{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:38:46Z","timestamp":1790253526108,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["57.3767\/2008-4"],"award-info":[{"award-number":["57.3767\/2008-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (BR)","award":["110.034\/2014 CONICET"],"award-info":[{"award-number":["110.034\/2014 CONICET"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00705-017-3261-0","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T07:19:52Z","timestamp":1487315992000},"page":"1577-1587","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus"],"prefix":"10.1007","volume":"162","author":[{"given":"Raquel","family":"Amorim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Dami\u00e3o Ferreira","family":"de Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Cesar","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"da Silva Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio Ayres","family":"Caldas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Cesar","family":"Cirne-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vin\u00edcius Palmeira","family":"de Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Mendon\u00e7a Teles","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Carla","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabel Christina Nunes","family":"de Palmer Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata de Mendon\u00e7a","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid E.","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Malirat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Maria Rolim","family":"Bernardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moacyr Alcoforado","family":"Rebello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis Fernandes","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"3261_CR1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0220-2015","author":"CB Marcondes","year":"2015","unstructured":"Marcondes CB, Ximenes MF (2015) Zika virus in Brazil and the danger of infestation by Aedes (Stegomyia) mosquitoes. Rev Soc Bras Med Trop. doi: 10.1590\/0037-8682-0220-2015","journal-title":"Rev Soc Bras Med Trop"},{"issue":"6","key":"3261_CR2","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1590\/0037-8682-0246-2014","volume":"47","author":"ML Figueiredo","year":"2014","unstructured":"Figueiredo ML, Figueiredo LT (2014) Emerging alphaviruses in the Americas: Chikungunya and Mayaro. Rev Soc Bras Med Trop 47(6):677\u2013683. doi: 10.1590\/0037-8682-0246-2014","journal-title":"Rev Soc Bras Med Trop"},{"issue":"1","key":"3261_CR3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1086\/515070","volume":"28","author":"RB Tesh","year":"1999","unstructured":"Tesh RB, Watts DM, Russell KL, Damodaran C, Calampa C, Cabezas C, Ramirez G, Vasquez B, Hayes CG, Rossi CA, Powers AM, Hice CL, Chandler LJ, Cropp BC, Karabatsos N, Roehrig JT, Gubler DJ (1999) Mayaro virus disease: an emerging mosquito-borne zoonosis in tropical South America. Clin Infect Dis 28(1):67\u201373. doi: 10.1086\/515070","journal-title":"Clin Infect Dis"},{"issue":"4","key":"3261_CR4","doi-asserted-by":"publisher","first-page":"750","DOI":"10.4269\/ajtmh.2011.11-0359","volume":"85","author":"KC Long","year":"2011","unstructured":"Long KC, Ziegler SA, Thangamani S, Hausser NL, Kochel TJ, Higgs S, Tesh RB (2011) Experimental transmission of Mayaro virus by Aedes aegypti. Am J Trop Med Hyg 85(4):750\u2013757. doi: 10.4269\/ajtmh.2011.11-0359","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"3261_CR5","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1089\/vbz.2016.1952","volume":"16","author":"PF Vasconcelos","year":"2016","unstructured":"Vasconcelos PF, Calisher CH (2016) Emergence of human arboviral diseases in the Americas, 2000\u20132016. Vector Borne Zoonotic Dis 16(5):295\u2013301. doi: 10.1089\/vbz.2016.1952","journal-title":"Vector Borne Zoonotic Dis"},{"key":"3261_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.actatropica.2015.03.020","volume":"147","author":"CJ Vieira","year":"2015","unstructured":"Vieira CJ, Silva DJ, Barreto ES, Siqueira CE, Colombo TE, Ozanic K, Schmidt DJ, Drumond BP, Mondini A, Nogueira ML, Bronzoni RV (2015) Detection of Mayaro virus infections during a dengue outbreak in Mato Grosso, Brazil. Acta Trop 147:12\u201316. doi: 10.1016\/j.actatropica.2015.03.020","journal-title":"Acta Trop"},{"issue":"4","key":"3261_CR7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1099\/0022-1317-49-4-313","volume":"49","author":"DF Ferreira","year":"2000","unstructured":"Ferreira DF, Santo MP, Rebello MA, Rebello MC (2000) Weak bases affect late stages of Mayaro virus replication cycle