{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:28:05Z","timestamp":1790886485572,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Medical Science and Technology Project of Zhejiang Province, China","award":["2013RCB011"],"award-info":[{"award-number":["2013RCB011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s00705-016-3012-7","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T11:55:18Z","timestamp":1471002918000},"page":"3073-3080","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy and safety of interferon-\u03b12b spray in the treatment of hand, foot, and mouth disease: a multicenter, randomized, double-blind trial"],"prefix":"10.1007","volume":"161","author":[{"given":"Hailong","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaichun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1666-6339","authenticated-orcid":false,"given":"Chan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,12]]},"reference":[{"key":"3012_CR1","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1017\/S0950268809991555","volume":"138","author":"SS Wong","year":"2010","unstructured":"Wong SS, Yip CC, Lau SK, Yuen KY (2010) Human enterovirus 71 and hand, foot and mouth disease. Epidemiol Infect 138:1071\u20131089","journal-title":"Epidemiol Infect"},{"key":"3012_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.4103\/0378-6323.107631","volume":"79","author":"N Sarma","year":"2013","unstructured":"Sarma N (2013) Hand, foot, and mouth disease: current scenario and Indian perspective. Indian J Dermatol Venereol Leprol 79:165\u2013175","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"3012_CR3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1055\/s-0031-1286056","volume":"31","author":"R Rosencrantz","year":"2011","unstructured":"Rosencrantz R, Schilsky M (2011) Wilson disease: pathogenesis and clinical considerations in diagnosis and treatment. Semin Liver Dis J 31:245\u2013259","journal-title":"Semin Liver Dis J"},{"key":"3012_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0168-1702(99)00019-2","volume":"61","author":"S AbuBakar","year":"1999","unstructured":"AbuBakar S, Chee HY, Al-Kobaisi MF, Xiaoshan J, Chua KB, Lam SK (1999) Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia. Virus Res 61:1\u20139","journal-title":"Virus Res"},{"key":"3012_CR5","first-page":"629","volume":"47","author":"Centers for Disease Control and Prevention (CDC)","year":"1998","unstructured":"Centers for Disease Control and Prevention (CDC) (1998) Deaths among children during an outbreak of hand, foot, and mouth disease\u2013Taiwan, Republic of China, April-July 1998. MMWR Morb Mortal Wkly Rep 47:629\u2013632","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"3012_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.virusres.2009.06.006","volume":"145","author":"NZ Ding","year":"2009","unstructured":"Ding NZ, Wang XM, Sun SW, Song Q, Li SN, He CQ (2009) Appearance of mosaic enterovirus 71 in the 2008 outbreak of China. Virus Res 145:157\u2013161","journal-title":"Virus Res"},{"key":"3012_CR7","doi-asserted-by":"publisher","first-page":"e1076","DOI":"10.1016\/j.ijid.2010.07.006","volume":"14","author":"Y Wu","year":"2010","unstructured":"Wu Y, Yeo A, Phoon MC, Tan EL, Poh CL, Quak SH, Chow VT (2010) The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis 14:e1076\u2013e1081","journal-title":"Int J Infect Dis"},{"key":"3012_CR8","doi-asserted-by":"publisher","first-page":"6400","DOI":"10.3390\/v7122947","volume":"7","author":"ZC Zhuang","year":"2015","unstructured":"Zhuang ZC, Kou ZQ, Bai YJ, Cong X, Wang LH, Li C, Zhao L, Yu XJ, Wang ZY, Wen HL (2015) Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China. Viruses 7:6400\u20136411","journal-title":"Viruses"},{"key":"3012_CR9","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1586\/14787210.2015.1058156","volume":"13","author":"L Bian","year":"2015","unstructured":"Bian L, Wang Y, Yao X, Mao Q, Xu M, Liang Z (2015) Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks world wide. Expert Rev Anti Infect Ther. 13:1061\u20131071","journal-title":"Expert Rev Anti Infect Ther."