{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:53:11Z","timestamp":1790297591034,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,2,15]],"date-time":"2015-02-15T00:00:00Z","timestamp":1423958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s00705-015-2340-3","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T11:03:18Z","timestamp":1424170998000},"page":"1097-1104","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Molecular epidemiology of coxsackievirus A6 associated with outbreaks of hand, foot, and mouth disease in Tianjin, China, in 2013"],"prefix":"10.1007","volume":"160","author":[{"given":"Xiaojuan","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Jorba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,15]]},"reference":[{"key":"2340_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1702(99)00019-2","volume":"61","author":"S AbuBakar","year":"1999","unstructured":"AbuBakar S, Chee HY, Al-Kobaisi MF, Xiaoshan J, Chua KB, Lam SK (1999) Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia. Virus Res 61:1\u20139","journal-title":"Virus Res"},{"key":"2340_CR2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3201\/eid1712.110395","volume":"17","author":"MA Bracho","year":"2011","unstructured":"Bracho MA, Gonzalez-Candelas F, Valero A, Cordoba J, Salazar A (2011) Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008. Emerg Infect Dis 17:2223\u20132231","journal-title":"Emerg Infect Dis"},{"key":"2340_CR3","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1086\/314032","volume":"31","author":"LG Chan","year":"2000","unstructured":"Chan LG, Parashar UD, Lye MS, Ong FG, Zaki SR, Alexander JP, Ho KK, Han LL, Pallansch MA, Suleiman AB, Jegathesan M, Anderson LJ (2000) Deaths of children during an outbreak of hand, foot, and mouth disease in Sarawak, Malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group. Clin Infect Dis 31:678\u2013683","journal-title":"Clin Infect Dis"},{"key":"2340_CR4","doi-asserted-by":"crossref","first-page":"e52432","DOI":"10.1371\/journal.pone.0052432","volume":"7","author":"YJ Chen","year":"2012","unstructured":"Chen YJ, Chang SC, Tsao KC, Shih SR, Yang SL, Lin TY, Huang YC (2012) Comparative genomic analysis of coxsackievirus A6 strains of different clinical disease entities. PLoS One 7:e52432","journal-title":"PLoS One"},{"key":"2340_CR5","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1371\/journal.pbio.0040088","volume":"4","author":"AJ Drummond","year":"2006","unstructured":"Drummond AJ, Ho SY, Phillips MJ, Rambaut A (2006) Relaxed phylogenetics and dating with confidence. PLoS Biol 4:e88","journal-title":"PLoS Biol"},{"key":"2340_CR6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF01734359","volume":"17","author":"J Felsenstein","year":"1981","unstructured":"Felsenstein J (1981) Evolutionary trees from DNA sequences: a maximum likelihood approach. J Mol Evol 17:368\u2013376","journal-title":"J Mol Evol"},{"key":"2340_CR7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3201\/eid1802.111147","volume":"18","author":"T Fujimoto","year":"2012","unstructured":"Fujimoto T, Iizuka S, Enomoto M, Abe K, Yamashita K, Hanaoka N, Okabe N, Yoshida H, Yasui Y, Kobayashi M, Fujii Y, Tanaka H, Yamamoto M, Shimizu H (2012) Hand, foot, and mouth disease caused by coxsackievirus A6, Japan, 2011. Emerg Infect Dis 18:337\u2013339","journal-title":"Emerg Infect Dis"},{"key":"2340_CR8","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1099\/jmm.0.036400-0","volume":"61","author":"V Gopalkrishna","year":"2012","unstructured":"Gopalkrishna V, Patil PR, Patil GP, Chitambar SD (2012) Circulation of multiple enterovirus serotypes causing hand, foot and mouth disease in India. J Med Microbiol 61:420\u2013425","journal-title":"J Med Microbiol"},{"key":"2340_CR9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jinf.2014.03.015","volume":"69","author":"JF Han","year":"2014","unstructured":"Han JF, Xu S, Zhang Y, Zhu SY, Wu DL, Yang XD, Liu H, Sun BX, Wu XY, Qin CF (2014) Hand, foot, and mouth disease outbreak caused by coxsackievirus A6, China, 2013. J Infect 69:303\u2013305","journal-title":"J Infect"},{"key":"2340_CR10","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1128\/JCM.01231-13","volume":"51","author":"YQ He","year":"2013","unstructured":"He YQ, Chen L, Xu WB, Yang H, Wang HZ, Zong WP, Xian HX, Chen HL, Yao XJ, Hu ZL, Luo M, Zhang HL, Ma HW, Cheng JQ, Feng QJ, Zhao DJ (2013) Emergence, circulation, and spatiotemporal phylogenetic analysis of coxsackievirus a6- and coxsackievirus a10-associated hand, foot, and mouth disease