in vertebrate cells. J Med Microbiol 49(4):313\u2013318","journal-title":"J Med Microbiol"},{"issue":"6","key":"3261_CR8","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000050069","volume":"44","author":"FM Burlandy","year":"2001","unstructured":"Burlandy FM, Rebello MA (2001) Inhibition of Mayaro virus replication by prostaglandin A(1) in Vero cells. Intervirology 44(6):344\u2013349 (pii: int44344)","journal-title":"Intervirology"},{"issue":"6","key":"3261_CR9","first-page":"357","volume":"43","author":"LJ Costa Da","year":"1999","unstructured":"Da Costa LJ, Rebello MA (1999) Effect of brefeldin A on Mayaro virus replication in Aedes albopictus and Vero cells. Acta Virol 43(6):357\u2013360","journal-title":"Acta Virol"},{"issue":"2","key":"3261_CR10","first-page":"113","volume":"47","author":"RM Campos De","year":"2003","unstructured":"De Campos RM, Ferreira DF, Da Veiga VF, Rebello MA, Rebello MC (2003) Effect of monensin on Mayaro virus replication in monkey kidney and Aedes albopictus cells. Acta Virol 47(2):113\u2013119","journal-title":"Acta Virol"},{"issue":"16","key":"3261_CR11","doi-asserted-by":"publisher","first-page":"5765","DOI":"10.1016\/j.bmc.2006.03.013","volume":"14","author":"AM Bernardino","year":"2006","unstructured":"Bernardino AM, da Silva Pinheiro LC, Rodrigues CR, Loureiro NI, Castro HC, Lanfredi-Rangel A, Sabatini-Lopes J, Borges JC, Carvalho JM, Romeiro GA, Ferreira VF, Frugulhetti IC, Vannier-Santos MA (2006) Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives. Bioorg Med Chem 14(16):5765\u20135770. doi: 10.1016\/j.bmc.2006.03.013","journal-title":"Bioorg Med Chem"},{"key":"3261_CR12","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/1756-3305-7-130","volume":"7","author":"AE Santos dos","year":"2014","unstructured":"dos Santos AE, Kuster RM, Yamamoto KA, Salles TS, Campos R, de Meneses MD, Soares MR, Ferreira D (2014) Quercetin and quercetin 3-O-glycosides from Bauhinia longifolia (Bong.) Steud. show anti-Mayaro virus activity. Parasit Vectors 7:130. doi: 10.1186\/1756-3305-7-130","journal-title":"Parasit Vectors"},{"key":"3261_CR13","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1186\/s13071-014-0537-z","volume":"7","author":"KC Spindola","year":"2014","unstructured":"Spindola KC, Simas NK, Salles TS, de Meneses MD, Sato A, Ferreira D, Romao W, Kuster RM (2014) Anti-Mayaro virus activity of Cassia australis extracts (Fabaceae, Leguminosae). Parasit Vectors 7:537. doi: 10.1186\/s13071-014-0537-z","journal-title":"Parasit Vectors"},{"issue":"24","key":"3261_CR14","doi-asserted-by":"publisher","first-page":"7216","DOI":"10.1016\/j.bmcl.2010.10.105","volume":"20","author":"L Zhao","year":"2010","unstructured":"Zhao L, Zhang Y, Dai C, Guzi T, Wiswell D, Seghezzi W, Parry D, Fischmann T, Siddiqui MA (2010) Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors. Bioorg Med Chem Lett 20(24):7216\u20137221. doi: 10.1016\/j.bmcl.2010.10.105","journal-title":"Bioorg Med Chem Lett"},{"issue":"8","key":"3261_CR15","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1016\/j.bmc.2011.03.021","volume":"19","author":"I Pevet","year":"2011","unstructured":"Pevet I, Brul\u00e9 C, Tizot A, Gohier A, Cruzalegui F, Boutin JA, Goldstein S (2011) Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors. Bioorg Med Chem 19(8):2517\u20132528. doi: 10.1016\/j.bmc.2011.03.021","journal-title":"Bioorg Med Chem"},{"issue":"9","key":"3261_CR16","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1016\/j.bmcl.2009.03.069","volume":"19","author":"SA Galal","year":"2009","unstructured":"Galal SA, Abd El-All AS, Abdallah MM, El-Diwani HI (2009) Synthesis of potent antitumor and antiviral benzofuran derivatives. Bioorg Med Chem Lett 19(9):2420\u20132428. doi: 10.1016\/j.bmcl.2009.03.069","journal-title":"Bioorg Med Chem Lett"},{"issue":"2","key":"3261_CR17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.plefa.2004.10.011","volume":"72","author":"A Jakubowski","year":"2005","unstructured":"Jakubowski A, Chlopicki S, Olszanecki R, Jawien J, Lomnicka M, Dupin JP, Gryglewski RJ (2005) Endothelial action of thienopyridines and thienopyrimidinones in the isolated guinea pig heart. Prostaglandins Leukot Essent Fatty Acids 72(2):139\u2013145. doi: 10.1016\/j.plefa.2004.10.011","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"5127","key":"3261_CR18","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1126\/science.7690156","volume":"261","author":"G Karupiah","year":"1993","unstructured":"Karupiah G, Xie QW, Buller RM, Nathan C, Duarte C, MacMicking JD (1993) Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science 261(5127):1445\u20131448","journal-title":"Science"},{"issue":"6","key":"3261_CR19","first-page":"407","volume":"10","author":"AMR