{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:08:00Z","timestamp":1788368880273,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00702-026-03141-z","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T15:55:29Z","timestamp":1775490929000},"page":"1543-1551","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal serum uric acid levels are not associated with dopamine transporter binding in progressive supranuclear palsy"],"prefix":"10.1007","volume":"133","author":[{"given":"Dominic","family":"Buchinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora","family":"Aleksic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Br\u00fccke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Berger-Sieczkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Nakuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Traub-Weidinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-0243","authenticated-orcid":false,"given":"Ivan","family":"Milenkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"issue":"2","key":"3141_CR1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3233\/JAD-220432","volume":"90","author":"Q Aerqin","year":"2022","unstructured":"Aerqin Q, Jia SS, Shen XN, Li Q, Chen KL, Ou YN, Huang YY, Dong Q, Chen SF, Yu JT (2022) Serum uric acid levels in neurodegenerative disorders: a cross-sectional study. J Alzheimers Dis 90(2):761\u2013773. https:\/\/doi.org\/10.3233\/JAD-220432","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"3141_CR2","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/mds.21502","volume":"22","author":"T Annanmaki","year":"2007","unstructured":"Annanmaki T, Muuronen A, Murros K (2007) Low plasma uric acid level in Parkinson\u2019s disease. Mov Disord 22(8):1133\u20131137. https:\/\/doi.org\/10.1002\/mds.21502","journal-title":"Mov Disord"},{"key":"3141_CR3","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/B978-0-12-804766-8.00016-9","volume":"167","author":"MJ Armstrong","year":"2019","unstructured":"Armstrong MJ, McFarland N (2019) Recognizing and treating atypical Parkinson disorders. Handb Clin Neurol 167:301\u2013320. https:\/\/doi.org\/10.1016\/B978-0-12-804766-8.00016-9","journal-title":"Handb Clin Neurol"},{"issue":"5","key":"3141_CR4","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/ene.14152","volume":"27","author":"K Baik","year":"2020","unstructured":"Baik K, Chung SJ, Yoo HS, Lee YH, Jung JH, Sohn YH, Lee PH (2020) Sex-dependent association of urate on the patterns of striatal dopamine depletion in Parkinson\u2019s disease. Eur J Neurol 27(5):773\u2013778. https:\/\/doi.org\/10.1111\/ene.14152","journal-title":"Eur J Neurol"},{"issue":"3","key":"3141_CR5","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/s002590000460","volume":"28","author":"J Booij","year":"2001","unstructured":"Booij J, Speelman JD, Horstink MW, Wolters EC (2001) The clinical benefit of imaging striatal dopamine transporters with [123I]FP-CIT SPET in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism. Eur J Nucl Med 28(3):266\u2013272. https:\/\/doi.org\/10.1007\/s002590000460","journal-title":"Eur J Nucl Med"},{"issue":"8","key":"3141_CR6","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.2337\/dc08-0349","volume":"31","author":"A Brandstatter","year":"2008","unstructured":"Brandstatter A, Kiechl S, Kollerits B, Hunt SC, Heid IM, Coassin S, Willeit J, Adams TD, Illig T, Hopkins PN, Kronenberg F (2008) Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI. Diabetes Care 31(8):1662\u20131667. https:\/\/doi.org\/10.2337\/dc08-0349","journal-title":"Diabetes Care"},{"issue":"5","key":"3141_CR7","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/mds.26535","volume":"31","author":"DM Brody","year":"2016","unstructured":"Brody DM, Litvan I, Warner S, Riley DE, Hall DA, Kluger BM, Shprecher DR, Cunningham CR (2016) Relationship between uric acid levels and progressive supranuclear palsy. Mov Disord 31(5):663\u2013667. https:\/\/doi.org\/10.1002\/mds.26535","journal-title":"Mov Disord"},{"key":"3141_CR8","doi-asserted-by":"publisher","unstructured":"B\u00fcrkner P-C (2017) brms: an R package for Bayesian multilevel models using stan. J Stat Softw 80(1). https:\/\/doi.org\/10.18637\/jss.v080.i01","DOI":"10.18637\/jss.v080.i01"},{"issue":"7","key":"3141_CR9","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1007\/s00259-023-06171-x","volume":"50","author":"Y