},{"key":"3012_CR10","first-page":"1","volume":"14","author":"QY Mao","year":"2016","unstructured":"Mao QY, Wang Y, Bian L, Xu M, Liang Z (2016) EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD). Expert Rev Vaccines. 14:1\u20138","journal-title":"Expert Rev Vaccines."},{"key":"3012_CR11","doi-asserted-by":"publisher","first-page":"5919","DOI":"10.3390\/v7112916","volume":"7","author":"EA Caine","year":"2015","unstructured":"Caine EA, Fuchs J, Das SC, Partidos CD, Osorio JE (2015) Efficacy of a trivalent hand, foot, and mouth disease vaccine against enterovirus 71 and coxsackieviruses A16 and A6 in mice. Viruses 7:5919\u20135932","journal-title":"Viruses"},{"key":"3012_CR12","first-page":"5","volume":"60","author":"FI Ershov","year":"2015","unstructured":"Ershov FI, Narovlyansky AN (2015) Usage of interferon inducers during viral infections. Vopr Virusol 60:5\u201310","journal-title":"Vopr Virusol"},{"key":"3012_CR13","first-page":"61","volume":"90","author":"AA Shul\u2019diakov","year":"2012","unstructured":"Shul\u2019diakov AA, Barkhatova TS, Satarova SA, Perminova TA (2012) Herpetic infection in patients with psoriasis: the improvement of therapy. Klin Med (Mosk) 90:61\u201363","journal-title":"Klin Med (Mosk)"},{"key":"3012_CR14","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1423-0127-21-14","volume":"21","author":"CW Tan","year":"2014","unstructured":"Tan CW, Lai JK, Sam IC, Chan YF (2014) Recent developments in antiviral agents against enterovirus 71 infection. J Biomed Sci 21:14","journal-title":"J Biomed Sci"},{"key":"3012_CR15","doi-asserted-by":"publisher","first-page":"e739","DOI":"10.1016\/j.ijid.2009.12.002","volume":"14","author":"D Zhang","year":"2010","unstructured":"Zhang D, Lu J, Lu J (2010) Enterovirus 71 vaccine: close but still far. Int J Infect Dis 14:e739\u2013e743","journal-title":"Int J Infect Dis"},{"key":"3012_CR16","first-page":"23","volume":"94","author":"RP Larke","year":"1966","unstructured":"Larke RP (1966) Interferon: a changing picture. Can Med Assoc J. 94:23\u201331","journal-title":"Can Med Assoc J."},{"key":"3012_CR17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.immuni.2006.08.007","volume":"25","author":"DB Stetson","year":"2006","unstructured":"Stetson DB, Medzhitov R (2006) Type I interferons in host defense. Immunity. 25:373\u2013381","journal-title":"Immunity."},{"key":"3012_CR18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nri3133","volume":"12","author":"JM Gonzalez-Navajas","year":"2012","unstructured":"Gonzalez-Navajas JM, Lee J, David M, Raz E (2012) Immunomodulatory functions of type I interferons. Nat Rev Immunol 12:125\u2013135","journal-title":"Nat Rev Immunol"},{"key":"3012_CR19","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nrgastro.2010.101","volume":"7","author":"A Aghemo","year":"2010","unstructured":"Aghemo A, Rumi MG, Colombo M (2010) Pegylated interferons alpha2a and alpha2b in the treatment of chronic hepatitis C. Nature reviews Gastroenterology & hepatology. 7:485\u2013494","journal-title":"Nature reviews Gastroenterology & hepatology."},{"key":"3012_CR20","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1046\/j.1365-2893.2003.00487.x","volume":"11","author":"D Lavanchy","year":"2014","unstructured":"Lavanchy D (2014) Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral hepatit 11:97\u2013107","journal-title":"J Viral hepatit"},{"key":"3012_CR21","doi-asserted-by":"publisher","first-page":"580968","DOI":"10.1155\/2013\/580968","volume":"2013","author":"A Boasso","year":"2013","unstructured":"Boasso A, Type I (2013) Interferon at the interface of antiviral immunity and immune regulation: the curious case of HIV-1. Scientifica 2013:580968","journal-title":"Scientifica"},{"key":"3012_CR22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pep.2008.04.013","volume":"61","author":"HL