{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:04:36Z","timestamp":1788498276542,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"FAPEMIG Funda\u00e7\u00e3o de Apoio a Pesquisa do Estado de Minas Gerais","award":["CBB \u2013 AUC-00071-15, CBB \u2013 APQ-01670-11"],"award-info":[{"award-number":["CBB \u2013 AUC-00071-15, CBB \u2013 APQ-01670-11"]}]},{"name":"FAPEMIG\/PPSUS Pesquisa Para o Servi\u00e7o \u00danico de Sa\u00fade","award":["CBB \u2013 APQ -04178-17"],"award-info":[{"award-number":["CBB \u2013 APQ -04178-17"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s00705-021-05021-1","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T14:03:22Z","timestamp":1615212202000},"page":"1433-1438","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of kinase inhibitors as potential therapeutics for flavivirus infections"],"prefix":"10.1007","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9272-7095","authenticated-orcid":false,"given":"Hugo J.","family":"Valencia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara C. A. M.","family":"de Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana A.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo C.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik V.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00eddia E. C.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00e2nia P.","family":"Drumond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio A.","family":"Bonjardim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"5021_CR1","unstructured":"MS\/SVS\u2014Minist\u00e9rio da Sa\u00fade\/Secretaria de Vigil\u00e2ncia em Sa\u00fade (2015) Boletim Epidemiol\u00f3gico Reemerg\u00eancia da Febre Amarela Silvestre no Brasil, 2014\/2015: situa\u00e7\u00e3o epidemiol\u00f3gica e a import\u00e2ncia da vacina\u00e7\u00e3o preventiva e da vigil\u00e2ncia intensificada no per\u00edodo sazonal 2015. http:\/\/portalarquivos.saude.gov.br\/images\/pdf\/2015\/outubro\/19\/2015-032---FA-ok.pdf. Accessed 26 Aug 2019"},{"key":"5021_CR2","unstructured":"MS\/SVS\u2014Minist\u00e9rio da Sa\u00fade\/Secretaria de Vigil\u00e2ncia em Sa\u00fade (2015) Boletim Epidemiol\u00f3gico Monitoramento dos casos de dengue, febre de chikungunya e febre pelo v\u00edrus Zika at\u00e9 a Semana Epidemiol\u00f3gica 52, 2015. http:\/\/portalarquivos.saude.gov.br\/images\/pdf\/2016\/janeiro\/15\/svs2016-be003-dengue-se52.pdf. Accessed 26 Aug 2019"},{"key":"5021_CR3","unstructured":"MS\/SVS\u2014Minist\u00e9rio da Sa\u00fade\/Secretaria de Vigil\u00e2ncia em Sa\u00fade (2016) Boletim Epidemiol\u00f3gico Monitoramento dos casos de dengue, febre de chikungunya e febre pelo v\u00edrus Zika at\u00e9 a Semana Epidemiol\u00f3gica 52, 2016. http:\/\/portalarquivos.saude.gov.br\/images\/pdf\/2017\/abril\/06\/2017-002-Monitoramento-dos-casos-de-dengue\u2014febre-de-chikungunya-e-febre-pelo-v--rus-Zika-ate-a-Semana-Epidemiologica-52--2016.pdf. Accessed 26 Aug 2019"},{"key":"5021_CR4","unstructured":"MS\/SVS\u2014Minist\u00e9rio da Sa\u00fade\/Secretaria de Vigil\u00e2ncia em Sa\u00fade (2017) Boletim Epidemiol\u00f3gico Monitoramento integrado de altera\u00e7\u00f5es no crescimento e desenvolvimento relacionadas \u00e0 infec\u00e7\u00e3o pelo v\u00edrus Zika e outras etiologias infecciosas, da Semana Epidemiol\u00f3gica 45\/2015 at\u00e9 a Semana Epidemiol\u00f3gica 02\/2017. http:\/\/portalarquivos.saude.gov.br\/images\/pdf\/2017\/fevereiro\/27\/2017_003.pdf. Accessed 26 Aug 2019"},{"key":"5021_CR5","unstructured":"MS\/SVS\u2014Minist\u00e9rio da Sa\u00fade\/Secretaria de Vigil\u00e2ncia em Sa\u00fade (2017) Boletim Epidemiol\u00f3gico Emerg\u00eancia epidemiol\u00f3gica de febre amarela no Brasil, no per\u00edodo de dezembro de 2016 a julho de 