{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:00:05Z","timestamp":1778590805158,"version":"3.51.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100008370","name":"National Pork Board","doi-asserted-by":"publisher","award":["NPB# 09-213"],"award-info":[{"award-number":["NPB# 09-213"]}],"id":[{"id":"10.13039\/100008370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s00705-016-2812-0","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T07:49:14Z","timestamp":1458719354000},"page":"1579-1589","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Development of a porcine reproductive and respiratory syndrome virus-like-particle-based vaccine and evaluation of its immunogenicity in pigs"],"prefix":"10.1007","volume":"161","author":[{"given":"Basavaraj","family":"Binjawadagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashavanth Shaan","family":"Lakshmanappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Longchao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Dhakal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagadish","family":"Hiremath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan-Liang","family":"Shyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Arcos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang","family":"Pengcheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Gilbertie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Zuckermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi B.","family":"Torrelles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daral","family":"Jackwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gourapura J.","family":"Renukaradhya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"2812_CR1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4049\/jimmunol.1100823","volume":"187","author":"J Arcos","year":"2011","unstructured":"Arcos J, Sasindran SJ, Fujiwara N, Turner J, Schlesinger LS, Torrelles JB (2011) Human lung hydrolases delineate Mycobacterium tuberculosis-macrophage interactions and the capacity to control infection. J Immunol 187:372\u2013381","journal-title":"J Immunol"},{"key":"2812_CR2","first-page":"1519","volume":"9","author":"B Binjawadagi","year":"2014","unstructured":"Binjawadagi B, Dwivedi V, Manickam C, Ouyang K, Torrelles JB, Renukaradhya GJ (2014) An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination. Int J Nanomedicine 9:1519\u20131535","journal-title":"Int J Nanomedicine"},{"key":"2812_CR3","first-page":"679","volume":"9","author":"B Binjawadagi","year":"2014","unstructured":"Binjawadagi B, Dwivedi V, Manickam C, Ouyang K, Wu Y, Lee LJ, Torrelles JB, Renukaradhya GJ (2014) Adjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs. Int J Nanomedicine 9:679\u2013694","journal-title":"Int J Nanomedicine"},{"key":"2812_CR4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/vr.141.19.497","volume":"141","author":"A Botner","year":"1997","unstructured":"Botner A, Strandbygaard B, Sorensen KJ, Have P, Madsen KG, Madsen ES, Alexandersen S (1997) Appearance of acute PRRS-like symptoms in sow herds after vaccination with a modified live PRRS vaccine. Vet Rec 141:497\u2013499","journal-title":"Vet Rec"},{"key":"2812_CR5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3390\/v5020663","volume":"5","author":"A Burgara-Estrella","year":"2013","unstructured":"Burgara-Estrella A, Diaz I, Rodriguez-Gomez IM, Essler SE, Hernandez J, Mateu E (2013) Predicted peptides from non-structural proteins of porcine reproductive and respiratory syndrome virus are able to induce IFN-gamma and IL-10. Viruses 5:663\u2013677","journal-title":"Viruses"},{"key":"2812_CR6","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1128\/JVI.01616-10","volume":"85","author":"G Calzada-Nova","year":"2011","unstructured":"Calzada-Nova G, Schnitzlein WM, Husmann RJ, Zuckermann FA (2011) North American porcine reproductive and respiratory syndrome viruses inhibit type I interferon production by plasmacytoid dendritic cells. J Virol 85:2703\u20132713","journal-title":"J Virol"},{"key":"2812_CR7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.vetimm.2012.05.008","volume":"148","author":"G Calzada-Nova","year":"2012","unstructured":"Calzada-Nova G, Husmann RJ, Schnitzlein WM, Zuckermann FA (2012) Effect of the host cell line on the vaccine efficacy of an attenuated porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol 