{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:57:13Z","timestamp":1785603433995,"version":"3.56.0"},"reference-count":149,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007642","name":"Universit\u00e0 degli Studi di Roma Tor Vergata","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007642","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neural Transm"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acid-sensing ion channels (ASICs) are increasingly recognized as promising therapeutic targets within both the central and peripheral nervous systems, with significant relevance to neurodegenerative and neuroinflammatory pathologies. Among these, ASIC1a has been most closely implicated in the progression of neurodegeneration, primarily through its roles in mediating excitotoxicity, intracellular Ca\u00b2\u207a overload, and pro-inflammatory signalling cascades. Pathological acidification, a common feature of many neurological disorders, activates ASICs, contributing to neuronal injury and the activation of glial cells, which together sustain a deleterious cycle of inflammation and neurodegeneration. Importantly, ASICs are not confined to neurons but are also expressed in glial populations, including astrocytes and microglia, where their activation by extracellular acidosis can initiate and amplify immune responses. This glial involvement positions ASICs as modulators of neuroimmune dynamics, suggesting that their inhibition could mitigate both neuronal and glial-mediated pathology. A growing body of preclinical evidence supports the therapeutic potential of ASICs inhibition, with several pharmacological antagonists demonstrating the capacity to preserve synaptic integrity, attenuate glial activation, and reduce neuronal loss. Targeting ASICs thus offers a dual-pronged strategy that addresses both neuronal damage and glial-driven inflammation. This review aims to examine the roles of ASICs in both neuronal and glial cells across the CNS and PNS, and to evaluate whether modulation of ASICs activity may represent a strategy to move beyond symptomatic relief toward disease-modifying therapies that target the underlying mechanisms of neurodegenerative disorders.<\/jats:p>","DOI":"10.1007\/s00702-026-03165-5","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:20:49Z","timestamp":1777980049000},"page":"987-1003","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The multifaceted role of ASICs channels into the nervous system and their potential use as a therapeutic target for neuro-disorders"],"prefix":"10.1007","volume":"133","author":[{"given":"Nunzia","family":"Maisto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Dashtiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asia","family":"D\u2019Ettorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"di Nuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"Mango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"3165_CR1","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.cell.2024.12.002","volume":"188","author":"MJ Adams","year":"2025","unstructured":"Adams MJ, Streit F, Meng X et al (2025) Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. Cell 188:640-652.e9. https:\/\/doi.org\/10.1016\/j.cell.2024.12.002","journal-title":"Cell"},{"key":"3165_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112854","volume":"23","author":"L Agnello","year":"2022","unstructured":"Agnello L, Ciaccio M (2022) Neurodegenerative diseases: from molecular basis to therapy. Int J Mol Sci 23:12854. https:\/\/doi.org\/10.3390\/ijms232112854","journal-title":"Int J Mol Sci"},{"key":"3165_CR3","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1113\/jphysiol.2002.020297","volume":"543","author":"NJ Allen","year":"2002","unstructured":"Allen NJ, Attwell D (2002) Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals. J Physiol 543:521\u2013529. https:\/\/doi.org\/10.1113\/jphysiol.2002.020297","journal-title":"J Physiol"},{"key":"3165_CR4","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/brain\/aws325","volume":"136","author":"T Arun","year":"2013","unstructured":"Arun T, Tomassini V, Sbardella E et al (2013) Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride. Brain 136:106\u2013115. https:\/\/doi.org\/10.1093\/brain\/aws325","journal-title":"Brain"},{"key":"3165_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102253","volume":"51","author":"IS Azoulay","year":"2022","unstructured":"Azoulay IS, Qi X, Rozenfeld M et al (2022) ASIC1a senses lactate uptake to regulate metabolism in neurons. Redox Biol 51:102253. https:\/\/doi.org\/10.1016\/j.redox.2022.102253","journal-title":"Redox Biol"},{"key":"3165_CR6","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.cell.2014.01.011","volume":"156","author":"I Baconguis","year":"2014","unstructured":"Baconguis I, Bohlen CJ, Goehring A et al (2014) X-Ray Structure of Acid-Sensing Ion Channel 1\u2013Snake Toxin Complex Reveals Open State of a Na+-Selective Channel. Cell 156:717\u2013729. https:\/\/doi.org\/10.1016\/j.cell.2014.01.011","journal-title":"Cell"},{"key":"3165_CR7","doi-asserted-by":"publisher","first-page":"8281","DOI":"10.1073\/pnas.1324060111","volume":"111","author":"T Bartoi","year":"2014","unstructured":"Bartoi T, Augustinowski K, Polleichtner G et al (2014) Acid-sensing ion channel (ASIC) 1a\/2a heteromers have a flexible 2:1\/1:2 stoichiometry. Proc Natl Acad Sci USA 111:8281\u20138286. https:\/\/doi.org\/10.1073\/pnas.1324060111","journal-title":"Proc Natl Acad Sci USA"},{"key":"3165_CR8","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1080\/19336950.2017.1394557","volume":"11","author":"OI Barygin","year":"2017","unstructured":"Barygin OI, Komarova MS, Tikhonova TB et al (2017) Complex action of tyramine, tryptamine and histamine on native and recombinant ASICs. Channels 11:648\u2013659. https:\/\/doi.org\/10.1080\/19336950.2017.1394557","journal-title":"Channels"},{"key":"3165_CR9","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1080\/01616412.2019.1580462","volume":"41","author":"E Bektur","year":"2019","unstructured":"Bektur E, \u015eahin E, Ceyhan E et al (2019) Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion. Neurol Res 41:544\u2013553. https:\/\/doi.org\/10.1080\/01616412.2019.1580462","journal-title":"Neurol Res"},{"key":"3165_CR10","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1021\/acsmedchemlett.8b00591","volume":"10","author":"LI Bencheva","year":"2019","unstructured":"Bencheva LI, De Matteo M, Ferrante L et al (2019) Identification of Isoform 2 acid-sensing ion channel inhibitors as tool compounds for target validation studies in CNS. ACS Med Chem Lett 10:627\u2013632. https:\/\/doi.org\/10.1021\/acsmedchemlett.8b00591","journal-title":"ACS Med Chem Lett"},{"key":"3165_CR11","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/nature10607","volume":"479","author":"CJ Bohlen","year":"2011","unstructured":"Bohlen CJ, Chesler AT, Sharif-Naeini R et al (2011) A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature 479:410\u2013414. https:\/\/doi.org\/10.1038\/nature10607","journal-title":"Nature"},{"key":"3165_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s10545-013-9643-x","volume":"37","author":"FE Bolsover","year":"2014","unstructured":"Bolsover FE, Murphy E, Cipolotti L et al (2014) Cognitive dysfunction and depression in Fabry disease: a systematic review. J Inherit Metab Dis 37:177\u2013187. https:\/\/doi.org\/10.1007\/s10545-013-9643-x","journal-title":"J Inherit Metab Dis"},{"key":"3165_CR13","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1111\/bph.13533","volume":"173","author":"E Boscardin","year":"2016","unstructured":"Boscardin