2017. https:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2017\/setembro\/06\/2017_027.pdf. Accessed 26 Aug 2019"},{"key":"5021_CR6","unstructured":"MS\/SVS\u2014Minist\u00e9rio da Sa\u00fade\/Secretaria de Vigil\u00e2ncia em Sa\u00fade (2017) Boletim Epidemiol\u00f3gico Monitoramento dos casos de dengue, febre de chikungunya e febre pelo v\u00edrus Zika at\u00e9 a Semana Epidemiol\u00f3gica 52, 2017. https:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2018\/janeiro\/23\/Boletim-2018-001-Dengue.pdf. Accessed 26 Aug 2019"},{"key":"5021_CR7","unstructured":"MS\/SVS\u2014Minist\u00e9rio da Sa\u00fade\/Secretaria de Vigil\u00e2ncia em Sa\u00fade (2018) Boletim Epidemiol\u00f3gico Monitoramento integrado de altera\u00e7\u00f5es no crescimento e desenvolvimento relacionadas \u00e0 infec\u00e7\u00e3o pelo v\u00edrus Zika e outras etiologias infecciosas, at\u00e9 a Semana Epidemiol\u00f3gica 45 de 2018. https:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2018\/dezembro\/14\/2018-061.pdf. Accessed 26 Aug 2019"},{"key":"5021_CR8","unstructured":"MS\/SVS\u2014Minist\u00e9rio da Sa\u00fade\/Secretaria de Vigil\u00e2ncia em Sa\u00fade (2018) Boletim Epidemiol\u00f3gico Monitoramento dos casos de dengue, febre de chikungunya e doen\u00e7a aguda pelo v\u00edrus Zika at\u00e9 a Semana Epidemiol\u00f3gica 48 de 2018. https:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2018\/dezembro\/18\/2018-064.pdf. Accessed 26 Aug 2019"},{"key":"5021_CR9","unstructured":"MS\/SVS\u2014Minist\u00e9rio da Sa\u00fade\/Secretaria de Vigil\u00e2ncia em Sa\u00fade (2019) Boletim Epidemiol\u00f3gico Monitoramento dos casos de arboviroses urbanas transmitidas pelo Aedes (dengue, chikungunya e Zika) at\u00e9 a Semana Epidemiol\u00f3gica 12 de 2019 e Levantamento R\u00e1pido de \u00cdndices para Aedes aegypti (LIRAa). https:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2019\/abril\/30\/2019-013-Monitoramento-dos-casos-de-arboviroses-urbanas-transmitidas-pelo-Aedes-publicacao.pdf. Accessed 26 Aug 2019"},{"key":"5021_CR10","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3389\/fcimb.2017.00486","volume":"7","author":"R Mittal","year":"2017","unstructured":"Mittal R, Nguyen D, Debs LH, Patel AP, Liu G, Jhaveri VM, Kay S-I, Mittal J, Bandstra ES, Younis RT, Chapagain P, Jayaweera DT, Liu XZ (2017) Zika virus: an emerging global health threat. Front Cell Infect Microbiol 7:486","journal-title":"Front Cell Infect Microbiol"},{"key":"5021_CR11","first-page":"121","volume":"1287","author":"MT Brown","year":"1996","unstructured":"Brown MT, Cooper JA (1996) Regulation, substrates and functions of src. Biochim Biophys Acta 1287:121\u2013149","journal-title":"Biochim Biophys Acta"},{"key":"5021_CR12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.virol.2016.12.011","volume":"507","author":"CA Bonjardim","year":"2017","unstructured":"Bonjardim CA (2017) Viral exploitation of the MEK\/ERK pathway\u2014a tale of vaccinia virus and other viruses. Virology 507:267\u2013275","journal-title":"Virology"},{"key":"5021_CR13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.5501\/wjv.v2.i2.71","volume":"2","author":"MA Pagano","year":"2013","unstructured":"Pagano MA, Tibaldi E, Pal\u00f9 G, Brunati AM (2013) Viral proteins and Src family kinases: mechanisms of pathogenicity from a \u201cliaison dangereuse.