148:116\u2013125","journal-title":"Vet Immunol Immunopathol"},{"issue":"Pt 2","key":"2812_CR8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1470-8744.1999.tb00543.x","volume":"29","author":"JI Casal","year":"1999","unstructured":"Casal JI (1999) Use of parvovirus-like particles for vaccination and induction of multiple immune responses. Biotechnol Appl Biochem 29(Pt 2):141\u2013150","journal-title":"Biotechnol Appl Biochem"},{"key":"2812_CR9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1586\/14760584.6.3.381","volume":"6","author":"B Chackerian","year":"2007","unstructured":"Chackerian B (2007) Virus-like particles: flexible platforms for vaccine development. Expert Rev Vaccines 6:381\u2013390","journal-title":"Expert Rev Vaccines"},{"key":"2812_CR10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/104063870101300207","volume":"13","author":"J Christopher-Hennings","year":"2001","unstructured":"Christopher-Hennings J, Holler LD, Benfield DA, Nelson EA (2001) Detection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boars. J Vet Diagn Invest 13:133\u2013142","journal-title":"J Vet Diagn Invest"},{"key":"2812_CR11","doi-asserted-by":"crossref","first-page":"e1000899","DOI":"10.1371\/journal.ppat.1000899","volume":"6","author":"P Das","year":"2010","unstructured":"Das P, Lahiri A, Chakravortty D (2010) Modulation of the arginase pathway in the context of microbial pathogenesis: a metabolic enzyme moonlighting as an immune modulator. PLoS Pathog 6:e1000899","journal-title":"PLoS Pathog"},{"key":"2812_CR12","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1128\/JVI.01774-09","volume":"84","author":"PB Das","year":"2010","unstructured":"Das PB, Dinh PX, Ansari IH, de Lima M, Osorio FA, Pattnaik AK (2010) The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163. J Virol 84:1731\u20131740","journal-title":"J Virol"},{"key":"2812_CR13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virol.2009.04.017","volume":"390","author":"M Lima de","year":"2009","unstructured":"de Lima M, Ansari IH, Das PB, Ku BJ, Martinez-Lobo FJ, Pattnaik AK, Osorio FA (2009) GP3 is a structural component of the PRRSV type II (US) virion. Virology 390:31\u201336","journal-title":"Virology"},{"key":"2812_CR14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.molimm.2004.06.028","volume":"42","author":"L Deml","year":"2005","unstructured":"Deml L, Speth C, Dierich MP, Wolf H, Wagner R (2005) Recombinant HIV-1 Pr55gag virus-like particles: potent stimulators of innate and acquired immune responses. Mol Immunol 42:259\u2013277","journal-title":"Mol Immunol"},{"key":"2812_CR15","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s11262-012-0790-1","volume":"45","author":"Y Du","year":"2012","unstructured":"Du Y, Qi J, Lu Y, Wu J, Yoo D, Liu X, Zhang X, Li J, Sun W, Cong X, Shi J, Wang J (2012) Evaluation of a DNA vaccine candidate co-expressing GP3 and GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) with interferon alpha\/gamma in immediate and long-lasting protection against HP-PRRSV challenge. Virus Genes 45:474\u2013487","journal-title":"Virus Genes"},{"key":"2812_CR16","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1016\/j.vaccine.2011.03.006","volume":"29","author":"V Dwivedi","year":"2011","unstructured":"Dwivedi V, Manickam C, Patterson R, Dodson K, Murtaugh M, Torrelles JB, Schlesinger LS, Renukaradhya GJ (2011) Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant. Vaccine 29:4058\u20134066","journal-title":"Vaccine"},{"key":"2812_CR17","doi-asserted-by":"crossref","first-page":"e51794","DOI":"10.1371\/journal.pone.0051794","volume":"7","author":"V Dwivedi","year":"2012","unstructured":"Dwivedi V, Manickam C, Binjawadagi B, Joyappa D, Renukaradhya GJ (2012) Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs. PLoS One 7:e51794","journal-title":"PLoS One"},{"key":"2812_CR18","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1128\/JVI.73.5.4465-4469.1999","volume":"73","author":"C Goldmann","year":"1999","unstructured":"Goldmann C, Petry H, Frye S, Ast O, Ebitsch S, Jentsch KD, Kaup FJ, Weber F, Trebst C, Nisslein T, Hunsmann G, Weber T, Luke W (1999) Molecular cloning and expression of major structural protein VP1 of the human polyomavirus JC virus: formation of virus-like particles useful for immunological and therapeutic studies. J Virol 73:4465\u20134469","journal-title":"J