infections from 2008 to 2012 in Shenzhen, China. J Clin Microbiol 51:3560\u20133566","journal-title":"J Clin Microbiol"},{"key":"2340_CR11","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","volume":"341","author":"M Ho","year":"1999","unstructured":"Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, Wang JR, Shih SR (1999) An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med 341:929\u2013935","journal-title":"N Engl J Med"},{"key":"2340_CR12","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.3201\/eid1812.120929","volume":"18","author":"TH Khanh","year":"2012","unstructured":"Khanh TH, Sabanathan S, Thanh TT, le Thoa PK, Thuong TC, Hang V, Farrar J, Hien TT, Chau N, van Doorn HR (2012) Enterovirus 71-associated hand, foot, and mouth disease, Southern Vietnam, 2011. Emerg Infect Dis 18:2002\u20132005","journal-title":"Emerg Infect Dis"},{"key":"2340_CR13","doi-asserted-by":"crossref","first-page":"O442","DOI":"10.1111\/1469-0691.12468","volume":"20","author":"J Lu","year":"2014","unstructured":"Lu J, Zeng H, Zheng H, Yi L, Guo X, Liu L, Sun L, Tan X, Li H, Ke C, Lin J (2014) Hand, foot and mouth disease in Guangdong, China, in 2013: new trends in the continuing epidemic. Clin Microbiol Infect\u00a020:O442\u2013O445","journal-title":"Clin Microbiol Infect"},{"key":"2340_CR14","doi-asserted-by":"crossref","first-page":"e52073","DOI":"10.1371\/journal.pone.0052073","volume":"7","author":"QB Lu","year":"2012","unstructured":"Lu QB, Zhang XA, Wo Y, Xu HM, Li XJ, Wang XJ, Ding SJ, Chen XD, He C, Liu LJ, Li H, Yang H, Li TY, Liu W, Cao WC (2012) Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009-2011. PLoS One 7:e52073","journal-title":"PLoS One"},{"key":"2340_CR15","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1542\/peds.2012-3175","volume":"132","author":"EF Mathes","year":"2013","unstructured":"Mathes EF, Oza V, Frieden IJ, Cordoro KM, Yagi S, Howard R, Kristal L, Ginocchio CC, Schaffer J, Maguiness S, Bayliss S, Lara-Corrales I, Garcia-Romero MT, Kelly D, Salas M, Oberste MS, Nix WA, Glaser C, Antaya R (2013) \u201cEczema coxsackium\u201d and unusual cutaneous findings in an enterovirus outbreak. Pediatrics 132:e149\u2013e157","journal-title":"Pediatrics"},{"key":"2340_CR16","doi-asserted-by":"crossref","first-page":"E110","DOI":"10.1111\/j.1469-0691.2012.03789.x","volume":"18","author":"A Mirand","year":"2012","unstructured":"Mirand A, Henquell C, Archimbaud C, Ughetto S, Antona D, Bailly JL, Peigue-Lafeuille H (2012) Outbreak of hand, foot and mouth disease\/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. Clin Microbiol Infect 18:E110\u2013E118","journal-title":"Clin Microbiol Infect"},{"key":"2340_CR17","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1128\/JCM.00542-06","volume":"44","author":"WA Nix","year":"2006","unstructured":"Nix WA, Oberste MS, Pallansch MA (2006) Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol 44:2698\u20132704","journal-title":"J Clin Microbiol"},{"key":"2340_CR18","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1128\/JVI.73.3.1941-1948.1999","volume":"73","author":"MS Oberste","year":"1999","unstructured":"Oberste MS, Maher K, Kilpatrick DR, Pallansch MA (1999) Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification. J Virol 73:1941\u20131948","journal-title":"J Virol"},{"key":"2340_CR19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1099\/vir.0.81179-0","volume":"87","author":"MS Oberste","year":"2006","unstructured":"Oberste MS, Maher K, Williams AJ, Dybdahl-Sissoko N, Brown BA, Gookin MS, Penaranda S, Mishrik N, Uddin M, Pallansch MA (2006) Species-specific RT-PCR amplification of human enteroviruses: a tool for rapid species identification of uncharacterized enteroviruses. J Gen Virol 87:119\u2013128","journal-title":"J Gen Virol"},{"key":"2340_CR20","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/bioinformatics\/14.9.817","volume":"14","author":"D Posada","year":"1998","unstructured":"Posada D, Crandall KA (1998) MODELTEST: testing the model of DNA substitution. Bioinformatics 14:817\u2013818","journal-title":"Bioinformatics"},{"key":"2340_CR21","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3201\/eid1904.121666","volume":"19","author":"J Puenpa","year":"2013","unstructured":"Puenpa J, Chieochansin T, Linsuwanon P, Korkong S, Thongkomplew S, Vichaiwattana P, Theamboonlers A, Poovorawan Y (2013) Hand, foot, and mouth disease caused by coxsackievirus A6, Thailand, 2012. Emerg Infect Dis 19:641\u2013643","journal-title":"Emerg Infect