Chahid","year":"2023","unstructured":"Chahid Y, Sheikh ZH, Mitropoulos M, Booij J (2023) A systematic review of the potential effects of medications and drugs of abuse on dopamine transporter imaging using [(123)I]I-FP-CIT SPECT in routine practice. Eur J Nucl Med Mol Imaging 50(7):1974\u20131987. https:\/\/doi.org\/10.1007\/s00259-023-06171-x","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"1","key":"3141_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00433-5","volume":"8","author":"H Chang","year":"2022","unstructured":"Chang H, Wang B, Shi Y, Zhu R (2022) Dose-response meta-analysis on urate, gout, and the risk for Parkinson\u2019s disease. NPJ Parkinsons Dis 8(1):160. https:\/\/doi.org\/10.1038\/s41531-022-00433-5","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"3141_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s0006-8993(02)03101-3","volume":"951","author":"JW Chirichigno","year":"2002","unstructured":"Chirichigno JW, Manfredi G, Beal MF, Albers DS (2002) Stress-induced mitochondrial depolarization and oxidative damage in PSP cybrids. Brain Res 951(1):31\u201335. https:\/\/doi.org\/10.1016\/s0006-8993(02)03101-3","journal-title":"Brain Res"},{"issue":"2","key":"3141_CR12","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1111\/ane.12012","volume":"127","author":"R Constantinescu","year":"2013","unstructured":"Constantinescu R, Andreasson U, Holmberg B, Zetterberg H (2013) Serum and cerebrospinal fluid urate levels in synucleinopathies versus tauopathies. Acta Neurol Scand 127(2):e8-12. https:\/\/doi.org\/10.1111\/ane.12012","journal-title":"Acta Neurol Scand"},{"key":"3141_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58020245","author":"A Danau","year":"2022","unstructured":"Danau A, Dumitrescu L, Lefter A, Popescu BO (2022) Serum uric acid levels in Parkinson\u2019s Disease: a cross-sectional electronic medical record database study from a tertiary referral centre in Romania. Medicina (Kaunas). https:\/\/doi.org\/10.3390\/medicina58020245","journal-title":"Medicina (Kaunas)"},{"issue":"5","key":"3141_CR14","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/ana.20663","volume":"58","author":"LM de Lau","year":"2005","unstructured":"de Lau LM, Koudstaal PJ, Hofman A, Breteler MM (2005) Serum uric acid levels and the risk of Parkinson disease. Ann Neurol 58(5):797\u2013800. https:\/\/doi.org\/10.1002\/ana.20663","journal-title":"Ann Neurol"},{"issue":"1","key":"3141_CR15","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1186\/s12883-022-02874-0","volume":"22","author":"A Fazlollahi","year":"2022","unstructured":"Fazlollahi A, Zahmatyar M, Alizadeh H, Noori M, Jafari N, Nejadghaderi SA, Sullman MJM, Gharagozli K, Kolahi AA, Safiri S (2022) Association between gout and the development of Parkinson\u2019s disease: a systematic review and meta-analysis. BMC Neurol 22(1):383. https:\/\/doi.org\/10.1186\/s12883-022-02874-0","journal-title":"BMC Neurol"},{"issue":"7","key":"3141_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.tins.2010.04.003","volume":"33","author":"M Goedert","year":"2010","unstructured":"Goedert M, Clavaguera F, Tolnay M (2010) The propagation of prion-like protein inclusions in neurodegenerative diseases. Trends Neurosci 33(7):317\u2013325. https:\/\/doi.org\/10.1016\/j.tins.2010.04.003","journal-title":"Trends Neurosci"},{"issue":"5","key":"3141_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/ar2519","volume":"10","author":"AE Hak","year":"2008","unstructured":"Hak AE, Choi HK (2008) Menopause, postmenopausal hormone use and serum uric acid levels in US women\u2013the Third National Health and Nutrition Examination Survey. Arthritis Res Ther 10(5):R116. https:\/\/doi.org\/10.1186\/ar2519","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"3141_CR18","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.3233\/JPD-202064","volume":"10","author":"YG Hasimoglu","year":"2020","unstructured":"Hasimoglu YG, Chen X, Bakshi R, Schwarzschild MA, Macklin EA (2020) Does serum urate change as Parkinson\u2019s disease progresses? J Parkinsons Dis 10(4):1571\u20131576. https:\/\/doi.org\/10.3233\/JPD-202064","journal-title":"J Parkinsons Dis"},{"issue":"6","key":"3141_CR19","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/mds.26987","volume":"32","author":"GU Hoglinger","year":"2017","unstructured":"Hoglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Muller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I, Movement