Zhao","year":"2008","unstructured":"Zhao HL, Yao XQ, Xue C, Wang Y, Xiong XH, Liu ZM (2008) Increasing the homogeneity, stability and activity of human serum albumin and interferon-alpha2b fusion protein by linker engineering. Protein Express Purific 61:73\u201377","journal-title":"Protein Express Purific"},{"key":"3012_CR23","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/imm.12206","volume":"141","author":"CD Russell","year":"2014","unstructured":"Russell CD, Schwarze J (2014) The role of pro-resolution lipid mediators in infectious disease. Immunology 141:166\u2013173","journal-title":"Immunology"},{"key":"3012_CR24","first-page":"1213","volume":"30","author":"M Khademian","year":"2014","unstructured":"Khademian M, Farhangpajouh N, Shahsanaee A, Bahreynian M, Mirshamsi M, Kelishadi R (2014) Effects of zinc supplementation on subscales of anorexia in children: a randomized controlled trial. Pak J Med Sci 30:1213\u20131217","journal-title":"Pak J Med Sci"},{"key":"3012_CR25","doi-asserted-by":"publisher","first-page":"6400","DOI":"10.3390\/v7122947","volume":"7","author":"ZC Zhuang","year":"2015","unstructured":"Zhuang ZC, Kou ZQ, Bai YJ, Cong X, Wang LH, Li C, Zhao L, Yu XJ, Wang ZY, Wen HL (2015) Epidemiological research on hand, foot, and mouth disease in Mainland China. Viruses 7:6400\u20136411","journal-title":"Viruses"},{"key":"3012_CR26","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1093\/jpids\/pit017","volume":"2","author":"S Gantt","year":"2013","unstructured":"Gantt S, Yao L, Kollmann TR, Casper C, Zhang J, Self SG (2013) Implications of Age-Dependent Immune Responses to Enterovirus 71 Infection for Disease Pathogenesis and Vaccine Design. J Pediatric Infect Dis Soc 2:162\u2013170","journal-title":"J Pediatric Infect Dis Soc"},{"key":"3012_CR27","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1159\/000334619","volume":"21","author":"H Tian","year":"2012","unstructured":"Tian H, Yang QZ, Liang J, Dong SY, Liu ZJ, Wang LX (2012) Clinical features and management outcomes of severe hand, foot and mouth disease. Med Princ Pract 21:355\u2013359","journal-title":"Med Princ Pract"},{"key":"3012_CR28","first-page":"349","volume":"24","author":"Q Zhu","year":"2011","unstructured":"Zhu Q, Hao Y, Ma J, Yu S, Wang Y (2011) Surveillance of hand, foot, and mouth disease in mainland China (2008\u20132009). Biomed Environ Sci 24:349\u2013356","journal-title":"Biomed Environ Sci"},{"key":"3012_CR29","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3109\/00365548.2014.907929","volume":"46","author":"Y Fang","year":"2014","unstructured":"Fang Y, Wang S, Zhang L, Guo Z, Huang Z, Tu C, Zhu BP (2014) Risk factors of severe hand, foot and mouth disease: a meta-analysis. Scand J Infect Dis 46:515\u2013522","journal-title":"Scand J Infect Dis"},{"key":"3012_CR30","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s00234-011-0979-3","volume":"54","author":"H Zeng","year":"2012","unstructured":"Zeng H, Wen F, Gan Y, Huang W (2012) MRI and associated clinical characteristics of EV71-induced brainstem encephalitis in children with hand-foot-mouth disease. J Neuroradiol 54:623\u2013630","journal-title":"J Neuroradiol"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-016-3012-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00705-016-3012-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-016-3012-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T16:36:46Z","timestamp":1659112606000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00705-016-3012-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,12]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["3012"],"URL":"https:\/\/doi.org\/10.1007\/s00705-016-3012-7","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,12]]},"assertion":[{"value":"16 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"We declare there is no financial and personal conflict of interest with other people or any organizations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}