-title":"Int Psychogeriatr"},{"key":"2648_CR189","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jagp.2020.04.008","volume":"28","author":"N Solomonov","year":"2020","unstructured":"Solomonov N, Victoria LW, Dunlop K, Respino M, Hoptman MJ, Zilcha-Mano S, Oberlin L, Liston C, Are\u00e1n PA, Gunning FM, Alexopoulos GS (2020) Resting state functional connectivity and outcomes of psychotherapies for late-life depression. Am J Geriatr Psychiatry 28:859\u2013868","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR190","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5711","author":"J Stafford","year":"2022","unstructured":"Stafford J, Chung WT, Sommerlad A, Kirkbride JB, Howard R (2022) Psychiatric disorders and risk of subsequent dementia: systematic review and meta-analysis of longitudinal studies. Int J Geriatr Psychiatry. https:\/\/doi.org\/10.1002\/gps.5711","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR191","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3233\/JAD-2012-111922","volume":"31","author":"K Steenland","year":"2012","unstructured":"Steenland K, Karnes C, Seals R, Carnevale C, Hermida A, Levey A (2012) Late-life depression as a risk factor for mild cognitive impairment or Alzheimer\u2019s disease in 30 US Alzheimer\u2019s disease centers. J Alzheimers Dis 31:265\u2013275","journal-title":"J Alzheimers Dis"},{"key":"2648_CR192","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/01.STR.0000018405.59799.D5","volume":"33","author":"DC Steffens","year":"2002","unstructured":"Steffens DC, Krishnan KR, Crump C, Burke GL (2002) Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study. Stroke 33:1636\u20131644","journal-title":"Stroke"},{"key":"2648_CR193","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/JGP.0b013e3181d6c245","volume":"19","author":"DC Steffens","year":"2011","unstructured":"Steffens DC, McQuoid DR, Payne ME, Potter GG (2011a) Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study. Am J Geriatr Psychiatry 19:4\u201312","journal-title":"Am J Geriatr Psychiatry"},{"key":"2648_CR194","doi-asserted-by":"crossref","first-page":"e22697","DOI":"10.1371\/journal.pone.0022697","volume":"6","author":"DC Steffens","year":"2011","unstructured":"Steffens DC, Taylor WD, Denny KL, Bergman SR, Wang L (2011b) Structural integrity of the uncinate fasciculus and resting state functional connectivity of the ventral prefrontal cortex in late life depression. PLoS ONE 6:e22697","journal-title":"PLoS ONE"},{"key":"2648_CR195","doi-asserted-by":"crossref","first-page":"102178","DOI":"10.1016\/j.nicl.2020.102178","volume":"25","author":"JS Suh","year":"2020","unstructured":"Suh JS, Minuzzi L, Raamana PR, Davis A, Hall GB, Harris J, Hassel S, Zamyadi M, Arnott SR, Alders GL, Sassi RB, Milev R, Lam RW, MacQueen GM, Strother SC, Kennedy SH, Frey BN (2020) An investigation of cortical thickness and antidepressant response in major depressive disorder: a CAN-BIND study report. Neuroimage Clin 25:102178","journal-title":"Neuroimage Clin"},{"key":"2648_CR196","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/ggi.12901","volume":"17","author":"SM Szymkowicz","year":"2017","unstructured":"Szymkowicz SM, McLaren ME, O\u2019Shea A, Woods AJ, Anton SD, Dotson VM (2017) Depressive symptoms modify age effects on hippocampal subfields in older adults. Geriatr Gerontol Int 17:1494\u20131500","journal-title":"Geriatr Gerontol Int"},{"key":"2648_CR197","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0891988713516539","volume":"27","author":"R Tadayonnejad","year":"2014","unstructured":"Tadayonnejad R, Ajilore O (2014) Brain network dysfunction in late-life depression: a literature review. J Geriatr Psychiatry Neurol 27:5\u201312","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"2648_CR198","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jad.2022.12.019","volume":"323","author":"W Tan","year":"2023","unstructured":"Tan