Disorder Society-endorsed PSPSG (2017) Clinical diagnosis of progressive supranuclear palsy: the Movement Disorder Society criteria. Mov Disord 32(6):853\u2013864. https:\/\/doi.org\/10.1002\/mds.26987","journal-title":"Mov Disord"},{"issue":"4","key":"3141_CR20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000323265","volume":"8","author":"K Ikeda","year":"2011","unstructured":"Ikeda K, Nakamura Y, Kiyozuka T, Aoyagi J, Hirayama T, Nagata R, Ito H, Iwamoto K, Murata K, Yoshii Y, Kawabe K, Iwasaki Y (2011) Serological profiles of urate, paraoxonase-1, ferritin and lipid in Parkinson\u2019s disease: changes linked to disease progression. Neurodegener Dis 8(4):252\u2013258. https:\/\/doi.org\/10.1159\/000323265","journal-title":"Neurodegener Dis"},{"issue":"8","key":"3141_CR21","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","volume":"20","author":"CR Jack Jr.","year":"2024","unstructured":"Jack CR Jr., Andrews JS, Beach TG, Buracchio T, Dunn B, Graf A, Hansson O, Ho C, Jagust W, McDade E, Molinuevo JL, Okonkwo OC, Pani L, Rafii MS, Scheltens P, Siemers E, Snyder HM, Sperling R, Teunissen CE, Carrillo MC (2024) Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup. Alzheimers Dement 20(8):5143\u20135169. https:\/\/doi.org\/10.1002\/alz.13859","journal-title":"Alzheimers Dement"},{"issue":"9","key":"3141_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnha.2024.100319","volume":"28","author":"Z Jiang","year":"2024","unstructured":"Jiang Z, Chen J, Wu S, Ji S, Yang Y, Fang W, Li Z, Lin J, Chen J, Wu C, Kwan HY, Lai Y, Zhao X (2024) Serum uric acid levels associated with outcomes of neurodegenerative disorders and brain health: findings from the UK Biobank. J Nutr Health Aging 28(9):100319. https:\/\/doi.org\/10.1016\/j.jnha.2024.100319","journal-title":"J Nutr Health Aging"},{"issue":"5","key":"3141_CR23","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3233\/JPD-230007","volume":"13","author":"C Koros","year":"2023","unstructured":"Koros C, Simitsi AM, Papagiannakis N, Bougea A, Prentakis A, Papadimitriou D, Pachi I, Beratis I, Stanitsa E, Angelopoulou E, Antonelou R, Bregianni M, Lourentzos K, Papageorgiou SG, Bonakis A, Trapali XG, Stamelou M, Stefanis L (2023) Serum uric acid as a putative biomarker in prodromal Parkinson\u2019s disease: longitudinal data from the PPMI study. J Parkinsons Dis 13(5):811\u2013818. https:\/\/doi.org\/10.3233\/JPD-230007","journal-title":"J Parkinsons Dis"},{"issue":"11","key":"3141_CR24","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1136\/jclinpath-2019-205952","volume":"72","author":"GG Kovacs","year":"2019","unstructured":"Kovacs GG (2019) Molecular pathology of neurodegenerative diseases: principles and practice. J Clin Pathol 72(11):725\u2013735. https:\/\/doi.org\/10.1136\/jclinpath-2019-205952","journal-title":"J Clin Pathol"},{"issue":"11","key":"3141_CR25","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1002\/mds.22207","volume":"23","author":"GG Kovacs","year":"2008","unstructured":"Kovacs GG, Milenkovic IJ, Preusser M, Budka H (2008) Nigral burden of alpha-synuclein correlates with striatal dopamine deficit. Mov Disord 23(11):1608\u20131612. https:\/\/doi.org\/10.1002\/mds.22207","journal-title":"Mov Disord"},{"issue":"2","key":"3141_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00401-020-02158-2","volume":"140","author":"GG Kovacs","year":"2020","unstructured":"Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Roeber S, Xie SX, Lee VM, Trojanowski JQ, Hoglinger GU (2020) Distribution patterns of tau pathology in progressive supranuclear palsy. Acta Neuropathol 140(2):99\u2013119. https:\/\/doi.org\/10.1007\/s00401-020-02158-2","journal-title":"Acta Neuropathol"},{"key":"3141_CR27","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.parkreldis.2018.03.023","volume":"52","author":"Y Lee","year":"2018","unstructured":"Lee Y, Park YH, Lee JJ, Sohn YH, Lee JM, Lee PH (2018) Gender-specific effect of uric acid on resting-state functional networks in de novo Parkinson\u2019s disease. Parkinsonism Relat Disord 52:49\u201354. https:\/\/doi.org\/10.1016\/j.parkreldis.2018.03.023","journal-title":"Parkinsonism Relat Disord"},{"key":"3141_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.parkreldis.2020.05.012","volume":"75","author":"YH Lee","year":"2020","unstructured":"Lee