{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:42:48Z","timestamp":1793256168186,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00705-015-2519-7","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T11:15:49Z","timestamp":1436872549000},"page":"2435-2443","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever"],"prefix":"10.1007","volume":"160","author":[{"given":"Rupali","family":"Bachal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalichamy","family":"Alagarasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Salunke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paresh","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayaraj","family":"Cecilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,15]]},"reference":[{"key":"2519_CR1","unstructured":"Dengue and severe dengue (Fact sheet N\u00b0117) (2013): WHO Media Centre, updated September. http:\/\/www.who.int\/factsheets"},{"key":"2519_CR2","volume-title":"Dengue Guidelines for diagnosis, treatment, prevention and control","author":"WHO","year":"2009","unstructured":"WHO (2009) Dengue Guidelines for diagnosis, treatment, prevention and control. WHO, Geneva (new edition)"},{"key":"2519_CR3","doi-asserted-by":"publisher","first-page":"e1188","DOI":"10.1371\/journal.pntd.0001188","volume":"5","author":"R de Alwis","year":"2011","unstructured":"de Alwis R, Beltramello M, Messer WB, Sukupolvi-Petty S, Wahala WM, Kraus A et al (2011) In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection. PLoS Negl Trop Dis 5:e1188","journal-title":"PLoS Negl Trop Dis"},{"key":"2519_CR4","doi-asserted-by":"publisher","first-page":"11418","DOI":"10.1128\/JVI.01257-06","volume":"80","author":"K Clyde","year":"2006","unstructured":"Clyde K, Kyle JL, Harris E (2006) Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis. J Virol 80:11418\u201311431","journal-title":"J Virol"},{"key":"2519_CR5","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1002\/jmv.23577","volume":"85","author":"MM Ngwe Tun","year":"2013","unstructured":"Ngwe Tun MM, Thant KZ, Inoue S, Kurosawa Y, Lwin YY, Lin S et al (2013) Serological characterization of dengue virus infections observed among dengue hemorrhagic fever\/dengue shock syndrome cases in upper Myanmar. J Med Virol 85:1258\u20131266","journal-title":"J Med Virol"},{"key":"2519_CR6","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1016\/j.ajpath.2013.02.027","volume":"182","author":"VV Costa","year":"2013","unstructured":"Costa VV, Fagundes CT, Souza DG, Teixeira MM (2013) Inflammatory and innate immune responses in\u00a0dengue infection: protection versus disease induction. Am J Pathol 182:1950\u20131956","journal-title":"Am J Pathol"},{"key":"2519_CR7","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0065-3527(03)60011-4","volume":"60","author":"SB Halstead","year":"2003","unstructured":"Halstead SB (2003) Neutralization and\u00a0antibody-dependent enhancement of dengue viruses. Adv Virus Res 60:421\u2013467","journal-title":"Adv Virus Res"},{"key":"2519_CR8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jcv.2006.04.010","volume":"37","author":"G Garc\u00eda","year":"2006","unstructured":"Garc\u00eda G, Arango M, P\u00e9rez AB, Fonte L, Sierra B, Rodr\u00edguez-Roche R et al (2006) Antibodies from patients with\u00a0dengue\u00a0viral infection mediate cellular cytotoxicity. J Clin Virol 37:53\u201357","journal-title":"J Clin Virol"},{"key":"2519_CR9","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1126\/science.1185181","volume":"328","author":"W Dejnirattisai","year":"2010","unstructured":"Dejnirattisai W, Jumnainsong A, Onsirisakul N, Fitton P, Vasanawathana S, Limpitikul W et al (2010) Cross-reacting antibodies enhance dengue virus infection in humans. Science 328:745\u2013748","journal-title":"Science"},{"key":"2519_CR10","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1258\/ebm.2011.010339","volume":"236","author":"YS Lin","year":"2011","unstructured":"Lin YS, Yeh TM, Lin CF, Wan SW, Chuang YC, Hsu TK et al (2011) Molecular mimicry\u00a0between virus and host and its implications for\u00a0dengue\u00a0disease pathogenesis. Exp Biol Med (Maywood) 236:515\u2013523","journal-title":"Exp Biol Med (Maywood)"},{"key":"2519_CR11","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1086\/500949","volume":"193","author":"P Avirutnan","year":"2006","unstructured":"Avirutnan P, Punyadee N, Noisakran S, Komoltri C, Thiemmeca S, Auethavornanan K et al (2006) Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement. J Infect Dis 193:1078\u20131088","journal-title":"J Infect Dis"},{"key":"2519_CR12","doi-asserted-by":"publisher","first-page":"e6782","DOI":"10.1371\/journal.pone.0006782","volume":"4","author":"EJM Nascimento","year":"2009","unstructured":"Nascimento EJM, Silva AM, Cordeiro MT, Brito CA, Gil LH, Braga-Neto U et al (2009) Alternative complement pathway deregulation is correlated with dengue severity. PLoS ONE 4:e6782","journal-title":"PLoS ONE"},{"key":"2519_CR13","first-page":"102","volume":"86","author":"VA