W, Ouyang X, Huang D, Wu Z, Liu Z, He Z, Long Y (2023) Disrupted intrinsic functional brain network in patients with late-life depression: evidence from a multi-site dataset. J Affect Disord 323:631\u2013639","journal-title":"J Affect Disord"},{"key":"2648_CR199","doi-asserted-by":"crossref","first-page":"104114","DOI":"10.1016\/j.ijnurstu.2021.104114","volume":"125","author":"T Tang","year":"2022","unstructured":"Tang T, Jiang J, Tang X (2022) Prevalence of depression among older adults living in care homes in China: a systematic review and meta-analysis. Int J Nurs Stud 125:104114","journal-title":"Int J Nurs Stud"},{"key":"2648_CR200","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1001\/archpsyc.60.11.1090","volume":"60","author":"WD Taylor","year":"2003","unstructured":"Taylor WD, Steffens DC, MacFall JR, McQuoid DR, Payne ME, Provenzale JM, Krishnan KR (2003) White matter hyperintensity progression and late-life depression outcomes. Arch Gen Psychiatry 60:1090\u20131096","journal-title":"Arch Gen Psychiatry"},{"key":"2648_CR201","doi-asserted-by":"crossref","first-page":"109638","DOI":"10.1016\/j.celrep.2021.109638","volume":"36","author":"HBC Taylor","year":"2021","unstructured":"Taylor HBC, Emptage NJ, Jeans AF (2021) Long-term depression links amyloid-beta to the pathological hyperphosphorylation of tau. Cell Rep 36:109638","journal-title":"Cell Rep"},{"key":"2648_CR202","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1192\/bjp.bp.107.036756","volume":"191","author":"A Teodorczuk","year":"2007","unstructured":"Teodorczuk A, O\u2019Brien JT, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, Wallin A, Wahlund LO, Gouw A, Waldemar G, Schmidt R, Ferro JM, Chabriat H, Bazner H, Inzitari D (2007) White matter changes and late-life depressive symptoms: longitudinal study. Br J Psychiatry 191:212\u2013217","journal-title":"Br J Psychiatry"},{"key":"2648_CR203","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3390\/ijms21072317","volume":"21","author":"I Tonhajzerova","year":"2020","unstructured":"Tonhajzerova I, Sekaninova N, Bona Olexova L, Visnovcova Z (2020) Novel insight into neuroimmune regulatory mechanisms and biomarkers linking major depression and vascular diseases: the dilemma continues. Int J Mol Sci 21:2317","journal-title":"Int J Mol Sci"},{"key":"2648_CR204","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/mp.2015.65","volume":"21","author":"SG Torres-Platas","year":"2016","unstructured":"Torres-Platas SG, Nagy C, Wakid M, Turecki G, Mechawar N (2016) Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and downregulated in the thalamus and caudate nucleus of depressed suicides. Mol Psychiatry 21:509\u2013515","journal-title":"Mol Psychiatry"},{"key":"2648_CR205","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1093\/brain\/awac361","volume":"146","author":"NT Trapp","year":"2023","unstructured":"Trapp NT, Bruss JE, Manzel K, Grafman J, Tranel D, Boes AD (2023) Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience. Brain 146:1672\u20131685","journal-title":"Brain"},{"key":"2648_CR206","doi-asserted-by":"crossref","first-page":"afac315","DOI":"10.1093\/ageing\/afac315","volume":"52","author":"F Triolo","year":"2023","unstructured":"Triolo F, Sj\u00f6berg L, Calder\u00f3n-Larra\u00f1aga A, Belvederi Murri M, Liborio Vetrano D, Fratiglioni L, Dekhtyar S (2023) Late-life depression and multimorbidity trajectories: the role of symptom complexity and severity. Age Ageing 52:afac315","journal-title":"Age Ageing"},{"key":"2648_CR207","doi-asserted-by":"crossref","first-page":"885393","DOI":"10.3389\/fnagi.2022.885393","volume":"14","author":"CF Tsai","year":"2022","unstructured":"Tsai CF, Chuang CH, Wang YP, Lin YB, Tu PC, Liu PY, Wu PS, Lin CY, Lu CL (2022) Differences in gut microbiota correlate with symptoms and regional brain volumes in patients with late-life depression. Front Aging Neurosci 