{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:56:12Z","timestamp":1791870972246,"version":"4.3.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Key Technology R&D Program of China","award":["2017ZX10104001"],"award-info":[{"award-number":["2017ZX10104001"]}]},{"name":"National Key Technology R&D Program of China","award":["2018ZX10713002"],"award-info":[{"award-number":["2018ZX10713002"]}]},{"name":"National Key Technology R&D Program of China","award":["2018ZX10711001"],"award-info":[{"award-number":["2018ZX10711001"]}]},{"name":"Natural Science Foundation of Beijing Municipality","award":["L192014"],"award-info":[{"award-number":["L192014"]}]},{"name":"Key Technology Research and Development Program of China","award":["2018ZX10101002-004-006"],"award-info":[{"award-number":["2018ZX10101002-004-006"]}]},{"name":"Key Technology R&D program of China","award":["2018ZX10101002-005-008"],"award-info":[{"award-number":["2018ZX10101002-005-008"]}]},{"name":"Key Technology R&D program of China","award":["2018ZX10101002-001-003"],"award-info":[{"award-number":["2018ZX10101002-001-003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Virol"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s00705-021-05128-5","type":"journal-article","created":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:02:27Z","timestamp":1622937747000},"page":"2225-2234","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Coxsackievirus B4: an underestimated pathogen associated with a hand, foot, and mouth disease outbreak"],"prefix":"10.1007","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0791-0923","authenticated-orcid":false,"given":"Jinbo","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-5437","authenticated-orcid":false,"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowen","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"issue":"9","key":"5128_CR1","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1007\/s00705-019-04306-w","volume":"164","author":"PJ Walker","year":"2019","unstructured":"Walker PJ, Siddell SG, Lefkowitz EJ, Mushegian AR, Dempsey DM, Dutilh BE et al (2019) Changes to virus taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2019). Arch Virol 164(9):2417\u20132429. https:\/\/doi.org\/10.1007\/s00705-019-04306-w","journal-title":"Arch Virol"},{"issue":"10","key":"5128_CR2","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1099\/jgv.0.000911","volume":"98","author":"R Zell","year":"2017","unstructured":"Zell R, Delwart E, Gorbalenya AE, Hovi T, King AMQ, Knowles NJ et al (2017) ICTV virus taxonomy profile: picornaviridae. J Gen Virol 98(10):2421\u20132422. https:\/\/doi.org\/10.1099\/jgv.0.000911","journal-title":"J Gen Virol"},{"key":"5128_CR3","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.virol.2015.06.006","volume":"484","author":"J Sin","year":"2015","unstructured":"Sin J, Mangale V, Thienphrapa W, Gottlieb RA, Feuer R (2015) Recent progress in understanding coxsackievirus replication, dissemination, and pathogenesis. Virology 484:288\u2013304. https:\/\/doi.org\/10.1016\/j.virol.2015.06.006","journal-title":"Virology"},{"key":"5128_CR4","first-page":"1","volume":"223","author":"RL Crowell","year":"1997","unstructured":"Crowell RL, Landau BJ (1997) A short history and introductory background on the coxsackieviruses of group B. Curr Top Microbiol Immunol 223:1\u201311","journal-title":"Curr Top Microbiol Immunol"},{"key":"5128_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205201","author":"G Gonzalez","year":"2019","unstructured":"Gonzalez G, Carr MJ, Kobayashi M, Hanaoka N, Fujimoto T (2019) Enterovirus-associated hand-foot and mouth disease and neurological complications in Japan and the rest of the world. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20205201","journal-title":"Int J Mol Sci"},{"issue":"12","key":"5128_CR6","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1017\/S0950268817001522","volume":"145","author":"M Angez","year":"2017","unstructured":"Angez M, Shaukat S, Zahra R, Alam MM, Sharif S, Khurshid A et al (2017) Characterization of group B coxsackieviruses isolated from non-polio acute flaccid paralysis patients in Pakistan: vital assessment before polio eradication. Epidemiol Infect 145(12):2473\u20132481. https:\/\/doi.org\/10.1017\/S0950268817001522","journal-title":"Epidemiol Infect"},{"key":"5128_CR7","doi-asserted-by":"publisher","DOI":"10.1001\/10.3389\/fmicb.2019.01001","author":"M Wang","year":"2019","unstructured":"Wang M, Li J, Yao M-X, Zhang Y-W, Hu T, Carr MJ et al (2019) Genome analysis of coxsackievirus a4 isolates from hand, foot, and mouth disease cases in Shandong China. Front Microbiol. https:\/\/doi.org\/10.1001\/10.3389\/fmicb.2019.01001","journal-title":"Front Microbiol"},{"issue":"4","key":"5128_CR8","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s00705-015-2340-3","volume":"160","author":"X Tan","year":"2015","unstructured":"Tan X, Li L, Zhang B, Jorba J, Su X, Ji T et al (2015) Molecular epidemiology of coxsackievirus A6 associated with outbreaks of hand, foot, and mouth disease in Tianjin, China, in 2013. Arch Virol 160(4):1097\u20131104. https:\/\/doi.org\/10.1007\/s00705-015-2340-3","journal-title":"Arch Virol"},{"issue":"12","key":"5128_CR9","doi-asserted-by":"publisher","first-page":"e0169021","DOI":"10.1371\/journal.pone.0169021","volume":"11","author":"Q Yang","year":"2016","unstructured":"Yang Q, Zhang Y, Yan D, Zhu S, Wang D, Ji T et al (2016) Two genotypes of coxsackievirus A2 associated with hand, foot, and mouth disease circulating in China since 2008. PLoS ONE 11(12):e0169021. https:\/\/doi.org\/10.1371\/journal.pone.0169021","journal-title":"PLoS ONE"},{"issue":"1","key":"5128_CR10","doi-asserted-by":"publisher","first-page":"e84233","DOI":"10.1371\/journal.pone.0084233","volume":"9","author":"H Tian","year":"2014","unstructured":"Tian H, Zhang Y, Sun Q, Zhu S, Li X, Pan Z et al (2014) Prevalence of multiple enteroviruses associated with hand, foot, and mouth disease in Shijiazhuang City, Hebei province, China: outbreaks of coxsackieviruses a10 and b3. PLoS ONE 9(1):e84233. https:\/\/doi.org\/10.1371\/journal.pone.0084233","journal-title":"PLoS ONE"},{"issue":"1","key":"5128_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/1096-9071(200009)62:1<70::AID-JMV11>3.0.CO;2-R","volume":"62","author":"S Tracy","year":"2000","unstructured":"Tracy S, H\u00f6fling K, Pirruccello S, Lane PH, Reyna SM, Gauntt CJ (2000) Group B coxsackievirus myocarditis and pancreatitis: connection between viral virulence phenotypes in mice. J Med Virol 62(1):70\u201381","journal-title":"J Med Virol"},{"issue":"2","key":"5128_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1089\/vim.2006.19.133","volume":"19","author":"PE Tam","year":"2006","unstructured":"Tam PE (2006) Coxsackievirus myocarditis: interplay between virus and host in the pathogenesis of heart disease. Viral Immunol 19(2):133\u2013146","journal-title":"Viral Immunol"},{"issue":"5","key":"5128_CR13","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1086\/605089","volume":"49","author":"NA Verma","year":"2009","unstructured":"Verma NA, Zheng XT, Harris MU, Cadichon SB, Melin-Aldana H, Khetsuriani N et al (2009) Outbreak of life-threatening coxsackievirus B1 myocarditis in neonates. Clin Infect Dis 49(5):759\u2013763. https:\/\/doi.org\/10.1086\/605089","journal-title":"Clin Infect Dis"},{"issue":"6","key":"5128_CR14","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1128\/jcm.33.6.1628-1631.1995","volume":"33","author":"PN Goldwater","year":"1995","unstructured":"Goldwater PN (1995) Immunoglobulin M capture immunoassay in investigation of coxsackievirus B5 and B6 outbreaks in South Australia. J Clin Microbiol 33(6):1628\u20131631","journal-title":"J Clin Microbiol"},{"issue":"11","key":"5128_CR15","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.3201\/eid1811.120090","volume":"18","author":"Z