{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:45:07Z","timestamp":1790887507980,"version":"4.1.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T00:00:00Z","timestamp":1334188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s00705-012-1308-9","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T07:50:30Z","timestamp":1334130630000},"page":"1383-1386","source":"Crossref","is-referenced-by-count":3,"title":["Live cell imaging fails to support viral-protein-mediated intercellular trafficking"],"prefix":"10.1007","volume":"157","author":[{"given":"Fuqing","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,12]]},"reference":[{"key":"1308_CR1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/(SICI)1521-2254(199907\/08)1:4<275::AID-JGM44>3.0.CO;2-M","volume":"1","author":"A Aints","year":"1999","unstructured":"Aints A, Dilber MS, Smith CI (1999) Intercellular spread of GFP-VP22. J Gene Med 1:275\u2013279","journal-title":"J Gene Med"},{"key":"1308_CR2","first-page":"841","volume":"19","author":"AM Beerens","year":"2007","unstructured":"Beerens AM, Rots MG, de Vries EF, Haisma HJ (2007) Fusion of herpes simplex virus thymidine kinase to VP22 does not result in intercellular trafficking of the protein. Int J Mol Med 19:841\u2013849","journal-title":"Int J Mol Med"},{"key":"1308_CR3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nbt0102-20","volume":"20","author":"RP Bennett","year":"2002","unstructured":"Bennett RP, Dalby B, Guy PM (2002) Protein delivery using VP22. Nat Biotechnol 20:20","journal-title":"Nat Biotechnol"},{"key":"1308_CR4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0092-8674(00)81843-7","volume":"88","author":"G Elliott","year":"1997","unstructured":"Elliott G, O\u2019Hare P (1997) Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88:223\u2013233","journal-title":"Cell"},{"key":"1308_CR5","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/sj.gt.3300741","volume":"5","author":"B Fang","year":"1998","unstructured":"Fang B, Xu B, Koch P, Roth JA (1998) Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells. Gene Ther 5:1420\u20131424","journal-title":"Gene Ther"},{"key":"1308_CR6","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1073\/pnas.91.2.664","volume":"91","author":"S Fawell","year":"1994","unstructured":"Fawell S, Seery J, Daikh Y, Moore C, Chen LL, Pepinsky B, Barsoum J (1994) Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 91:664\u2013668","journal-title":"Proc Natl Acad Sci USA"},{"key":"1308_CR7","first-page":"162","volume":"9","author":"L Guan","year":"2006","unstructured":"Guan L, Wang H, Lai B (2006) Cellular localization and intercellular trafficking of bovine herpesvirus structural protein BVP22. Zhongguo Fei Ai Za Zhi 9:162\u2013166","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"1308_CR8","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/jgm.737","volume":"7","author":"T Hakkarainen","year":"2005","unstructured":"Hakkarainen T, Wahlfors T, Merilainen O, Loimas S, Hemminki A, Wahlfors J (2005) VP22 does not significantly enhance enzyme prodrug cancer gene therapy as a part of a VP22-HSVTk-GFP triple fusion construct. J Gene Med 7:898\u2013907","journal-title":"J Gene Med"},{"key":"1308_CR9","doi-asserted-by":"crossref","first-page":"8697","DOI":"10.1128\/JVI.75.18.8697-8711.2001","volume":"75","author":"A Kotsakis","year":"2001","unstructured":"Kotsakis A, Pomeranz LE, Blouin A, Blaho JA (2001) Microtubule reorganization during herpes simplex virus type 1 infection facilitates the nuclear localization of VP22, a major virion tegument protein. J Virol 75:8697\u20138711","journal-title":"J Virol"},{"key":"1308_CR10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1525-0016(03)00151-5","volume":"8","author":"JA Leifert","year":"2003","unstructured":"Leifert JA, Whitton JL (2003) \u201cTranslocatory proteins\u201d and \u201cprotein transduction domains\u201d: a critical analysis of their biological effects and the underlying mechanisms. Mol Ther 8:13\u201320","journal-title":"Mol Ther"},{"key":"1308_CR11","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/sj.mt.6300013","volume":"15","author":"ML Lemken","year":"2007","unstructured":"Lemken ML, Wolf C, Wybranietz WA, Schmidt U, Smirnow I, Buhring HJ, Mack AF, Lauer UM, Bitzer M (2007) Evidence for intercellular trafficking of VP22 in living cells. Mol Ther 15:310\u2013319","journal-title":"Mol Ther"},{"key":"1308_CR12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/90741","volume":"19","author":"M Lundberg","year":"2001","unstructured":"Lundberg M, Johansson M (2001) Is VP22 nuclear homing an artifact? Nat Biotechnol 19:713\u2013714","journal-title":"Nat Biotechnol"},{"key":"1308_CR13","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1128\/JVI.76.10.4961-4970.2002","volume":"76","author":"A Martin","year":"2002","unstructured":"Martin A, O\u2019Hare P, McLauchlan J, Elliott G (2002) Herpes simplex virus tegument protein VP22 contains overlapping domains for cytoplasmic localization, microtubule interaction, and chromatin binding. J Virol 76:4961\u20134970","journal-title":"J Virol"},{"key":"1308_CR14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molbrainres.2005.02.004","volume":"136","author":"I Mori","year":"2005","unstructured":"Mori I, Koshizuka T, Goshima F, Ito H, Koide N, Yoshida T, Yokochi T, Kimura Y, Nishiyama Y (2005) Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain. Brain Res Mol Brain Res 136:158\u2013163","journal-title":"Brain Res Mol Brain Res"},{"key":"1308_CR15","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.vaccine.2004.10.033","volume":"23","author":"SD Perkins","year":"2005","unstructured":"Perkins SD, Hartley MG, Lukaszewski RA, Phillpotts RJ, Stevenson FK, Bennett AM (2005) VP22 enhances antibody responses from DNA vaccines but not by intercellular spread. Vaccine 23:1931\u20131940","journal-title":"Vaccine"},{"key":"1308_CR16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0955-0674(00)00108-3","volume":"12","author":"A Prochiantz","year":"2000","unstructured":"Prochiantz A (2000) Messenger proteins: homeoproteins, TAT and others. Curr Opin Cell Biol 12:400\u2013406","journal-title":"Curr Opin Cell Biol"},{"key":"1308_CR17","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/jgm.741","volume":"7","author":"D Zavaglia","year":"2005","unstructured":"Zavaglia D, Lin EH, Guidetti M, Pluquet O, Hainaut P, Favrot MC, Coll JL (2005) Poor intercellular transport and absence of enhanced antiproliferative activity after non-viral gene transfer of VP22-P53 or P53-VP22 fusions into p53 null cell lines in vitro or in vivo. J Gene Med 7:936\u2013944","journal-title":"J Gene Med"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-012-1308-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00705-012-1308-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-012-1308-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T05:01:55Z","timestamp":1559106115000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00705-012-1308-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,12]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["1308"],"URL":"https:\/\/doi.org\/10.1007\/s00705-012-1308-9","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,12]]}}}