14:885393","journal-title":"Front Aging Neurosci"},{"key":"2648_CR208","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1192\/bjp.bp.110.078816","volume":"198","author":"C Tsopelas","year":"2011","unstructured":"Tsopelas C, Stewart R, Savva GM, Brayne C, Ince P, Thomas A, Matthews FE (2011) Neuropathological correlates of late-life depression in older people. Br J Psychiatry 198:109\u2013114","journal-title":"Br J Psychiatry"},{"key":"2648_CR209","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/jamapsychiatry.2017.0984","volume":"74","author":"MJM van Agtmaal","year":"2017","unstructured":"van Agtmaal MJM, Houben A, Pouwer F, Stehouwer CDA, Schram MT (2017) Association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis. JAMA Psychiat 74:729\u2013739","journal-title":"JAMA Psychiat"},{"key":"2648_CR210","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3233\/JAD-140405","volume":"42","author":"S Van der Mussele","year":"2014","unstructured":"Van der Mussele S, Fransen E, Struyfs H, Luyckx J, Mari\u00ebn P, Saerens J, Somers N, Goeman J, De Deyn PP, Engelborghs S (2014) Depression in mild cognitive impairment is associated with progression to Alzheimer\u2019s disease: a longitudinal study. J Alzheimers Dis 42:1239\u20131250","journal-title":"J Alzheimers Dis"},{"key":"2648_CR211","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1176\/appi.ajp.2014.14050578","volume":"172","author":"TT van Sloten","year":"2015","unstructured":"van Sloten TT, Sigurdsson S, van Buchem MA, Phillips CL, Jonsson PV, Ding J, Schram MT, Harris TB, Gudnason V, Launer LJ (2015) Cerebral small vessel disease and association with higher incidence of depressive symptoms in a general elderly population: the AGES-Reykjavik study. Am J Psychiatry 172:570\u2013578","journal-title":"Am J Psychiatry"},{"key":"2648_CR212","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/gps.1477","volume":"21","author":"CE Versluis","year":"2006","unstructured":"Versluis CE, van der Mast RC, van Buchem MA, Bollen EL, Blauw GJ, Eekhof JA, van der Wee NJ, de Craen AJ (2006) Progression of cerebral white matter lesions is not associated with development of depressive symptoms in elderly subjects at risk of cardiovascular disease: the PROSPER Study. Int J Geriatr Psychiatry 21:375\u2013381","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR213","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1176\/appi.ajp.161.11.1957","volume":"161","author":"P Videbech","year":"2004","unstructured":"Videbech P, Ravnkilde B (2004) Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 161:1957\u20131966","journal-title":"Am J Psychiatry"},{"key":"2648_CR214","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00213-007-0806-z","volume":"193","author":"AN Voineskos","year":"2007","unstructured":"Voineskos AN, Wilson AA, Boovariwala A, Sagrati S, Houle S, Rusjan P, Sokolov S, Spencer EP, Ginovart N, Meyer JH (2007) Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography. Psychopharmacology 193:539\u2013545","journal-title":"Psychopharmacology"},{"key":"2648_CR215","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1038\/s41386-021-01072-9","volume":"46","author":"SM Wang","year":"2021","unstructured":"Wang SM, Kim NY, Um YH, Kang DW, Na HR, Lee CU, Lim HK (2021) Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults. Neuropsychopharmacology 46:2180\u20132187","journal-title":"Neuropsychopharmacology"},{"key":"2648_CR216","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jad.2022.03.063","volume":"307","author":"M Wang","year":"2022","unstructured":"Wang M, Yin D, Liu L, Zhou S, Liu Q, Tian H, Wei J, Zhang K, Wang G, Chen Q, Zhu G, Wang X, Si T, Yu X, Lv X, Zhang N (2022) Features of cognitive impairment and related risk factors in patients with major depressive disorder: a case-control study. J Affect Disord 307:29\u201336","journal-title":"J Affect