E, Alijevic O, Hummler E et al (2016) The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC): IUPHAR Review 19. Br J Pharmacol 173:2671\u20132701. https:\/\/doi.org\/10.1111\/bph.13533","journal-title":"Br J Pharmacol"},{"key":"3165_CR14","doi-asserted-by":"publisher","first-page":"4449","DOI":"10.1021\/jm5017329","volume":"58","author":"A Buta","year":"2015","unstructured":"Buta A, Maximyuk O, Kovalskyy D et al (2015) Novel potent orthosteric antagonist of ASIC1a prevents NMDAR-dependent LTP induction. J Med Chem 58:4449\u20134461. https:\/\/doi.org\/10.1021\/jm5017329","journal-title":"J Med Chem"},{"key":"3165_CR15","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jep.2010.06.009","volume":"131","author":"B-Y Cao","year":"2010","unstructured":"Cao B-Y, Yang Y-P, Luo W-F et al (2010) Paeoniflorin, a potent natural compound, protects PC12 cells from MPP\u2009+\u2009and acidic damage via autophagic pathway. J Ethnopharmacol 131:122\u2013129. https:\/\/doi.org\/10.1016\/j.jep.2010.06.009","journal-title":"J Ethnopharmacol"},{"key":"3165_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166927","volume":"1870","author":"LCS Castellanos","year":"2024","unstructured":"Castellanos LCS, Gatto RG, Malnati GOM et al (2024) Redistribution of ASIC1a channels triggered by IL-6: potential role of ASIC1a in neuroinflammation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870:166927. https:\/\/doi.org\/10.1016\/j.bbadis.2023.166927","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"3165_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104824","author":"LCS Castellanos","year":"2020","unstructured":"Castellanos LCS, Rozenfeld P, Gatto RG et al (2020) Upregulation of ASIC1a channels in an in vitro model of Fabry disease. Neurochemistry International. https:\/\/doi.org\/10.1016\/j.neuint.2020.104824","journal-title":"Neurochemistry International"},{"key":"3165_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12020119","volume":"12","author":"V Cegielski","year":"2022","unstructured":"Cegielski V, Chakrabarty R, Ding S et al (2022) Acid-sensing ion channels in glial cells. Membranes 12:119. https:\/\/doi.org\/10.3390\/membranes12020119","journal-title":"Membranes"},{"key":"3165_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1010993","volume":"19","author":"M Chafa\u00ef","year":"2023","unstructured":"Chafa\u00ef M, Delrocq A, Inquimbert P et al (2023) Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling. PLoS Comput Biol 19:e1010993. https:\/\/doi.org\/10.1371\/journal.pcbi.1010993","journal-title":"PLoS Comput Biol"},{"key":"3165_CR20","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.1073\/pnas.1614728114","volume":"114","author":"IR Chassagnon","year":"2017","unstructured":"Chassagnon IR, McCarthy CA, Chin Y-Y et al (2017) Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proc Natl Acad Sci USA 114:3750\u20133755. https:\/\/doi.org\/10.1073\/pnas.1614728114","journal-title":"Proc Natl Acad Sci USA"},{"key":"3165_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-18-82","volume":"18","author":"W-H Chen","year":"2011","unstructured":"Chen W-H, Hsieh C-L, Huang C-P et al (2011) Acid-sensing ion channel 3 mediates peripheral anti-hyperalgesia effects of acupuncture in mice inflammatory pain. J Biomed Sci 18:82. https:\/\/doi.org\/10.1186\/1423-0127-18-82","journal-title":"J Biomed Sci"},{"key":"3165_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/srep10143","volume":"5","author":"P-H Chiang","year":"2015","unstructured":"Chiang P-H, Chien T-C, Chen C-C et al (2015) ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory. Sci Rep 5:10143. https:\/\/doi.org\/10.1038\/srep10143","journal-title":"Sci Rep"},{"key":"3165_CR23","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.msec.2016.04.048","volume":"65","author":"K Dalamagkas","year":"2016","unstructured":"Dalamagkas K, Tsintou M, Seifalian A (2016) Advances in peripheral nervous system regenerative therapeutic strategies: a biomaterials approach. Materials Science and Engineering: C 65:425\u2013432. https:\/\/doi.org\/10.1016\/j.msec.2016.04.048","journal-title":"Materials Science and Engineering: C"},{"key":"3165_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104714","volume":"136","author":"AP De Ara\u00fajo Boleti","year":"2020","unstructured":"De Ara\u00fajo Boleti AP, De Oliveira Flores TM, Moreno SE et al (2020) Neuroinflammation: an overview of neurodegenerative and metabolic diseases and of biotechnological studies. Neurochem Int 136:104714. https:\/\/doi.org\/10.1016\/j.neuint.2020.104714","journal-title":"Neurochem Int"},{"key":"3165_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.neuropharm.2015.02.009","volume":"94","author":"E Deval","year":"2015","unstructured":"Deval E, Lingueglia E (2015) Acid-sensing ion channels and nociception in the peripheral and central nervous systems. Neuropharmacology 94:49\u201357. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.02.009","journal-title":"Neuropharmacology"},{"key":"3165_CR26","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1038\/emboj.2008.213","volume":"27","author":"E Deval","year":"2008","unstructured":"Deval E, No\u00ebl J, Lay N et al (2008) ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J 27:3047\u20133055. https:\/\/doi.org\/10.1038\/emboj.2008.213","journal-title":"EMBO J"},{"key":"3165_CR27","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/sj.emboj.7600177","volume":"23","author":"S Diochot","year":"2004","unstructured":"Diochot S, Baron A, Rash LD et al (2004) A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. EMBO J 23:1516\u20131525. https:\/\/doi.org\/10.1038\/sj.emboj.7600177","journal-title":"EMBO J"},{"key":"3165_CR28","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/nature11494","volume":"490","author":"S Diochot","year":"2012","unstructured":"Diochot S, Baron A, Salinas M et al (2012) Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature 490:552\u2013555. https:\/\/doi.org\/10.1038\/nature11494","journal-title":"Nature"},{"key":"3165_CR29","doi-asserted-by":"publisher","first-page":"8961","DOI":"10.1073\/pnas.1407018111","volume":"111","author":"J Du","year":"2014","unstructured":"Du J, Reznikov LR, Price MP et al (2014) Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proc Natl Acad Sci USA 111:8961\u20138966. https:\/\/doi.org\/10.1073\/pnas.1407018111","journal-title":"Proc Natl Acad Sci USA"},{"key":"3165_CR30","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1523\/JNEUROSCI.4351-10.2011","volume":"31","author":"B Duan","year":"2011","unstructured":"Duan B, Wang Y-Z, Yang T et al (2011) Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci 31:2101\u20132112. https:\/\/doi.org\/10.1523\/JNEUROSCI.4351-10.2011","journal-title":"J Neurosci"},{"key":"3165_CR31","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.pain.2005.05.021","volume":"117","author":"GR Dub\u00e9","year":"2005","unstructured":"Dub\u00e9 GR, Lehto SG, Breese NM et al (2005) Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain 117:88\u201396. https:\/\/doi.org\/10.1016\/j.pain.2005.05.021","journal-title":"Pain"},{"key":"3165_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.723295","volume":"15","author":"DE Duzhyy","year":"2021","unstructured":"Duzhyy DE, Voitenko NV, Belan PV (2021) Peripheral inflammation results in increased excitability of capsaicin-insensitive nociceptive DRG neurons mediated by upregulation of ASICs and voltage-gated ion channels. Front Cell Neurosci 15:723295. https:\/\/doi.org\/10.3389\/fncel.2021.723295","journal-title":"Front Cell