Virol"},{"key":"2812_CR19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ymeth.2006.07.018","volume":"40","author":"EV Grgacic","year":"2006","unstructured":"Grgacic EV, Anderson DA (2006) Virus-like particles: passport to immune recognition. Methods 40:60\u201365","journal-title":"Methods"},{"key":"2812_CR20","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/JCM.43.2.778-785.2005","volume":"43","author":"MG Han","year":"2005","unstructured":"Han MG, Wang Q, Smiley JR, Chang KO, Saif LJ (2005) Self-assembly of the recombinant capsid protein of a bovine norovirus (BoNV) into virus-like particles and evaluation of cross-reactivity of BoNV with human noroviruses. J Clin Microbiol 43:778\u2013785","journal-title":"J Clin Microbiol"},{"key":"2812_CR21","unstructured":"Holtkamp D, Kliebenstein J (2011) PRRS costs industry $664 million annually. Pork Checkoff Study. http:\/\/www.pork.org\/News\/1265\/PRRSCostsIndustry664Million.aspx"},{"key":"2812_CR22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1637\/10312-080212-Reg.1","volume":"57","author":"DJ Jackwood","year":"2013","unstructured":"Jackwood DJ (2013) Multivalent virus-like-particle vaccine protects against classic and variant infectious bursal disease viruses. Avian Dis 57:41\u201350","journal-title":"Avian Dis"},{"key":"2812_CR23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1128\/CVI.00365-09","volume":"17","author":"HJ Jeong","year":"2010","unstructured":"Jeong HJ, Song YJ, Lee SW, Lee JB, Park SY, Song CS, Ha GW, Oh JS, Oh YK, Choi IS (2010) Comparative measurement of cell-mediated immune responses of swine to the M and N proteins of porcine reproductive and respiratory syndrome virus. Clin Vaccine Immunol 17:503\u2013512","journal-title":"Clin Vaccine Immunol"},{"key":"2812_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2007.03.007","volume":"123","author":"WI Kim","year":"2007","unstructured":"Kim WI, Lee DS, Johnson W, Roof M, Cha SH, Yoon KJ (2007) Effect of genotypic and biotypic differences among PRRS viruses on the serologic assessment of pigs for virus infection. Vet Microbiol 123:1\u201314","journal-title":"Vet Microbiol"},{"key":"2812_CR25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/08820139.2011.614306","volume":"41","author":"G Li","year":"2012","unstructured":"Li G, Shi N, Suo S, Cui J, Zarlenga D, Ren X (2012) Vaccination of mice with ORF5 plasmid DNA of PRRSV; enhanced effects by co-immunizing with porcine IL-15. Immunol Invest 41:231\u2013248","journal-title":"Immunol Invest"},{"key":"2812_CR26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1211\/jpp.58.6.0004","volume":"58","author":"ME Lutsiak","year":"2006","unstructured":"Lutsiak ME, Kwon GS, Samuel J (2006) Biodegradable nanoparticle delivery of a Th2-biased peptide for induction of Th1 immune responses. J Pharm Pharmacol 58:739\u2013747","journal-title":"J Pharm Pharmacol"},{"key":"2812_CR27","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1016\/j.vaccine.2005.06.031","volume":"23","author":"M Manocha","year":"2005","unstructured":"Manocha M, Pal PC, Chitralekha KT, Thomas BE, Tripathi V, Gupta SD, Paranjape R, Kulkarni S, Rao DN (2005) Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex Europaeus-I lectin as M cell target. Vaccine 23:5599\u20135617","journal-title":"Vaccine"},{"key":"2812_CR28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/viro.1996.0356","volume":"221","author":"H Mardassi","year":"1996","unstructured":"Mardassi H, Massie B, Dea S (1996) Intracellular synthesis, processing, and transport of proteins encoded by ORFs 5 to 7 of porcine reproductive and respiratory syndrome virus. Virology 221:98\u2013112","journal-title":"Virology"},{"key":"2812_CR29","doi-asserted-by":"crossref","first-page":"e51559","DOI":"10.1371\/journal.pone.0051559","volume":"7","author":"I Margine","year":"2012","unstructured":"Margine I, Martinez-Gil L, Chou YY, Krammer F (2012) Residual baculovirus in insect cell-derived influenza virus-like particle preparations enhances immunogenicity. PLoS One 7:e51559","journal-title":"PLoS One"},{"key":"2812_CR30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0042-6822(95)80030-1","volume":"206","author":"JJ Meulenberg","year":"1995","unstructured":"Meulenberg JJ, Petersen-den Besten A, De Kluyver EP, Moormann RJ, Schaaper WM, Wensvoort G (1995) Characterization of proteins encoded by ORFs 2 to 7 of Lelystad virus. Virology 