Bernardino","year":"2004","unstructured":"Bernardino AMR, Pinheiro LCS, Ferreira VF, Azevedo AR (2004) Synthesis and antiviral activity of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives. Heterocycl Commun 10(6):407\u2013410","journal-title":"Heterocycl Commun"},{"issue":"7","key":"3261_CR20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00044-007-9035-6","volume":"16","author":"AMR Bernardino","year":"2007","unstructured":"Bernardino AMR, de Azevedo AR, Pinheiro LCS, Borges JC, Carvalho VL, Miranda MD, de Meneses MDF, Nascimento M, Ferreira D, Rebello MA (2007) Synthesis and antiviral activity of new 4-(phenylamino)\/4-[(methylpyridin-2-yl) amino]-1-phenyl-1H-pyrazolo [3,4-b]pyridine-4-carboxylic acids derivatives. Med Chem Res 16(7):352\u2013369","journal-title":"Med Chem Res"},{"key":"3261_CR21","doi-asserted-by":"publisher","first-page":"e52065","DOI":"10.3791\/52065","volume":"93","author":"A Baer","year":"2014","unstructured":"Baer A, Kehn-Hall K (2014) Viral concentration determination through plaque assays: using traditional and novel overlay systems. J Vis Exp 93:e52065. doi: 10.3791\/52065","journal-title":"J Vis Exp"},{"issue":"2\u20133","key":"3261_CR22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-4274(85)90046-3","volume":"24","author":"E Borenfreund","year":"1985","unstructured":"Borenfreund E, Puerner JA (1985) Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett 24(2\u20133):119\u2013124","journal-title":"Toxicol Lett"},{"issue":"3","key":"3261_CR23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","volume":"27","author":"LJ Reed","year":"1938","unstructured":"Reed LJ, Muench H (1938) A simple method of estimating fifity per cent endpoints. Am J Epidemiol 27(3):493\u2013497","journal-title":"Am J Epidemiol"},{"issue":"5259","key":"3261_CR24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227(5259):680\u2013685","journal-title":"Nature"},{"issue":"1\u20133","key":"3261_CR25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"CA Lipinski","year":"2001","unstructured":"Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46(1\u20133):3\u201326 (pii: S0169-409X(00)00129-0)","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"3261_CR26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3855\/T2.2.140","volume":"2","author":"R Ravichandran","year":"2008","unstructured":"Ravichandran R, Manian M (2008) Ribavirin therapy for Chikungunya arthritis. J Infect Dev Ctries 2(2):140\u2013142","journal-title":"J Infect Dev Ctries"},{"issue":"7","key":"3261_CR27","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1128\/JVI.63.7.2921-2928.1989","volume":"63","author":"M Elgizoli","year":"1989","unstructured":"Elgizoli M, Dai Y, Kempf C, Koblet H, Michel MR (1989) Semliki Forest virus capsid protein acts as a pleiotropic regulator of host cellular protein synthesis. J Virol 63(7):2921\u20132928","journal-title":"J Virol"},{"issue":"2","key":"3261_CR28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.virol.2013.03.022","volume":"441","author":"RK Patel","year":"2013","unstructured":"Patel RK, Burnham AJ, Gebhart NN, Sokoloski KJ, Hardy RW (2013) Role for subgenomic mRNA in host translation inhibition during Sindbis virus infection of mammalian cells. Virology 441(2):171\u2013181. doi: 10.1016\/j.virol.2013.03.022","journal-title":"Virology"},{"issue":"8","key":"3261_CR29","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1248\/bpb.30.1573","volume":"30","author":"K Kanekiyo","year":"2007","unstructured":"Kanekiyo K, Hayashi K, Takenaka H, Lee JB, Hayashi T (2007) Anti-herpes simplex virus target of an acidic polysaccharide, nostoflan, from the edible blue-green alga Nostoc flagelliforme. Biol Pharm Bull 30(8):1573\u20131575 (pii: JST.JSTAGE\/bpb\/30.1573)","journal-title":"Biol Pharm Bull"},{"issue":"9","key":"3261_CR30","doi-asserted-by":"crossref","first-page":"7349","DOI":"10.1128\/JVI.72.9.7349-7356.1998","volume":"72","author":"AP Byrnes","year":"1998","unstructured":"Byrnes AP, Griffin DE (1998) Binding of Sindbis virus to cell surface heparan sulfate. J Virol 72(9):7349\u20137356","journal-title":"J Virol"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-017-3261-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00705-017-3261-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-017-3261-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T16:11:17Z","timestamp":1601655077000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00705-017-3261-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["3261"],"URL":"https:\/\/doi.org\/10.1007\/s00705-017-3261-0","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]}}}