Neurosci"},{"key":"3165_CR33","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202012655","volume":"153","author":"S Fechner","year":"2021","unstructured":"Fechner S, D\u2019Alessandro I, Wang L et al (2021) DEG\/ENaC\/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs. J Gen Physiol 153:e202012655. https:\/\/doi.org\/10.1085\/jgp.202012655","journal-title":"J Gen Physiol"},{"key":"3165_CR34","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1002\/glia.20693","volume":"56","author":"DH Feldman","year":"2008","unstructured":"Feldman DH, Horiuchi M, Keachie K et al (2008) Characterization of acid-sensing ion channel expression in oligodendrocyte\u2010lineage cells. Glia 56:1238\u20131249. https:\/\/doi.org\/10.1002\/glia.20693","journal-title":"Glia"},{"key":"3165_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.738043","volume":"15","author":"VS Foster","year":"2021","unstructured":"Foster VS, Rash LD, King GF, Rank MM (2021) Acid-sensing ion channels: expression and function in resident and infiltrating immune cells in the central nervous system. Front Cell Neurosci 15:738043. https:\/\/doi.org\/10.3389\/fncel.2021.738043","journal-title":"Front Cell Neurosci"},{"key":"3165_CR36","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1038\/nm1668","volume":"13","author":"MA Friese","year":"2007","unstructured":"Friese MA, Craner MJ, Etzensperger R et al (2007) Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Med 13:1483\u20131489. https:\/\/doi.org\/10.1038\/nm1668","journal-title":"Nat Med"},{"key":"3165_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1118754","volume":"10","author":"MJ Fuller","year":"2023","unstructured":"Fuller MJ, Gupta SC, Fan R et al (2023) Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse. Front Mol Biosci 10:1118754. https:\/\/doi.org\/10.3389\/fmolb.2023.1118754","journal-title":"Front Mol Biosci"},{"key":"3165_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801362","volume":"30","author":"D Furtado","year":"2018","unstructured":"Furtado D, Bj\u00f6rnmalm M, Ayton S et al (2018) Overcoming the Blood\u2013Brain Barrier: the role of nanomaterials in treating neurological diseases. Adv Mater 30:1801362. https:\/\/doi.org\/10.1002\/adma.201801362","journal-title":"Adv Mater"},{"key":"3165_CR39","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.phrs.2016.02.018","volume":"107","author":"X Gan","year":"2016","unstructured":"Gan X, Wu J, Ren C et al (2016) Potentiation of acid-sensing ion channel activity by peripheral group I metabotropic glutamate receptor signaling. Pharmacol Res 107:19\u201326. https:\/\/doi.org\/10.1016\/j.phrs.2016.02.018","journal-title":"Pharmacol Res"},{"key":"3165_CR40","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s12640-015-9530-3","volume":"28","author":"S Gao","year":"2015","unstructured":"Gao S, Yu Y, Ma Z-Y et al (2015) NMDAR-mediated hippocampal neuronal death is exacerbated by activities of ASIC1a. Neurotox Res 28:122\u2013137. https:\/\/doi.org\/10.1007\/s12640-015-9530-3","journal-title":"Neurotox Res"},{"key":"3165_CR41","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.neuron.2005.10.011","volume":"48","author":"J Gao","year":"2005","unstructured":"Gao J, Duan B, Wang D-G et al (2005) Coupling between NMDA Receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron 48:635\u2013646. https:\/\/doi.org\/10.1016\/j.neuron.2005.10.011","journal-title":"Neuron"},{"key":"3165_CR42","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1096\/fj.12-220400","volume":"27","author":"M Gautam","year":"2013","unstructured":"Gautam M, Benson CJ (2013) Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits. FASEB J 27:793\u2013802. https:\/\/doi.org\/10.1096\/fj.12-220400","journal-title":"FASEB J"},{"key":"3165_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176173","volume":"963","author":"L Gei","year":"2024","unstructured":"Gei L, Yan Y, Xing W et al (2024) Amiloride alleviates morphine tolerance by suppressing ASIC3-dependent neuroinflammation in the spinal cord. Eur J Pharmacol 963:176173. https:\/\/doi.org\/10.1016\/j.ejphar.2023.176173","journal-title":"Eur J Pharmacol"},{"key":"3165_CR44","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.neuroscience.2021.01.022","volume":"460","author":"MN Gobetto","year":"2021","unstructured":"Gobetto MN, Gonz\u00e1lez-Inchauspe C, Uchitel OD (2021) Histamine and corticosterone modulate acid sensing ion channels (ASICs) dependent long-term potentiation at the mouse Anterior Cingulate Cortex. Neuroscience 460:145\u2013160. https:\/\/doi.org\/10.1016\/j.neuroscience.2021.01.022","journal-title":"Neuroscience"},{"key":"3165_CR45","doi-asserted-by":"publisher","first-page":"8333","DOI":"10.1021\/acs.jmedchem.1c00305","volume":"64","author":"D Gornati","year":"2021","unstructured":"Gornati D, Ciccone R, Vinciguerra A et al (2021) Synthesis and characterization of novel Mono- and Bis-Guanyl Hydrazones as potent and selective ASIC1 inhibitors able to reduce brain ischemic insult. J Med Chem 64:8333\u20138353. https:\/\/doi.org\/10.1021\/acs.jmedchem.1c00305","journal-title":"J Med Chem"},{"key":"3165_CR46","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.psyneuen.2007.09.004","volume":"32","author":"I Goshen","year":"2007","unstructured":"Goshen I, Kreisel T, Ounallah-Saad H et al (2007) A dual role for interleukin-1 in hippocampal-dependent memory processes. Psychoneuroendocrinology 32:1106\u20131115. https:\/\/doi.org\/10.1016\/j.psyneuen.2007.09.004","journal-title":"Psychoneuroendocrinology"},{"key":"3165_CR47","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1093\/oxfordhb\/9780190669164.013.12","volume-title":"The Oxford Handbook of Neuronal Ion Channels","author":"S Gr\u00fcnder","year":"2020","unstructured":"Gr\u00fcnder S (2020) Acid-Sensing Ion Channels. In: Bhattacharjee A (ed) The Oxford Handbook of Neuronal Ion Channels, 1st edn. Oxford University Press, pp 646\u2013695","edition":"1"},{"key":"3165_CR48","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1007\/s11064-016-2011-0","volume":"41","author":"X-S Gu","year":"2016","unstructured":"Gu X-S, Wang F, Zhang C-Y et al (2016) Neuroprotective effects of paeoniflorin on 6-OHDA-Lesioned rat model of Parkinson\u2019s Disease. Neurochem Res 41:2923\u20132936. https:\/\/doi.org\/10.1007\/s11064-016-2011-0","journal-title":"Neurochem Res"},{"key":"3165_CR49","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12017-015-8380-8","volume":"18","author":"A Gugliandolo","year":"2016","unstructured":"Gugliandolo A, Gangemi C, Caccamo D et al (2016) The RS685012 Polymorphism of ACCN2, the Human Ortholog of Murine Acid-Sensing Ion Channel (ASIC1) Gene, is Highly Represented in Patients with Panic Disorder. Neuromol Med 18:91\u201398. https:\/\/doi.org\/10.1007\/s12017-015-8380-8","journal-title":"Neuromol Med"},{"key":"3165_CR50","doi-asserted-by":"publisher","first-page":"11006","DOI":"10.1074\/jbc.M313507200","volume":"279","author":"M Hesselager","year":"2004","unstructured":"Hesselager M, Timmermann DB, Ahring PK (2004) pH dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits. J Biol Chem 279:11006\u201311015. https:\/\/doi.org\/10.1074\/jbc.M313507200","journal-title":"J Biol Chem"},{"key":"3165_CR51","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1016\/j.bpj.2024.03.038","volume":"123","author":"CM Holm","year":"2024","unstructured":"Holm CM, Topaktas AB, Dannesboe J et al (2024) Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions. Biophys J 123:2122\u20132135. https:\/\/doi.org\/10.1016\/j.bpj.2024.03.038","journal-title":"Biophys J"},{"key":"3165_CR52","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1002\/glia.21017","volume":"58","author":"C