YH, Chung SJ, Yoo HS, Lee Y, Sohn YH, Cha J, Lee PH (2020) Gender-specific effect of urate on white matter integrity in Parkinson\u2019s disease. Parkinsonism Relat Disord 75:41\u201347. https:\/\/doi.org\/10.1016\/j.parkreldis.2020.05.012","journal-title":"Parkinsonism Relat Disord"},{"issue":"Pt 1","key":"3141_CR29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/brain\/120.1.65","volume":"120","author":"I Litvan","year":"1997","unstructured":"Litvan I, Campbell G, Mangone CA, Verny M, McKee A, Chaudhuri KR, Jellinger K, Pearce RK, D\u2019Olhaberriague L (1997) Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study. Brain 120(Pt 1):65\u201374. https:\/\/doi.org\/10.1093\/brain\/120.1.65","journal-title":"Brain"},{"issue":"1","key":"3141_CR30","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3233\/JAD-2011-110587","volume":"27","author":"W Maetzler","year":"2011","unstructured":"Maetzler W, Stapf AK, Schulte C, Hauser AK, Lerche S, Wurster I, Schleicher E, Melms A, Berg D (2011) Serum and cerebrospinal fluid uric acid levels in Lewy body disorders: associations with disease occurrence and amyloid-beta pathway. J Alzheimers Dis 27(1):119\u2013126. https:\/\/doi.org\/10.3233\/JAD-2011-110587","journal-title":"J Alzheimers Dis"},{"issue":"4 Movement Diso","key":"3141_CR31","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1212\/CON.0000000000000348","volume":"22","author":"NR McFarland","year":"2016","unstructured":"McFarland NR (2016) Diagnostic approach to atypical Parkinsonian Syndromes. Continuum Minneap Minn 22(4 Movement Disorders):1117\u20131142. https:\/\/doi.org\/10.1212\/CON.0000000000000348","journal-title":"Continuum Minneap Minn"},{"issue":"1","key":"3141_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0609-2","volume":"17","author":"TR Merriman","year":"2015","unstructured":"Merriman TR (2015) An update on the genetic architecture of hyperuricemia and gout. Arthritis Res Ther 17(1):98. https:\/\/doi.org\/10.1186\/s13075-015-0609-2","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"3141_CR33","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/ane.12295","volume":"131","author":"M Moccia","year":"2015","unstructured":"Moccia M, Pappata S, Erro R, Picillo M, Vitale C, Amboni M, Longo K, Palladino R, Barone P, Pellecchia MT (2015) Uric acid relates to dopamine transporter availability in Parkinson\u2019s disease. Acta Neurol Scand 131(2):127\u2013131. https:\/\/doi.org\/10.1111\/ane.12295","journal-title":"Acta Neurol Scand"},{"issue":"3","key":"3141_CR34","doi-asserted-by":"publisher","first-page":"399","DOI":"10.2967\/jnumed.111.095224","volume":"53","author":"M Oh","year":"2012","unstructured":"Oh M, Kim JS, Kim JY, Shin KH, Park SH, Kim HO, Moon DH, Oh SJ, Chung SJ, Lee CS (2012) Subregional patterns of preferential striatal dopamine transporter loss differ in Parkinson disease, progressive supranuclear palsy, and multiple-system atrophy. J Nucl Med 53(3):399\u2013406. https:\/\/doi.org\/10.2967\/jnumed.111.095224","journal-title":"J Nucl Med"},{"issue":"3","key":"3141_CR35","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/mds.26466","volume":"31","author":"JM Oropesa-Ruiz","year":"2016","unstructured":"Oropesa-Ruiz JM, Huertas-Fernandez I, Jesus S, Caceres-Redondo MT, Vargas-Gonzalez L, Carrillo F, Carballo M, Gomez-Garre P, Mir P (2016) Low serum uric acid levels in progressive supranuclear palsy. Mov Disord 31(3):402\u2013405. https:\/\/doi.org\/10.1002\/mds.26466","journal-title":"Mov Disord"},{"issue":"1","key":"3141_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.598","volume":"7","author":"H Sakuta","year":"2017","unstructured":"Sakuta H, Suzuki K, Miyamoto T, Miyamoto M, Numao A, Fujita H, Watanabe Y, Hirata K (2017) Serum uric acid levels in Parkinson\u2019s disease and related disorders. Brain Behav 7(1):e00598. https:\/\/doi.org\/10.1002\/brb3.598","journal-title":"Brain Behav"},{"issue":"9","key":"3141_CR37","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s00702-017-1743-6","volume":"124","author":"T Schirinzi","year":"2017","unstructured":"Schirinzi T, Di Lazzaro G, Colona VL, Imbriani P, Alwardat M, Sancesario GM, Martorana A, Pisani A (2017) Assessment of serum uric acid as risk factor for tauopathies. J Neural Transm 124(9):1105\u20131108. https:\/\/doi.org\/10.1007\/s00702-017-1743-6","journal-title":"J Neural