{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:58:10Z","timestamp":1791655090243,"version":"4.3.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,3,11]],"date-time":"2012-03-11T00:00:00Z","timestamp":1331424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s00705-012-1245-7","type":"journal-article","created":{"date-parts":[[2012,3,10]],"date-time":"2012-03-10T10:54:24Z","timestamp":1331376864000},"page":"1051-1061","source":"Crossref","is-referenced-by-count":19,"title":["Dysregulation of the \u03b23 integrin-VEGFR2 complex in Hantaan virus\u2013directed hyperpermeability upon treatment with VEGF"],"prefix":"10.1007","volume":"157","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Xing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Yun","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Qiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Fan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,11]]},"reference":[{"key":"1245_CR1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1537-1891(03)00009-0","volume":"39","author":"NV Bogatcheva","year":"2002","unstructured":"Bogatcheva NV, Garcia JG, Verin AD (2002) Role of tyrosine kinase signaling in endothelial cell barrier regulation. Vascul Pharmacol 39:201\u2013212","journal-title":"Vascul Pharmacol"},{"key":"1245_CR2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.mvr.2008.06.003","volume":"76","author":"NV Bogatcheva","year":"2008","unstructured":"Bogatcheva NV, Verin AD (2008) The role of cytoskeleton in the regulation of vascular endothelial barrier function. Microvasc Res 76:202\u2013207","journal-title":"Microvasc Res"},{"key":"1245_CR3","first-page":"1029","volume":"146","author":"HF Dvorak","year":"1995","unstructured":"Dvorak HF, Brown LF, Detmar M, Dvorak AM (1995) Vascular permeability factor\/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146:1029\u20131039","journal-title":"Am J Pathol"},{"key":"1245_CR4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.yexcr.2005.11.026","volume":"312","author":"HF Dvorak","year":"2006","unstructured":"Dvorak HF (2006) Discovery of vascular permeability factor (VPF). Exp Cell Res 312:522\u2013526","journal-title":"Exp Cell Res"},{"key":"1245_CR5","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/hh2401.101084","volume":"89","author":"BP Eliceiri","year":"2001","unstructured":"Eliceiri BP (2001) Integrin and growth factor receptor crosstalk. Circ Res 89:1104\u20131110","journal-title":"Circ Res"},{"key":"1245_CR6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.yexcr.2004.01.030","volume":"296","author":"SY Eum","year":"2004","unstructured":"Eum SY, Lee YW, Hennig B, Toborek M (2004) VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells. Exp Cell Res 296:231\u2013244","journal-title":"Exp Cell Res"},{"key":"1245_CR7","doi-asserted-by":"crossref","first-page":"8276","DOI":"10.1074\/jbc.M608836200","volume":"282","author":"C Fuse","year":"2007","unstructured":"Fuse C, Ishida Y, Hikita T, Asai T, Oku N (2007) Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma. J Biol Chem 282:8276\u20138283","journal-title":"J Biol Chem"},{"key":"1245_CR8","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1073\/pnas.95.12.7074","volume":"95","author":"IN Gavrilovskaya","year":"1998","unstructured":"Gavrilovskaya IN, Shepley M, Shaw R, Ginsberg MH, Mackow ER (1998) beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci USA 95:7074\u20137079","journal-title":"Proc Natl Acad Sci USA"},{"key":"1245_CR9","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1128\/JVI.73.5.3951-3959.1999","volume":"73","author":"IN Gavrilovskaya","year":"1999","unstructured":"Gavrilovskaya IN, Brown EJ, Ginsberg MH, Mackow ER (1999) Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol 73:3951\u20133959","journal-title":"J Virol"},{"key":"1245_CR10","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00705-002-0852-0","volume":"147","author":"IN Gavrilovskaya","year":"2002","unstructured":"Gavrilovskaya IN, Peresleni T, Geimonen E, Mackow ER (2002) Pathogenic hantaviruses selectively inhibit beta3 integrin directed endothelial cell migration. Arch Virol 147:1913\u20131931","journal-title":"Arch Virol"},{"key":"1245_CR11","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1128\/JVI.02397-07","volume":"82","author":"IN Gavrilovskaya","year":"2008","unstructured":"Gavrilovskaya IN, Gorbunova EE, Mackow NA, Mackow ER (2008) Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability. J Virol 82:5797\u20135806","journal-title":"J Virol"},{"key":"1245_CR12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/35099066","volume":"2","author":"B Geiger","year":"2001","unstructured":"Geiger B, Bershadsky A, Pankov R, Yamada KM (2001) Transmembrane crosstalk between the extracellular matrix\u2013cytoskeleton crosstalk. Natl Rev Mol Cell Biol 2:793\u2013805","journal-title":"Natl Rev Mol Cell Biol"},{"key":"1245_CR13","first-page":"82","volume":"36","author":"HW Lee","year":"1982","unstructured":"Lee HW (1982) Hemorrhagic fever with renal syndrome (HFRS). Scand J Infect Dis 36:82\u201385","journal-title":"Scand J Infect Dis"},{"key":"1245_CR14","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1128\/JVI.79.12.7319-7326.2005","volume":"79","author":"RS Larson","year":"2005","unstructured":"Larson RS, Brown DC, Ye C, Hjelle B (2005) Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor. J Virol 79:7319\u20137326","journal-title":"J Virol"},{"key":"1245_CR15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.pu.13.050192.000455","volume":"13","author":"JW LeDuc","year":"1992","unstructured":"LeDuc JW, Childs CJ, Glass GE (1992) The Hantaviruses, etiologic agents of hemorrhagic fever with renal syndrome: a possible cause of hypertension and chronic renal disease in the United States. Annu Rev Public Health 13:79\u201398","journal-title":"Annu Rev Public Health"},{"key":"1245_CR16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-3-642-56753-7_6","volume":"256","author":"ER Mackow","year":"2001","unstructured":"Mackow ER, Gavrilovskaya IN (2001) Cellular receptors and hantavirus pathogenesis. Curr Top Microbiol Immunol 256:91\u2013115","journal-title":"Curr Top Microbiol Immunol"},{"key":"1245_CR17","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1084\/jem.20060807","volume":"203","author":"GH Mahabeleshwar","year":"2006","unstructured":"Mahabeleshwar GH, Feng W, Phillips DR, Byzova TV (2006) Integrin signaling is critical for pathological angiogenesis. J Exp Med 203:2495\u20132507","journal-title":"J Exp Med"},{"key":"1245_CR18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bbrc.2005.11.049","volume":"339","author":"DL Mou","year":"2006","unstructured":"Mou DL, Wang YP, Huang CX, Li GY, Pan L, Yang WS, Bai XF (2006) Cellular entry of Hantaan virus A9 strain: specific interactions with beta3 integrins and a novel 70kDa protein. Biochem Biophys Res Commun 339:611\u2013617","journal-title":"Biochem Biophys Res Commun"},{"key":"1245_CR19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<310::AID-PATH525>3.0.CO;2-P","volume":"190","author":"FW Orr","year":"2000","unstructured":"Orr FW, Wang HH, Lafrenie RM, Scherbarth S, Nance DM (2000) Interactions between cancer cells and the endothelium in metastasis. J Pathol 190:310\u2013329","journal-title":"J Pathol"},{"key":"1245_CR20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1114\/1.176","volume":"27","author":"SP Palecek","year":"1999","unstructured":"Palecek SP, Horwitz AF, Lauffenburger DA (1999) Kinetic model for integrin-mediated adhesion release during cell migration. Ann Biomed Eng 27:219\u2013235","journal-title":"Ann Biomed Eng"},{"key":"1245_CR21","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1091\/mbc.6.10.1349","volume":"6","author":"GE Plopper","year":"1995","unstructured":"Plopper GE, McNamee HP, Dike LE, Bojanowski K, Ingber DE (1995) Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell 6:1349\u20131365","journal-title":"Mol Biol Cell"},{"key":"1245_CR22","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/emboj\/18.4.882","volume":"18","author":"R Soldi","year":"1999","unstructured":"Soldi R, Mitola S, Strasly M, Defilippi P, Tarone G, Bussolino F (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 18:882\u2013892","journal-title":"EMBO J"},{"key":"1245_CR23","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.tim.2007.10.001","volume":"15","author":"PL Stewart","year":"2007","unstructured":"Stewart PL, Nemerow GR (2007) Cell integrins: commonly used receptors for diverse viral pathogens. Trends Microbiol 15:500\u2013507","journal-title":"Trends Microbiol"},{"key":"1245_CR24","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/ki.1997.199","volume":"51","author":"T Sugimori","year":"1997","unstructured":"Sugimori T, Griffith DL, Arnaout MA (1997) Emerging paradigms of integrin ligand binding and activation. Kidney Int 51:1454\u20131462","journal-title":"Kidney Int"},{"key":"1245_CR25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.pathol.1.110304.100031","volume":"1","author":"G Valbuena","year":"2006","unstructured":"Valbuena G, Walker DH (2006) The endothelium as a target for infections. Annu Rev Pathol 1:171\u2013198","journal-title":"Annu Rev Pathol"},{"key":"1245_CR26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1113\/jphysiol.2005.096537","volume":"569","author":"MH Wu","year":"2005","unstructured":"Wu MH (2005) Endothelial focal adhesions and barrier function. J Physiol 569:359\u2013366","journal-title":"J Physiol"},{"key":"1245_CR27","doi-asserted-by":"crossref","first-page":"E75","DOI":"10.1038\/ncb0402-e75","volume":"4","author":"KM Yamada","year":"2002","unstructured":"Yamada KM, Even-Ram S (2002) Integrin regulation of growth factor receptors. Nat Cell Biol 4:E75\u2013E76","journal-title":"Nat Cell Biol"},{"key":"1245_CR28","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0008-6363(00)00268-6","volume":"49","author":"I Zachary","year":"2001","unstructured":"Zachary I, Gliki G (2001) Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49:568\u2013581","journal-title":"Cardiovasc Res"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-012-1245-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00705-012-1245-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-012-1245-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T01:42:15Z","timestamp":1593826935000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00705-012-1245-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,11]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["1245"],"URL":"https:\/\/doi.org\/10.1007\/s00705-012-1245-7","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,11]]}}}