Huang","year":"2010","unstructured":"Huang C, Hu Z, Wu W et al (2010) Existence and distinction of acid-evoked currents in rat astrocytes. Glia 58:1415\u20131424. https:\/\/doi.org\/10.1002\/glia.21017","journal-title":"Glia"},{"key":"3165_CR53","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuropharm.2014.12.010","volume":"94","author":"Y Huang","year":"2015","unstructured":"Huang Y, Jiang N, Li J et al (2015) Two aspects of ASIC function: synaptic plasticity and neuronal injury. Neuropharmacology 94:42\u201348. https:\/\/doi.org\/10.1016\/j.neuropharm.2014.12.010","journal-title":"Neuropharmacology"},{"key":"3165_CR54","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/cne.21204","volume":"500","author":"PA Hughes","year":"2007","unstructured":"Hughes PA, Brierley SM, Young RL, Blackshaw LA (2007) Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. J Comp Neurol 500:863\u2013875. https:\/\/doi.org\/10.1002\/cne.21204","journal-title":"J Comp Neurol"},{"key":"3165_CR55","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.jpain.2008.10.010","volume":"10","author":"M Ikeuchi","year":"2009","unstructured":"Ikeuchi M, Kolker SJ, Sluka KA (2009) Acid-Sensing Ion Channel 3 expression in mouse knee joint afferents and effects of Carrageenan-induced arthritis. J Pain 10:336\u2013342. https:\/\/doi.org\/10.1016\/j.jpain.2008.10.010","journal-title":"J Pain"},{"key":"3165_CR56","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/nn0901-869","volume":"4","author":"DC Immke","year":"2001","unstructured":"Immke DC, McCleskey EW (2001) Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons. Nat Neurosci 4:869\u2013870. https:\/\/doi.org\/10.1038\/nn0901-869","journal-title":"Nat Neurosci"},{"key":"3165_CR57","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/nature06163","volume":"449","author":"J Jasti","year":"2007","unstructured":"Jasti J, Furukawa H, Gonzales EB, Gouaux E (2007b) Structure of acid-sensing ion channel 1 at 1.9 \u00c5 resolution and low pH. Nature 449:316\u2013323. https:\/\/doi.org\/10.1038\/nature06163","journal-title":"Nature"},{"key":"3165_CR58","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1111\/j.1476-5381.2010.00918.x","volume":"161","author":"J Karczewski","year":"2010","unstructured":"Karczewski J, Spencer RH, Garsky VM et al (2010) Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2. Br J Pharmacol 161:950\u2013960. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00918.x","journal-title":"Br J Pharmacol"},{"key":"3165_CR59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008489","volume":"15","author":"EA King","year":"2019","unstructured":"King EA, Davis JW, Degner JF (2019) Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval. PLoS Genet 15:e1008489. https:\/\/doi.org\/10.1371\/journal.pgen.1008489","journal-title":"PLoS Genet"},{"key":"3165_CR60","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nn.3750","volume":"17","author":"CJ Kreple","year":"2014","unstructured":"Kreple CJ, Lu Y, Taugher RJ et al (2014) Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Nat Neurosci 17:1083\u20131091. https:\/\/doi.org\/10.1038\/nn.3750","journal-title":"Nat Neurosci"},{"key":"3165_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112355","volume":"9","author":"C-C Kung","year":"2020","unstructured":"Kung C-C, Huang Y-C, Hung T-Y et al (2020) Deletion of Acid-Sensing Ion Channel 3 relieves the late phase of neuropathic pain by preventing neuron degeneration and promoting neuron repair. Cells 9:2355. https:\/\/doi.org\/10.3390\/cells9112355","journal-title":"Cells"},{"key":"3165_CR62","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/s41586-024-07684-7","volume":"631","author":"K Lai","year":"2024","unstructured":"Lai K, Priti\u0161anac I, Liu Z-Q et al (2024a) Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. Nature 631:826\u2013834. https:\/\/doi.org\/10.1038\/s41586-024-07684-7","journal-title":"Nature"},{"key":"3165_CR63","doi-asserted-by":"crossref","unstructured":"Lai K, Priti\u0161anac I, Liu Z-Q, et al (2024b) Glutamate as a co-agonist for acid-sensing ion channels to aggravate ischemic brain damage","DOI":"10.1101\/2024.02.17.580727"},{"key":"3165_CR64","doi-asserted-by":"publisher","first-page":"13299","DOI":"10.1021\/acs.jmedchem.1c00447","volume":"64","author":"L Leisle","year":"2021","unstructured":"Leisle L, Margreiter M, Ortega-Ram\u00edrez A et al (2021) Dynorphin neuropeptides decrease apparent proton affinity of ASIC1a by occluding the acidic pocket. J Med Chem 64:13299\u201313311. https:\/\/doi.org\/10.1021\/acs.jmedchem.1c00447","journal-title":"J Med Chem"},{"key":"3165_CR65","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1097\/j.pain.0000000000002910","volume":"164","author":"S Li","year":"2023","unstructured":"Li S, Brimmers A, van Boekel RLM et al (2023) A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses. Pain 164:1891\u20131911. https:\/\/doi.org\/10.1097\/j.pain.0000000000002910","journal-title":"Pain"},{"key":"3165_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13770","volume":"7","author":"W-G Li","year":"2016","unstructured":"Li W-G, Liu M-G, Deng S et al (2016) ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nat Commun 7:13770. https:\/\/doi.org\/10.1038\/ncomms13770","journal-title":"Nat Commun"},{"key":"3165_CR67","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.1523\/JNEUROSCI.0213-19.2019","volume":"39","author":"H-S Li","year":"2019","unstructured":"Li H-S, Su X-Y, Song X-L et al (2019) Protein Kinase C Lambda mediates acid-sensing ion channel 1a-dependent cortical synaptic plasticity and pain hypersensitivity. J Neurosci 39:5773\u20135793. https:\/\/doi.org\/10.1523\/JNEUROSCI.0213-19.2019","journal-title":"J Neurosci"},{"key":"3165_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/biom15010142","author":"W Li","year":"2025","unstructured":"Li W, Zhou H, Li X et al (2025) Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment. Biomolecules. https:\/\/doi.org\/10.3390\/biom15010142","journal-title":"Biomolecules"},{"key":"3165_CR69","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1213\/ANE.0b013e31820a511c","volume":"112","author":"J Lin","year":"2011","unstructured":"Lin J, Chu X, Maysami S et al (2011) Inhibition of acid sensing ion channel currents by Lidocaine in cultured mouse cortical neurons. Anesth Analg 112:977\u2013981. https:\/\/doi.org\/10.1213\/ANE.0b013e31820a511c","journal-title":"Anesth Analg"},{"key":"3165_CR70","doi-asserted-by":"publisher","DOI":"10.1038\/srep23350","volume":"6","author":"M-G Liu","year":"2016","unstructured":"Liu M-G, Li H-S, Li W-G et al (2016) Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms. Sci Rep 6:23350. https:\/\/doi.org\/10.1038\/srep23350","journal-title":"Sci Rep"},{"key":"3165_CR71","doi-asserted-by":"publisher","first-page":"12357","DOI":"10.1021\/acsnano.8b06322","volume":"12","author":"Z Liu","year":"2018","unstructured":"Liu Z, Pei H, Zhang L, Tian Y (2018) Mitochondria-targeted DNA nanoprobe for real-time imaging and simultaneous quantification of Ca2+ and pH in neurons. ACS Nano 12:12357\u201312368. https:\/\/doi.org\/10.1021\/acsnano.8b06322","journal-title":"ACS Nano"},{"key":"3165_CR72","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.neuroscience.2019.03.044","volume":"406","author":"C-L Ma","year":"2019","unstructured":"Ma C-L, Sun H, Yang L et al (2019) Acid-sensing ion channel 1a modulates NMDA receptor function through targeting NR1\/NR2A\/NR2B triheteromeric receptors. Neuroscience 406:389\u2013404. https:\/\/doi.org\/10.1016\/j.neuroscience.2019.03.044","journal-title":"Neuroscience"},{"issue":"12","key":"3165_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.101057","volume":"14","author":"N Maisto","year":"2024","unstructured":"Maisto N, Mango D (2024) Nose to brain strategy coupled to nano vesicular system for natural products delivery: focus on synaptic plasticity in Alzheimer\u2019s disease. J Pharm Anal 101057. https:\/\/doi.org\/10.1016\/j.jpha.2024.101057","journal-title":"J Pharm Anal"},{"key":"3165_CR74","doi-asserted-by":"crossref","unstructured":"Malcher-Lopes R, Buzzi M (2009) Chap.