{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:50:22Z","timestamp":1783525822521,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Key Research and Development Programs of China","award":["2017YFC1200201"],"award-info":[{"award-number":["2017YFC1200201"]}]},{"name":"Jiangsu Provincial Key Research and Development Projects","award":["BE2017693"],"award-info":[{"award-number":["BE2017693"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31402211"],"award-info":[{"award-number":["31402211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Professional Research Foundation for Advanced Talents of Jiangsu University","award":["12JDG085"],"award-info":[{"award-number":["12JDG085"]}]},{"name":"Professional Research Foundation for Advanced Talents of Jiangsu University","award":["13JDG087"],"award-info":[{"award-number":["13JDG087"]}]},{"name":"Postdoctoral Foundation of Jiangsu Province","award":["1302057C"],"award-info":[{"award-number":["1302057C"]}]},{"name":"Postdoctoral Foundation of Jiangsu Province","award":["1302058C"],"award-info":[{"award-number":["1302058C"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s00705-018-3875-x","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T01:08:16Z","timestamp":1526864896000},"page":"2471-2476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Full-length and defective enterovirus G genomes with distinct torovirus protease insertions are highly prevalent on a Chinese pig farm"],"prefix":"10.1007","volume":"163","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingli","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieji","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xutao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Delwart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongling","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"3875_CR1","doi-asserted-by":"publisher","first-page":"e97517","DOI":"10.1371\/journal.pone.0097517","volume":"9","author":"S Anbalagan","year":"2014","unstructured":"Anbalagan S, Hesse RA, Hause BM (2014) First identification and characterization of porcine enterovirus G in the United States. PLoS ONE 9:e97517","journal-title":"PLoS ONE"},{"key":"3875_CR2","doi-asserted-by":"publisher","first-page":"12511","DOI":"10.1128\/JVI.01294-14","volume":"88","author":"YM Baez-Santos","year":"2014","unstructured":"Baez-Santos YM, Mielech AM, Deng X, Baker S, Mesecar AD (2014) Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus. J Virol 88:12511\u201312527","journal-title":"J Virol"},{"key":"3875_CR3","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1002\/pro.5560051107","volume":"5","author":"N Blom","year":"1996","unstructured":"Blom N, Hansen J, Blaas D, Brunak S (1996) Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks. Protein Sci 5:2203\u20132216","journal-title":"Protein Sci"},{"key":"3875_CR4","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.meegid.2011.04.003","volume":"11","author":"A Boros","year":"2011","unstructured":"Boros A, Pankovics P, Reuter G (2011) Characterization of a novel porcine enterovirus in domestic pig in Hungary. Infect Genet Evol 11:1096\u20131102","journal-title":"Infect Genet Evol"},{"key":"3875_CR5","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1099\/vir.0.041335-0","volume":"93","author":"A Boros","year":"2012","unstructured":"Boros A, Pankovics P, Knowles NJ, Reuter G (2012) Natural interspecies recombinant bovine\/porcine enterovirus in sheep. J Gen Virol 93:1941\u20131951","journal-title":"J Gen Virol"},{"key":"3875_CR6","first-page":"489","volume":"163","author":"J Bunke","year":"2018","unstructured":"Bunke J, Receveur K, Oeser AC, Fickenscher H, Zell R, Krumbholz A (2018) High genetic diversity of porcine enterovirus G in Schleswig-Holstein, Germany. Adv Virol 163:489\u2013493","journal-title":"Adv Virol"},{"key":"3875_CR7","doi-asserted-by":"publisher","first-page":"vex024","DOI":"10.1093\/ve\/vex024","volume":"3","author":"N Conceicao-Neto","year":"2017","unstructured":"Conceicao-Neto N, Theuns S, Cui T, Zeller M, Yinda CK, Christiaens I, Heylen E, Van Ranst M, Carpentier S, Nauwynck HJ, Matthijnssens J (2017) Identification of an enterovirus recombinant with a torovirus-like gene insertion during a diarrhea outbreak in fattening pigs. VIRUS Evol 3:vex024","journal-title":"VIRUS Evol"},{"key":"3875_CR8","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1093\/nar\/gkv002","volume":"43","author":"X Deng","year":"2015","unstructured":"Deng X, Naccache SN, Ng T, Federman S, Li L, Chiu CY, Delwart EL (2015) An ensemble strategy that significantly improves de novo assembly of microbial genomes from metagenomic next-generation sequencing data. Nucleic Acids Res 43:e46","journal-title":"Nucleic Acids Res"},{"key":"3875_CR9","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1749-6632.1980.tb27967.x","volume":"354","author":"N Kitamura","year":"1980","unstructured":"Kitamura N, Adler C, Wimmer E (1980) Structure and expression of the picornavirus genome. Ann N Y Acad Sci 354:183\u2013201","journal-title":"Ann N Y Acad Sci"},{"key":"3875_CR10","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1099\/jgv.0.000799","volume":"98","author":"TP Knutson","year":"2017","unstructured":"Knutson TP, Velayudhan BT, Marthaler DG (2017) A porcine enterovirus G associated with enteric disease contains a novel papain-like cysteine protease. J Gen Virol 98:1305\u20131310","journal-title":"J Gen Virol"},{"key":"3875_CR11","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/cmi.2016.40","volume":"13","author":"J Li","year":"2016","unstructured":"Li J, Chai QY, Liu CH (2016) The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions. Cell Mol Immunol 13:560\u2013576","journal-title":"Cell Mol