Dis"},{"key":"2340_CR22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0140-6736(12)61200-8","volume":"380","author":"A Seiff","year":"2012","unstructured":"Seiff A (2012) Cambodia unravels cause of mystery illness. Lancet 380:206","journal-title":"Lancet"},{"key":"2340_CR23","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","volume":"28","author":"K Tamura","year":"2011","unstructured":"Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S (2011) MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28:2731\u20132739","journal-title":"Mol Biol Evol"},{"key":"2340_CR24","doi-asserted-by":"crossref","first-page":"e25662","DOI":"10.1371\/journal.pone.0025662","volume":"6","author":"X Tan","year":"2011","unstructured":"Tan X, Huang X, Zhu S, Chen H, Yu Q, Wang H, Huo X, Zhou J, Wu Y, Yan D, Zhang Y, Wang D, Cui A, An H, Xu W (2011) The persistent circulation of enterovirus 71 in People\u2019s Republic of China: causing emerging nationwide epidemics since 2008. PLoS One 6:e25662","journal-title":"PLoS One"},{"key":"2340_CR25","doi-asserted-by":"crossref","first-page":"e84233","DOI":"10.1371\/journal.pone.0084233","volume":"9","author":"H Tian","year":"2014","unstructured":"Tian H, Zhang Y, Sun Q, Zhu S, Li X, Pan Z, Xu W, Xu B (2014) Prevalence of multiple enteroviruses associated with hand, foot, and mouth disease in Shijiazhuang City, Hebei province, China: outbreaks of coxsackieviruses a10 and b3. PLoS One 9:e84233","journal-title":"PLoS One"},{"key":"2340_CR26","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/jmv.21006","volume":"79","author":"FC Tseng","year":"2007","unstructured":"Tseng FC, Huang HC, Chi CY, Lin TL, Liu CC, Jian JW, Hsu LC, Wu HS, Yang JY, Chang YW, Wang HC, Hsu YW, Su IJ, Wang JR (2007) Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: analysis of sentinel physician surveillance data. J Med Virol 79:1850\u20131860","journal-title":"J Med Virol"},{"key":"2340_CR27","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/1471-2334-11-346","volume":"11","author":"SH Wei","year":"2011","unstructured":"Wei SH, Huang YP, Liu MC, Tsou TP, Lin HC, Lin TL, Tsai CY, Chao YN, Chang LY, Hsu CM (2011) An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010. BMC Infect Dis 11:346","journal-title":"BMC Infect Dis"},{"key":"2340_CR28","doi-asserted-by":"crossref","first-page":"e1076","DOI":"10.1016\/j.ijid.2010.07.006","volume":"14","author":"Y Wu","year":"2010","unstructured":"Wu Y, Yeo A, Phoon MC, Tan EL, Poh CL, Quak SH, Chow VT (2010) The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis 14:e1076\u2013e1081","journal-title":"Int J Infect Dis"},{"key":"2340_CR29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1473-3099(13)70342-6","volume":"14","author":"W Xing","year":"2014","unstructured":"Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu JT, Chang Z, Liu F, Fang VJ, Zheng Y, Cowling BJ, Varma JK, Farrar JJ, Leung GM, Yu H (2014) Hand, foot, and mouth disease in China, 2008\u201312: an epidemiological study. Lancet Infect Dis\u00a014:308\u2013318","journal-title":"Lancet Infect Dis"},{"key":"2340_CR30","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/1743-422X-8-508","volume":"8","author":"F Yang","year":"2011","unstructured":"Yang F, Zhang T, Hu Y, Wang X, Du J, Li Y, Sun S, Sun X, Li Z, Jin Q (2011) Survey of enterovirus infections from hand, foot and mouth disease outbreak in China, 2009. Virol J 8:508","journal-title":"Virol J"},{"key":"2340_CR31","first-page":"105","volume":"39","author":"Z Yang","year":"1994","unstructured":"Yang Z (1994) Estimating the pattern of nucleotide substitution. J Mol Evol 39:105\u2013111","journal-title":"J Mol Evol"},{"key":"2340_CR32","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jcv.2009.02.002","volume":"44","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Tan XJ, Wang HY, Yan DM, Zhu SL, Wang DY, Ji F, Wang XJ, Gao YJ, Chen L, An HQ, Li DX, Wang SW, Xu AQ, Wang ZJ, Xu WB (2009) An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol 44:262\u2013267","journal-title":"J Clin Virol"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-015-2340-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00705-015-2340-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-015-2340-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T02:10:05Z","timestamp":1598753405000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00705-015-2340-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,15]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["2340"],"URL":"https:\/\/doi.org\/10.1007\/s00705-015-2340-3","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,15]]}}}