Disord"},{"key":"2648_CR217","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11920-012-0278-7","volume":"14","author":"SL Weisenbach","year":"2012","unstructured":"Weisenbach SL, Boore LA, Kales HC (2012) Depression and cognitive impairment in older adults. Curr Psychiatry Rep 14:280\u2013288","journal-title":"Curr Psychiatry Rep"},{"key":"2648_CR218","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jamapsychiatry.2022.0020","volume":"79","author":"J Wen","year":"2022","unstructured":"Wen J, Fu CHY, Tosun D, Veturi Y, Yang Z, Abdulkadir A, Mamourian E, Srinivasan D, Skampardoni I, Singh A, Nawani H, Bao J, Erus G, Shou H, Habes M, Doshi J, Varol E, Mackin RS, Sotiras A, Fan Y, Saykin AJ, Sheline YI, Shen L, Ritchie MD, Wolk DA, Albert M, Resnick SM, Davatzikos C (2022) Characterizing heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with late-life depression. JAMA Psychiat 79:464\u2013474","journal-title":"JAMA Psychiat"},{"key":"2648_CR219","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/ageing\/afs184","volume":"42","author":"S Weyerer","year":"2013","unstructured":"Weyerer S, Eifflaender-Gorfer S, Wiese B, Luppa M, Pentzek M, Bickel H, Bachmann C, Scherer M, Maier W, Riedel-Heller SG (2013) Incidence and predictors of depression in non-demented primary care attenders aged 75 years and older: results from a 3-year follow-up study. Age Ageing 42:173\u2013180","journal-title":"Age Ageing"},{"key":"2648_CR220","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1532-5415.2004.52217.x","volume":"52","author":"EM Whyte","year":"2004","unstructured":"Whyte EM, Mulsant BH, Vanderbilt J, Dodge HH, Ganguli M (2004) Depression after stroke: a prospective epidemiological study. J Am Geriatr Soc 52:774\u2013778","journal-title":"J Am Geriatr Soc"},{"key":"2648_CR221","doi-asserted-by":"crossref","first-page":"707580","DOI":"10.3389\/fpsyt.2021.707580","volume":"12","author":"WA Wiels","year":"2021","unstructured":"Wiels WA, Wittens MMJ, Zeeuws D, Baeken C, Engelborghs S (2021) Neuropsychiatric symptoms in mild cognitive impairment and dementia due to AD: relation with disease stage and cognitive deficits. Front Psychiatry 12:707580","journal-title":"Front Psychiatry"},{"key":"2648_CR222","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1212\/01.WNL.0000092914.04345.97","volume":"61","author":"RS Wilson","year":"2003","unstructured":"Wilson RS, Schneider JA, Bienias JL, Arnold SE, Evans DA, Bennett DA (2003) Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons. Neurology 61:1102\u20131107","journal-title":"Neurology"},{"key":"2648_CR223","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1001\/jamapsychiatry.2013.2224","volume":"70","author":"RS Wilson","year":"2013","unstructured":"Wilson RS, Nag S, Boyle PA, Hizel LP, Yu L, Buchman AS, Shah RC, Schneider JA, Arnold SE, Bennett DA (2013) Brainstem aminergic nuclei and late-life depressive symptoms. JAMA Psychiat 70:1320\u20131328","journal-title":"JAMA Psychiat"},{"key":"2648_CR224","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1212\/WNL.0000000000000715","volume":"83","author":"RS Wilson","year":"2014","unstructured":"Wilson RS, Capuano AW, Boyle PA, Hoganson GM, Hizel LP, Shah RC, Nag S, Schneider JA, Arnold SE, Bennett DA (2014) Clinical-pathologic study of depressive symptoms and cognitive decline in old age. Neurology 83:702\u2013709","journal-title":"Neurology"},{"key":"2648_CR225","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1037\/neu0000223","volume":"30","author":"RS Wilson","year":"2016","unstructured":"Wilson RS, Boyle PA, Capuano AW, Shah RC, Hoganson GM, Nag S, Bennett DA (2016) Late-life depression is not associated with dementia-related pathology. Neuropsychology 30:135\u2013142","journal-title":"Neuropsychology"},{"key":"2648_CR226","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41525-019-0113-8","volume":"5","author":"TS Wingo","year":"2020","unstructured":"Wingo TS, Yang