Transm"},{"issue":"11","key":"3141_CR38","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003620","volume":"3","author":"L Shen","year":"2013","unstructured":"Shen L, Ji HF (2013) Low uric acid levels in patients with Parkinson\u2019s disease: evidence from meta-analysis. BMJ Open 3(11):e003620. https:\/\/doi.org\/10.1136\/bmjopen-2013-003620","journal-title":"BMJ Open"},{"issue":"2","key":"3141_CR39","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1006\/abbi.2000.1721","volume":"376","author":"GL Squadrito","year":"2000","unstructured":"Squadrito GL, Cueto R, Splenser AE, Valavanidis A, Zhang H, Uppu RM, Pryor WA (2000) Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid. Arch Biochem Biophys 376(2):333\u2013337. https:\/\/doi.org\/10.1006\/abbi.2000.1721","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"3141_CR40","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3233\/JPD-201988","volume":"10","author":"DJ van Wamelen","year":"2020","unstructured":"van Wamelen DJ, Taddei RN, Calvano A, Titova N, Leta V, Shtuchniy I, Jenner P, Martinez-Martin P, Katunina E, Chaudhuri KR (2020) Serum uric acid levels and non-motor symptoms in Parkinson\u2019s disease. J Parkinsons Dis 10(3):1003\u20131010. https:\/\/doi.org\/10.3233\/JPD-201988","journal-title":"J Parkinsons Dis"},{"key":"3141_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2024.112503","volume":"194","author":"M Wang","year":"2024","unstructured":"Wang M, Tang Z (2024) No causal relationship between serum urate and neurodegenerative diseases: a Mendelian randomization study. Exp Gerontol 194:112503. https:\/\/doi.org\/10.1016\/j.exger.2024.112503","journal-title":"Exp Gerontol"},{"issue":"5","key":"3141_CR42","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/aje\/kwm127","volume":"166","author":"MG Weisskopf","year":"2007","unstructured":"Weisskopf MG, O\u2019Reilly E, Chen H, Schwarzschild MA, Ascherio A (2007) Plasma urate and risk of Parkinson\u2019s disease. Am J Epidemiol 166(5):561\u2013567. https:\/\/doi.org\/10.1093\/aje\/kwm127","journal-title":"Am J Epidemiol"},{"issue":"3","key":"3141_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173731","volume":"12","author":"M Wen","year":"2017","unstructured":"Wen M, Zhou B, Chen YH, Ma ZL, Gou Y, Zhang CL, Yu WF, Jiao L (2017) Serum uric acid levels in patients with Parkinson\u2019s disease: a meta-analysis. PLoS ONE 12(3):e0173731. https:\/\/doi.org\/10.1371\/journal.pone.0173731","journal-title":"PLoS ONE"},{"issue":"30","key":"3141_CR44","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038947","volume":"103","author":"J Zhang","year":"2024","unstructured":"Zhang J, Zeng L, Bu L, Liao H, Wang M, Xiong Y, Cao F (2024a) Association between high uric acid and the risk of Parkinson\u2019s disease: a meta-analysis. Med (Baltim) 103(30):e38947. https:\/\/doi.org\/10.1097\/MD.0000000000038947","journal-title":"Med (Baltim)"},{"issue":"1","key":"3141_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01476-x","volume":"16","author":"T Zhang","year":"2024","unstructured":"Zhang T, An Y, Shen Z, Yang H, Jiang J, Chen L, Lu Y, Xia Y (2024b) Serum urate levels and neurodegenerative outcomes: a prospective cohort study and Mendelian randomization analysis of the UK Biobank. Alzheimers Res Ther 16(1):106. https:\/\/doi.org\/10.1186\/s13195-024-01476-x","journal-title":"Alzheimers Res Ther"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-026-03141-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00702-026-03141-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-026-03141-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:07:38Z","timestamp":1785600458000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00702-026-03141-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["3141"],"URL":"https:\/\/doi.org\/10.1007\/s00702-026-03141-z","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"29 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the local ethics committee (EK Nr. 1265\/2020) and was conducted in accordance with the principles of the Declaration of Helsinki and its later amendments.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was conducted retrospectively using data obtained for clinical purposes. In view of the retrospective nature of the study and the use of fully anonymized data, informed consent to participate was not required.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}}]}}