206:155\u2013163","journal-title":"Virology"},{"key":"2812_CR31","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1073\/pnas.1131929100","volume":"100","author":"K Murata","year":"2003","unstructured":"Murata K, Lechmann M, Qiao M, Gunji T, Alter HJ, Liang TJ (2003) Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection. Proc Natl Acad Sci USA 100:6753\u20136758","journal-title":"Proc Natl Acad Sci USA"},{"key":"2812_CR32","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00705-013-1612-z","volume":"158","author":"HM Nam","year":"2013","unstructured":"Nam HM, Chae KS, Song YJ, Lee NH, Lee JB, Park SY, Song CS, Seo KH, Kang SM, Kim MC, Choi IS (2013) Immune responses in mice vaccinated with virus-like particles composed of the GP5 and M proteins of porcine reproductive and respiratory syndrome virus. Arch Virol 158:1275\u20131285","journal-title":"Arch Virol"},{"key":"2812_CR33","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1099\/0022-1317-82-6-1263","volume":"82","author":"HS Nielsen","year":"2001","unstructured":"Nielsen HS, Oleksiewicz MB, Forsberg R, Stadejek T, Botner A, Storgaard T (2001) Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations. J Gen Virol 82:1263\u20131272","journal-title":"J Gen Virol"},{"key":"2812_CR34","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0966-842X(03)00208-7","volume":"11","author":"R Noad","year":"2003","unstructured":"Noad R, Roy P (2003) Virus-like particles as immunogens. Trends Microbiol 11:438\u2013444","journal-title":"Trends Microbiol"},{"key":"2812_CR35","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1128\/JVI.75.7.3277-3290.2001","volume":"75","author":"MB Oleksiewicz","year":"2001","unstructured":"Oleksiewicz MB, Botner A, Toft P, Normann P, Storgaard T (2001) Epitope mapping porcine reproductive and respiratory syndrome virus by phage display: the nsp2 fragment of the replicase polyprotein contains a cluster of B-cell epitopes. J Virol 75:3277\u20133290","journal-title":"J Virol"},{"key":"2812_CR36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.virusres.2012.06.024","volume":"169","author":"R Parida","year":"2012","unstructured":"Parida R, Choi IS, Peterson DA, Pattnaik AK, Laegreid W, Zuckermann FA, Osorio FA (2012) Location of T-cell epitopes in nonstructural proteins 9 and 10 of type-II porcine reproductive and respiratory syndrome virus. Virus Res 169:13\u201321","journal-title":"Virus Res"},{"key":"2812_CR37","doi-asserted-by":"crossref","first-page":"23739","DOI":"10.1074\/jbc.M110.126359","volume":"285","author":"TE Rajapaksa","year":"2010","unstructured":"Rajapaksa TE, Bennett KM, Hamer M, Lytle C, Rodgers VG, Lo DD (2010) Intranasal M cell uptake of nanoparticles is independently influenced by targeting ligands and buffer ionic strength. J Biol Chem 285:23739\u201323746","journal-title":"J Biol Chem"},{"key":"2812_CR38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1089\/vim.2010.0051","volume":"23","author":"GJ Renukaradhya","year":"2010","unstructured":"Renukaradhya GJ, Alekseev K, Jung K, Fang Y, Saif LJ (2010) Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs. Viral Immunol 23:457\u2013466","journal-title":"Viral Immunol"},{"key":"2812_CR39","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1016\/j.vaccine.2015.04.102","volume":"33","author":"GJ Renukaradhya","year":"2015","unstructured":"Renukaradhya GJ, Meng XJ, Calvert JG, Roof M, Lager KM (2015) Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: current status and future direction. Vaccine 33:3065\u20133072","journal-title":"Vaccine"},{"key":"2812_CR40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000150482","volume":"39","author":"R Schirmbeck","year":"1996","unstructured":"Schirmbeck R, Bohm W, Reimann J (1996) Virus-like particles induce MHC class I-restricted T-cell responses. Lessons learned from the hepatitis B small surface antigen. Intervirology 39:111\u2013119","journal-title":"Intervirology"},{"issue":"Pt 5","key":"2812_CR41","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1099\/0022-1317-79-5-961","volume":"79","author":"EJ Snijder","year":"1998","unstructured":"Snijder EJ, Meulenberg JJ (1998) The molecular biology of arteriviruses. J Gen Virol 79(Pt 5):961\u2013979","journal-title":"J Gen Virol"},{"key":"2812_CR42","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1099\/vir.0.056341-0","volume":"94","author":"EJ Snijder","year":"2013","unstructured":"Snijder EJ, Kikkert