J, Fan W, Min Canon S, Gerasimov ES, Lori A, Logsdon B, Yao B, Seyfried NT, Lah JJ, Levey AI, Boyle PA, Schneider JA, De Jager PL, Bennett DA, Wingo AP (2020) Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia. NPJ Genom Med 5:6","journal-title":"NPJ Genom Med"},{"key":"2648_CR227","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrn.2016.69","volume":"17","author":"ES Wohleb","year":"2016","unstructured":"Wohleb ES, Franklin T, Iwata M, Duman RS (2016) Integrating neuroimmune systems in the neurobiology of depression. Nat Rev Neurosci 17:497\u2013511","journal-title":"Nat Rev Neurosci"},{"key":"2648_CR228","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/da.20686","volume":"27","author":"OM Wolkowitz","year":"2010","unstructured":"Wolkowitz OM, Epel ES, Reus VI, Mellon SH (2010) Depression gets old fast: do stress and depression accelerate cell aging? Depress Anxiety 27:327\u2013338","journal-title":"Depress Anxiety"},{"key":"2648_CR246","unstructured":"World Health Organization  (2017) Depression and other common mental disorders. Global health estimates. World Health Organization, Geneva https:\/\/www.who.int\/publications\/i\/item\/depression-global-health-estimates"},{"key":"2648_CR229","doi-asserted-by":"crossref","first-page":"e01016","DOI":"10.1002\/brb3.1016","volume":"8","author":"KY Wu","year":"2018","unstructured":"Wu KY, Lin KJ, Chen CH, Chen CS, Liu CY, Huang SY, Yen TC, Hsiao IT (2018) Diversity of neurodegenerative pathophysiology in nondemented patients with major depressive disorder: evidence of cerebral amyloidosis and hippocampal atrophy. Brain Behav 8:e01016","journal-title":"Brain Behav"},{"key":"2648_CR230","doi-asserted-by":"crossref","first-page":"857940","DOI":"10.3389\/fnagi.2022.857940","volume":"14","author":"KY Wu","year":"2022","unstructured":"Wu KY, Lin KJ, Chen CH, Liu CY, Wu YM, Chen CS, Yen TC, Hsiao IT (2022a) Decreased cerebral amyloid-beta depositions in patients with a lifetime history of major depression with suspected non-Alzheimer pathophysiology. Front Aging Neurosci 14:857940","journal-title":"Front Aging Neurosci"},{"key":"2648_CR231","doi-asserted-by":"crossref","first-page":"751756","DOI":"10.3389\/fpsyt.2021.751756","volume":"12","author":"P Wu","year":"2022","unstructured":"Wu P, Zhang A, Sun N, Lei L, Liu P, Wang Y, Li H, Yang C, Zhang K (2022b) Cortical thickness predicts response following 2 weeks of SSRI regimen in first-episode, drug-naive major depressive disorder: an MRI study. Front Psychiatry 12:751756","journal-title":"Front Psychiatry"},{"key":"2648_CR232","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2023.03.002","author":"KY Wu","year":"2023","unstructured":"Wu KY, Lin KJ, Chen CH, Liu CY, Wu YM, Yen TC, Hsiao IT (2023) Atrophy, hypometabolism and implication regarding pathology in late-life major depression with suspected non-Alzheimer pathophysiology (SNAP). Biomed J. https:\/\/doi.org\/10.1016\/j.bj.2023.03.002","journal-title":"Biomed J"},{"key":"2648_CR233","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00401-012-1021-5","volume":"124","author":"A Xekardaki","year":"2012","unstructured":"Xekardaki A, Santos M, Hof P, K\u00f6vari E, Bouras C, Giannakopoulos G (2012) Neuropathological substrates and structural changes in late-life depression: the impact of vascular burden. Acta Neuropathol 124:453\u2013464","journal-title":"Acta Neuropathol"},{"key":"2648_CR234","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbr.2012.08.007","volume":"235","author":"C Xie","year":"2012","unstructured":"Xie C, Li W, Chen G, Douglas Ward B, Franczak MB, Jones JL, Antuono PG, Li SJ, Goveas JS (2012) The co-existence of geriatric depression and amnestic mild cognitive impairment detrimentally affect gray matter volumes: voxel-based morphometry study. Behav Brain Res 235:244\u2013250","journal-title":"Behav Brain Res"},{"key":"2648_CR235","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/gps.4409","volume":"31","author":"F