Bokisch","year":"1973","unstructured":"Bokisch VA, Muller-Eberhard HJ, Dixon FJ (1973) The role of complement in hemorrhagic shock syndrome (dengue). Trans Assoc Am Physicians 86:102\u2013110","journal-title":"Trans Assoc Am Physicians"},{"key":"2519_CR14","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1084\/jem.166.5.1351","volume":"166","author":"M Bruggemann","year":"1987","unstructured":"Bruggemann M, Williams GT, Bindon CI, Clark MR, Walker MR, Jefferis R et al (1987) Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J Exp Med 166:1351\u20131361","journal-title":"J Exp Med"},{"key":"2519_CR15","doi-asserted-by":"publisher","first-page":"4332","DOI":"10.1128\/JCM.39.12.4332-4338.2001","volume":"39","author":"P Koraka","year":"2001","unstructured":"Koraka P, Suharti C, Setiati TE, Mairuhu AT, Van Gorp E, Hack CE et al (2001) Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection. J Clin Microbiol 39:4332\u20134338","journal-title":"J Clin Microbiol"},{"key":"2519_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/jmv.10358","volume":"70","author":"P Koraka","year":"2003","unstructured":"Koraka P, Murgue B, Deparis X, Setiati TE, Suharti C, van Gorp EC et al (2003) Elevated levels of total and dengue virus-specific immunoglobulin E in patients with varying disease severity. J Med Virol 70:91\u201398","journal-title":"J Med Virol"},{"key":"2519_CR17","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/jmv.1890400205","volume":"40","author":"S Thein","year":"1993","unstructured":"Thein S, Aaskov J, Myint TT, Shwe TN, Saw TT, Zaw A (1993) Changes in levels of anti-dengue virus IgG subclasses in patients with disease of varying severity. J Med Virol 40:102\u2013106","journal-title":"J Med Virol"},{"key":"2519_CR18","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jcv.2004.10.013","volume":"33","author":"S V\u00e1zquez","year":"2005","unstructured":"V\u00e1zquez S, P\u00e9rez AB, Ruiz D, Rodr\u00edguez R, Pupo M, Calzada N et al (2005) Serological markers during dengue 3 primary and secondary infections. J Clin Virol 33:132\u2013137","journal-title":"J Clin Virol"},{"key":"2519_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23833","author":"S Vazquez","year":"2013","unstructured":"Vazquez S, Lozano C, Perez AB, Castellanos Y, Ruiz D, Calzada N et al (2013) Dengue specific immunoglobulins M, A, and E in primary and secondary dengue 4 infected salvadorian children. J Med Virol. doi:10.1002\/jmv.23833","journal-title":"J Med Virol"},{"key":"2519_CR20","doi-asserted-by":"publisher","first-page":"e8709","DOI":"10.1371\/journal.pone.0008709","volume":"5","author":"D Priyadarshini","year":"2010","unstructured":"Priyadarshini D, Gadia RR, Tripathy A, Gurukumar KR, Bhagat A, Patwardhan S et al (2010) Clinical findings and pro-inflammatory cytokines in dengue patients in western india: a facility-based study. PLoS ONE 5:e8709","journal-title":"PLoS ONE"},{"key":"2519_CR21","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.humimm.2013.01.027","volume":"74","author":"K Alagarasu","year":"2013","unstructured":"Alagarasu K, Mulay AP, Singh R, Gawade VB, Shah PS, Cecilia D (2013) Association of HLA-DRB1 and TNF genotypes with dengue hemorrhagic fever. Hum Immunol 74:610\u2013661","journal-title":"Hum Immunol"},{"key":"2519_CR22","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1016\/j.humimm.2013.08.004","volume":"74","author":"K Alagarasu","year":"2013","unstructured":"Alagarasu K, Mulay AP, Mohsen S, Rashmika D, Shah PS, Cecilia D (2013) Profile of human leukocyte antigen class I alleles in patients with dengue infection from Western India. Hum Immunol 74:1624\u20131628","journal-title":"Hum Immunol"},{"key":"2519_CR23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/2224-3151.206879","volume":"3","author":"D Cecilia","year":"2014","unstructured":"Cecilia D (2014) Current status of dengue and chikungunya. WHO South-East Asia J Public Health 3:22\u201327","journal-title":"WHO South-East Asia J Public Health"},{"key":"2519_CR24","unstructured":"World Health Organisation (1999): Prevention and control of Dengue and Dengue haemorrhagic fever: Comprehensive guidelines. WHO Regional Publication SEARO No. 29, pp 11\u201319"},{"key":"2519_CR25","doi-asserted-by":"publisher","first-page":"e2274","DOI":"10.1371\/journal.pntd.0002274","volume":"7","author":"A Puschnik","year":"2013","unstructured":"Puschnik A, Lau L, Cromwell EA, Balmaseda A, Zompi S, Harris E (2013) Correlation between dengue-specific neutralizing antibodies and serum avidity in primary and secondary dengue virus 3 natural infections in humans. PLoS Negl Trop Dis 7:e2274","journal-title":"PLoS Negl Trop Dis"},{"key":"2519_CR26","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1086\/315215","volume":"181","author":"DW Vaughn","year":"2000","unstructured":"Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S et al (2000) Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis 181:2\u20139","journal-title":"J Infect