Immunol"},{"key":"3875_CR12","doi-asserted-by":"publisher","first-page":"3757","DOI":"10.2174\/1381612043382657","volume":"10","author":"E Martinez-Salas","year":"2004","unstructured":"Martinez-Salas E, Fernandez-Miragall O (2004) Picornavirus IRES: structure function relationship. Curr Pharm Des 10:3757\u20133767","journal-title":"Curr Pharm Des"},{"key":"3875_CR13","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.virusres.2014.01.025","volume":"194","author":"AM Mielech","year":"2014","unstructured":"Mielech AM, Chen Y, Mesecar AD, Baker SC (2014) Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities. Virus Res 194:184\u2013190","journal-title":"Virus Res"},{"key":"3875_CR14","doi-asserted-by":"publisher","first-page":"e00450","DOI":"10.1128\/JVI.00450-17","volume":"91","author":"P Shang","year":"2017","unstructured":"Shang P, Misra S, Hause B, Fang Y (2017) A naturally occurring recombinant enterovirus expresses a torovirus deubiquitinase. J Virol 91:e00450","journal-title":"J Virol"},{"key":"3875_CR15","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1128\/JVI.79.7.4550-4551.2005","volume":"79","author":"T Sulea","year":"2005","unstructured":"Sulea T, Lindner HA, Purisima EO, Menard R (2005) Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease? J Virol 79:4550\u20134551","journal-title":"J Virol"},{"key":"3875_CR16","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1128\/JVI.06466-11","volume":"86","author":"Z Sun","year":"2012","unstructured":"Sun Z, Li Y, Ransburgh R, Snijder EJ, Fang Y (2012) Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15. J Virol 86:3839\u20133850","journal-title":"J Virol"},{"key":"3875_CR17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1099\/vir.0.061978-0","volume":"95","author":"N Dung Van","year":"2014","unstructured":"Van Dung N, Anh PH, Van Cuong N, Hoa NT, Carrique-Mas J, Hien VB, Campbell J, Baker S, Farrar J, Woolhouse ME, Bryant JE, Simmonds P (2014) Prevalence, genetic diversity and recombination of species G enteroviruses infecting pigs in Vietnam. J Gen Virol 95:549\u2013556","journal-title":"J Gen Virol"},{"key":"3875_CR18","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1242\/jcs.205468","volume":"130","author":"C Villarroya-Beltri","year":"2017","unstructured":"Villarroya-Beltri C, Guerra S, Sanchez-Madrid F (2017) ISGylation - a key to lock the cell gates for preventing the spread of threats. J Cell Sci 130:2961\u20132969","journal-title":"J Cell Sci"},{"key":"3875_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/1743-422X-10-99","volume":"10","author":"S Yang","year":"2013","unstructured":"Yang S, Wang Y, Shen Q, Zhang W, Hua X (2013) Prevalence of porcine enterovirus 9 in pigs in middle and eastern China. Virol J 10:99","journal-title":"Virol J"},{"key":"3875_CR20","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1099\/vir.0.059014-0","volume":"95","author":"X Yang","year":"2014","unstructured":"Yang X, Chen X, Bian G, Tu J, Xing Y, Wang Y, Chen Z (2014) Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease. J Gen Virol 95:614\u2013626","journal-title":"J Gen Virol"},{"issue":"Pt 9","key":"3875_CR21","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1099\/0022-1317-80-9-2299","volume":"80","author":"R Zell","year":"1999","unstructured":"Zell R, Sidigi K, Henke A, Schmidt-Brauns J, Hoey E, Martin S, Stelzner A (1999) Functional features of the bovine enterovirus 5\u2019-non-translated region. J Gen Virol 80(Pt 9):2299\u20132309","journal-title":"J Gen Virol"},{"key":"3875_CR22","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1099\/jgv.0.000911","volume":"98","author":"R Zell","year":"2017","unstructured":"Zell R, Delwart E, Gorbalenya AE, Hovi T, King AMQ, Knowles NJ, Lindberg AM, Pallansch MA, Palmenberg AC, Reuter G, Simmonds P, Skern T, Stanway G, Yamashita T, Ictv Report C (2017) ICTV virus taxonomy profile: picornaviridae. J Gen Virol 98:2421\u20132422","journal-title":"J Gen Virol"},{"key":"3875_CR23","doi-asserted-by":"publisher","first-page":"7008","DOI":"10.1128\/JVI.00711-12","volume":"86","author":"W Zhang","year":"2012","unstructured":"Zhang W, Yang S, Shen Q, Ren L, Shan T, Wei J, Cui L, Hua X (2012) Complete genome sequence of a novel porcine enterovirus strain in China. J Virol 86:7008\u20137009","journal-title":"J Virol"},{"key":"3875_CR24","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1099\/vir.0.069674-0","volume":"95","author":"W Zhang","year":"2014","unstructured":"Zhang W, Li L, Deng X, Kapusinszky B, Pesavento PA, Delwart E (2014) Faecal virome of cats in an animal shelter. J Gen Virol 95:2553\u20132564","journal-title":"J Gen Virol"},{"key":"3875_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.virusres.2008.07.014","volume":"139","author":"J Zoll","year":"2009","unstructured":"Zoll J, Heus HA, van Kuppeveld FJ, Melchers WJ (2009) The structure-function relationship of the enterovirus 3\u2019-UTR. Virus Res 139:209\u2013216","journal-title":"Virus Res"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00705-018-3875-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-018-3875-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-018-3875-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T14:56:37Z","timestamp":1558450597000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00705-018-3875-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,21]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["3875"],"URL":"https:\/\/doi.org\/10.1007\/s00705-018-3875-x","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,21]]},"assertion":[{"value":"25 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research reported here did not involve experimentation with human participants or animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}