Tao","year":"2012","unstructured":"Tao Z, Song Y, Li Y, Liu Y, Jiang P, Lin X et al (2012) Coxsackievirus B3, Shandong Province, China, 1990\u20132010. Emerg Infect Dis 18(11):1865\u20131867. https:\/\/doi.org\/10.3201\/eid1811.120090","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"5128_CR16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1186\/s12879-019-4107-z","volume":"19","author":"Z Han","year":"2019","unstructured":"Han Z, Zhang Y, Huang K, Wang J, Tian H, Song Y et al (2019) Two Coxsackievirus B3 outbreaks associated with hand, foot, and mouth disease in China and the evolutionary history worldwide. BMC Infect Dis 19(1):466. https:\/\/doi.org\/10.1186\/s12879-019-4107-z","journal-title":"BMC Infect Dis"},{"key":"5128_CR17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ijid.2014.02.005","volume":"23","author":"N Liu","year":"2014","unstructured":"Liu N, Jia L, Yin J, Wu Z, Wang Z, Li P et al (2014) An outbreak of aseptic meningitis caused by a distinct lineage of coxsackievirus B5 in China. Int J Infect Dis 23:101\u2013104. https:\/\/doi.org\/10.1016\/j.ijid.2014.02.005","journal-title":"Int J Infect Dis"},{"issue":"10","key":"5128_CR18","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1007\/s00705-013-1709-4","volume":"158","author":"H Ma","year":"2013","unstructured":"Ma H, Huang X, Kang K, Li X, Tang X, Ren Y et al (2013) Recombination in human coxsackievirus B5 strains that caused an outbreak of viral encephalitis in Henan, China. Arch Virol 158(10):2169\u20132173. https:\/\/doi.org\/10.1007\/s00705-013-1709-4","journal-title":"Arch Virol"},{"issue":"Pt 7","key":"5128_CR19","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1099\/0022-1317-68-7-1835","volume":"68","author":"O Jenkins","year":"1987","unstructured":"Jenkins O, Booth JD, Minor PD, Almond JW (1987) The complete nucleotide sequence of coxsackievirus B4 and its comparison to other members of the Picornaviridae. J Gen Virol 68(Pt 7):1835\u20131848","journal-title":"J Gen Virol"},{"issue":"12","key":"5128_CR20","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.2105\/AJPH.40.12.1508","volume":"40","author":"G Dalldorf","year":"1950","unstructured":"Dalldorf G (1950) The coxsackie viruses*. Am J Public Health Nations Health 40(12):1508\u20131511","journal-title":"Am J Public Health Nations Health"},{"issue":"6 Pt 1","key":"5128_CR21","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.diabet.2008.05.008","volume":"34","author":"H Ja\u00efdane","year":"2008","unstructured":"Ja\u00efdane H, Hober D (2008) Role of coxsackievirus B4 in the pathogenesis of type 1 diabetes. Diabetes Metab 34(6 Pt 1):537\u2013548. https:\/\/doi.org\/10.1016\/j.diabet.2008.05.008","journal-title":"Diabetes Metab"},{"issue":"3","key":"5128_CR22","doi-asserted-by":"publisher","first-page":"e90379","DOI":"10.1371\/journal.pone.0090379","volume":"9","author":"X Tian","year":"2014","unstructured":"Tian X, Zhang Y, Gu S, Fan Y, Sun Q, Zhang B et al (2014) New coxsackievirus B4 genotype circulating in Inner Mongolia Autonomous Region, China. PLoS ONE 9(3):e90379. https:\/\/doi.org\/10.1371\/journal.pone.0090379","journal-title":"PLoS ONE"},{"issue":"21","key":"5128_CR23","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1056\/NEJM197905243002102","volume":"300","author":"JW Yoon","year":"1979","unstructured":"Yoon JW, Austin M, Onodera T, Notkins AL (1979) Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300(21):1173\u20131179","journal-title":"N Engl J Med"},{"issue":"5","key":"5128_CR24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s12519-018-0189-8","volume":"14","author":"X-W Li","year":"2018","unstructured":"Li X-W, Ni X, Qian S-Y, Wang Q, Jiang R-M, Xu W-B et al (2018) Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition). World J Pediatr 14(5):437\u2013447. https:\/\/doi.org\/10.1007\/s12519-018-0189-8","journal-title":"World