\u201d World J Virol 2:71\u201378","journal-title":"World J Virol"},{"key":"5021_CR14","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1089\/adt.2010.0321","volume":"8","author":"D Shum","year":"2010","unstructured":"Shum D, Smith JL, Hirsch AJ, Bhinder B, Radu C, Stein DA, Nelson JA, Fr\u00fch K, Djaballah H (2010) High-content assay to identify inhibitors of dengue virus infection. Assay Drug Dev Technol 8:553\u2013570","journal-title":"Assay Drug Dev Technol"},{"key":"5021_CR15","doi-asserted-by":"publisher","first-page":"3520","DOI":"10.1073\/pnas.0611681104","volume":"104","author":"JJH Chu","year":"2007","unstructured":"Chu JJH, Yang PL (2007) c-Src protein kinase inhibitors block assembly and maturation of dengue virus. Proc Natl Acad Sci USA 104:3520\u20133525","journal-title":"Proc Natl Acad Sci USA"},{"key":"5021_CR16","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00705-020-04524-7","volume":"165","author":"LC Oliveira","year":"2020","unstructured":"Oliveira LC, Ribeiro AM, Albarnaz JD, Torres AA, Guimar\u00e3es LFZ, Pinto AK, Parker S, Doronin K, Brien JD, Buller MR, Bonjardim CA (2020) The small molecule AZD6244 inhibits dengue virus replication in vitro and protects against lethal challenge in a mouse model. Arch Virol 165:671\u2013681","journal-title":"Arch Virol"},{"key":"5021_CR17","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.antiviral.2014.09.004","volume":"111","author":"JD Albarnaz","year":"2014","unstructured":"Albarnaz JD, De OLC, Torres AA, Palhares RM, Casteluber MC, Rodrigues CM, Cardozo PL, De SAMRR, Pacca CC, Ferreira PCP, Kroon EG, Nogueira ML, Bonjardim CA (2014) MEK\/ERK activation plays a decisive role in yellow fever virus replication: implication as an antiviral therapeutic target. Antiviral Res 111:82\u201392","journal-title":"Antiviral Res"},{"key":"5021_CR18","doi-asserted-by":"publisher","first-page":"e0155772","DOI":"10.1371\/journal.pone.0155772","volume":"11","author":"L \u015aliwka","year":"2016","unstructured":"\u015aliwka L, Wiktorska K, Suchocki P, Milczarek M, Mielczarek S, Lubelska K, Cierpia\u0142 T, \u0141yzwa P, Kie\u0142basi\u0144ski P, Jaromin A, Flis A, Chilmonczyk Z (2016) The comparison of MTT and CVS assays for the assessment of anticancer agent interactions. PLoS ONE 11:e0155772","journal-title":"PLoS ONE"},{"key":"5021_CR19","doi-asserted-by":"publisher","first-page":"e0005048","DOI":"10.1371\/journal.pntd.0005048","volume":"10","author":"CL Donald","year":"2016","unstructured":"Donald CL, Brennan B, Cumberworth SL, Rezelj VV, Clark JJ, Cordeiro MT, de Oliveira F, Fran\u00e7a R, Pena LJ, Wilkie GS, Da Silva Filipe A, Davis C, Hughes J, Varjak M, Selinger M, Zuvanov L, Owsianka AM, Patel AH, McLauchlan J, Lindenbach BD, Fall G, Sall AA, Biek R, Rehwinkel J, Schnettler E, Kohl A (2016) Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil. PLoS Negl Trop Dis 10:e0005048","journal-title":"PLoS Negl Trop Dis"},{"key":"5021_CR20","doi-asserted-by":"publisher","first-page":"e104516","DOI":"10.1371\/journal.pone.0104516","volume":"9","author":"LB Figueiredo","year":"2014","unstructured":"Figueiredo LB, Sakamoto T, Leomil Coelho LF, De Oliveira Rocha ES, Gomes Cota MM, Portela Ferreira G, De Oliveira JG, Kroon EG (2014) Dengue virus 2 American-Asian genotype identified during the 2006\/2007 outbreak in Piau\u00ed, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil. PLoS ONE 9:e104516","journal-title":"PLoS ONE"},{"key":"5021_CR21","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3201\/eid1402.070278","volume":"14","author":"LB Figueiredo","year":"2008","unstructured":"Figueiredo LB, Cec\u00edlio AB, Ferreira GP, Drumond BP, De OJG, Bonjardim CA, Ferreira PCP, Kroon EG (2008) Dengue virus 3 genotype 1 associated with dengue fever and dengue hemorrhagic fever, Brazil. Emerg Infect Dis 14:314\u2013316","journal-title":"Emerg Infect Dis"},{"key":"5021_CR22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.biologicals.2005.09.005","volume":"34","author":"RS Marchevsky","year":"2006","unstructured":"Marchevsky RS, da Luz Leal M, Homma A, Coutinho ESF, Camacho LAB, Jabor AV, Galler R, Freire MS (2006) Molecular and phenotypic analysis of a working seed lot of