Dis"},{"key":"2519_CR27","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1086\/340365","volume":"185","author":"DH Libraty","year":"2002","unstructured":"Libraty DH, Endy TP, Houng HS, Green S, Kalayanarooj S, Suntayakorn S et al (2002) Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections. J Infect Dis 185:1213\u20131221","journal-title":"J Infect Dis"},{"key":"2519_CR28","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1128\/jvi.64.9.4356-4363.1990","volume":"64","author":"B Falgout","year":"1990","unstructured":"Falgout B, Bray M, Schlesinger JJ, Lai CJ (1990) Immunization of mice with recombinant vaccinia virus expressing authentic\u00a0dengue\u00a0virus nonstructural protein NS1 protects against lethal\u00a0dengue\u00a0virus encephalitis. J Virol 64:4356\u20134363","journal-title":"J Virol"},{"key":"2519_CR29","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1086\/512860","volume":"195","author":"K Laoprasopwattana","year":"2007","unstructured":"Laoprasopwattana K, Libraty DH, Endy TP, Nisalak A, Chunsuttiwat S, Ennis FA et al (2007) Antibody-dependent\u00a0cellular\u00a0cytotoxicity\u00a0mediated by plasma obtained before secondary\u00a0dengue virus infections: potential involvement in early control of viral replication. J Infect Dis 195:1108\u20131116","journal-title":"J Infect Dis"},{"key":"2519_CR30","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1007\/s00705-013-1645-3","volume":"158","author":"MG Guzman","year":"2013","unstructured":"Guzman MG, Alvarez M, Halstead SB (2013) Secondary infection as a risk factor for dengue hemorrhagic fever\/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch Virol 158:1445\u20131459","journal-title":"Arch Virol"},{"key":"2519_CR31","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4269\/ajtmh.2008.79.262","volume":"79","author":"IL De Rivera","year":"2008","unstructured":"De Rivera IL, Parham L, Murillo W, Moncada W, Vazquez S (2008) Humoral immune response of dengue hemorrhagic fever cases in children from Tegucigalpa, Honduras. Am J Trop Med Hyg 79:262\u2013266","journal-title":"Am J Trop Med Hyg"},{"key":"2519_CR32","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1365-2249.2006.03076.x","volume":"144","author":"YH Yang","year":"2006","unstructured":"Yang YH, Huang YH, Lin YL, Wang LC, Chuang YH, Yu HH et al (2006) Circulating IgA from acute stage of childhood Henoch-Sch\u00f6nlein purpura can enhance endothelial interleukin (IL)-8 production through MEK\/ERK signalling pathway. Clin Exp Immunol 144:247\u2013253","journal-title":"Clin Exp Immunol"},{"key":"2519_CR33","first-page":"521","volume":"21","author":"BK Upadhaya","year":"2010","unstructured":"Upadhaya BK, Sharma A, Khaira A, Dinda AK, Agarwal SK, Tiwari SC (2010) Transient IgA nephropathy with acute kidney injury in a patient with dengue fever. Saudi J Kidney Dis Transpl 21:521\u2013525","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"2519_CR34","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1084\/jem.188.6.1135","volume":"188","author":"J Boesiger","year":"1998","unstructured":"Boesiger J, Tsai M, Maurer M, Yamaguchi M, Brown LF, Claffey KP et al (1998) Mast cells can secrete vascular permeability factor\/vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression. J Exp Med 188:1135\u20131145","journal-title":"J Exp Med"},{"key":"2519_CR35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4049\/jimmunol.146.1.63","volume":"146","author":"L Borish","year":"1991","unstructured":"Borish L, Mascali JJ, Rosenwasser LJ (1991) IgE-dependent cytokine production by human peripheral blood mononuclear phagocytes. J Immunol 146:63\u201367","journal-title":"J Immunol"},{"key":"2519_CR36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1574-695X.2000.tb01474.x","volume":"28","author":"UC Chaturvedi","year":"2000","unstructured":"Chaturvedi UC, Agarwal R, Elbishbishi EA, Mustafa AS (2000) Cytokine cascade in dengue\u00a0hemorrhagic fever: implications for pathogenesis. FEMS Immunol Med Microbiol 28:183\u2013188","journal-title":"FEMS Immunol Med Microbiol"},{"key":"2519_CR37","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","volume":"17","author":"TR Mosmann","year":"1996","unstructured":"Mosmann TR, Sad S (1996) The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17:138\u2013146","journal-title":"Immunol Today"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-015-2519-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00705-015-2519-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-015-2519-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-015-2519-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T06:14:34Z","timestamp":1691820874000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00705-015-2519-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,15]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["2519"],"URL":"https:\/\/doi.org\/10.1007\/s00705-015-2519-7","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,15]]},"assertion":[{"value":"30 April 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}