J Pediatr"},{"issue":"4","key":"5128_CR25","doi-asserted-by":"publisher","first-page":"e92","DOI":"10.1097\/INF.0000000000000120","volume":"33","author":"T Hubiche","year":"2014","unstructured":"Hubiche T, Schuffenecker I, Boralevi F, L\u00e9aut\u00e9-Labr\u00e8ze C, Bornebusch L, Chiaverini C et al (2014) Dermatological spectrum of hand, foot and mouth disease from classical to generalized exanthema. Pediatr Infect Dis J 33(4):e92\u2013e98. https:\/\/doi.org\/10.1097\/INF.0000000000000120","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"5128_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jcv.2010.06.022","volume":"49","author":"MS Oberste","year":"2010","unstructured":"Oberste MS, Pe\u00f1aranda S, Rogers SL, Henderson E, Nix WA (2010) Comparative evaluation of Taqman real-time PCR and semi-nested VP1 PCR for detection of enteroviruses in clinical specimens. J Clin Virol 49(1):73\u201374. https:\/\/doi.org\/10.1016\/j.jcv.2010.06.022","journal-title":"J Clin Virol"},{"issue":"Pt 1","key":"5128_CR27","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1099\/vir.0.81179-0","volume":"87","author":"MS Oberste","year":"2006","unstructured":"Oberste MS, Maher K, Williams AJ, Dybdahl-Sissoko N, Brown BA, Gookin MS et al (2006) Species-specific RT-PCR amplification of human enteroviruses: a tool for rapid species identification of uncharacterized enteroviruses. J Gen Virol 87(Pt 1):119\u2013128","journal-title":"J Gen Virol"},{"issue":"2","key":"5128_CR28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jcv.2011.03.006","volume":"51","author":"A Kroneman","year":"2011","unstructured":"Kroneman A, Vennema H, Deforche K, Avoort HV, Pe\u00f1aranda S, Oberste MS et al (2011) An automated genotyping tool for enteroviruses and noroviruses. J Clin Virol 51(2):121\u2013125. https:\/\/doi.org\/10.1016\/j.jcv.2011.03.006","journal-title":"J Clin Virol"},{"issue":"5","key":"5128_CR29","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/nar\/gkh340","volume":"32","author":"RC Edgar","year":"2004","unstructured":"Edgar RC (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 32(5):1792\u20131797","journal-title":"Nucleic Acids Res"},{"key":"5128_CR30","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/1471-2105-5-113","volume":"5","author":"RC Edgar","year":"2004","unstructured":"Edgar RC (2004) MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinform 5:113","journal-title":"BMC Bioinform"},{"issue":"9","key":"5128_CR31","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033%JBioinformatics","volume":"30","author":"A Stamatakis","year":"2014","unstructured":"Stamatakis A (2014) RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics 30(9):1312\u20131313. https:\/\/doi.org\/10.1093\/bioinformatics\/btu033%JBioinformatics","journal-title":"Bioinformatics"},{"issue":"24","key":"5128_CR32","doi-asserted-by":"publisher","first-page":"8791","DOI":"10.1073\/pnas.1401884111","volume":"111","author":"EM Goss","year":"2014","unstructured":"Goss EM, Tabima JF, Cooke DEL, Restrepo S, Fry WE, Forbes GA et al (2014) The Irish potato famine pathogen Phytophthora infestans originated in central Mexico rather than the Andes. Proc Natl Acad Sci USA 111(24):8791\u20138796. https:\/\/doi.org\/10.1073\/pnas.1401884111","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"5128_CR33","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","volume":"33","author":"S Kumar","year":"2016","unstructured":"Kumar S, Stecher G, Tamura K (2016) MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol 33(7):1870\u20131874. https:\/\/doi.org\/10.1093\/molbev\/msw054","journal-title":"Mol Biol Evol"},{"issue":"5","key":"5128_CR34","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1128\/JCM.37.5.1288-1293.1999","volume":"37","author":"MS Oberste","year":"1999","unstructured":"Oberste MS, Maher K, Kilpatrick DR, Flemister MR, Brown BA, Pallansch MA (1999) Typing of human enteroviruses