{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:52:50Z","timestamp":1757454770525,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00705-021-04992-5","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T19:09:59Z","timestamp":1613243399000},"page":"1125-1131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serological and virological response in patients with hepatitis B virus genotype E treated with entecavir or tenofovir: a prospective study"],"prefix":"10.1007","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8326-4930","authenticated-orcid":false,"given":"Lucio","family":"Boglione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"De Benedetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Lupia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Cusato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Cariti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Di Perri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"4992_CR1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2017.20817","author":"EASL","year":"2017","unstructured":"EASL (2017) EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. https:\/\/doi.org\/10.5152\/tjg.2017.20817","journal-title":"J Hepatol"},{"key":"4992_CR2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3748\/wjg.v13.i1.14","volume":"13","author":"S Schaefer","year":"2007","unstructured":"Schaefer S (2007) Hepatitis B virus taxonomy and hepatitis B virus genotypes. World J Gastroenterol 13:14\u201321. https:\/\/doi.org\/10.3748\/wjg.v13.i1.14","journal-title":"World J Gastroenterol"},{"key":"4992_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1872-034X.2009.00601.x","volume":"40","author":"F Kurbanov","year":"2010","unstructured":"Kurbanov F, Tanaka Y, Mizokami M (2010) Geographical and genetic diversity of the human hepatitis B virus. Hepatol Res 40:14\u201330. https:\/\/doi.org\/10.1111\/j.1872-034X.2009.00601.x","journal-title":"Hepatol Res"},{"key":"4992_CR4","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s12072-008-9112-z","volume":"3","author":"BJ McMahon","year":"2009","unstructured":"McMahon BJ (2009) The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B. Hepatol Int 3:334\u2013342. https:\/\/doi.org\/10.1007\/s12072-008-9112-z","journal-title":"Hepatol Int"},{"key":"4992_CR5","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1053\/jhep.2002.33161","volume":"35","author":"CJ Chu","year":"2002","unstructured":"Chu CJ, Lok ASF (2002) Clinical significance of hepatitis B virus genotypes. Hepatology 35:1274\u20131276. https:\/\/doi.org\/10.1053\/jhep.2002.33161","journal-title":"Hepatology"},{"key":"4992_CR6","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1086\/421502","volume":"190","author":"MN Mulders","year":"2004","unstructured":"Mulders MN, Venard V, Njayou M et al (2004) Low genetic diversity despite hyperendemicity of hepatitis B virus genotype E throughout West Africa. J Infect Dis 190:400\u2013408. https:\/\/doi.org\/10.1086\/421502","journal-title":"J Infect Dis"},{"key":"4992_CR7","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1002\/jmv","volume":"81","author":"A Erhardt","year":"2009","unstructured":"Erhardt A, Gobel T, Ludwig A, Lau GKK (2009) Response to antiviral treatment in patients infected with hepatitis B virus genotypes E\u2013H. J Med Virol 81:1716\u20131720. https:\/\/doi.org\/10.1002\/jmv","journal-title":"J Med Virol"},{"key":"4992_CR8","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4103\/npmj.npmj_59_19","volume":"26","author":"AE Ahmad","year":"2019","unstructured":"Ahmad AE, Bakari AG, Musa BOP et al (2019) Pattern of prevalent hepatitis B virus genotypes in Zaria, Nigeria. Niger Postgrad Med J 26:80\u201386. https:\/\/doi.org\/10.4103\/npmj.npmj_59_19","journal-title":"Niger Postgrad Med J"},{"key":"4992_CR9","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/rmv","volume":"19","author":"IE Andernach","year":"2009","unstructured":"Andernach IE, Hubschen JM, Muller CP (2009) Hepatitis B virus: the genotype E puzzle. Rev Med Virol 19:231\u2013240. https:\/\/doi.org\/10.1002\/rmv","journal-title":"Rev Med Virol"},{"key":"4992_CR10","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1002\/jmv","volume":"86","author":"L Boglione","year":"2014","unstructured":"Boglione L, Cardellino CS, De Nicol\u00f2 A (2014) Different HBsAg decline after 3\u00a0years of therapy with entecavir in patients affected by chronic hepatitis B HBeAg-negative and genotype A, D and E. J Med Virol 86:1845\u20131850. https:\/\/doi.org\/10.1002\/jmv","journal-title":"J Med Virol"},{"key":"4992_CR11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0016-5085(03)00700-5","volume":"125","author":"C Westland","year":"2003","unstructured":"Westland C, Delaney W IV, Yang H et al (2003) Hepatitis B virus genotypes and virologic response in 694 patients in phase III studies of adefovir dipivoxil. Gastroenterology 