M, Fang Y (2013) Arterivirus molecular biology and pathogenesis. J Gen Virol 94:2141\u20132163","journal-title":"J Gen Virol"},{"key":"2812_CR43","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1016\/j.vaccine.2014.10.005","volume":"32","author":"S Subramaniam","year":"2014","unstructured":"Subramaniam S, Pineyro P, Tian D, Overend C, Yugo DM, Matzinger SR, Rogers AJ, Haac ME, Cao Q, Heffron CL, Catanzaro N, Kenney SP, Huang YW, Opriessnig T, Meng XJ (2014) In vivo targeting of porcine reproductive and respiratory syndrome virus antigen through porcine DC-SIGN to dendritic cells elicits antigen-specific CD4T cell immunity in pigs. Vaccine 32:6768\u20136775","journal-title":"Vaccine"},{"key":"2812_CR44","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0022-2275(20)36719-5","volume":"16","author":"K Takayama","year":"1975","unstructured":"Takayama K, Schnoes HK, Armstrong EL, Boyle RW (1975) Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis. J Lipid Res 16:308\u2013317","journal-title":"J Lipid Res"},{"key":"2812_CR45","doi-asserted-by":"crossref","first-page":"e1000730","DOI":"10.1371\/journal.ppat.1000730","volume":"6","author":"W Breedam Van","year":"2010","unstructured":"Van Breedam W, Van Gorp H, Zhang JQ, Crocker PR, Delputte PL, Nauwynck HJ (2010) The M\/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner. PLoS Pathog 6:e1000730","journal-title":"PLoS Pathog"},{"issue":"Suppl","key":"2812_CR46","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jip.2011.05.001","volume":"107","author":"MM Oers van","year":"2011","unstructured":"van Oers MM (2011) Opportunities and challenges for the baculovirus expression system. J Invertebr Pathol 107(Suppl):S3\u201315","journal-title":"J Invertebr Pathol"},{"issue":"Suppl","key":"2812_CR47","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.jip.2011.05.004","volume":"107","author":"T Vicente","year":"2011","unstructured":"Vicente T, Roldao A, Peixoto C, Carrondo MJ, Alves PM (2011) Large-scale production and purification of VLP-based vaccines. J Invertebr Pathol 107(Suppl):S42\u2013S48","journal-title":"J Invertebr Pathol"},{"key":"2812_CR48","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.1016\/j.vaccine.2012.09.048","volume":"30","author":"W Wang","year":"2012","unstructured":"Wang W, Chen X, Xue C, Du Y, Lv L, Liu Q, Li X, Ma Y, Shen H, Cao Y (2012) Production and immunogenicity of chimeric virus-like particles containing porcine reproductive and respiratory syndrome virus GP5 protein. Vaccine 30:7072\u20137077","journal-title":"Vaccine"},{"key":"2812_CR49","doi-asserted-by":"crossref","first-page":"12495","DOI":"10.1128\/JVI.79.19.12495-12506.2005","volume":"79","author":"EH Wissink","year":"2005","unstructured":"Wissink EH, Kroese MV, van Wijk HA, Rijsewijk FA, Meulenberg JJ, Rottier PJ (2005) Envelope protein requirements for the assembly of infectious virions of porcine reproductive and respiratory syndrome virus. J Virol 79:12495\u201312506","journal-title":"J Virol"},{"key":"2812_CR50","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.virusres.2005.06.014","volume":"114","author":"WH Wu","year":"2005","unstructured":"Wu WH, Fang Y, Rowland RR, Lawson SR, Christopher-Hennings J, Yoon KJ, Nelson EA (2005) The 2b protein as a minor structural component of PRRSV. Virus Res 114:177\u2013181","journal-title":"Virus Res"},{"key":"2812_CR51","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1007\/s00705-014-2178-0","volume":"159","author":"C Xue","year":"2014","unstructured":"Xue C, Wang W, Liu Q, Miao Z, Liu K, Shen H, Lv L, Li X, Chen X, Cao Y (2014) Chimeric influenza-virus-like particles containing the porcine reproductive and respiratory syndrome virus GP5 protein and the influenza virus HA and M1 proteins. Arch Virol 159:3043\u20133051","journal-title":"Arch Virol"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-016-2812-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00705-016-2812-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-016-2812-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T07:05:01Z","timestamp":1718435101000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00705-016-2812-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,23]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["2812"],"URL":"https:\/\/doi.org\/10.1007\/s00705-016-2812-0","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,23]]}}}