by partial sequencing of VP1. J Clin Microbiol 37(5):1288\u20131293","journal-title":"J Clin Microbiol"},{"issue":"3","key":"5128_CR35","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1128\/JVI.73.3.1941-1948.1999","volume":"73","author":"MS Oberste","year":"1999","unstructured":"Oberste MS, Maher K, Kilpatrick DR, Pallansch MA (1999) Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification. J Virol 73(3):1941\u20131948","journal-title":"J Virol"},{"issue":"Pt 3","key":"5128_CR36","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1099\/0022-1317-81-3-803","volume":"81","author":"MN Mulders","year":"2000","unstructured":"Mulders MN, Salminen M, Kalkkinen N, Hovi T (2000) Molecular epidemiology of coxsackievirus B4 and disclosure of the correct VP1\/2A(pro) cleavage site: evidence for high genomic diversity and long-term endemicity of distinct genotypes. J Gen Virol 81(Pt 3):803\u2013812","journal-title":"J Gen Virol"},{"key":"5128_CR37","unstructured":"Hall TA (1999) BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT. Nucl Acids Symp Ser 41(41):95\u201398"},{"issue":"1","key":"5128_CR38","doi-asserted-by":"publisher","first-page":"vey016","DOI":"10.1093\/ve\/vey016","volume":"4","author":"MA Suchard","year":"2018","unstructured":"Suchard MA, Lemey P, Baele G, Ayres DL, Drummond AJ, Rambaut A (2018) Bayesian phylogenetic and phylodynamic data integration using BEAST 110. Virus Evol 4(1):vey016. https:\/\/doi.org\/10.1093\/ve\/vey016","journal-title":"Virus Evol"},{"issue":"8","key":"5128_CR39","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1093\/molbev\/mss075","volume":"29","author":"AJ Drummond","year":"2012","unstructured":"Drummond AJ, Suchard MA, Xie D, Rambaut A (2012) Bayesian phylogenetics with BEAUti and the BEAST 1.7. Mol Biol Evol 29(8):1969\u20131973. https:\/\/doi.org\/10.1093\/molbev\/mss075","journal-title":"Mol Biol Evol"},{"key":"5128_CR40","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/1471-2148-7-214","volume":"7","author":"AJ Drummond","year":"2007","unstructured":"Drummond AJ, Rambaut A (2007) BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol 7:214","journal-title":"BMC Evol Biol"},{"issue":"5","key":"5128_CR41","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1093\/sysbio\/syy032","volume":"67","author":"A Rambaut","year":"2018","unstructured":"Rambaut A, Drummond AJ, Xie D, Baele G, Suchard MA (2018) Posterior summarization in Bayesian phylogenetics using Tracer 1.7. Syst Biol 67(5):901\u2013904. https:\/\/doi.org\/10.1093\/sysbio\/syy032","journal-title":"Syst Biol"},{"issue":"5","key":"5128_CR42","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1093\/molbev\/msi103","volume":"22","author":"AJ Drummond","year":"2005","unstructured":"Drummond AJ, Rambaut A, Shapiro B, Pybus OG (2005) Bayesian coalescent inference of past population dynamics from molecular sequences. Mol Biol Evol 22(5):1185\u20131192","journal-title":"Mol Biol Evol"},{"issue":"1","key":"5128_CR43","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12879-018-3659-7","volume":"19","author":"H Ji","year":"2019","unstructured":"Ji H, Fan H, Lu P-X, Zhang X-F, Ai J, Shi C et al (2019) Surveillance for severe hand, foot, and mouth disease from 2009 to 2015 in Jiangsu province: epidemiology, etiology, and disease burden. BMC Infect Dis 19(1):79. https:\/\/doi.org\/10.1186\/s12879-018-3659-7","journal-title":"BMC Infect Dis"},{"issue":"1","key":"5128_CR44","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1017\/S0950268815001569","volume":"144","author":"ZL Wang","year":"2016","unstructured":"Wang ZL, Xia AM, Li YF, Su HL, Zhan LW, Chen YP et al (2016) Socioeconomic burden of hand, foot and mouth disease in children in Shanghai China. Epidemiol Infect 144(1):138\u2013143. https:\/\/doi.org\/10.1017\/S0950268815001569","journal-title":"Epidemiol Infect"},{"key":"5128_CR45","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz284","author":"LNT