{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:16:21Z","timestamp":1778710581072,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Guangdong Province Public Welfare Research and Capacity Building Project","award":["2014B020212007"],"award-info":[{"award-number":["2014B020212007"]}]},{"name":"Guangzhou Science and Technology Project","award":["201508020018"],"award-info":[{"award-number":["201508020018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s00705-018-3859-x","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T07:17:06Z","timestamp":1526455026000},"page":"2459-2463","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Development and evaluation of a rapid recombinase polymerase amplification assay for the detection of human enterovirus 71"],"prefix":"10.1007","volume":"163","author":[{"given":"Dan","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"issue":"4","key":"3859_CR1","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/S1473-3099(13)70342-6","volume":"14","author":"W Xing","year":"2014","unstructured":"Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu JT, Chang Z, Liu F, Fang VJ, Zheng Y, Cowling BJ, Varma JK, Farrar JJ, Leung GM, Yu H (2014) Hand, foot, and mouth disease in China, 2008\u201312: an epidemiological study. Lancet Infect Dis 14(4):308\u2013318. \n                    https:\/\/doi.org\/10.1016\/s1473-3099(13)70342-6","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"3859_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.7774\/cevr.2017.6.1.4","volume":"6","author":"EJ Yi","year":"2017","unstructured":"Yi EJ, Shin YJ, Kim JH, Kim TG, Chang SY (2017) Enterovirus 71 infection and vaccines. Clin Exp Vaccine Res 6(1):4\u201314. \n                    https:\/\/doi.org\/10.7774\/cevr.2017.6.1.4","journal-title":"Clin Exp Vaccine Res"},{"key":"3859_CR3","doi-asserted-by":"publisher","unstructured":"Yang B, Liu F, Liao Q, Wu P, Chang Z, Huang J, Long L, Luo L, Li Y, Leung GM, Cowling BJ, Yu H (2017) Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine. Eur Surveill Bull Europeen sur les maladies transmissibles Eur Commun Dis Bull 22(50). \n                    https:\/\/doi.org\/10.2807\/1560-7917.es.2017.22.50.16-00824","DOI":"10.2807\/1560-7917.es.2017.22.50.16-00824"},{"issue":"1","key":"3859_CR4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/infdis\/jiw502","volume":"215","author":"M Wei","year":"2017","unstructured":"Wei M, Meng F, Wang S, Li J, Zhang Y, Mao Q, Hu Y, Liu P, Shi N, Tao H, Chu K, Wang Y, Liang Z, Li X, Zhu F (2017) 2-year efficacy, immunogenicity, and safety of Vigoo Enterovirus 71 vaccine in healthy Chinese children: a randomized open-label study. J Infect Dis 215(1):56\u201363. \n                    https:\/\/doi.org\/10.1093\/infdis\/jiw502","journal-title":"J Infect Dis"},{"key":"3859_CR5","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1743-422X-7-94","volume":"7","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Zhu Z, Yang W, Ren J, Tan X, Wang Y, Mao N, Xu S, Zhu S, Cui A, Zhang Y, Yan D, Li Q, Dong X, Zhang J, Zhao Y, Wan J, Feng Z, Sun J, Wang S, Li D, Xu W (2010) An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China. Virol J 7:94. \n                    https:\/\/doi.org\/10.1186\/1743-422X-7-94","journal-title":"Virol J"},{"issue":"6","key":"3859_CR6","doi-asserted-by":"publisher","first-page":"e11388","DOI":"10.1371\/journal.pone.0011388","volume":"5","author":"F Xu","year":"2010","unstructured":"Xu F, Yan Q, Wang H, Niu J, Li L, Zhu F, He S, Zhang S, Weng Z, Cheng T, Cai Y, He D, Chen Y, Ge S, Yeo AE, Zhang J, Ng MH, Xia N (2010) Performance of detecting IgM antibodies against enterovirus 71 for early diagnosis. PloS One 5(6):e11388. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0011388","journal-title":"PloS One"},{"issue":"3","key":"3859_CR7","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1080\/15321819.2011.559297","volume":"32","author":"Y Lin","year":"2011","unstructured":"Lin Y, Wen K, Pan Y, Wang Y, Che X, Wang B (2011) Cross-reactivity of anti-EV71 IgM and neutralizing antibody in series sera of patients infected with Enterovirus 71 and Coxsackievirus A 16. J Immunoass Immunochem 32(3):233\u2013243. \n                    https:\/\/doi.org\/10.1080\/15321819.2011.559297","journal-title":"J Immunoass Immunochem"},{"issue":"11","key":"3859_CR8","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","volume":"9","author":"MH Ooi","year":"2010","unstructured":"Ooi MH, Wong SC, Lewthwaite P, Cardosa MJ, Solomon T (2010) Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol 9(11):1097\u20131105. \n                    https:\/\/doi.org\/10.1016\/s1474-4422(10)70209-x","journal-title":"Lancet Neurol"},{"issue":"2","key":"3859_CR9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jcv.2008.01.001","volume":"42","author":"EL Tan","year":"2008","unstructured":"Tan EL, Yong LL, Quak SH, Yeo WC, Chow VT, Poh CL (2008) Rapid detection of enterovirus 71 by real-time TaqMan RT-PCR. J Clin Virol Off Publ Pan Am Soc Clin Virol 42(2):203\u2013206. \n                    https:\/\/doi.org\/10.1016\/j.jcv.2008.01.001","journal-title":"J Clin Virol Off Publ Pan Am Soc Clin Virol"},{"issue":"2","key":"3859_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S1386-6532(00)00065-2","volume":"16","author":"BA Brown","year":"2000","unstructured":"Brown BA, Kilpatrick DR, Oberste MS, Pallansch MA (2000) Serotype-specific identification of enterovirus 71 by PCR. J Clin Virol Off Publ Pan Am Soc Clin Virol 16(2):107\u2013112","journal-title":"J Clin Virol Off Publ Pan Am Soc Clin Virol"},{"key":"3859_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2334-4-11","volume":"4","author":"D Perera","year":"2004","unstructured":"Perera D, Podin Y, Akin W, Tan CS, Cardosa MJ (2004) Incorrect identification of recent Asian strains of Coxsackievirus A16 as human enterovirus 71: improved primers for the specific detection of human enterovirus 71 by RT PCR. BMC Infect Dis 4:11. \n                    https:\/\/doi.org\/10.1186\/1471-2334-4-11","journal-title":"BMC Infect Dis"},{"key":"3859_CR12","doi-asserted-by":"publisher","unstructured":"Boyle DS, Lehman DA, Lillis L, Peterson D, Singhal M, Armes N, Parker M, Piepenburg O, Overbaugh J (2013) Rapid detection of HIV-1 proviral DNA for early infant diagnosis using recombinase polymerase amplification. mBio 4(2). \n                    https:\/\/doi.org\/10.1128\/mbio.00135-13","DOI":"10.1128\/mbio.00135-13"},{"issue":"3","key":"3859_CR13","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1128\/JCM.02648-14","volume":"53","author":"BT Teoh","year":"2015","unstructured":"Teoh BT, Sam SS, Tan KK, Danlami MB, Shu MH, Johari J, Hooi PS, Brooks D, Piepenburg O, Nentwich O, Wilder-Smith A, Franco L, Tenorio A, AbuBakar S (2015) Early detection of dengue virus by use of reverse transcription-recombinase polymerase amplification. J Clin Microbiol 53(3):830\u2013837. \n                    https:\/\/doi.org\/10.1128\/JCM.02648-14","journal-title":"J Clin Microbiol"},{"key":"3859_CR14","doi-asserted-by":"publisher","first-page":"40244","DOI":"10.1038\/srep40244","volume":"7","author":"MD Moore","year":"2017","unstructured":"Moore MD, Jaykus LA (2017) Development of a recombinase polymerase amplification assay for detection of epidemic human noroviruses. Sci Rep 7:40244. \n                    https:\/\/doi.org\/10.1038\/srep40244","journal-title":"Sci Rep"},{"issue":"4","key":"3859_CR15","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jcv.2009.02.002","volume":"44","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Tan XJ, Wang HY, Yan DM, Zhu SL, Wang DY, Ji F, Wang XJ, Gao YJ, Chen L, An HQ, Li DX, Wang SW, Xu AQ, Wang ZJ, Xu WB (2009) An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol Off Publ Pan Am Soc Clin Virol 44(4):262\u2013267. \n                    https:\/\/doi.org\/10.1016\/j.jcv.2009.02.002","journal-title":"J Clin Virol Off Publ Pan Am Soc Clin Virol"},{"issue":"1","key":"3859_CR16","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s00705-016-3100-8","volume":"162","author":"K Wang","year":"2017","unstructured":"Wang K, Wu Y, Yin D, Tang S, Hu G, He Y (2017) Development and evaluation of a rapid recombinase polymerase amplification assay for detection of coxsackievirus A6. Arch Virol 162(1):287\u2013290. \n                    https:\/\/doi.org\/10.1007\/s00705-016-3100-8","journal-title":"Arch Virol"},{"key":"3859_CR17","unstructured":"Hand foot and mouth disease prevention and control guide (2009 Edition). \n                    http:\/\/www.chinacdc.cn\/jkzt\/crb\/szkb\/jszl_2275\/200906\/t20090612_24707.htm\n                    \n                  ."