yellow fever virus 17DD vaccine strain produced from the secondary seed lot 102\/84 with an additional passage in chicken embryos. Biologicals 34:191\u2013197","journal-title":"Biologicals"},{"key":"5021_CR23","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1016\/j.bbrc.2017.11.177","volume":"495","author":"T Dochi","year":"2017","unstructured":"Dochi T, Akita A, Kishimoto N, Takamune N, Misumi S (2017) Trametinib suppresses HIV-1 replication by interfering with the disassembly of human immunodeficiency virus type 1 capsid core. Biochem Biophys Res Commun 495:1846\u20131850","journal-title":"Biochem Biophys Res Commun"},{"key":"5021_CR24","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.antiviral.2018.07.006","volume":"157","author":"T Schr\u00e4der","year":"2018","unstructured":"Schr\u00e4der T, Dudek SE, Schreiber A, Ehrhardt C, Planz O, Ludwig S (2018) The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression. Antiviral Res 157:80\u201392","journal-title":"Antiviral Res"},{"key":"5021_CR25","doi-asserted-by":"publisher","first-page":"e1002829","DOI":"10.1371\/journal.ppat.1002829","volume":"8","author":"N Menzel","year":"2012","unstructured":"Menzel N, Fischl W, Hueging K, Bankwitz D, Frentzen A, Haid S, Gentzsch J, Kaderali L, Bartenschlager R, Pietschmann T (2012) MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles. PLoS Pathog 8:e1002829","journal-title":"PLoS Pathog"},{"key":"5021_CR26","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nm.4184","volume":"22","author":"M Xu","year":"2016","unstructured":"Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F, Nguyen HN, Itkin M, Hanna C, Shinn P, Allen C, Michael SG, Simeonov A, Huang W, Christian KM, Goate A, Brennand KJ, Huang R, Xia M, Ming GL, Zheng W, Song H, Tang H (2016) Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med 22:1101\u20131107","journal-title":"Nat Med"},{"key":"5021_CR27","first-page":"23","volume":"39","author":"T Yamaguchi","year":"2011","unstructured":"Yamaguchi T, Kakefuda R, Tajima N, Sowa Y, Sakai T (2011) Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1\/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. Int J Oncol 39:23\u201331","journal-title":"Int J Oncol"},{"key":"5021_CR28","doi-asserted-by":"publisher","first-page":"102571","DOI":"10.1016\/j.autrev.2020.102571","volume":"19","author":"P Fagone","year":"2020","unstructured":"Fagone P, Ciurleo R, Lombardo SD, Iacobello C, Palermo CI, Shoenfeld Y, Bendtzen K, Bramanti P, Nicoletti F (2020) Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies. Autoimmun Rev 19:102571","journal-title":"Autoimmun Rev"},{"key":"5021_CR29","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1056\/NEJMoa1203421","volume":"367","author":"KT Flaherty","year":"2012","unstructured":"Flaherty KT, Robert C, Hersey P, Nathan P, Garbe C, Milhem M, Demidov LV, Hassel JC, Rutkowski P, Mohr P, Dummer R, Trefzer U, Larkin JMG, Utikal J, Dreno B, Nyakas M, Middleton MR, Becker JC, Casey M, Sherman LJ, Wu FS, Ouellet D, Martin AM, Patel K, Schadendorf D (2012) Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 367:107\u2013114","journal-title":"N Engl J Med"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-021-05021-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00705-021-05021-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-021-05021-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:34:43Z","timestamp":1744180483000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00705-021-05021-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["5021"],"URL":"https:\/\/doi.org\/10.1007\/s00705-021-05021-1","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,8]]},"assertion":[{"value":"3 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}