Nhan","year":"2019","unstructured":"Nhan LNT, Turner HC, Khanh TH, Hung NT, Lien LB, Hong NTT et al (2019) Economic burden attributed to children presenting to hospitals with hand, foot, and mouth disease in Vietnam. Open Forum Infect Dis. https:\/\/doi.org\/10.1093\/ofid\/ofz284","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"5128_CR46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.bsheal.2019.02.005","volume":"1","author":"T Ji","year":"2019","unstructured":"Ji T, Han T, Tan X, Zhu S, Yan D, Yang Q et al (2019) Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017. Biosaf Health. 1(1):32\u201340. https:\/\/doi.org\/10.1016\/j.bsheal.2019.02.005","journal-title":"Biosaf Health."},{"issue":"2","key":"5128_CR47","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1128\/JCM.02338-09","volume":"48","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Wang D, Yan D, Zhu S, Liu J, Wang H et al (2010) Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China. J Clin Microbiol 48(2):619\u2013622. https:\/\/doi.org\/10.1128\/JCM.02338-09","journal-title":"J Clin Microbiol"},{"issue":"9","key":"5128_CR48","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1586\/14787210.2015.1058156","volume":"13","author":"L Bian","year":"2015","unstructured":"Bian L, Wang Y, Yao X, Mao Q, Xu M, Liang Z (2015) Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide. Expert Rev Anti Infect Ther 13(9):1061\u20131071. https:\/\/doi.org\/10.1586\/14787210.2015.1058156","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"4","key":"5128_CR49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1080\/14787210.2019.1585242","volume":"17","author":"L Bian","year":"2019","unstructured":"Bian L, Gao F, Mao Q, Sun S, Wu X, Liu S et al (2019) Hand, foot, and mouth disease associated with coxsackievirus A10: more serious than it seems. Expert Rev Anti Infect Ther 17(4):233\u2013242. https:\/\/doi.org\/10.1080\/14787210.2019.1585242","journal-title":"Expert Rev Anti Infect Ther"},{"key":"5128_CR50","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1743-422X-7-94","volume":"7","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Zhu Z, Yang W, Ren J, Tan X, Wang Y et al (2010) An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China. Virol J. 7:94. https:\/\/doi.org\/10.1186\/1743-422X-7-94","journal-title":"Virol J."},{"key":"5128_CR51","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.meegid.2013.04.011","volume":"17","author":"DC Rao","year":"2013","unstructured":"Rao DC, Babu MA, Raghavendra A, Dhananjaya D, Kumar S, Maiya PP (2013) Non-polio enteroviruses and their association with acute diarrhea in children in India. Infect Genet Evol 17:153\u2013161. https:\/\/doi.org\/10.1016\/j.meegid.2013.04.011","journal-title":"Infect Genet Evol"}],"container-title":["Archives of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-021-05128-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00705-021-05128-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00705-021-05128-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T13:17:56Z","timestamp":1625836676000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00705-021-05128-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,6]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["5128"],"URL":"https:\/\/doi.org\/10.1007\/s00705-021-05128-5","relation":{},"ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,6]]},"assertion":[{"value":"11 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that no competing interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Review Committee of the National Institute for Viral Diseases Control and Prevention, Chinese Center for Disease Control and Prevention. Written informed consent for the use of clinical samples was obtained from all individuals, including written informed consent from guardians of children.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}