},{"issue":"2","key":"3859_CR18","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jviromet.2011.05.020","volume":"175","author":"K Nie","year":"2011","unstructured":"Nie K, Zhang Y, Luo L, Yang M-J, Hu X-M, Wang M, Zhu S-L, Han F, Xu W-B, Ma X-J (2011) Visual detection of human enterovirus 71 subgenotype C4 and Coxsackievirus A16 by reverse transcription loop-mediated isothermal amplification with the hydroxynaphthol blue dye. J Virol Methods 175(2):283\u2013286. \n                    https:\/\/doi.org\/10.1016\/j.jviromet.2011.05.020","journal-title":"J Virol Methods"},{"issue":"2","key":"3859_CR19","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.jviromet.2011.11.019","volume":"179","author":"X Wang","year":"2012","unstructured":"Wang X, Zhu JP, Zhang Q, Xu ZG, Zhang F, Zhao ZH, Zheng WZ, Zheng LS (2012) Detection of enterovirus 71 using reverse transcription loop-mediated isothermal amplification (RT-LAMP). J Virol Methods 179(2):330\u2013334. \n                    https:\/\/doi.org\/10.1016\/j.jviromet.2011.11.019","journal-title":"J Virol Methods"},{"issue":"3","key":"3859_CR20","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.diagmicrobio.2011.07.014","volume":"71","author":"JF Xia","year":"2011","unstructured":"Xia JF, Yan XF, Yu H, Qu D, Long JE (2011) Simple and rapid detection of human enterovirus 71 by reverse-transcription and loop-mediated isothermal amplification: cryopreservation affected the detection ability. Diagn Microbiol Infect Dis 71(3):244\u2013251. \n                    https:\/\/doi.org\/10.1016\/j.diagmicrobio.2011.07.014","journal-title":"Diagn Microbiol Infect Dis"},{"key":"3859_CR21","doi-asserted-by":"publisher","unstructured":"Faye O, Faye O, Soropogui B, Patel P, El Wahed AA, Loucoubar C, Fall G, Kiory D, Magassouba N, Keita S, Konde MK, Diallo AA, Koivogui L, Karlberg H, Mirazimi A, Nentwich O, Piepenburg O, Niedrig M, Weidmann M, Sall AA (2015) Development and deployment of a rapid recombinase polymerase amplification Ebola virus detection assay in Guinea in 2015. Eur Surveill Bull Europeen sur les maladies transmissibles Eur Commun Dis Bull 20(44). \n                    https:\/\/doi.org\/10.2807\/1560-7917.es.2015.20.44.30053","DOI":"10.2807\/1560-7917.es.2015.20.44.30053"},{"issue":"4","key":"3859_CR22","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s00705-015-2357-7","volume":"160","author":"X Xia","year":"2015","unstructured":"Xia X, Yu Y, Hu L, Weidmann M, Pan Y, Yan S, Wang Y (2015) Rapid detection of infectious hypodermal and hematopoietic necrosis virus (IHHNV) by real-time, isothermal recombinase polymerase amplification assay. Arch Virol 160(4):987\u2013994. \n                    https:\/\/doi.org\/10.1007\/s00705-015-2357-7","journal-title":"Arch Virol"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00705-018-3859-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-018-3859-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-018-3859-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T21:28:32Z","timestamp":1557955712000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00705-018-3859-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,16]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["3859"],"URL":"https:\/\/doi.org\/10.1007\/s00705-018-3859-x","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,16]]},"assertion":[{"value":"13 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of the Nanfang Hospital, Southern Medical University, Guangzhou, China.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}