\u00a011 Glucocorticoid\u2010Regulated Crosstalk Between Arachidonic Acid and Endocannabinoid Biochemical Pathways Coordinates Cognitive\u2010, Neuroimmune\u2010, and Energy Homeostasis\u2010Related Adaptations to Stress. In: Vitamins & Hormones. Elsevier, pp 263\u2013313","DOI":"10.1016\/S0083-6729(09)81011-X"},{"key":"3165_CR75","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.phrs.2017.01.028","volume":"119","author":"D Mango","year":"2017","unstructured":"Mango D, Braksator E, Battaglia G et al (2017) Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus. Pharmacological Research 119:12\u201319. https:\/\/doi.org\/10.1016\/j.phrs.2017.01.028","journal-title":"Pharmacological Research"},{"key":"3165_CR76","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.phrs.2018.03.016","volume":"131","author":"D Mango","year":"2018","unstructured":"Mango D, Nistic\u00f2 R (2018) Role of ASIC1a in A\u03b2-induced synaptic alterations in the hippocampus. Pharmacol Res 131:61\u201365. https:\/\/doi.org\/10.1016\/j.phrs.2018.03.016","journal-title":"Pharmacol Res"},{"key":"3165_CR77","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00555","volume":"10","author":"D Mango","year":"2019","unstructured":"Mango D, Nistic\u00f2 R (2019) Acid-sensing ion channel 1a is involved in N-Methyl D-Aspartate receptor-dependent long-term depression in the hippocampus. Front Pharmacol 10:555. https:\/\/doi.org\/10.3389\/fphar.2019.00555","journal-title":"Front Pharmacol"},{"key":"3165_CR78","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ceca.2010.07.002","volume":"48","author":"Y Mari","year":"2010","unstructured":"Mari Y, Katnik C, Cuevas J (2010) ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca2+ overload during ischemia and acidosis. Cell Calcium 48:70\u201382. https:\/\/doi.org\/10.1016\/j.ceca.2010.07.002","journal-title":"Cell Calcium"},{"key":"3165_CR79","doi-asserted-by":"publisher","first-page":"414","DOI":"10.15252\/embj.201592335","volume":"35","author":"S Marra","year":"2016","unstructured":"Marra S, Ferru-Cl\u00e9ment R, Breuil V et al (2016) Non\u2010acidic activation of pain\u2010related acid\u2010sensing ion channel 3 by lipids. EMBO J 35:414\u2013428. https:\/\/doi.org\/10.15252\/embj.201592335","journal-title":"EMBO J"},{"key":"3165_CR80","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.neuropharm.2015.08.040","volume":"99","author":"CA McCarthy","year":"2015","unstructured":"McCarthy CA, Rash LD, Chassagnon IR et al (2015) PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a. Neuropharmacology 99:650\u2013657. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.08.040","journal-title":"Neuropharmacology"},{"key":"3165_CR81","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-1-35","volume":"1","author":"DC Molliver","year":"2005","unstructured":"Molliver DC, Immke DC, Fierro L et al (2005) ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons. Mol Pain 1:1744-8069-1\u201335. https:\/\/doi.org\/10.1186\/1744-8069-1-35","journal-title":"Mol Pain"},{"key":"3165_CR82","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neulet.2016.08.047","volume":"632","author":"EI Nagaeva","year":"2016","unstructured":"Nagaeva EI, Tikhonova TB, Magazanik LG, Tikhonov DB (2016) Histamine selectively potentiates acid-sensing ion channel 1a. Neurosci Lett 632:136\u2013140. https:\/\/doi.org\/10.1016\/j.neulet.2016.08.047","journal-title":"Neurosci Lett"},{"key":"3165_CR83","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/s41578-021-00394-w","volume":"7","author":"E Nance","year":"2021","unstructured":"Nance E, Pun SH, Saigal R, Sellers DL (2021) Drug delivery to the central nervous system. Nat Rev Mater 7:314\u2013331. https:\/\/doi.org\/10.1038\/s41578-021-00394-w","journal-title":"Nat Rev Mater"},{"key":"3165_CR84","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1097\/j.pain.0000000000003030","volume":"165","author":"A Negm","year":"2024","unstructured":"Negm A, Stobbe K, Ben Fradj S et al (2024) Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice. Pain 165:470\u2013486. https:\/\/doi.org\/10.1097\/j.pain.0000000000003030","journal-title":"Pain"},{"key":"3165_CR85","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2019046118","volume":"118","author":"MF Noterman","year":"2021","unstructured":"Noterman MF, Chaubey K, Lin-Rahardja K et al (2021) Dual-process brain mitochondria isolation preserves function and clarifies protein composition. Proc Natl Acad Sci U S A 118:e2019046118. https:\/\/doi.org\/10.1073\/pnas.2019046118","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3165_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/3728096","volume":"2017","author":"A Ortega-Ram\u00edrez","year":"2017","unstructured":"Ortega-Ram\u00edrez A, Vega R, Soto E (2017) Acid-sensing ion channels as potential therapeutic targets in neurodegeneration and neuroinflammation. Mediators Inflamm 2017:1\u201318. https:\/\/doi.org\/10.1155\/2017\/3728096","journal-title":"Mediators Inflamm"},{"key":"3165_CR87","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac256","volume":"4","author":"M Papalampropoulou-Tsiridou","year":"2022","unstructured":"Papalampropoulou-Tsiridou M, Shiers S, Wang F et al (2022) Distribution of acid-sensing ion channel subunits in human sensory neurons contrasts with that in rodents. Brain Commun 4:fcac256. https:\/\/doi.org\/10.1093\/braincomms\/fcac256","journal-title":"Brain Commun"},{"key":"3165_CR88","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00103","volume":"14","author":"M Papalampropoulou-Tsiridou","year":"2020","unstructured":"Papalampropoulou-Tsiridou M, Labrecque S, Godin AG et al (2020) Differential expression of acid \u2013 sensing ion channels in mouse primary afferents in na\u00efve and injured conditions. Front Cell Neurosci 14:103. https:\/\/doi.org\/10.3389\/fncel.2020.00103","journal-title":"Front Cell Neurosci"},{"key":"3165_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2337\/db2022-01","volume":"2022","author":"R Pop-Busui","year":"2022","unstructured":"Pop-Busui R, Ang L, Boulton A et al (2022) Diagnosis and treatment of painful diabetic peripheral neuropathy. ADA Clin Compend 2022:1\u201332. https:\/\/doi.org\/10.2337\/db2022-01","journal-title":"ADA Clin Compend"},{"key":"3165_CR90","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.849498","author":"X Qi","year":"2022","unstructured":"Qi X, Lu J-F, Huang Z-Y et al (2022) Pharmacological Validation of ASIC1a as a Druggable Target for Neuroprotection in Cerebral Ischemia Using an Intravenously Available Small Molecule Inhibitor. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2022.849498","journal-title":"Front Pharmacol"},{"key":"3165_CR91","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0238-z","volume":"8","author":"LA Quagliato","year":"2018","unstructured":"Quagliato LA, Freire RC, Nardi AE (2018) The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies. Transl Psychiatry 8:185. https:\/\/doi.org\/10.1038\/s41398-018-0238-z","journal-title":"Transl Psychiatry"},{"key":"3165_CR92","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1007\/s11064-012-0708-2","volume":"37","author":"JS Rao","year":"2012","unstructured":"Rao JS, Kellom M, Kim H-W et al (2012) Neuroinflammation and Synaptic Loss. Neurochem Res 37:903\u2013910. https:\/\/doi.org\/10.1007\/s11064-012-0708-2","journal-title":"Neurochem Res"},{"key":"3165_CR93","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1161\/CIRCULATIONAHA.121.054360","volume":"144","author":"MA Redd","year":"2021","unstructured":"Redd MA, Scheuer SE, Saez NJ et al (2021) Therapeutic inhibition of acid-sensing ion channel 1a recovers heart function after ischemia\u2013reperfusion injury. Circulation 144:947\u2013960. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.121.054360","journal-title":"Circulation"},{"key":"3165_CR94","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1093\/eurheartj\/ehad793","volume":"45","author":"MA Redd","year":"2024","unstructured":"Redd MA, Yoshikawa Y, Khan N et al (2024) Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal 45:1571\u20131574. https:\/\/doi.org\/10.1093\/eurheartj\/ehad793","journal-title":"European Heart Journal"},{"key":"3165_CR95","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijpharm.2013.02.030","volume":"447","author":"J Renukuntla","year":"2013","unstructured":"Renukuntla J, Vadlapudi AD, Patel A et al (2013) Approaches for enhancing oral bioavailability of peptides and proteins. International Journal of Pharmaceutics 447:75\u201393. https:\/\/doi.org\/10.1016\/j.ijpharm.2013.02.030","journal-title":"International Journal of Pharmaceutics"},{"key":"3165_CR96","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400063","volume":"21","author":"H Ribeiro Liberato","year":"2024","unstructured":"Ribeiro Liberato H, Bezerra Maciel J, Wlisses Da Silva A et al (2024) Neuromodulation of acid-sensitive ion channels (ASICs) and anti\u2010inflammatory potential by Lichenxanthone in adult zebrafish (Danio rerio): experimental and docking studies. Chem Biodivers 21:e202400063. https:\/\/doi.org\/10.1002\/cbdv.202400063","journal-title":"Chem Biodivers"},{"key":"3165_CR97","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1113\/JP278707","volume":"599","author":"ML Rook","year":"2021","unstructured":"Rook ML, Musgaard M, MacLean DM (2021) Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors. J Physiol 599:417\u2013430. https:\/\/doi.org\/10.1113\/JP278707","journal-title":"J Physiol"},{"key":"3165_CR98","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51111","volume":"9","author":"ML Rook","year":"2020","unstructured":"Rook ML, Williamson A, Lueck JD et al (2020) \u03b211\u201312 linker isomerization governs acid-sensing ion channel desensitization and recovery. eLife 9:e51111. https:\/\/doi.org\/10.7554\/eLife.51111","journal-title":"eLife"},{"key":"3165_CR99","doi-asserted-by":"publisher","first-page":"31851","DOI":"10.1074\/jbc.M109.043984","volume":"284","author":"M Salinas","year":"2009","unstructured":"Salinas M, Lazdunski M, Lingueglia E (2009) Structural elements for the generation of sustained currents by the acid pain sensor ASIC3. J Biol Chem 284:31851\u201331859. https:\/\/doi.org\/10.1074\/jbc.M109.043984","journal-title":"J Biol Chem"},{"key":"3165_CR100","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41593-018-0325-8","volume":"22","author":"M Santello","year":"2019","unstructured":"Santello M, Toni N, Volterra A (2019) Astrocyte function from information processing to cognition and cognitive impairment. Nat Neurosci 22:154\u2013166. https:\/\/doi.org\/10.1038\/s41593-018-0325-8","journal-title":"Nat Neurosci"},{"key":"3165_CR101","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/jnc.14971","volume":"153","author":"I Savic Azoulay","year":"2020","unstructured":"Savic Azoulay I, Liu F, Hu Q et al (2020) ASIC1a channels regulate mitochondrial ion signaling and energy homeostasis in neurons. J Neurochem 153:203\u2013215. https:\/\/doi.org\/10.1111\/jnc.14971","journal-title":"J Neurochem"},{"key":"3165_CR102","doi-asserted-by":"publisher","unstructured":"Shaw BC, Anders VR, Tinkey RA, et al (2023) Immunity impacts cognitive deficits across neurological disorders. Journal of Neurochemistry jnc.15999. https:\/\/doi.org\/10.1111\/jnc.15999","DOI":"10.1111\/jnc.15999"},{"issue":"3","key":"3165_CR103","first-page":"997","volume":"11","author":"Y Sheng","year":"2021","unstructured":"Sheng Y, Wu B, Leng T et al (2021) Acid-sensing ion channel 1 (ASIC1) mediates weak acid-induced migration of human malignant glioma cells. Am J Cancer Res 11(3):997\u20131008","journal-title":"Am J Cancer Res"},{"key":"3165_CR104","doi-asserted-by":"publisher","first-page":"14371","DOI":"10.1523\/JNEUROSCI.2186-09.2009","volume":"29","author":"TW Sherwood","year":"2009","unstructured":"Sherwood TW, Askwith CC (2009) Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death. J Neurosci 29:14371\u201314380. https:\/\/doi.org\/10.1523\/JNEUROSCI.2186-09.2009","journal-title":"J Neurosci"},{"key":"3165_CR105","doi-asserted-by":"publisher","first-page":"9723","DOI":"10.1523\/JNEUROSCI.1665-11.2011","volume":"31","author":"TW Sherwood","year":"2011","unstructured":"Sherwood TW, Lee KG, Gormley MG, Askwith CC (2011) Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death. J Neurosci 31:9723\u20139734. https:\/\/doi.org\/10.1523\/JNEUROSCI.1665-11.2011","journal-title":"J Neurosci"},{"key":"3165_CR106","doi-asserted-by":"publisher","first-page":"C699","DOI":"10.1152\/ajpcell.00188.2012","volume":"303","author":"TW Sherwood","year":"2012","unstructured":"Sherwood TW, Frey EN, Askwith CC (2012) Structure and activity of the acid-sensing ion channels. Am J Physiol Cell Physiol 303:C699\u2013C710. https:\/\/doi.org\/10.1152\/ajpcell.00188.2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"3165_CR107","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s10571-017-0561-6","volume":"38","author":"VY Shteinikov","year":"2018","unstructured":"Shteinikov VY, Tikhonova TB, Korkosh VS, Tikhonov DB (2018) Potentiation and block of ASIC1a by memantine. Cell Mol Neurobiol 38:869\u2013881. https:\/\/doi.org\/10.1007\/s10571-017-0561-6","journal-title":"Cell Mol Neurobiol"},{"key":"3165_CR108","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.pain.2006.09.038","volume":"129","author":"KA Sluka","year":"2007","unstructured":"Sluka KA, Radhakrishnan R, Benson CJ et al (2007) ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain 129:102\u2013112. https:\/\/doi.org\/10.1016\/j.pain.2006.09.038","journal-title":"Pain"},{"key":"3165_CR109","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.neuroscience.2006.12.024","volume":"145","author":"ES Smith","year":"2007","unstructured":"Smith ES, Cadiou H, McNaughton PA (2007) Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action. Neuroscience 145:686\u2013698. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.12.024","journal-title":"Neuroscience"},{"key":"3165_CR110","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.biopsych.2013.12.018","volume":"76","author":"JW Smoller","year":"2014","unstructured":"Smoller JW, Gallagher PJ, Duncan LE et al (2014) The human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function. Biol Psychiatry 76:902\u2013910. https:\/\/doi.org\/10.1016\/j.biopsych.2013.12.018","journal-title":"Biol Psychiatry"},{"key":"3165_CR111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuropharm.2014.08.018","volume":"89","author":"TB Tikhonova","year":"2015","unstructured":"Tikhonova TB, Nagaeva EI, Barygin OI et al (2015) Monoamine NMDA receptor channel blockers inhibit and potentiate native and recombinant proton-gated ion channels. Neuropharmacology 89:1\u201310. https:\/\/doi.org\/10.1016\/j.neuropharm.2014.08.018","journal-title":"Neuropharmacology"},{"key":"3165_CR112","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.molbrainres.2004.12.003","volume":"135","author":"A T\u00f3th","year":"2005","unstructured":"T\u00f3th A, Bocz\u00e1n J, Kedei N et al (2005) Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain. Mol Brain Res 135:162\u2013168. https:\/\/doi.org\/10.1016\/j.molbrainres.2004.12.003","journal-title":"Mol Brain Res"},{"key":"3165_CR113","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/978-3-030-74046-7_10","volume-title":"Recent Advances in NGF and Related Molecules","author":"V Triaca","year":"2021","unstructured":"Triaca V, Ruberti F, Canu N (2021) NGF and the Amyloid Precursor Protein in Alzheimer\u2019s Disease: From Molecular Players to Neuronal Circuits. In: Calz\u00e0 L, Aloe L, Giardino L (eds) Recent Advances in NGF and Related Molecules. Springer International Publishing, Cham, pp 145\u2013165"},{"key":"3165_CR114","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/glia.23961","volume":"69","author":"AD Umpierre","year":"2021","unstructured":"Umpierre AD, Wu L (2021) How microglia sense and regulate neuronal activity. Glia 69:1637\u20131653. https:\/\/doi.org\/10.1002\/glia.23961","journal-title":"Glia"},{"key":"3165_CR115","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/brain\/awq337","volume":"134","author":"S Vergo","year":"2011","unstructured":"Vergo S, Craner MJ, Etzensperger R et al (2011) Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in Multiple Sclerosis and its animal model. Brain 134:571\u2013584. https:\/\/doi.org\/10.1093\/brain\/awq337","journal-title":"Brain"},{"key":"3165_CR116","doi-asserted-by":"publisher","first-page":"19220","DOI":"10.1074\/jbc.M603100200","volume":"281","author":"WH Vila-Carriles","year":"2006","unstructured":"Vila-Carriles WH, Kovacs GG, Jovov B et al (2006) Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. J Biol Chem 281:19220\u201319232. https:\/\/doi.org\/10.1074\/jbc.M603100200","journal-title":"J Biol Chem"},{"key":"3165_CR117","doi-asserted-by":"publisher","first-page":"8026","DOI":"10.1523\/JNEUROSCI.21-20-08026.2001","volume":"21","author":"N Voilley","year":"2001","unstructured":"Voilley N, De Weille J, Mamet J, Lazdunski M (2001) Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J Neurosci 21:8026\u20138033. https:\/\/doi.org\/10.1523\/JNEUROSCI.21-20-08026.2001","journal-title":"J Neurosci"},{"key":"3165_CR118","doi-asserted-by":"publisher","first-page":"3768","DOI":"10.1073\/pnas.1620560114","volume":"114","author":"S Vullo","year":"2017","unstructured":"Vullo S, Bonifacio G, Roy S et al (2017) Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating. Proc Natl Acad Sci USA 114:3768\u20133773. https:\/\/doi.org\/10.1073\/pnas.1620560114","journal-title":"Proc Natl Acad Sci USA"},{"key":"3165_CR119","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36125-5","volume":"8","author":"A Vyvers","year":"2018","unstructured":"Vyvers A, Schmidt A, Wiemuth D, Gr\u00fcnder S (2018) Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators. Sci Rep 8:18000. https:\/\/doi.org\/10.1038\/s41598-018-36125-5","journal-title":"Sci Rep"},{"key":"3165_CR120","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1016\/j.pain.2011.06.027","volume":"152","author":"RY Walder","year":"2011","unstructured":"Walder RY, Gautam M, Wilson SP et al (2011) Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation. Pain 152:2348\u20132356. https:\/\/doi.org\/10.1016\/j.pain.2011.06.027","journal-title":"Pain"},{"key":"3165_CR121","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jpain.2009.07.004","volume":"11","author":"RY Walder","year":"2010","unstructured":"Walder RY, Rasmussen LA, Rainier JD et al (2010) ASIC1 and ASIC3 play different roles in the development of hyperalgesia after inflammatory muscle injury. J Pain 11:210\u2013218. https:\/\/doi.org\/10.1016\/j.jpain.2009.07.004","journal-title":"J Pain"},{"key":"3165_CR122","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/386173a0","volume":"386","author":"R Waldmann","year":"1997","unstructured":"Waldmann R, Champigny G, Bassilana F et al (1997) A proton-gated cation channel involved in acid-sensing. Nature 386:173\u2013177. https:\/\/doi.org\/10.1038\/386173a0","journal-title":"Nature"},{"key":"3165_CR123","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S0959-4388(98)80070-6","volume":"8","author":"R Waldmann","year":"1998","unstructured":"Waldmann R, Lazdunski M (1998) H+-gated cation channels: neuronal acid sensors in the NaC\/DEG family of ion channels. Curr Opin Neurobiol 8:418\u2013424. https:\/\/doi.org\/10.1016\/S0959-4388(98)80070-6","journal-title":"Curr Opin Neurobiol"},{"key":"3165_CR124","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1159\/000488624","volume":"46","author":"Y Wang","year":"2018","unstructured":"Wang Y, Fu X, Huang L et al (2018) Increased Asics expression via the Camkii-CREB pathway in a novel mouse model of trigeminal pain. Cell Physiol Biochem 46:568\u2013578. https:\/\/doi.org\/10.1159\/000488624","journal-title":"Cell Physiol Biochem"},{"key":"3165_CR125","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113835","volume":"155","author":"Y Wang","year":"2022","unstructured":"Wang Y, Zhou H, Sun Y, Huang Y (2022) Acid-sensing ion channel 1: potential therapeutic target for tumor. Biomed Pharmacother 155:113835. https:\/\/doi.org\/10.1016\/j.biopha.2022.113835","journal-title":"Biomed Pharmacother"},{"key":"3165_CR126","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jare.2023.11.004","volume":"63","author":"Y-M Wang","year":"2024","unstructured":"Wang Y-M, Tang H, Tang Y-J et al (2024) ASIC1\/RIP1 accelerates atherosclerosis via disrupting lipophagy. J Adv Res 63:195\u2013206. https:\/\/doi.org\/10.1016\/j.jare.2023.11.004","journal-title":"J Adv Res"},{"key":"3165_CR127","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05682","volume":"4","author":"Y-Z Wang","year":"2015","unstructured":"Wang Y-Z, Wang J-J, Huang Y et al (2015) Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. Elife 4:e05682. https:\/\/doi.org\/10.7554\/eLife.05682","journal-title":"Elife"},{"key":"3165_CR128","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1038\/cdd.2013.90","volume":"20","author":"Y-Z Wang","year":"2013","unstructured":"Wang Y-Z, Zeng W-Z, Xiao X et al (2013) Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death. Cell Death Differ 20:1359\u20131369. https:\/\/doi.org\/10.1038\/cdd.2013.90","journal-title":"Cell Death Differ"},{"key":"3165_CR129","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1002\/jnr.25060","volume":"100","author":"S Wei","year":"2022","unstructured":"Wei S, Liu T, Hu W, Qiu C (2022) Resveratrol inhibits the activity of acid-sensing ion channels in male rat dorsal root ganglion neurons. J Neurosci Res 100:1755\u20131764. https:\/\/doi.org\/10.1002\/jnr.25060","journal-title":"J Neurosci Res"},{"key":"3165_CR130","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106340","volume":"82","author":"X Wei","year":"2020","unstructured":"Wei X, Sun C, Zhou R-P et al (2020) Nerve growth factor promotes ASIC1a expression via the NF-\u03baB pathway and enhances acid-induced chondrocyte apoptosis. Int Immunopharmacol 82:106340. https:\/\/doi.org\/10.1016\/j.intimp.2020.106340","journal-title":"Int Immunopharmacol"},{"key":"3165_CR131","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nrn3529","volume":"14","author":"JA Wemmie","year":"2013","unstructured":"Wemmie JA, Taugher RJ, Kreple CJ (2013) Acid-sensing ion channels in pain and disease. Nat Rev Neurosci 14:461\u2013471. https:\/\/doi.org\/10.1038\/nrn3529","journal-title":"Nat Rev