Yasuno","year":"2016","unstructured":"Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Kosaka J, Kudo T, Iida H, Kishimoto T, Nagatsuka K (2016) High amyloid-beta deposition related to depressive symptoms in older individuals with normal cognition: a pilot study. Int J Geriatr Psychiatry 31:920\u2013928","journal-title":"Int J Geriatr Psychiatry"},{"key":"2648_CR236","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-151129","volume":"52","author":"Q Ye","year":"2016","unstructured":"Ye Q, Bai F, Zhang Z (2016) Shared genetic risk factors for late-life depression and Alzheimer\u2019s disease. J Alzheimers Dis 52:1\u201315","journal-title":"J Alzheimers Dis"},{"key":"2648_CR237","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1017\/neu.2016.62","volume":"30","author":"A Yrondi","year":"2018","unstructured":"Yrondi A, P\u00e9ran P, Sauvaget A, Schmitt L, Arbus C (2018) Structural\u2013functional brain changes in depressed patients during and after electroconvulsive therapy. Acta Neuropsychiatr 30:17\u201328","journal-title":"Acta Neuropsychiatr"},{"key":"2648_CR238","doi-asserted-by":"crossref","first-page":"114347","DOI":"10.1016\/j.ejmech.2022.114347","volume":"236","author":"C Zhang","year":"2022","unstructured":"Zhang C, Wang L, Xu Y, Huang Y, Huang J, Zhu J, Wang W, Li W, Sun A, Li X, Zhang H, Li J (2022) Discovery of novel dual RAGE\/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer\u2019s disease and depression. Eur J Med Chem 236:114347","journal-title":"Eur J Med Chem"},{"key":"2648_CR239","doi-asserted-by":"crossref","first-page":"1017203","DOI":"10.3389\/fpsyt.2023.1017203","volume":"14","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Wu X, Tang M, Shi L, Gong S, Mei X, Zhao Z, He J, Huang L, Cui W (2023) Late-life depression: epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic. Front Psychiatry 14:1017203","journal-title":"Front Psychiatry"},{"key":"2648_CR240","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jad.2014.07.024","volume":"168","author":"S Zhong","year":"2014","unstructured":"Zhong S, Wang Y, Zhao G, Xiang Q, Ling X, Liu S, Huang L, Jia Y (2014) Similarities of biochemical abnormalities between major depressive disorder and bipolar depression: a proton magnetic resonance spectroscopy study. J Affect Disord 168:380\u2013386","journal-title":"J Affect Disord"},{"key":"2648_CR241","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1176\/appi.ajp.2021.21010088","volume":"178","author":"P Zhukovsky","year":"2021","unstructured":"Zhukovsky P, Anderson JAE, Coughlan G, Mulsant BH, Cipriani A, Voineskos AN (2021) Coordinate-based network mapping of brain structure in major depressive disorder in younger and older adults: a systematic review and meta-analysis. Am J Psychiatry 178:1119\u20131128","journal-title":"Am J Psychiatry"},{"key":"2648_CR242","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jad.2022.09.145","volume":"320","author":"JL Zijlmans","year":"2023","unstructured":"Zijlmans JL, Vernooij MW, Ikram MA, Luik AI (2023) The role of cognitive and brain reserve in late-life depressive events: The Rotterdam Study. J Affect Disord 320:211\u2013217","journal-title":"J Affect Disord"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-023-02648-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00702-023-02648-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-023-02648-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T11:38:01Z","timestamp":1744198681000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00702-023-02648-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":246,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["2648"],"URL":"https:\/\/doi.org\/10.1007\/s00702-023-02648-z","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,5]]},"assertion":[{"value":"16 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}