125:107\u2013116. https:\/\/doi.org\/10.1016\/S0016-5085(03)00700-5","journal-title":"Gastroenterology"},{"key":"4992_CR12","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1002\/hep.25749","volume":"57","author":"P Lampertico","year":"2013","unstructured":"Lampertico P, Vigan\u00f2 M, Cheroni C et al (2013) IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B. Hepatology 57:890\u2013896. https:\/\/doi.org\/10.1002\/hep.25749","journal-title":"Hepatology"},{"key":"4992_CR13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jinf.2014.02.018","volume":"69","author":"L Boglione","year":"2014","unstructured":"Boglione L, Cusato J, Cariti G et al (2014) The E genotype of hepatitis B: clinical and virological characteristics, and response to interferon. J Infect 69:81\u201387. https:\/\/doi.org\/10.1016\/j.jinf.2014.02.018","journal-title":"J Infect"},{"key":"4992_CR14","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/liv.12403","volume":"34","author":"M Martinot-Peignoux","year":"2014","unstructured":"Martinot-Peignoux M, Lapalus M, Asselah T, Marcellin P (2014) HBsAg quantification: useful for monitoring natural history and treatment outcome. Liver Int 34:97\u2013107. https:\/\/doi.org\/10.1111\/liv.12403","journal-title":"Liver Int"},{"key":"4992_CR15","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/liv.12091","volume":"33","author":"L Boglione","year":"2013","unstructured":"Boglione L, D\u2019Avolio A, Cariti G et al (2013) Kinetics and prediction of HBsAg loss during therapy with analogues in patients affected by chronic hepatitis B HBeAg negative and genotype D. Liver Int 33:580\u2013585. https:\/\/doi.org\/10.1111\/liv.12091","journal-title":"Liver Int"},{"key":"4992_CR16","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1111\/apt.14636","volume":"47","author":"L Kuhnhenn","year":"2018","unstructured":"Kuhnhenn L, Jiang B, Kubesch A et al (2018) Impact of HBV genotype and mutations on HBV DNA and qHBsAg levels in patients with HBeAg-negative chronic HBV infection. Aliment Pharmacol Ther 47:1523\u20131535. https:\/\/doi.org\/10.1111\/apt.14636","journal-title":"Aliment Pharmacol Ther"},{"key":"4992_CR17","doi-asserted-by":"publisher","first-page":"e0195045","DOI":"10.1371\/journal.pone.0195045","volume":"13","author":"V Malagnino","year":"2018","unstructured":"Malagnino V, Salpini R, Maffongelli G et al (2018) High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: virological characteristics associated with poor immune clearance. PLoS ONE 13:e0195045. https:\/\/doi.org\/10.1371\/journal.pone.0195045","journal-title":"PLoS ONE"},{"key":"4992_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/hep.21698","volume":"46","author":"AS Lok","year":"2007","unstructured":"Lok AS, Zoulim F, Locarnini S et al (2007) Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management. Hepatology 46:254\u2013265. https:\/\/doi.org\/10.1002\/hep.21698","journal-title":"Hepatology"},{"key":"4992_CR19","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.cld.2007.08.013","volume":"11","author":"C Fournier","year":"2007","unstructured":"Fournier C, Zoulim F (2007) Antiviral therapy of chronic hepatitis B: prevention of drug resistance. Clin Liver Dis 11:869\u2013892","journal-title":"Clin Liver Dis"},{"key":"4992_CR20","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1053\/j.gastro.2008.09.068","volume":"136","author":"S Villet","year":"2009","unstructured":"Villet S, Billioud G, Pichoud C et al (2009) In vitro characterization of viral fitness of therapy-resistant hepatitis B variants. Gastroenterology 136:168-176.e2. https:\/\/doi.org\/10.1053\/j.gastro.2008.09.068","journal-title":"Gastroenterology"},{"key":"4992_CR21","doi-asserted-by":"crossref","unstructured":"Bartholomew MM, Jansen RW, Jeffers LJ et al (1997) Early reports hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation amplified from serum and sequenced through a conserved within the YMDD locus of the HBV polymerase gene in all orthotopic liver transplant. Lancet 349(9044):20\u201322","DOI":"10.1016\/S0140-6736(96)02266-0"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-021-04992-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00705-021-04992-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-021-04992-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T19:15:15Z","timestamp":1615490115000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00705-021-04992-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["4992"],"URL":"https:\/\/doi.org\/10.1007\/s00705-021-04992-5","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"type":"print","value":"0304-8608"},{"type":"electronic","value":"1432-8798"}],"subject":[],"published":{"date-parts":[[2021,2,12]]},"assertion":[{"value":"8 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the local ethics committee as \u201cHBV-Analogues Study\u201d (Prot. N\u00b0002360; 26\/1\/2015) and all included subjects provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval statement"}}]}}