Neurosci"},{"key":"3165_CR132","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.tins.2006.06.014","volume":"29","author":"JA Wemmie","year":"2006","unstructured":"Wemmie JA, Price MP, Welsh MJ (2006) Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci 29:578\u2013586. https:\/\/doi.org\/10.1016\/j.tins.2006.06.014","journal-title":"Trends Neurosci"},{"key":"3165_CR133","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0896-6273(02)00661-X","volume":"34","author":"JA Wemmie","year":"2002","unstructured":"Wemmie JA, Chen J, Askwith CC et al (2002) The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron 34:463\u2013477. https:\/\/doi.org\/10.1016\/S0896-6273(02)00661-X","journal-title":"Neuron"},{"key":"3165_CR134","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.molmed.2019.08.013","volume":"25","author":"EC Wright-Jin","year":"2019","unstructured":"Wright-Jin EC, Gutmann DH (2019) Microglia as dynamic cellular mediators of brain function. Trends Mol Med 25:967\u2013979. https:\/\/doi.org\/10.1016\/j.molmed.2019.08.013","journal-title":"Trends Mol Med"},{"key":"3165_CR135","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/s41401-020-00559-3","volume":"42","author":"B Wu","year":"2021","unstructured":"Wu B, Bargaineer J, Zhang L et al (2021) Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through the JNK pathway. Acta Pharmacol Sin 42:1248\u20131255. https:\/\/doi.org\/10.1038\/s41401-020-00559-3","journal-title":"Acta Pharmacol Sin"},{"key":"3165_CR136","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-016-0185-7","volume":"9","author":"J Wu","year":"2016","unstructured":"Wu J, Xu Y, Jiang Y-Q et al (2016) ASIC subunit ratio and differential surface trafficking in the brain. Mol Brain 9:4. https:\/\/doi.org\/10.1186\/s13041-016-0185-7","journal-title":"Mol Brain"},{"key":"3165_CR137","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00086","volume":"13","author":"W-L Wu","year":"2019","unstructured":"Wu W-L, Cheng S-J, Lin S-H et al (2019) The effect of ASIC3 knockout on corticostriatal circuit and mouse self-grooming behavior. Front Cell Neurosci 13:86. https:\/\/doi.org\/10.3389\/fncel.2019.00086","journal-title":"Front Cell Neurosci"},{"key":"3165_CR138","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.cell.2004.08.026","volume":"118","author":"Z-G Xiong","year":"2004","unstructured":"Xiong Z-G, Zhu X-M, Chu X-P et al (2004) Neuroprotection in ischemia. Cell 118:687\u2013698. https:\/\/doi.org\/10.1016\/j.cell.2004.08.026","journal-title":"Cell"},{"key":"3165_CR139","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41423-025-01275-w","volume":"22","author":"W Xu","year":"2025","unstructured":"Xu W, Huang Y, Zhou R (2025) NLRP3 inflammasome in neuroinflammation and central nervous system diseases. Cell Mol Immunol 22:341\u2013355. https:\/\/doi.org\/10.1038\/s41423-025-01275-w","journal-title":"Cell Mol Immunol"},{"key":"3165_CR140","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s00109-023-02330-7","volume":"101","author":"Y Yang","year":"2023","unstructured":"Yang Y, Jin S, Zhang J et al (2023) Acid-sensing ion channel 1a exacerbates renal ischemia\u2013reperfusion injury through the NF-\u03baB\/NLRP3 inflammasome pathway. J Mol Med 101:877\u2013890. https:\/\/doi.org\/10.1007\/s00109-023-02330-7","journal-title":"J Mol Med"},{"key":"3165_CR141","doi-asserted-by":"publisher","first-page":"6752","DOI":"10.1073\/pnas.0308636100","volume":"101","author":"O Yermolaieva","year":"2004","unstructured":"Yermolaieva O, Leonard AS, Schnizler MK et al (2004) Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a. Proc Natl Acad Sci U S A 101:6752\u20136757. https:\/\/doi.org\/10.1073\/pnas.0308636100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3165_CR142","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56527","volume":"9","author":"N Yoder","year":"2020","unstructured":"Yoder N, Gouaux E (2020) The His-Gly motif of acid-sensing ion channels resides in a reentrant \u2018loop\u2019 implicated in gating and ion selectivity. eLife 9:e56527. https:\/\/doi.org\/10.7554\/eLife.56527","journal-title":"eLife"},{"key":"3165_CR143","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nature25782","volume":"555","author":"N Yoder","year":"2018","unstructured":"Yoder N, Yoshioka C, Gouaux E (2018) Gating mechanisms of acid-sensing ion channels. Nature 555:397\u2013401. https:\/\/doi.org\/10.1038\/nature25782","journal-title":"Nature"},{"key":"3165_CR144","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/glia.22766","volume":"63","author":"X Yu","year":"2015","unstructured":"Yu X, Hu Z, Ni M et al (2015) Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia. Glia 63:483\u2013496. https:\/\/doi.org\/10.1002\/glia.22766","journal-title":"Glia"},{"key":"3165_CR145","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01624-6","volume":"9","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Chen M, Zhan W et al (2023) Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention. Cell Death Discovery 9:330. https:\/\/doi.org\/10.1038\/s41420-023-01624-6","journal-title":"Cell Death Discovery"},{"key":"3165_CR146","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12941","volume":"54","author":"K Zhao","year":"2021","unstructured":"Zhao K, An R, Xiang Q et al (2021) Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration. Cell Proliferation 54:e12941. https:\/\/doi.org\/10.1111\/cpr.12941","journal-title":"Cell Proliferation"},{"key":"3165_CR147","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175394","volume":"938","author":"AS Zhigulin","year":"2023","unstructured":"Zhigulin AS, Tikhonov DB, Barygin OI (2023) Mechanisms of acid-sensing ion channels inhibition by nafamostat, sepimostat and diminazene. European Journal of Pharmacology 938:175394. https:\/\/doi.org\/10.1016\/j.ejphar.2022.175394","journal-title":"European Journal of Pharmacology"},{"key":"3165_CR148","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1695","volume":"13","author":"X Zhou","year":"2021","unstructured":"Zhou X, Smith QR, Liu X (2021) Brain penetrating peptides and peptide\u2013drug conjugates to overcome the blood\u2013brain barrier and target CNS diseases. WIREs Nanomed Nanobiotechnol 13:e1695. https:\/\/doi.org\/10.1002\/wnan.1695","journal-title":"WIREs Nanomed Nanobiotechnol"},{"key":"3165_CR149","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1515\/tjb-2023-0101","volume":"49","author":"C Zontul","year":"2024","unstructured":"Zontul C, Tas A, Hayta E, Silig Y (2024) The relationship between ASIC3 gene polymorphism and fibromyalgia syndrome. Turkish Journal of Biochemistry 49:123\u2013130. https:\/\/doi.org\/10.1515\/tjb-2023-0101","journal-title":"Turkish Journal of Biochemistry"}],"container-title":["Journal of Neural Transmission"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-026-03165-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00702-026-03165-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00702-026-03165-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:07:39Z","timestamp":1785600459000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00702-026-03165-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":149,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["3165"],"URL":"https:\/\/doi.org\/10.1007\/s00702-026-03165-5","relation":{},"ISSN":["0300-9564","1435-1463"],"issn-type":[{"value":"0300-9564","type":"print"},{"value":"1435-1463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"23 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors agree to public on Journal of Neural Transmission.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}