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However, knowledge of correlations between abnormal OM, disease severity and clinical assessment\u00a0in PD patients is still lacking.\u00a0To evaluate these correlations,\u00a0PD patients (215 patients, mean age 69\u2009\u00b1\u20099.1 years, 79 females) with severe (H&amp;Y\u2009&gt;\u20093) and mild to moderate (H&amp;Y\u2009\u2264\u20092) disease, and 215 age-matched healthy subjects were enrolled. All patients were evaluated using MDS-UPDRS and an oculometric test using computer vision and deep learning algorithms. Comparisons of OM between groups and correlations between OM and MDS-UPDRS scores were calculated.\u00a0Saccadic latency (ms) was prolonged in patients with severe compared with mild to moderate disease (pro-saccades: 267\u2009\u00b1\u200969 vs. 238\u2009\u00b1\u200953, <jats:italic>p<\/jats:italic>\u2009=\u20090.0011; anti-saccades: 386\u2009\u00b1\u2009119 vs. 352\u2009\u00b1\u2009106, <jats:italic>p<\/jats:italic>\u2009=\u20090.0393) and in patients with mild to moderate disease versus healthy subjects (pro-saccades: 238\u2009\u00b1\u200953 vs. 220\u2009\u00b1\u200945, <jats:italic>p<\/jats:italic>\u2009=\u20090.0003; anti-saccades: 352\u2009\u00b1\u2009106 vs. 289\u2009\u00b1\u200971, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Error rate (%) was higher among patients with severe (64.06\u2009\u00b1\u200923.08) versus mild to moderate disease (49.84\u2009\u00b1\u200924.81, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001), and versus healthy subjects (49.84\u2009\u00b1\u200924.81 vs. 28.31\u2009\u00b1\u200921.72, <jats:italic>p<\/jats:italic>\u2009=\u20090.00001). Response accuracy (%) was lower for patients with severe (75.66\u2009\u00b1\u200913.11) versus mild to moderate disease (79.66\u2009\u00b1\u200913.56, <jats:italic>p<\/jats:italic>\u2009=\u20090.0462), and versus healthy subjects (79.66\u2009\u00b1\u200913.56 vs. 90.27\u2009\u00b1\u20098.79, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Pro- and anti-saccadic latency, error rate and accuracy were correlated with MDS-UPDRS scores (r\u2009=\u20090.32, 0.28, 0.36 and -0.30, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and similar correlations were found with its axial subscore (R\u2009=\u20090.38, 0.29, 0.44, and -0.30, respectively, p\u2009&lt;\u20090.0001). Several OM were different in patients under levodopa treatment.\u00a0OM worsened as PD severity increases, and were correlated with MDS-UPDRS scores. Using OM can be implemented for PD patients\u2019 assessment as a tool to follow disease progression.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00702-023-02681-y","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T03:30:21Z","timestamp":1691551821000},"page":"1241-1248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Oculometric measures as a tool for assessment of clinical symptoms and severity of Parkinson\u2019s disease"],"prefix":"10.1007","volume":"130","author":[{"given":"Johnathan","family":"Reiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liron","family":"Franken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7102-1261","authenticated-orcid":false,"given":"Eitan","family":"Raveh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Rosset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivka","family":"Kreitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Ben-Ami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Djaldetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"2681_CR1","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1002\/mds.26134","volume":"30","author":"CA Antoniades","year":"2015","unstructured":"Antoniades CA, Demeyere N, Kennard C et al (2015) Antisaccades and executive dysfunction in early drug-naive Parkinson\u2019s disease: the discovery study: antisaccades in early PD. 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