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The objective of this study is to test whether degeneration of the LC is associated with orthostatic hypotension (OH) in PD. A total of 22 cognitively intact PD patients and 52 age-matched healthy volunteers underwent 3\u00a0T magnetic resonance (MRI) with neuromelanin-sensitive T1-weighted sequences (LC-MRI). For each subject, a template space-based LC-MRI was used to calculate LC signal intensity (LC contrast ratio\u2014LC<jats:sub>CR<\/jats:sub>) and the estimated number of voxels (LC<jats:sub>VOX<\/jats:sub>) belonging to LC. Then, we compared the LC-MRI parameters in PD patients with OH (PD<jats:sup>OH+<\/jats:sup>) versus without OH (PD<jats:sup>OH\u2212<\/jats:sup>) (matched for sex, age, and disease duration) using one-way analysis of variance followed by multiple comparison tests. We also tested for correlations between subject\u2019s LC-MRI features and orthostatic drop in systolic blood pressure (SBP). PD<jats:sup>OH\u2212<\/jats:sup> and PD<jats:sup>OH+<\/jats:sup> did not differ significantly (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) based on demographics and clinical characteristics, except for blood pressure measurements and SCOPA-AUT cardiovascular domain (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). LC<jats:sub>CR<\/jats:sub> and LC<jats:sub>VOX<\/jats:sub> measures were significantly lower in PD compared to HC, while no differences were observed between PD<jats:sup>OH\u2212<\/jats:sup> and PD<jats:sup>OH+<\/jats:sup>. Additionally, no correlation was found between the LC-MRI parameters and the orthostatic drop in SBP or the clinical severity of autonomic symptoms (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Conversely, RBD symptom severity negatively correlated with several LC-MRI parameters. Our results failed to indicate a link between the LC-MRI features and the presence of OH in PD but confirmed a marked alteration of LC signal in PD patients.<\/jats:p>","DOI":"10.1007\/s00702-023-02721-7","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T15:02:22Z","timestamp":1701356542000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neurogenic orthostatic hypotension in Parkinson\u2019s disease: is there a role for locus coeruleus magnetic resonance imaging?"],"prefix":"10.1007","volume":"131","author":[{"given":"Giovanni","family":"Palermo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Galgani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Morganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Paoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"De Cori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Frijia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Siciliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ceravolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo Sean","family":"Giorgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"issue":"9","key":"2721_CR1","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1093\/brain\/awz193","volume":"142","author":"MJ Betts","year":"2019","unstructured":"Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF et al (2019) Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. 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